{"id":"https://openalex.org/W4366372159","doi":"https://doi.org/10.1016/j.vaccine.2023.04.004","title":"A thermostable, dry formulation inactivated Hikojima whole cell/cholera toxin B subunit oral cholera vaccine","display_name":"A thermostable, dry formulation inactivated Hikojima whole cell/cholera toxin B subunit oral cholera vaccine","publication_year":2023,"publication_date":"2023-04-19","ids":{"openalex":"https://openalex.org/W4366372159","doi":"https://doi.org/10.1016/j.vaccine.2023.04.004","pmid":"https://pubmed.ncbi.nlm.nih.gov/37085452"},"language":"en","primary_location":{"id":"doi:10.1016/j.vaccine.2023.04.004","doi":"https://doi.org/10.1016/j.vaccine.2023.04.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2023.04.004","pdf_url":null,"source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.vaccine.2023.04.004","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027780128","display_name":"Manuela Terrinoni","orcid":"https://orcid.org/0000-0002-2664-3210","observed_orcids":["https://orcid.org/0000-0002-2664-3210"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Manuela Terrinoni","raw_affiliation_strings":["Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, SE-405 30 G\u00f6teborg, Sweden. Electronic address: manuela.terrinoni@gu.se","Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, SE-405 30 G\u00f6teborg, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-2664-3210","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, SE-405 30 G\u00f6teborg, Sweden. Electronic address: manuela.terrinoni@gu.se","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, SE-405 30 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070342797","display_name":"Stefan L. Nordqvist","orcid":"https://orcid.org/0000-0003-4238-6004","observed_orcids":["https://orcid.org/0000-0003-4238-6004"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Stefan L. Nordqvist","raw_affiliation_strings":["Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, SE-405 30 G\u00f6teborg, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-4238-6004","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, SE-405 30 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004973964","display_name":"Madeleine L\u00f6fstrand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Madeleine L\u00f6fstrand","raw_affiliation_strings":["Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, SE-405 30 G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, SE-405 30 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009287074","display_name":"Frida Nilsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Frida Nilsson","raw_affiliation_strings":["Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, SE-405 30 G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, SE-405 30 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037478513","display_name":"Susanne K\u00e4llg\u00e5rd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Susanne K\u00e4llg\u00e5rd","raw_affiliation_strings":["Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, SE-405 30 G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, SE-405 30 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tarun Sharma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3176327385","display_name":"Hilleman Laboratories (India)","ror":"https://ror.org/02mdak015","country_code":"IN","type":"company","lineage":["https://openalex.org/I3176327385"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tarun Sharma","raw_affiliation_strings":["MSD-Wellcome Trust Hilleman Laboratories, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MSD-Wellcome Trust Hilleman Laboratories, New Delhi, India","institution_ids":["https://openalex.org/I3176327385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036325074","display_name":"Michael Lebens","orcid":"https://orcid.org/0000-0001-9458-9474","observed_orcids":["https://orcid.org/0000-0001-9458-9474"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Michael R. Lebens","raw_affiliation_strings":["Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, SE-405 30 G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, SE-405 30 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070753697","display_name":"Jan R. Holmgren","orcid":"https://orcid.org/0000-0003-1784-5918","observed_orcids":["https://orcid.org/0000-0003-1784-5918"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Jan Holmgren","raw_affiliation_strings":["Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, SE-405 30 G\u00f6teborg, Sweden. Electronic address: jan.holmgren@microbio.gu.se","Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, SE-405 30 G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, SE-405 30 G\u00f6teborg, Sweden. Electronic address: jan.holmgren@microbio.gu.se","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 435, SE-405 30 G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027780128","https://openalex.org/A5070753697"],"corresponding_institution_ids":["https://openalex.org/I881427289"],"apc_list":{"value":3350,"currency":"USD","value_usd":3350},"apc_paid":{"value":3350,"currency":"USD","value_usd":3350},"fwci":1.1065,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.68662911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"41","issue":"21","first_page":"3347","last_page":"3357"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11684","display_name":"Vibrio bacteria research studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11684","display_name":"Vibrio bacteria research studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-cholera-vaccine","display_name":"oral cholera vaccine","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cholera-toxin-b-subunit","display_name":"cholera toxin B subunit","score":0.9010000228881836},{"id":"https://openalex.org/keywords/freeze-drying","display_name":"freeze-drying","score":0.8960000276565552},{"id":"https://openalex.org/keywords/vaccine-storage-stability","display_name":"vaccine storage stability","score":0.593999981880188},{"id":"https://openalex.org/keywords/mucosal-antibody-response","display_name":"mucosal antibody response","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cholera-control","display_name":"cholera control","score":0.5529999732971191},{"id":"https://openalex.org/keywords/vaccine-stockpile","display_name":"vaccine stockpile","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2777047711","wikidata":"https://www.wikidata.org/wiki/Q1812946","display_name":"Cholera vaccine","level":4,"score":0.9634798765182495},{"id":"https://openalex.org/C2780722889","wikidata":"https://www.wikidata.org/wiki/Q12090","display_name":"Cholera","level":2,"score":0.9491022229194641},{"id":"https://openalex.org/C2777006276","wikidata":"https://www.wikidata.org/wiki/Q83586","display_name":"Cholera toxin","level":2,"score":0.8066965341567993},{"id":"https://openalex.org/C2778643871","wikidata":"https://www.wikidata.org/wiki/Q160821","display_name":"Vibrio cholerae","level":3,"score":0.7174779772758484},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.6847895979881287},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4921526312828064},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4490717351436615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40297338366508484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3390182852745056},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.33594653010368347},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28897416591644287},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.19761589169502258},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002771","descriptor_name":"Cholera","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014734","descriptor_name":"Vibrio cholerae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015164","descriptor_name":"Vaccines, Inactivated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022121","descriptor_name":"Cholera Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.vaccine.2023.04.004","doi":"https://doi.org/10.1016/j.vaccine.2023.04.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2023.04.004","pdf_url":null,"source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},{"id":"pmid:37085452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37085452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.vaccine.2023.04.004","doi":"https://doi.org/10.1016/j.vaccine.2023.04.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2023.04.004","pdf_url":null,"source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W578603601","https://openalex.org/W1871380448","https://openalex.org/W1966157023","https://openalex.org/W1980585308","https://openalex.org/W2013613990","https://openalex.org/W2014986829","https://openalex.org/W2018747439","https://openalex.org/W2095104780","https://openalex.org/W2150622562","https://openalex.org/W2153621410","https://openalex.org/W2309687270","https://openalex.org/W2607724803","https://openalex.org/W2897540414","https://openalex.org/W3095266496","https://openalex.org/W3157546717","https://openalex.org/W3175805786","https://openalex.org/W4200564754","https://openalex.org/W4211099692","https://openalex.org/W4220938900","https://openalex.org/W4228998143","https://openalex.org/W4299435584"],"related_works":["https://openalex.org/W7166527008","https://openalex.org/W3095266496","https://openalex.org/W2039213136","https://openalex.org/W2084274130","https://openalex.org/W3032583977","https://openalex.org/W3175805786","https://openalex.org/W2014986829","https://openalex.org/W2281999544","https://openalex.org/W1851047014","https://openalex.org/W1980585308"],"abstract_inverted_index":{"The":[0,154],"feared":[1],"diarrheal":[2],"disease":[3],"cholera":[4,14,26,40,90],"remains":[5],"an":[6],"important":[7],"global":[8,19,36,83],"health":[9],"problem.":[10],"Use":[11],"of":[12,130,139,143,186,193],"oral":[13,212],"vaccine":[15,84,117],"(OCV)":[16],"from":[17],"a":[18,28,113,119,132,136,140,149],"stockpile":[20,85],"against":[21],"both":[22,224],"epidemic":[23],"and":[24,50,55,61,67,73,77,160,175,189,196,208,218,226],"endemic":[25],"is":[27,158],"cornerstone":[29],"in":[30,81,96,100,214],"the":[31,88,128],"World":[32],"Health":[33],"Organisations":[34],"(WHOs)":[35],"program":[37],"for":[38,121,167,176],"\u201cEnding":[39],"by":[41],"2030\u201d.":[42],"Three":[43],"liquid":[44],"inactivated":[45],"whole-cell":[46],"OCVs":[47,79,220],"(Dukoral\u00ae,":[48],"ShancholTM,":[49],"Euvichol-Plus\u00ae)":[51],"are":[52],"WHO":[53],"prequalified":[54],"have":[56,210],"proved":[57,203],"to":[58,162,204,209,223],"be":[59,165,205],"safe":[60],"effective.":[62],"However,":[63],"their":[64],"multicomponent":[65],"composition":[66],"cold-chain":[68],"requirement":[69],"increase":[70],"manufacturing,":[71],"storage":[72],"transport":[74],"costs.":[75],"ShancholTM":[76,217],"Euvichol-Plus\u00ae":[78],"used":[80],"WHOs":[82,103],"also":[86,202],"lack":[87],"protective":[89,194],"toxin":[91],"B-subunit":[92],"(CTB)":[93],"antigen":[94],"present":[95],"Dukoral\u00ae,":[97],"which":[98,157],"results":[99],"suboptimal":[101],"efficacy.":[102],"Global":[104],"Task":[105],"Force":[106],"on":[107,135],"Cholera":[108],"Control":[109],"(GTFCC)":[110],"has":[111],"identified":[112],"thermostable,":[114],"dry":[115],"formulation":[116],"as":[118,216],"priority":[120],"further":[122],"OCV":[123],"development.":[124],"We":[125],"describe":[126],"here":[127],"development":[129],"such":[131],"vaccine,":[133,156],"based":[134],"lyophilized":[137],"mixture":[138],"single":[141],"strain":[142],"formalin-killed":[144],"Hikojima":[145],"bacteria":[146],"together":[147],"with":[148,184,190,221],"low-cost,":[150],"recombinantly":[151],"produced":[152],"CTB.":[153,200],"new":[155],"easy":[159],"inexpensive":[161],"manufacture,":[163],"could":[164],"stored":[166],"at":[168,172,177,181],"least":[169,178],"26":[170],"months":[171,180],"25":[173],"\u00b0C":[174,183],"8":[179],"40":[182],"preservation":[185],"cell":[187],"morphology":[188],"no":[191],"loss":[192],"Ogawa":[195],"Inaba":[197],"lipopolysaccharides":[198],"or":[199],"It":[201],"well":[206],"tolerated":[207],"equivalent":[211],"immunogenicity":[213],"mice":[215],"Dukoral\u00ae":[219],"regard":[222],"serum":[225],"intestinal-mucosal":[227],"antibody":[228],"responses.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-04-21T00:00:00"}
