{"id":"https://openalex.org/W4366390682","doi":"https://doi.org/10.1038/s41467-023-37464-2","title":"Disrupting the \u03b1-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson\u2019s disease","display_name":"Disrupting the \u03b1-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson\u2019s disease","publication_year":2023,"publication_date":"2023-04-19","ids":{"openalex":"https://openalex.org/W4366390682","doi":"https://doi.org/10.1038/s41467-023-37464-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/37076542","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10115881"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-023-37464-2","doi":"https://doi.org/10.1038/s41467-023-37464-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-37464-2","pdf_url":"https://www.nature.com/articles/s41467-023-37464-2.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-023-37464-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025922787","display_name":"Satra Nim","orcid":"https://orcid.org/0000-0002-7791-1238","observed_orcids":["https://orcid.org/0000-0002-7791-1238"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4405287053","display_name":"Donnelly Centre for Cellular and Biomolecular Research","ror":"https://ror.org/0400kyd42","country_code":"CA","type":"facility","lineage":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Satra Nim","raw_affiliation_strings":["Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada"],"raw_orcid":"https://orcid.org/0000-0002-7791-1238","affiliations":[{"raw_affiliation_string":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091243638","display_name":"Darren M. O\u2019Hara","orcid":"https://orcid.org/0000-0002-0766-2061","observed_orcids":["https://orcid.org/0000-0002-0766-2061"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]},{"id":"https://openalex.org/I4388446386","display_name":"Krembil Research Institute","ror":"https://ror.org/01f6jys10","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Darren M. O\u2019Hara","raw_affiliation_strings":["Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada"],"raw_orcid":"https://orcid.org/0000-0002-0766-2061","affiliations":[{"raw_affiliation_string":"Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006313881","display_name":"Carles Corbi\u2010Verge","orcid":"https://orcid.org/0000-0002-7654-4405","observed_orcids":["https://orcid.org/0000-0002-7654-4405"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4405287053","display_name":"Donnelly Centre for Cellular and Biomolecular Research","ror":"https://ror.org/0400kyd42","country_code":"CA","type":"facility","lineage":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Carles Corbi-Verge","raw_affiliation_strings":["Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada"],"raw_orcid":"https://orcid.org/0000-0002-7654-4405","affiliations":[{"raw_affiliation_string":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043085718","display_name":"Albert Perez\u2010Riba","orcid":"https://orcid.org/0000-0002-4659-0320","observed_orcids":["https://orcid.org/0000-0002-4659-0320"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4405287053","display_name":"Donnelly Centre for Cellular and Biomolecular Research","ror":"https://ror.org/0400kyd42","country_code":"CA","type":"facility","lineage":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Albert Perez-Riba","raw_affiliation_strings":["Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111642079","display_name":"Kazuko Fujisawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]},{"id":"https://openalex.org/I4388446386","display_name":"Krembil Research Institute","ror":"https://ror.org/01f6jys10","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kazuko Fujisawa","raw_affiliation_strings":["Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074830347","display_name":"Minesh Kapadia","orcid":"https://orcid.org/0000-0003-1380-7551","observed_orcids":["https://orcid.org/0000-0003-1380-7551"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]},{"id":"https://openalex.org/I4388446386","display_name":"Krembil Research Institute","ror":"https://ror.org/01f6jys10","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Minesh Kapadia","raw_affiliation_strings":["Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107903467","display_name":"Hien Chau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]},{"id":"https://openalex.org/I4388446386","display_name":"Krembil Research Institute","ror":"https://ror.org/01f6jys10","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hien Chau","raw_affiliation_strings":["Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000315421","display_name":"Federica Albanese","orcid":"https://orcid.org/0000-0002-1470-5322","observed_orcids":["https://orcid.org/0000-0002-1470-5322"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]},{"id":"https://openalex.org/I4388446386","display_name":"Krembil Research Institute","ror":"https://ror.org/01f6jys10","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Federica Albanese","raw_affiliation_strings":["Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058743156","display_name":"Grishma N. Pawar","orcid":"https://orcid.org/0000-0001-5223-152X","observed_orcids":["https://orcid.org/0000-0001-5223-152X"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]},{"id":"https://openalex.org/I4388446386","display_name":"Krembil Research Institute","ror":"https://ror.org/01f6jys10","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Grishma Pawar","raw_affiliation_strings":["Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066024929","display_name":"Mitchell L. de Snoo","orcid":"https://orcid.org/0000-0002-2057-7419","observed_orcids":["https://orcid.org/0000-0002-2057-7419"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]},{"id":"https://openalex.org/I4388446386","display_name":"Krembil Research Institute","ror":"https://ror.org/01f6jys10","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mitchell L. De Snoo","raw_affiliation_strings":["Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada"],"raw_orcid":"https://orcid.org/0000-0002-2057-7419","affiliations":[{"raw_affiliation_string":"Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065428288","display_name":"Sophie G. Ngana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]},{"id":"https://openalex.org/I4388446386","display_name":"Krembil Research Institute","ror":"https://ror.org/01f6jys10","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sophie G. Ngana","raw_affiliation_strings":["Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320577","display_name":"Ji\u2010Sun Kim","orcid":"https://orcid.org/0000-0002-4863-9773","observed_orcids":["https://orcid.org/0000-0002-4863-9773","https://orcid.org/0000-0002-0489-7682"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4405287053","display_name":"Donnelly Centre for Cellular and Biomolecular Research","ror":"https://ror.org/0400kyd42","country_code":"CA","type":"facility","lineage":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jisun Kim","raw_affiliation_strings":["Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada"],"raw_orcid":"https://orcid.org/0000-0002-4863-9773","affiliations":[{"raw_affiliation_string":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075526096","display_name":"Omar M. A. El\u2010Agnaf","orcid":"https://orcid.org/0000-0002-6850-8084","observed_orcids":["https://orcid.org/0000-0002-6850-8084","https://orcid.org/0000-0003-2509-7200"]},"institutions":[{"id":"https://openalex.org/I4210144839","display_name":"Hamad bin Khalifa University","ror":"https://ror.org/03eyq4y97","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210144839"]},{"id":"https://openalex.org/I92528248","display_name":"Qatar Foundation","ror":"https://ror.org/01cawbq05","country_code":"QA","type":"nonprofit","lineage":["https://openalex.org/I92528248"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Omar M. A. El-Agnaf","raw_affiliation_strings":["Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839","https://openalex.org/I92528248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078849720","display_name":"Enrico Rennella","orcid":"https://orcid.org/0000-0002-2941-7155","observed_orcids":["https://orcid.org/0000-0002-2941-7155"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Enrico Rennella","raw_affiliation_strings":["Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020050875","display_name":"Lewis E. Kay","orcid":"https://orcid.org/0000-0002-4054-4083","observed_orcids":["https://orcid.org/0000-0002-4054-4083"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I4405261154","display_name":"Sickkids Research Institute","ror":"https://ror.org/04wex6338","country_code":"CA","type":"facility","lineage":["https://openalex.org/I2801317318","https://openalex.org/I4405261154"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lewis E. Kay","raw_affiliation_strings":["Department of Biochemistry, University of Toronto, Toronto, ON, Canada","Department of Chemistry, University of Toronto, Toronto, ON, Canada","Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada","Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Chemistry, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada","institution_ids":["https://openalex.org/I2801317318","https://openalex.org/I4405261154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033165479","display_name":"Suneil Kumar Kalia","orcid":"https://orcid.org/0000-0003-2054-1915","observed_orcids":["https://orcid.org/0000-0003-2054-1915"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]},{"id":"https://openalex.org/I4388446386","display_name":"Krembil Research Institute","ror":"https://ror.org/01f6jys10","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Suneil K. Kalia","raw_affiliation_strings":["Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada. suneil.kalia@utoronto.ca","Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. suneil.kalia@utoronto.ca","Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada"],"raw_orcid":"https://orcid.org/0000-0003-2054-1915","affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada. suneil.kalia@utoronto.ca","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. suneil.kalia@utoronto.ca","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]},{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077133037","display_name":"Lorraine V. Kalia","orcid":"https://orcid.org/0000-0002-9384-1305","observed_orcids":["https://orcid.org/0000-0002-9384-1305"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]},{"id":"https://openalex.org/I4388446386","display_name":"Krembil Research Institute","ror":"https://ror.org/01f6jys10","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Lorraine V. Kalia","raw_affiliation_strings":["Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada. lorraine.kalia@utoronto.ca","Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. lorraine.kalia@utoronto.ca","Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada. lorraine.kalia@utoronto.ca","Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada"],"raw_orcid":"https://orcid.org/0000-0002-9384-1305","affiliations":[{"raw_affiliation_string":"Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada. lorraine.kalia@utoronto.ca","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. lorraine.kalia@utoronto.ca","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]},{"raw_affiliation_string":"Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada. lorraine.kalia@utoronto.ca","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043262709","display_name":"Philip M. Kim","orcid":"https://orcid.org/0000-0003-3683-152X","observed_orcids":["https://orcid.org/0000-0003-3683-152X"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4405287053","display_name":"Donnelly Centre for Cellular and Biomolecular Research","ror":"https://ror.org/0400kyd42","country_code":"CA","type":"facility","lineage":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Philip M. Kim","raw_affiliation_strings":["Department of Computer Science, University of Toronto, Toronto, ON, Canada. pi@kimlab.org","Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. pi@kimlab.org","Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada. pi@kimlab.org","Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada"],"raw_orcid":"https://orcid.org/0000-0003-3683-152X","affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Toronto, Toronto, ON, Canada. pi@kimlab.org","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. pi@kimlab.org","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada. pi@kimlab.org","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]},{"raw_affiliation_string":"Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5033165479","https://openalex.org/A5043262709","https://openalex.org/A5077133037"],"corresponding_institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I2799337515","https://openalex.org/I4388446386","https://openalex.org/I4405287053"],"apc_list":{"value":6290,"currency":"USD","value_usd":6290},"apc_paid":{"value":6290,"currency":"USD","value_usd":6290},"fwci":7.9202,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.98405895,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"14","issue":"1","first_page":"2150","last_page":"2150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9200000166893005},{"id":"https://openalex.org/keywords/chmp2b","display_name":"CHMP2B","score":0.8640000224113464},{"id":"https://openalex.org/keywords/escrt-iii","display_name":"ESCRT-III","score":0.996999979019165},{"id":"https://openalex.org/keywords/peptide-inhibitors","display_name":"peptide inhibitors","score":0.6880000233650208},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8190000057220459},{"id":"https://openalex.org/keywords/alpha-synuclein-oligomers","display_name":"alpha-synuclein oligomers","score":0.902999997138977},{"id":"https://openalex.org/keywords/endolysosomal-degradation","display_name":"endolysosomal degradation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/dopaminergic-neuron-degeneration","display_name":"dopaminergic neuron loss","score":0.8759999871253967},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9869999885559082},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.7540000081062317},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C143876685","wikidata":"https://www.wikidata.org/wiki/Q22327705","display_name":"ESCRT","level":4,"score":0.8316372632980347},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.8083382844924927},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.6441466212272644},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5799608826637268},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.5230908393859863},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5202599763870239},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.503145158290863},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5028390288352966},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.45275047421455383},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.4346204102039337},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42801207304000854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41036418080329895},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.30531489849090576},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.23778381943702698},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2213478982448578},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1985607147216797},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.14953911304473877},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09498152136802673},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056827","descriptor_name":"Endosomal Sorting Complexes Required for Transport","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41467-023-37464-2","doi":"https://doi.org/10.1038/s41467-023-37464-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-37464-2","pdf_url":"https://www.nature.com/articles/s41467-023-37464-2.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10115881","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10115881","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10115881/pdf/41467_2023_Article_37464.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:37076542","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37076542","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37464-2","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-023-37464-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:5d9353322078445d81d882610543e049","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5d9353322078445d81d882610543e049","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/26830174","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Disrupting_the_-synuclein-ESCRT_interaction_with_a_peptide_inhibitor_mitigates_neurodegeneration_in_preclinical_models_of_Parkinson_s_disease/26830174","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41467-023-37464-2","doi":"https://doi.org/10.1038/s41467-023-37464-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-37464-2","pdf_url":"https://www.nature.com/articles/s41467-023-37464-2.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1159994504","display_name":null,"funder_award_id":"PJT-159531","funder_id":"https://openalex.org/F4320319880","funder_display_name":"Government of Canada"},{"id":"https://openalex.org/G3944272166","display_name":"An integrated strategy to identify inhibitors of protein-protein interactions as potential therapeutics for Parkinson's disease","funder_award_id":"159531_1","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G4216855879","display_name":null,"funder_award_id":"PJT-153279","funder_id":"https://openalex.org/F4320319880","funder_display_name":"Government of Canada"},{"id":"https://openalex.org/G4889625718","display_name":null,"funder_award_id":"K-1405","funder_id":"https://openalex.org/F4320320021","funder_display_name":"Parkinson's UK"},{"id":"https://openalex.org/G5815818807","display_name":"Molecular mechanisms of neurodegeneration in Parkinson's disease","funder_award_id":"157081_1","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G7947564385","display_name":"A systematic strategy to develop inhibitors of protein-protein interactions as potential therapeutics","funder_award_id":"153279_1","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G8288261441","display_name":null,"funder_award_id":"MC2-157081","funder_id":"https://openalex.org/F4320319880","funder_display_name":"Government of Canada"},{"id":"https://openalex.org/G8643615015","display_name":null,"funder_award_id":"MJFF-001076","funder_id":"https://openalex.org/F4320306136","funder_display_name":"Michael J. Fox Foundation for Parkinson's Research"}],"funders":[{"id":"https://openalex.org/F4320306136","display_name":"Michael J. Fox Foundation for Parkinson's Research","ror":"https://ror.org/03arq3225"},{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320319880","display_name":"Government of Canada","ror":"https://ror.org/010q4q527"},{"id":"https://openalex.org/F4320320021","display_name":"Parkinson's UK","ror":"https://ror.org/02417p338"},{"id":"https://openalex.org/F4320322015","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366390682.pdf","grobid_xml":"https://content.openalex.org/works/W4366390682.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W1482884660","https://openalex.org/W1501858161","https://openalex.org/W1502339857","https://openalex.org/W1527671059","https://openalex.org/W1588992473","https://openalex.org/W1765263728","https://openalex.org/W1944127002","https://openalex.org/W1982702269","https://openalex.org/W1985010554","https://openalex.org/W1989913002","https://openalex.org/W1992515094","https://openalex.org/W1992983658","https://openalex.org/W1993871755","https://openalex.org/W2003516462","https://openalex.org/W2025829713","https://openalex.org/W2031365272","https://openalex.org/W2034183549","https://openalex.org/W2034887565","https://openalex.org/W2038636807","https://openalex.org/W2051821597","https://openalex.org/W2052885679","https://openalex.org/W2053202752","https://openalex.org/W2056587345","https://openalex.org/W2057332675","https://openalex.org/W2073852487","https://openalex.org/W2081320767","https://openalex.org/W2086117912","https://openalex.org/W2114723455","https://openalex.org/W2123431154","https://openalex.org/W2127342428","https://openalex.org/W2127406427","https://openalex.org/W2143604504","https://openalex.org/W2155613422","https://openalex.org/W2157155969","https://openalex.org/W2157826046","https://openalex.org/W2159400623","https://openalex.org/W2259877787","https://openalex.org/W2265477132","https://openalex.org/W2285587551","https://openalex.org/W2292990827","https://openalex.org/W2317462515","https://openalex.org/W2418039970","https://openalex.org/W2470937536","https://openalex.org/W2474991972","https://openalex.org/W2508840882","https://openalex.org/W2511932783","https://openalex.org/W2537916300","https://openalex.org/W2734347586","https://openalex.org/W2754278602","https://openalex.org/W2790505275","https://openalex.org/W2790799100","https://openalex.org/W2794348009","https://openalex.org/W2796239609","https://openalex.org/W2803017118","https://openalex.org/W2901376861","https://openalex.org/W2916149712","https://openalex.org/W2943944967","https://openalex.org/W2963495948","https://openalex.org/W2985101511","https://openalex.org/W2991305035","https://openalex.org/W2998827051","https://openalex.org/W3002184832","https://openalex.org/W3005869420","https://openalex.org/W3016940686","https://openalex.org/W3046672751","https://openalex.org/W3084230740","https://openalex.org/W3128563494","https://openalex.org/W3136029617","https://openalex.org/W3193129760","https://openalex.org/W3214442151","https://openalex.org/W4220687637","https://openalex.org/W4224228615","https://openalex.org/W4239908405","https://openalex.org/W4296816530"],"related_works":["https://openalex.org/W2765782666","https://openalex.org/W4407815731","https://openalex.org/W2016823921","https://openalex.org/W3207892387","https://openalex.org/W2418039970","https://openalex.org/W3036223681","https://openalex.org/W2145864424","https://openalex.org/W2533578222","https://openalex.org/W2049779453","https://openalex.org/W7159794993"],"abstract_inverted_index":{"Accumulation":[0],"of":[1,54,65],"\u03b1-synuclein":[2,31,55,77,99,112],"into":[3],"toxic":[4],"oligomers":[5],"or":[6],"fibrils":[7],"is":[8,140],"implicated":[9],"in":[10,13,101,124],"dopaminergic":[11,119],"neurodegeneration":[12],"Parkinson's":[14,130],"disease.":[15],"Here":[16],"we":[17],"performed":[18],"a":[19,63,141],"high-throughput,":[20],"proteome-wide":[21],"peptide":[22,44,91,116],"screen":[23],"to":[24],"identify":[25],"protein-protein":[26],"interaction":[27,49,139],"inhibitors":[28],"that":[29,40,76],"reduce":[30],"oligomer":[32],"levels":[33,100],"and":[34,56,96,106,128],"their":[35],"associated":[36],"cytotoxicity.":[37],"We":[38,74],"find":[39],"the":[41,47,51,66,90,115,137],"most":[42],"potent":[43],"inhibitor":[45,92,117],"disrupts":[46],"direct":[48],"between":[50],"C-terminal":[52],"region":[53],"CHarged":[57],"Multivesicular":[58],"body":[59],"Protein":[60],"2B":[61],"(CHMP2B),":[62],"component":[64],"Endosomal":[67],"Sorting":[68],"Complex":[69],"Required":[70],"for":[71,145],"Transport-III":[72],"(ESCRT-III).":[73],"show":[75],"impedes":[78],"endolysosomal":[79,94],"activity":[80],"via":[81],"this":[82],"interaction,":[83],"thereby":[84,97],"inhibiting":[85],"its":[86],"own":[87],"degradation.":[88],"Conversely,":[89],"restores":[93],"function":[95],"decreases":[98],"multiple":[102],"models,":[103],"including":[104],"female":[105,134],"male":[107],"human":[108],"cells":[109],"harboring":[110],"disease-causing":[111],"mutations.":[113],"Furthermore,":[114],"protects":[118],"neurons":[120],"from":[121],"\u03b1-synuclein-mediated":[122],"degeneration":[123],"hermaphroditic":[125],"C.":[126],"elegans":[127],"preclinical":[129],"disease":[131],"models":[132],"using":[133],"rats.":[135],"Thus,":[136],"\u03b1-synuclein-CHMP2B":[138],"potential":[142],"therapeutic":[143],"target":[144],"neurodegenerative":[146],"disorders.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-04-21T00:00:00"}
