{"id":"https://openalex.org/W4366351828","doi":"https://doi.org/10.2337/db22-0666","title":"TBC1D4-S711 Controls Skeletal Muscle Insulin Sensitization After Exercise and Contraction","display_name":"TBC1D4-S711 Controls Skeletal Muscle Insulin Sensitization After Exercise and Contraction","publication_year":2023,"publication_date":"2023-04-19","ids":{"openalex":"https://openalex.org/W4366351828","doi":"https://doi.org/10.2337/db22-0666","pmid":"https://pubmed.ncbi.nlm.nih.gov/37074686"},"language":"en","primary_location":{"id":"doi:10.2337/db22-0666","doi":"https://doi.org/10.2337/db22-0666","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db22-0666","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007664068","display_name":"Rasmus Kj\u00f8bsted","orcid":"https://orcid.org/0000-0002-0628-4994","observed_orcids":["https://orcid.org/0000-0002-0628-4994"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Rasmus Kj\u00f8bsted","raw_affiliation_strings":["1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-0628-4994","affiliations":[{"raw_affiliation_string":"1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078905570","display_name":"Jonas M. Kristensen","orcid":"https://orcid.org/0000-0002-8296-975X","observed_orcids":["https://orcid.org/0000-0002-8296-975X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jonas M. Kristensen","raw_affiliation_strings":["1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001002706","display_name":"Nicolas O. Eskesen","orcid":"https://orcid.org/0000-0002-3686-9264","observed_orcids":["https://orcid.org/0000-0002-3686-9264"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Nicolas O. Eskesen","raw_affiliation_strings":["1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053458160","display_name":"Kohei Kido","orcid":"https://orcid.org/0000-0003-0665-6572","observed_orcids":["https://orcid.org/0000-0003-0665-6572"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kohei Kido","raw_affiliation_strings":["1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062328179","display_name":"Klara Fjorder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Klara Fjorder","raw_affiliation_strings":["1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028592183","display_name":"Ditte F. Damgaard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ditte F. Damgaard","raw_affiliation_strings":["1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040013861","display_name":"Jeppe Kj\u00e6rgaard Larsen","orcid":"https://orcid.org/0000-0002-9304-1148","observed_orcids":["https://orcid.org/0000-0002-9304-1148"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I4391767703","display_name":"Novo Nordisk Foundation Center for Basic Metabolic Research","ror":"https://ror.org/02s32fb62","country_code":"DK","type":"other","lineage":["https://openalex.org/I124055696","https://openalex.org/I4391767703"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jeppe K. Larsen","raw_affiliation_strings":["1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark","2Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-9304-1148","affiliations":[{"raw_affiliation_string":"1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"2Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I4391767703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081145131","display_name":"Nicoline R. Andersen","orcid":"https://orcid.org/0000-0002-1512-2727","observed_orcids":["https://orcid.org/0000-0002-1512-2727"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Nicoline R. Andersen","raw_affiliation_strings":["1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082949907","display_name":"Jesper B. Birk","orcid":"https://orcid.org/0000-0001-9775-4789","observed_orcids":["https://orcid.org/0000-0001-9775-4789"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jesper B. Birk","raw_affiliation_strings":["1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018297537","display_name":"Anders Gudiksen","orcid":"https://orcid.org/0000-0003-1800-4838","observed_orcids":["https://orcid.org/0000-0003-1800-4838"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anders Gudiksen","raw_affiliation_strings":["3Department of Biology, Section for Cell Biology and Physiology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Biology, Section for Cell Biology and Physiology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029750430","display_name":"Jonas T. Treebak","orcid":"https://orcid.org/0000-0003-1488-7012","observed_orcids":["https://orcid.org/0000-0003-1488-7012"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I4391767703","display_name":"Novo Nordisk Foundation Center for Basic Metabolic Research","ror":"https://ror.org/02s32fb62","country_code":"DK","type":"other","lineage":["https://openalex.org/I124055696","https://openalex.org/I4391767703"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jonas T. Treebak","raw_affiliation_strings":["2Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I4391767703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062913067","display_name":"Peter Schjerling","orcid":"https://orcid.org/0000-0001-7138-3211","observed_orcids":["https://orcid.org/0000-0001-7138-3211"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801941904","display_name":"Bispebjerg Hospital","ror":"https://ror.org/00td68a17","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801941904","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Peter Schjerling","raw_affiliation_strings":["4Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark","5Center for Healthy Aging, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2801941904","https://openalex.org/I2802567020"]},{"raw_affiliation_string":"5Center for Healthy Aging, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039041871","display_name":"Henriette Pilegaard","orcid":"https://orcid.org/0000-0002-1071-0327","observed_orcids":["https://orcid.org/0000-0002-1071-0327"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Henriette Pilegaard","raw_affiliation_strings":["3Department of Biology, Section for Cell Biology and Physiology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Biology, Section for Cell Biology and Physiology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046158740","display_name":"J\u00f8rgen F. P. Wojtaszewski","orcid":"https://orcid.org/0000-0001-8185-3408","observed_orcids":["https://orcid.org/0000-0001-8185-3408","https://orcid.org/0000-0001-7102-7727","https://orcid.org/0000-0001-9785-6830"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"J\u00f8rgen F.P. Wojtaszewski","raw_affiliation_strings":["1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-8185-3408","affiliations":[{"raw_affiliation_string":"1August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5007664068","https://openalex.org/A5046158740"],"corresponding_institution_ids":["https://openalex.org/I124055696"],"apc_list":null,"apc_paid":null,"fwci":2.2664,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.89746927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"72","issue":"7","first_page":"857","last_page":"871"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tbc1d4","display_name":"TBC1D4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.6539999842643738},{"id":"https://openalex.org/keywords/skeletal-muscle-insulin-sensitivity","display_name":"skeletal muscle insulin sensitivity","score":0.8180000185966492},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.7870000004768372},{"id":"https://openalex.org/keywords/muscle-contraction","display_name":"muscle contraction","score":0.9700000286102295},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.8949999809265137},{"id":"https://openalex.org/keywords/glycogen-utilization","display_name":"glycogen utilization","score":0.8429999947547913},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.8330000042915344},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7929999828338623},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.7159863710403442},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7132233381271362},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6528280377388},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.638310968875885},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6209419965744019},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5188059210777283},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4871501624584198},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.42249345779418945},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.41642695665359497},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3784193992614746},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07662853598594666}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061386","descriptor_name":"Insulin, Regular, Human","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/db22-0666","doi":"https://doi.org/10.2337/db22-0666","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db22-0666","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:37074686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37074686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/0b96b318-1bed-4eff-b822-30f5fe36fc88","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/0b96b318-1bed-4eff-b822-30f5fe36fc88","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kj\u00f8bsted, R, Kristensen, J M, Eskesen, N O, Kido, K, Fjorder, K, Damgaard, D F, Larsen, J K, Andersen, N R, Birk, J B, Gudiksen, A, Treebak, J T, Schjerling, P, Pilegaard, H & Wojtaszewski, J 2023, 'TBC1D4-S711 controls skeletal muscle insulin sensitization after exercise and contraction', Diabetes, vol. 72, no. 7, pp. 857-871. https://doi.org/10.2337/db22-0666","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.823199987411499,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2329263959","display_name":"Uncovering a Novel Intramuscular Mechanism Coordinating Post-Exercise Adaptations in Glucose and Protein Metabolism","funder_award_id":"22K17687","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4343097196","display_name":null,"funder_award_id":"NNF17SA0031406]","funder_id":"https://openalex.org/F4320315655","funder_display_name":"Danish Diabetes Academy"},{"id":"https://openalex.org/G4431023582","display_name":null,"funder_award_id":"NNF0070370","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G4504918650","display_name":null,"funder_award_id":"NNF 18 CC0034900","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G45286030","display_name":null,"funder_award_id":"NNF21OC0070370","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G891534396","display_name":null,"funder_award_id":"FSS: 610-00498B","funder_id":"https://openalex.org/F4320322928","funder_display_name":"Danmarks Frie Forskningsfond"}],"funders":[{"id":"https://openalex.org/F4320315655","display_name":"Danish Diabetes Academy","ror":"https://ror.org/05xbkrn90"},{"id":"https://openalex.org/F4320322928","display_name":"Danmarks Frie Forskningsfond","ror":"https://ror.org/02sptwz63"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1783890436","https://openalex.org/W1794129251","https://openalex.org/W1872744326","https://openalex.org/W1977179130","https://openalex.org/W1985381832","https://openalex.org/W1991241396","https://openalex.org/W2000198788","https://openalex.org/W2017414380","https://openalex.org/W2029853063","https://openalex.org/W2042698420","https://openalex.org/W2073361547","https://openalex.org/W2101474138","https://openalex.org/W2101715194","https://openalex.org/W2102098190","https://openalex.org/W2108778776","https://openalex.org/W2112396418","https://openalex.org/W2129849378","https://openalex.org/W2138700089","https://openalex.org/W2140654407","https://openalex.org/W2143343312","https://openalex.org/W2145108000","https://openalex.org/W2147553969","https://openalex.org/W2152840919","https://openalex.org/W2153074450","https://openalex.org/W2153123820","https://openalex.org/W2167633432","https://openalex.org/W2169187688","https://openalex.org/W2170869159","https://openalex.org/W2180033063","https://openalex.org/W2181866290","https://openalex.org/W2493695600","https://openalex.org/W2540741681","https://openalex.org/W2596171931","https://openalex.org/W2882971477","https://openalex.org/W2889056797","https://openalex.org/W2902365759","https://openalex.org/W2938098774","https://openalex.org/W2948246123","https://openalex.org/W2983088929","https://openalex.org/W3002796788","https://openalex.org/W3016930086","https://openalex.org/W3161243615","https://openalex.org/W3163834596","https://openalex.org/W3165032979","https://openalex.org/W3211981286","https://openalex.org/W3217481038","https://openalex.org/W4226469192","https://openalex.org/W4235264311"],"related_works":["https://openalex.org/W2948246123","https://openalex.org/W2169187688","https://openalex.org/W2540741681","https://openalex.org/W2000198788","https://openalex.org/W1986952721","https://openalex.org/W2167698452","https://openalex.org/W2548437666","https://openalex.org/W2152840919","https://openalex.org/W2143343312","https://openalex.org/W1954224368"],"abstract_inverted_index":{"The":[0],"ability":[1],"of":[2,31,39,146,162,174],"insulin":[3,79,128],"to":[4,77,153],"stimulate":[5],"glucose":[6,20,108,181],"uptake":[7,21],"in":[8,24,75,116,124,137],"skeletal":[9,18,179],"muscle":[10,19,105,127,180],"is":[11,22,46,73],"important":[12],"for":[13,51,164],"whole-body":[14,96,125],"glycemic":[15,97],"control.":[16],"Insulin-stimulated":[17],"improved":[23],"the":[25,42,47,171],"period":[26],"after":[27,130],"a":[28,59,65,159],"single":[29],"bout":[30],"exercise,":[32],"and":[33,80,89,101,112,118,126,132,140,166,176],"accumulating":[34],"evidence":[35,152],"suggests":[36],"that":[37,72,155,169],"phosphorylation":[38,145],"TBC1D4":[40,60],"by":[41],"protein":[43],"kinase":[44],"AMPK":[45,81,113],"primary":[48],"mechanism":[49],"responsible":[50],"this":[52],"phenomenon.":[53],"To":[54],"investigate":[55],"this,":[56],"we":[57],"generated":[58],"knock-in":[61],"mouse":[62],"model":[63],"with":[64,143],"serine-to-alanine":[66],"point":[67,161],"mutation":[68],"at":[69],"residue":[70],"711":[71],"phosphorylated":[74],"response":[76],"both":[78],"activation.":[82],"Female":[83],"TBC1D4-S711A":[84,119],"mice":[85,139],"exhibited":[86],"normal":[87],"growth":[88],"eating":[90],"behavior":[91],"as":[92,94,158],"well":[93],"intact":[95],"control":[98],"on":[99,178],"chow":[100],"high-fat":[102],"diets.":[103],"Moreover,":[104],"contraction":[106],"increased":[107],"uptake,":[109],"glycogen":[110],"utilization,":[111],"activity":[114],"similarly":[115],"wild-type":[117,138],"mice.":[120],"In":[121],"contrast,":[122],"improvements":[123],"sensitivity":[129],"exercise":[131,175],"contractions":[133,177],"were":[134],"only":[135],"evident":[136],"occurred":[141],"concomitantly":[142],"enhanced":[144],"TBC1D4-S711.":[147],"These":[148],"results":[149],"provide":[150],"genetic":[151],"support":[154],"TBC1D4-S711":[156],"serves":[157],"major":[160],"convergence":[163],"AMPK-":[165],"insulin-induced":[167],"signaling":[168],"mediates":[170],"insulin-sensitizing":[172],"effect":[173],"uptake.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-04-21T00:00:00"}