{"id":"https://openalex.org/W4366332480","doi":"https://doi.org/10.1039/d3sc00455d","title":"A self-assembled nanophotosensitizer targets lysosomes and induces lysosomal membrane permeabilization to enhance photodynamic therapy","display_name":"A self-assembled nanophotosensitizer targets lysosomes and induces lysosomal membrane permeabilization to enhance photodynamic therapy","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4366332480","doi":"https://doi.org/10.1039/d3sc00455d","pmid":"https://pubmed.ncbi.nlm.nih.gov/37206384","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10189857"},"language":"en","primary_location":{"id":"doi:10.1039/d3sc00455d","doi":"https://doi.org/10.1039/d3sc00455d","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d3sc00455d","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2023/sc/d3sc00455d","source":{"id":"https://openalex.org/S184645833","display_name":"Chemical Science","issn_l":"2041-6520","issn":["2041-6520","2041-6539"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-3","ki-jl-2","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2023/sc/d3sc00455d","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101769707","display_name":"Youyou Li","orcid":"https://orcid.org/0000-0003-2474-0428","observed_orcids":["https://orcid.org/0000-0003-2474-0428","https://orcid.org/0000-0001-8185-4750"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youyou Li","raw_affiliation_strings":["Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wenbo Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenbo Han","raw_affiliation_strings":["Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027376406","display_name":"Deyan Gong","orcid":"https://orcid.org/0009-0000-7596-8970","observed_orcids":["https://orcid.org/0009-0000-7596-8970"]},"institutions":[{"id":"https://openalex.org/I4391768068","display_name":"State Key Laboratory of Applied Organic Chemistry","ror":"https://ror.org/050fgfc71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768068","https://openalex.org/I76214153"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Deyan Gong","raw_affiliation_strings":["Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China","institution_ids":["https://openalex.org/I4391768068","https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063738453","display_name":"Taokun Luo","orcid":"https://orcid.org/0000-0001-5894-0490","observed_orcids":["https://orcid.org/0000-0001-5894-0490"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taokun Luo","raw_affiliation_strings":["Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100306145","display_name":"Yingjie Fan","orcid":"https://orcid.org/0009-0004-2226-4063","observed_orcids":["https://orcid.org/0009-0004-2226-4063"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yingjie Fan","raw_affiliation_strings":["Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023691183","display_name":"Jianming Mao","orcid":"https://orcid.org/0000-0002-1604-6527","observed_orcids":["https://orcid.org/0000-0002-1604-6527"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianming Mao","raw_affiliation_strings":["Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061096747","display_name":"Wenwu Qin","orcid":"https://orcid.org/0000-0002-9782-6647","observed_orcids":["https://orcid.org/0000-0002-9782-6647"]},"institutions":[{"id":"https://openalex.org/I4391768068","display_name":"State Key Laboratory of Applied Organic Chemistry","ror":"https://ror.org/050fgfc71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768068","https://openalex.org/I76214153"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenwu Qin","raw_affiliation_strings":["Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China"],"raw_orcid":"https://orcid.org/0000-0002-9782-6647","affiliations":[{"raw_affiliation_string":"Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China","institution_ids":["https://openalex.org/I4391768068","https://openalex.org/I76214153"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057193669","display_name":"Wenbin Lin","orcid":"https://orcid.org/0000-0001-7035-7759","observed_orcids":["https://orcid.org/0000-0001-7035-7759","https://orcid.org/0000-0002-4282-066X"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wenbin Lin","raw_affiliation_strings":["Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA","Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL 60637, USA"],"raw_orcid":"https://orcid.org/0000-0001-7035-7759","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5057193669"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":3.466,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.94439384,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"14","issue":"19","first_page":"5106","last_page":"5115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.03310000151395798,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.8289999961853027},{"id":"https://openalex.org/keywords/nanophotosensitizers","display_name":"nanophotosensitizers","score":0.9210000038146973},{"id":"https://openalex.org/keywords/lysosomal-targeting","display_name":"lysosomal targeting","score":0.8169999718666077},{"id":"https://openalex.org/keywords/lysosomal-membrane-permeabilization","display_name":"lysosomal membrane permeabilization","score":0.9909999966621399},{"id":"https://openalex.org/keywords/self-assembly","display_name":"self-assembly","score":0.5730000138282776},{"id":"https://openalex.org/keywords/berberine-derivatives","display_name":"berberine derivatives","score":0.6389999985694885},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9649999737739563},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7870000004768372},{"id":"https://openalex.org/keywords/tumor-accumulation","display_name":"tumor accumulation","score":0.6729999780654907},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7160000205039978},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/metastasis-prevention","display_name":"metastasis prevention","score":0.8140000104904175},{"id":"https://openalex.org/keywords/nanoparticle-drug-delivery","display_name":"nanoparticle drug delivery","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.8250458240509033},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.786137580871582},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5441300868988037},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.5323859453201294},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46649619936943054},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.44659605622291565},{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.44304993748664856},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4069018065929413},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3847319781780243},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32883644104003906},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2907178997993469},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23196235299110413},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1782642900943756},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/d3sc00455d","doi":"https://doi.org/10.1039/d3sc00455d","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d3sc00455d","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2023/sc/d3sc00455d","source":{"id":"https://openalex.org/S184645833","display_name":"Chemical Science","issn_l":"2041-6520","issn":["2041-6520","2041-6539"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-3","ki-jl-2","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10189857","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10189857","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10189857/pdf/SC-014-D3SC00455D.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chem Sci","raw_type":"Text"},{"id":"pmid:37206384","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37206384","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1039/d3sc00455d","doi":"https://doi.org/10.1039/d3sc00455d","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d3sc00455d","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2023/sc/d3sc00455d","source":{"id":"https://openalex.org/S184645833","display_name":"Chemical Science","issn_l":"2041-6520","issn":["2041-6520","2041-6539"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-3","ki-jl-2","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3307977628","display_name":"Nanoscale Metal-Organic Frameworks Enable Radiotherapy-Radiodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Generate Tumor Vaccines and Potentiate Immunotherapy of Head and Neck Cancers","funder_award_id":"R01CA253655","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366332480.pdf","grobid_xml":"https://content.openalex.org/works/W4366332480.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1972695628","https://openalex.org/W2034915807","https://openalex.org/W2060244013","https://openalex.org/W2061263039","https://openalex.org/W2070789044","https://openalex.org/W2076598575","https://openalex.org/W2080878773","https://openalex.org/W2088303232","https://openalex.org/W2121987205","https://openalex.org/W2133452519","https://openalex.org/W2320574135","https://openalex.org/W2558284519","https://openalex.org/W2751401312","https://openalex.org/W2769635789","https://openalex.org/W2769731327","https://openalex.org/W2789162174","https://openalex.org/W2790756470","https://openalex.org/W2790960759","https://openalex.org/W2793142137","https://openalex.org/W2796997430","https://openalex.org/W2885264971","https://openalex.org/W2887961980","https://openalex.org/W2888292224","https://openalex.org/W2891177174","https://openalex.org/W2906631717","https://openalex.org/W2916429698","https://openalex.org/W2921165242","https://openalex.org/W2925775343","https://openalex.org/W2941302145","https://openalex.org/W2941897681","https://openalex.org/W2944794168","https://openalex.org/W2946957142","https://openalex.org/W2950336286","https://openalex.org/W2956160028","https://openalex.org/W2977694640","https://openalex.org/W2981066188","https://openalex.org/W2990755760","https://openalex.org/W3044858173","https://openalex.org/W3081996782","https://openalex.org/W3083273412","https://openalex.org/W3111184803","https://openalex.org/W3111994653","https://openalex.org/W3128195390","https://openalex.org/W3155834203","https://openalex.org/W3172111953","https://openalex.org/W3177653351","https://openalex.org/W3199808882","https://openalex.org/W3213403367","https://openalex.org/W4206387914","https://openalex.org/W4223498475","https://openalex.org/W4280594599","https://openalex.org/W4283375584","https://openalex.org/W4285004722"],"related_works":["https://openalex.org/W4415409153","https://openalex.org/W2965048408","https://openalex.org/W4404975565","https://openalex.org/W2737296390","https://openalex.org/W2339427936","https://openalex.org/W4385611888","https://openalex.org/W2606407786","https://openalex.org/W4384817673","https://openalex.org/W4393155780","https://openalex.org/W3005979432"],"abstract_inverted_index":{"We":[0],"report":[1],"the":[2,46,100],"self-assembly":[3],"of":[4,52,96],"amphiphilic":[5,109],"BDQ":[6,30],"photosensitizers":[7,112],"into":[8,33],"lysosome-targeting":[9],"nanophotosensitizer":[10],"BDQ-NP":[11,47,70],"for":[12],"highly":[13],"effective":[14],"photodynamic":[15],"therapy":[16],"(PDT).":[17],"Molecular":[18],"dynamics":[19],"simulation,":[20],"live":[21],"cell":[22],"imaging,":[23],"and":[24,59,82,110],"subcellular":[25],"colocalization":[26],"studies":[27],"showed":[28],"that":[29,105],"strongly":[31],"incorporated":[32],"lysosome":[34],"lipid":[35],"bilayers":[36],"to":[37,56,63,74,99,117],"cause":[38],"continuous":[39],"lysosomal":[40,58],"membrane":[41],"permeabilization.":[42],"Upon":[43],"light":[44],"irradiation,":[45],"generated":[48],"a":[49],"high":[50,65],"level":[51],"reactive":[53],"oxygen":[54],"species":[55],"disrupt":[57],"mitochondrial":[60],"functions,":[61],"leading":[62],"exceptionally":[64],"cytotoxicity.":[66],"The":[67],"intravenously":[68],"injected":[69],"accumulated":[71],"in":[72],"tumours":[73],"achieve":[75],"excellent":[76,115],"PDT":[77,92],"efficacy":[78],"on":[79],"subcutaneous":[80],"colorectal":[81],"orthotopic":[83],"breast":[84,97],"tumor":[85],"models":[86],"without":[87],"causing":[88],"systemic":[89],"toxicity.":[90],"BDQ-NP-mediated":[91],"also":[93],"prevented":[94],"metastasis":[95],"tumors":[98],"lungs.":[101],"This":[102],"work":[103],"shows":[104],"self-assembled":[106],"nanoparticles":[107],"from":[108],"organelle-specific":[111],"provide":[113],"an":[114],"strategy":[116],"enhance":[118],"PDT.":[119]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2023-04-20T00:00:00"}
