{"id":"https://openalex.org/W4366332824","doi":"https://doi.org/10.7759/cureus.37781","title":"Perampanel-Induced, New-Onset Thrombocytopenia in a Patient With Refractory Seizures: A Case Report","display_name":"Perampanel-Induced, New-Onset Thrombocytopenia in a Patient With Refractory Seizures: A Case Report","publication_year":2023,"publication_date":"2023-04-18","ids":{"openalex":"https://openalex.org/W4366332824","doi":"https://doi.org/10.7759/cureus.37781","pmid":"https://pubmed.ncbi.nlm.nih.gov/37213988","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10195002"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.37781","doi":"https://doi.org/10.7759/cureus.37781","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.37781","pdf_url":"https://assets.cureus.com/uploads/case_report/pdf/140284/20230418-9728-bnpvcq.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://assets.cureus.com/uploads/case_report/pdf/140284/20230418-9728-bnpvcq.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006116299","display_name":"Rakan Abdullah Almuhanna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199693650","display_name":"Umm al-Qura University","ror":"https://ror.org/01xjqrm90","country_code":"SA","type":"education","lineage":["https://openalex.org/I199693650"]},{"id":"https://openalex.org/I4210130698","display_name":"Security Forces Hospital","ror":"https://ror.org/035n3nf68","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4210130698"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Rakan A Almuhanna","raw_affiliation_strings":["Neurology, Security Forces Hospital, Makkah, SAU",". Internal Medicine, Security Forces Hospital, Makkah, SAU",". Medicine and Surgery, College of Medicine, Umm Al-Qura University, Makkah, SAU",". Medicine, College of Medicine, Umm Al-Qura University, Makkah, SAU"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, Security Forces Hospital, Makkah, SAU","institution_ids":["https://openalex.org/I4210130698"]},{"raw_affiliation_string":". Internal Medicine, Security Forces Hospital, Makkah, SAU","institution_ids":["https://openalex.org/I4210130698"]},{"raw_affiliation_string":". Medicine and Surgery, College of Medicine, Umm Al-Qura University, Makkah, SAU","institution_ids":["https://openalex.org/I199693650"]},{"raw_affiliation_string":". Medicine, College of Medicine, Umm Al-Qura University, Makkah, SAU","institution_ids":["https://openalex.org/I199693650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015668135","display_name":"Rabia Muddassir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199693650","display_name":"Umm al-Qura University","ror":"https://ror.org/01xjqrm90","country_code":"SA","type":"education","lineage":["https://openalex.org/I199693650"]},{"id":"https://openalex.org/I4210130698","display_name":"Security Forces Hospital","ror":"https://ror.org/035n3nf68","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4210130698"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Rabia Muddassir","raw_affiliation_strings":["Internal Medicine, Security Forces Hospital, Makkah, SAU",". Medicine and Surgery, College of Medicine, Umm Al-Qura University, Makkah, SAU",". Medicine, College of Medicine, Umm Al-Qura University, Makkah, SAU",". Neurology, Security Forces Hospital, Makkah, SAU"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Security Forces Hospital, Makkah, SAU","institution_ids":["https://openalex.org/I4210130698"]},{"raw_affiliation_string":". Medicine and Surgery, College of Medicine, Umm Al-Qura University, Makkah, SAU","institution_ids":["https://openalex.org/I199693650"]},{"raw_affiliation_string":". Medicine, College of Medicine, Umm Al-Qura University, Makkah, SAU","institution_ids":["https://openalex.org/I199693650"]},{"raw_affiliation_string":". Neurology, Security Forces Hospital, Makkah, SAU","institution_ids":["https://openalex.org/I4210130698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009149131","display_name":"Murouj Adnan Almaghrabi","orcid":"https://orcid.org/0000-0001-7357-9269","observed_orcids":["https://orcid.org/0000-0001-7357-9269"]},"institutions":[{"id":"https://openalex.org/I199693650","display_name":"Umm al-Qura University","ror":"https://ror.org/01xjqrm90","country_code":"SA","type":"education","lineage":["https://openalex.org/I199693650"]},{"id":"https://openalex.org/I4210130698","display_name":"Security Forces Hospital","ror":"https://ror.org/035n3nf68","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4210130698"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Murouj Almaghrabi","raw_affiliation_strings":["Medicine and Surgery, College of Medicine, Umm Al-Qura University, Makkah, SAU",". Internal Medicine, Security Forces Hospital, Makkah, SAU",". Medicine, College of Medicine, Umm Al-Qura University, Makkah, SAU",". Neurology, Security Forces Hospital, Makkah, SAU"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine and Surgery, College of Medicine, Umm Al-Qura University, Makkah, SAU","institution_ids":["https://openalex.org/I199693650"]},{"raw_affiliation_string":". Internal Medicine, Security Forces Hospital, Makkah, SAU","institution_ids":["https://openalex.org/I4210130698"]},{"raw_affiliation_string":". Medicine, College of Medicine, Umm Al-Qura University, Makkah, SAU","institution_ids":["https://openalex.org/I199693650"]},{"raw_affiliation_string":". Neurology, Security Forces Hospital, Makkah, SAU","institution_ids":["https://openalex.org/I4210130698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070619155","display_name":"Gadir Bokhari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199693650","display_name":"Umm al-Qura University","ror":"https://ror.org/01xjqrm90","country_code":"SA","type":"education","lineage":["https://openalex.org/I199693650"]},{"id":"https://openalex.org/I4210130698","display_name":"Security Forces Hospital","ror":"https://ror.org/035n3nf68","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4210130698"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Gadir Bokhari","raw_affiliation_strings":["Medicine, College of Medicine, Umm Al-Qura University, Makkah, SAU",". Internal Medicine, Security Forces Hospital, Makkah, SAU",". Medicine and Surgery, College of Medicine, Umm Al-Qura University, Makkah, SAU",". Neurology, Security Forces Hospital, Makkah, SAU"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, College of Medicine, Umm Al-Qura University, Makkah, SAU","institution_ids":["https://openalex.org/I199693650"]},{"raw_affiliation_string":". Internal Medicine, Security Forces Hospital, Makkah, SAU","institution_ids":["https://openalex.org/I4210130698"]},{"raw_affiliation_string":". Medicine and Surgery, College of Medicine, Umm Al-Qura University, Makkah, SAU","institution_ids":["https://openalex.org/I199693650"]},{"raw_affiliation_string":". Neurology, Security Forces Hospital, Makkah, SAU","institution_ids":["https://openalex.org/I4210130698"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034094838","display_name":"Abdulazuiz Al-Ghamdi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199693650","display_name":"Umm al-Qura University","ror":"https://ror.org/01xjqrm90","country_code":"SA","type":"education","lineage":["https://openalex.org/I199693650"]},{"id":"https://openalex.org/I4210130698","display_name":"Security Forces Hospital","ror":"https://ror.org/035n3nf68","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4210130698"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Abdulazuiz Al-Ghamdi","raw_affiliation_strings":["Neurology, Security Forces Hospital, Makkah, SAU",". Internal Medicine, Security Forces Hospital, Makkah, SAU",". Medicine and Surgery, College of Medicine, Umm Al-Qura University, Makkah, SAU",". Medicine, College of Medicine, Umm Al-Qura University, Makkah, SAU"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, Security Forces Hospital, Makkah, SAU","institution_ids":["https://openalex.org/I4210130698"]},{"raw_affiliation_string":". Internal Medicine, Security Forces Hospital, Makkah, SAU","institution_ids":["https://openalex.org/I4210130698"]},{"raw_affiliation_string":". Medicine and Surgery, College of Medicine, Umm Al-Qura University, Makkah, SAU","institution_ids":["https://openalex.org/I199693650"]},{"raw_affiliation_string":". Medicine, College of Medicine, Umm Al-Qura University, Makkah, SAU","institution_ids":["https://openalex.org/I199693650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009149131"],"corresponding_institution_ids":["https://openalex.org/I199693650","https://openalex.org/I4210130698"],"apc_list":null,"apc_paid":null,"fwci":0.7895,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.71428571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"15","issue":"4","first_page":"e37781","last_page":"e37781"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.04659999907016754,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perampanel","display_name":"perampanel","score":1.0},{"id":"https://openalex.org/keywords/drug-induced-thrombocytopenia","display_name":"drug-induced thrombocytopenia","score":0.9399999976158142},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"drug-resistant epilepsy","score":0.746999979019165},{"id":"https://openalex.org/keywords/generalized-tonic-clonic-seizures","display_name":"generalized tonic-clonic seizures","score":0.9610000252723694},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7509999871253967},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.6769999861717224},{"id":"https://openalex.org/keywords/platelet-count-reduction","display_name":"platelet count reduction","score":0.8519999980926514},{"id":"https://openalex.org/keywords/drug-withdrawal","display_name":"drug withdrawal","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C2780836401","wikidata":"https://www.wikidata.org/wiki/Q868658","display_name":"Perampanel","level":3,"score":0.9971588850021362},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8494613170623779},{"id":"https://openalex.org/C2778139780","wikidata":"https://www.wikidata.org/wiki/Q420077","display_name":"Lacosamide","level":3,"score":0.800452470779419},{"id":"https://openalex.org/C2777332695","wikidata":"https://www.wikidata.org/wiki/Q417227","display_name":"Levetiracetam","level":3,"score":0.762308657169342},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6366834044456482},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5648585557937622},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.48193955421447754},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4644842743873596},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.46424612402915955},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.40546321868896484},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3205649256706238},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25573301315307617},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1692310869693756},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07366907596588135},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.37781","doi":"https://doi.org/10.7759/cureus.37781","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.37781","pdf_url":"https://assets.cureus.com/uploads/case_report/pdf/140284/20230418-9728-bnpvcq.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10195002","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10195002","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10195002/pdf/cureus-0015-00000037781.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"},{"id":"pmid:37213988","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37213988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.7759/cureus.37781","doi":"https://doi.org/10.7759/cureus.37781","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.37781","pdf_url":"https://assets.cureus.com/uploads/case_report/pdf/140284/20230418-9728-bnpvcq.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366332824.pdf","grobid_xml":"https://content.openalex.org/works/W4366332824.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1498758291","https://openalex.org/W1986696455","https://openalex.org/W2071065489","https://openalex.org/W2135808877","https://openalex.org/W2140914231","https://openalex.org/W2196437720","https://openalex.org/W2559835151","https://openalex.org/W2766059845","https://openalex.org/W2781249920"],"related_works":["https://openalex.org/W2062475110","https://openalex.org/W3096319088","https://openalex.org/W2411056051","https://openalex.org/W2073906451","https://openalex.org/W2774202914","https://openalex.org/W2361961021","https://openalex.org/W2042784229","https://openalex.org/W7043337534","https://openalex.org/W3133571566","https://openalex.org/W2400404951"],"abstract_inverted_index":{"Perampanel":[0],"(Fycompa)":[1],"is":[2,126,139],"a":[3,10,44,49,91,103,130,133],"glutamate":[4],"receptor":[5],"antagonist":[6],"known":[7,127],"to":[8,25,65,87,121,128,150,158],"be":[9,129],"safe,":[11],"effective,":[12],"and":[13,32,59,84,156,162],"well-tolerated":[14],"medication;":[15],"nevertheless,":[16],"adverse":[17],"effects":[18],"are":[19,148],"possible.":[20,140],"This":[21],"case":[22,42],"report":[23],"aims":[24],"raise":[26],"the":[27,41,62,73,95,114,152],"suspicion":[28],"of":[29,43,82,112],"perampanel-induced":[30],"thrombocytopenia":[31,138,155],"discuss":[33],"its":[34],"possible":[35],"pathways":[36],"implicated.":[37],"Here,":[38],"we":[39],"present":[40],"66-year-old":[45],"female":[46],"patient":[47,63,76],"with":[48,55],"generalized":[50],"tonic-clonic":[51],"seizure":[52,96],"initially":[53],"managed":[54],"levetiracetam,":[56],"valproic":[57],"acid,":[58],"lacosamide;":[60],"however,":[61],"continued":[64],"have":[66],"seizures":[67],"clinically":[68],"as":[69,71,137],"well":[70],"on":[72,79],"electroencephalogram.":[74],"The":[75,141],"was":[77,97,108],"initiated":[78],"2":[80],"mg":[81,89],"perampanel":[83,101,125,157],"reached":[85],"up":[86,120],"12":[88],"within":[90],"week,":[92],"after":[93,100],"which":[94],"controlled.":[98],"Nevertheless,":[99],"initiation,":[102],"gradual":[104],"platelet":[105,115],"count":[106,116],"reduction":[107],"observed.":[109],"Upon":[110],"withdrawal":[111],"perampanel,":[113],"dramatically":[117],"improved":[118],"reaching":[119],"her":[122],"baseline.":[123],"Although":[124],"safe":[131],"medication,":[132],"hematological":[134],"complication":[135],"such":[136],"exact":[142],"mechanism":[143],"remains":[144],"unclear.":[145],"Further":[146],"studies":[147],"required":[149],"understand":[151],"association":[153],"between":[154],"identify":[159],"high-risk":[160],"populations":[161],"prevent":[163],"this":[164],"condition":[165],"sequentially.":[166]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-04-20T00:00:00"}