{"id":"https://openalex.org/W4366352190","doi":"https://doi.org/10.1021/acschembio.2c00805","title":"New High-Throughput Screen Discovers Novel Ligands of Full-Length Nuclear Receptor LRH-1","display_name":"New High-Throughput Screen Discovers Novel Ligands of Full-Length Nuclear Receptor LRH-1","publication_year":2023,"publication_date":"2023-04-19","ids":{"openalex":"https://openalex.org/W4366352190","doi":"https://doi.org/10.1021/acschembio.2c00805","pmid":"https://pubmed.ncbi.nlm.nih.gov/37074920","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10404069"},"language":"en","primary_location":{"id":"doi:10.1021/acschembio.2c00805","doi":"https://doi.org/10.1021/acschembio.2c00805","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschembio.2c00805","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10404069/pdf/nihms-1917437.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066232002","display_name":"M. Merced Malabanan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Merced Malabanan","raw_affiliation_strings":["Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061761504","display_name":"Pratima Chapagain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pratima Chapagain","raw_affiliation_strings":["Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080389467","display_name":"Zeinab Haratipour","orcid":"https://orcid.org/0000-0003-4577-204X","observed_orcids":["https://orcid.org/0000-0003-4577-204X"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zeinab Haratipour","raw_affiliation_strings":["Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020360145","display_name":"Woong Jae Choi","orcid":"https://orcid.org/0000-0002-7967-3501","observed_orcids":["https://orcid.org/0000-0002-7967-3501"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Woong Jae Choi","raw_affiliation_strings":["Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024738615","display_name":"Abigail R. Orun","orcid":"https://orcid.org/0000-0003-3090-1363","observed_orcids":["https://orcid.org/0000-0003-3090-1363"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abigail R. Orun","raw_affiliation_strings":["Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States"],"raw_orcid":"https://orcid.org/0000-0003-3090-1363","affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085188064","display_name":"Raymond D. Blind","orcid":"https://orcid.org/0000-0002-1358-6309","observed_orcids":["https://orcid.org/0000-0002-1358-6309"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Raymond D. Blind","raw_affiliation_strings":["Department of Biochemistry and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States","Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States"],"raw_orcid":"https://orcid.org/0000-0002-1358-6309","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5085188064"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.9238,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.63294386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"18","issue":"5","first_page":"1101","last_page":"1114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.40720000863075256,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.40720000863075256,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.16380000114440918,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.08560000360012054,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lrh-1","display_name":"LRH-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/nuclear-receptor-ligands","display_name":"nuclear receptor ligands","score":0.8519999980926514},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.7450000047683716},{"id":"https://openalex.org/keywords/abamectin","display_name":"abamectin","score":0.9020000100135803},{"id":"https://openalex.org/keywords/ligand-binding-domain","display_name":"ligand-binding domain","score":0.7400000095367432},{"id":"https://openalex.org/keywords/pgc-1alpha","display_name":"PGC-1\u03b1","score":0.8429999947547913},{"id":"https://openalex.org/keywords/dax-1","display_name":"DAX-1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/shp","display_name":"SHP","score":0.9399999976158142},{"id":"https://openalex.org/keywords/bile-acid-metabolism","display_name":"bile acid metabolism","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cholesterol-metabolism","display_name":"cholesterol metabolism","score":0.9980000257492065},{"id":"https://openalex.org/keywords/liver-disease","display_name":"liver disease","score":0.6990000009536743},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.7019517421722412},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5705885887145996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4926813244819641},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46252545714378357},{"id":"https://openalex.org/C183481951","wikidata":"https://www.wikidata.org/wiki/Q15312971","display_name":"Small heterodimer partner","level":5,"score":0.45303475856781006},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4342077672481537},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.42672306299209595},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4194728434085846},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.41768014430999756},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3960075080394745},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36589890718460083},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2644323706626892}],"mesh":[{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007559","descriptor_name":"Ivermectin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acschembio.2c00805","doi":"https://doi.org/10.1021/acschembio.2c00805","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschembio.2c00805","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},{"id":"pmid:37074920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37074920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10404069","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10404069","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10404069/pdf/nihms-1917437.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Chem Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10404069","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10404069","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10404069/pdf/nihms-1917437.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Chem Biol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1807390628","display_name":"A new kinase inhibitor for glioblastoma","funder_award_id":"R21CA243036","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G187284979","display_name":null,"funder_award_id":"IRG-58-009-56","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G3433274139","display_name":null,"funder_award_id":"P30 CA68485","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G5853943267","display_name":null,"funder_award_id":"CA68485","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G7351132091","display_name":"Full-length LRH-1 structural regulation","funder_award_id":"R01GM138873","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7603387250","display_name":null,"funder_award_id":"RSG-17-063-01","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G9000052735","display_name":null,"funder_award_id":"DK-020593","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000093838","display_name":"Multidisciplinary Training in Molecular Endocrinology","funder_award_id":"T32DK007563","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000251729","display_name":null,"funder_award_id":"DK007563","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000880732","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA068485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000900818","display_name":"Vanderbilt Diabetes Research Center","funder_award_id":"P30DK020593","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000901748","display_name":"VGM: Vanderbilt Genomic Medicine Training Program","funder_award_id":"T32HG008341","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G9000905140","display_name":"Research Training in Diabetes and Endocrinology","funder_award_id":"T32DK007061","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320338008","display_name":"Vanderbilt Institute of Chemical Biology, School of Medicine, Vanderbilt University","ror":null},{"id":"https://openalex.org/F4320338281","display_name":"Army Research Office","ror":"https://ror.org/05epdh915"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366352190.pdf","grobid_xml":"https://content.openalex.org/works/W4366352190.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W1418748993","https://openalex.org/W1804706871","https://openalex.org/W1887624773","https://openalex.org/W1964768060","https://openalex.org/W1972484381","https://openalex.org/W1977415187","https://openalex.org/W1980589913","https://openalex.org/W1982167352","https://openalex.org/W1983057459","https://openalex.org/W1990819179","https://openalex.org/W1991001144","https://openalex.org/W1997876636","https://openalex.org/W1998861353","https://openalex.org/W2000417208","https://openalex.org/W2003359771","https://openalex.org/W2003632029","https://openalex.org/W2003822865","https://openalex.org/W2004490930","https://openalex.org/W2013378362","https://openalex.org/W2017287612","https://openalex.org/W2020171663","https://openalex.org/W2024955650","https://openalex.org/W2033997896","https://openalex.org/W2035843765","https://openalex.org/W2043484714","https://openalex.org/W2045519188","https://openalex.org/W2047591801","https://openalex.org/W2060804452","https://openalex.org/W2064715676","https://openalex.org/W2065160277","https://openalex.org/W2068458442","https://openalex.org/W2069169201","https://openalex.org/W2069221705","https://openalex.org/W2079360548","https://openalex.org/W2085410723","https://openalex.org/W2090190311","https://openalex.org/W2099610645","https://openalex.org/W2102278945","https://openalex.org/W2108234281","https://openalex.org/W2111338419","https://openalex.org/W2111684219","https://openalex.org/W2111904970","https://openalex.org/W2122008165","https://openalex.org/W2134218333","https://openalex.org/W2136357797","https://openalex.org/W2138207763","https://openalex.org/W2142905631","https://openalex.org/W2148403724","https://openalex.org/W2161382947","https://openalex.org/W2169480215","https://openalex.org/W2195774733","https://openalex.org/W2287411540","https://openalex.org/W2415409325","https://openalex.org/W2416957212","https://openalex.org/W2557326422","https://openalex.org/W2599571494","https://openalex.org/W2752307709","https://openalex.org/W2767953856","https://openalex.org/W2785829537","https://openalex.org/W2793093815","https://openalex.org/W2796490565","https://openalex.org/W2891317111","https://openalex.org/W2891588020","https://openalex.org/W2900218118","https://openalex.org/W2908740952","https://openalex.org/W2921221839","https://openalex.org/W2967243590","https://openalex.org/W2980679484","https://openalex.org/W2991119006","https://openalex.org/W3028334871","https://openalex.org/W3033830627","https://openalex.org/W3040027928","https://openalex.org/W3046353648","https://openalex.org/W3047620770","https://openalex.org/W3049024851","https://openalex.org/W3158979174","https://openalex.org/W3203193755","https://openalex.org/W4220836914"],"related_works":["https://openalex.org/W4401146907","https://openalex.org/W4225370540","https://openalex.org/W4396746525","https://openalex.org/W4408651662","https://openalex.org/W2004490930","https://openalex.org/W3033830627","https://openalex.org/W2989918841","https://openalex.org/W2082125652","https://openalex.org/W3167953925","https://openalex.org/W6955096364"],"abstract_inverted_index":{")":[0],"is":[1],"a":[2,41,59],"lipid-regulated":[3],"transcription":[4],"factor":[5],"and":[6,40,124,163,173,198],"an":[7,45],"important":[8],"drug":[9],"target":[10,161],"for":[11],"several":[12],"liver":[13,153],"diseases.":[14],"Advances":[15],"toward":[16],"LRH-1":[17,33,39,52,61,84,106,123,127,159,168,192,201],"therapeutics":[18],"have":[19,187],"been":[20,188],"driven":[21],"recently":[22],"by":[23,90],"structural":[24],"biology,":[25],"with":[26,166],"fewer":[27],"contributions":[28],"from":[29],"compound":[30,66,193],"screening.":[31],"Standard":[32],"screens":[34,96,194],"detect":[35],"compound-induced":[36],"interaction":[37],"between":[38],"transcriptional":[42],"coregulator":[43,140],"peptide,":[44],"approach":[46],"that":[47,50,63,77],"excludes":[48],"compounds":[49,76,102,183],"regulate":[51,105,133,199],"through":[53],"alternative":[54],"mechanisms.":[55],"Here,":[56],"we":[57],"developed":[58],"FRET-based":[60],"screen":[62,178],"simply":[64],"detects":[65],"binding":[67],"to":[68,72,103,132,186],"LRH-1,":[69],"applying":[70],"it":[71],"discover":[73,182],"58":[74,101],"new":[75],"bind":[78,197],"the":[79,134,177],"canonical":[80],"ligand-binding":[81,136],"site":[82],"in":[83,108,111,128,138,170,190,202],"(2.5%":[85],"hit":[86],"rate),":[87],"also":[88,104],"supported":[89],"computational":[91],"docking.":[92],"Four":[93],"independent":[94],"functional":[95],"identified":[97,189],"15":[98,118],"of":[99,116,151],"these":[100,117],"function":[107],"vitro":[109],"or":[110,147],"living":[112],"cells.":[113,203],"Although":[114],"one":[115],"compounds,":[119],"abamectin,":[120],"directly":[121],"binds":[122],"regulates":[125],"full-length":[126,200],"cells,":[129],"abamectin":[130],"failed":[131],"isolated":[135],"domain":[137],"standard":[139,191],"peptide":[141],"recruitment":[142],"assays":[143],"using":[144],"PGC1\u03b1,":[145],"DAX-1,":[146],"SHP.":[148],"Abamectin":[149],"treatment":[150],"human":[152],"HepG2":[154],"cells":[155],"selectively":[156],"regulated":[157],"endogenous":[158],"ChIP-seq":[160],"genes":[162],"pathways":[164],"associated":[165],"known":[167],"functions":[169],"bile":[171],"acid":[172],"cholesterol":[174],"metabolism.":[175],"Thus,":[176],"reported":[179],"here":[180],"can":[181],"not":[184],"likely":[185],"but":[195],"which":[196]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-04-21T00:00:00"}