{"id":"https://openalex.org/W4366292563","doi":"https://doi.org/10.3389/fimmu.2023.1178337","title":"The generation, activation, and polarization of monocyte-derived macrophages in human malignancies","display_name":"The generation, activation, and polarization of monocyte-derived macrophages in human malignancies","publication_year":2023,"publication_date":"2023-04-18","ids":{"openalex":"https://openalex.org/W4366292563","doi":"https://doi.org/10.3389/fimmu.2023.1178337","pmid":"https://pubmed.ncbi.nlm.nih.gov/37143666","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10151765"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2023.1178337","doi":"https://doi.org/10.3389/fimmu.2023.1178337","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1178337","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1178337/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1178337/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001935974","display_name":"Paul Chaintreuil","orcid":"https://orcid.org/0000-0002-4845-7304","observed_orcids":["https://orcid.org/0000-0002-4845-7304"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210118704","display_name":"Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire","ror":"https://ror.org/029rfe283","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210118704"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Paul Chaintreuil","raw_affiliation_strings":["Inserm U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France","Universit\u00e9 C\u00f4te d'Azur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118704"]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I201841394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016117673","display_name":"Emeline Kerreneur","orcid":"https://orcid.org/0009-0009-4349-1931","observed_orcids":["https://orcid.org/0009-0009-4349-1931"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210118704","display_name":"Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire","ror":"https://ror.org/029rfe283","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210118704"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emeline Kerreneur","raw_affiliation_strings":["Inserm U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France","Universit\u00e9 C\u00f4te d'Azur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118704"]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I201841394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017419898","display_name":"Maxence Bourgoin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210118704","display_name":"Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire","ror":"https://ror.org/029rfe283","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210118704"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maxence Bourgoin","raw_affiliation_strings":["Inserm U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France","Universit\u00e9 C\u00f4te d'Azur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118704"]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I201841394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109699455","display_name":"Coline Savy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210118704","display_name":"Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire","ror":"https://ror.org/029rfe283","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210118704"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Coline Savy","raw_affiliation_strings":["Inserm U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France","Universit\u00e9 C\u00f4te d'Azur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118704"]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I201841394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112687604","display_name":"C\u00e9cile Favreau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210118704","display_name":"Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire","ror":"https://ror.org/029rfe283","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210118704"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9cile Favreau","raw_affiliation_strings":["Inserm U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France","Universit\u00e9 C\u00f4te d'Azur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118704"]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I201841394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051365781","display_name":"Guillaume Robert","orcid":"https://orcid.org/0000-0002-6350-2222","observed_orcids":["https://orcid.org/0000-0002-6350-2222"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210118704","display_name":"Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire","ror":"https://ror.org/029rfe283","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210118704"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guillaume Robert","raw_affiliation_strings":["Inserm U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France","Universit\u00e9 C\u00f4te d'Azur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118704"]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I201841394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034528977","display_name":"Arnaud Jacquel","orcid":"https://orcid.org/0000-0001-5062-8048","observed_orcids":["https://orcid.org/0000-0001-5062-8048"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210118704","display_name":"Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire","ror":"https://ror.org/029rfe283","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210118704"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Arnaud Jacquel","raw_affiliation_strings":["Inserm U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France","Universit\u00e9 C\u00f4te d'Azur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118704"]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I201841394"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039959145","display_name":"Patrick Auberger","orcid":"https://orcid.org/0000-0002-2481-8275","observed_orcids":["https://orcid.org/0000-0002-2481-8275"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210118704","display_name":"Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire","ror":"https://ror.org/029rfe283","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210118704"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Patrick Auberger","raw_affiliation_strings":["Inserm U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France","Universit\u00e9 C\u00f4te d'Azur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118704"]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I201841394"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5034528977","https://openalex.org/A5039959145"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210118704"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3225,"currency":"EUR","value_usd":3478},"fwci":2.5701,"has_fulltext":true,"cited_by_count":95,"citation_normalized_percentile":{"value":0.93014706,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"14","issue":null,"first_page":"1178337","last_page":"1178337"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monocyte-derived-macrophages","display_name":"monocyte-derived macrophages","score":0.9419999718666077},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.9819999933242798},{"id":"https://openalex.org/keywords/m1-macrophages","display_name":"M1 macrophages","score":0.9160000085830688},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":1.0},{"id":"https://openalex.org/keywords/m0-macrophages","display_name":"M0 macrophages","score":0.8209999799728394},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.8640000224113464},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.6159999966621399},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.5839999914169312},{"id":"https://openalex.org/keywords/resolution-of-inflammation","display_name":"inflammation resolution","score":0.3619999885559082}],"concepts":[{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.6805583834648132},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4951273500919342},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4119746685028076},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.41078561544418335},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3685248792171478},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3559650778770447},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.34429508447647095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.310221791267395},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10213208198547363},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09335029125213623}],"mesh":[{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2023.1178337","doi":"https://doi.org/10.3389/fimmu.2023.1178337","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1178337","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1178337/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10151765","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10151765","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10151765/pdf/fimmu-14-1178337.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:37143666","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37143666","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f5d1ea3aaa86476ab6e66bd573b42a17","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f5d1ea3aaa86476ab6e66bd573b42a17","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 14 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2023.1178337","doi":"https://doi.org/10.3389/fimmu.2023.1178337","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1178337","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1178337/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G143561721","display_name":null,"funder_award_id":"#ANR-11-LABX-0028-01","funder_id":"https://openalex.org/F4320322361","funder_display_name":"Fondation ARC pour la Recherche sur le Cancer"},{"id":"https://openalex.org/G2971310235","display_name":null,"funder_award_id":"2019-2023","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G3113876670","display_name":null,"funder_award_id":"PLBIO_2019","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G5094003450","display_name":null,"funder_award_id":"ANR-11-LABX-0028-01","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G8533281491","display_name":"R\u00e9seau d'Innovation sur les Voies de Signalisation en Sciences de la Vie","funder_award_id":"ANR-11-LABX-0028","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8534655814","display_name":null,"funder_award_id":"ANR-11-LABX-0028-01","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320322361","display_name":"Fondation ARC pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320323807","display_name":"Institut National Du Cancer","ror":"https://ror.org/03m8vkq32"},{"id":"https://openalex.org/F4320327346","display_name":"Institut Carnot Sant\u00e9 Animale","ror":"https://ror.org/011xwe428"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366292563.pdf","grobid_xml":"https://content.openalex.org/works/W4366292563.grobid-xml"},"referenced_works_count":187,"referenced_works":["https://openalex.org/W32707354","https://openalex.org/W92308566","https://openalex.org/W1480357432","https://openalex.org/W1518894239","https://openalex.org/W1573363574","https://openalex.org/W1573977017","https://openalex.org/W1590215790","https://openalex.org/W1592759509","https://openalex.org/W1738685314","https://openalex.org/W1771551064","https://openalex.org/W1894485240","https://openalex.org/W1966598736","https://openalex.org/W1969119554","https://openalex.org/W1971602395","https://openalex.org/W1971842725","https://openalex.org/W1973220859","https://openalex.org/W1975815647","https://openalex.org/W1980485314","https://openalex.org/W1983085370","https://openalex.org/W1983220630","https://openalex.org/W1984690727","https://openalex.org/W1984999956","https://openalex.org/W1988519760","https://openalex.org/W1990250019","https://openalex.org/W1991582729","https://openalex.org/W1995483790","https://openalex.org/W1999482916","https://openalex.org/W2001717792","https://openalex.org/W2004070471","https://openalex.org/W2007087804","https://openalex.org/W2010484682","https://openalex.org/W2011617127","https://openalex.org/W2012232274","https://openalex.org/W2012416768","https://openalex.org/W2013283818","https://openalex.org/W2014280822","https://openalex.org/W2014330166","https://openalex.org/W2015141049","https://openalex.org/W2024053153","https://openalex.org/W2027603639","https://openalex.org/W2032410318","https://openalex.org/W2048380290","https://openalex.org/W2048992492","https://openalex.org/W2049999948","https://openalex.org/W2050923912","https://openalex.org/W2060669212","https://openalex.org/W2063808705","https://openalex.org/W2063937258","https://openalex.org/W2065036402","https://openalex.org/W2065094661","https://openalex.org/W2071959986","https://openalex.org/W2072462631","https://openalex.org/W2072769614","https://openalex.org/W2073400944","https://openalex.org/W2073607907","https://openalex.org/W2075465392","https://openalex.org/W2076743146","https://openalex.org/W2081810806","https://openalex.org/W2083491398","https://openalex.org/W2087935186","https://openalex.org/W2089573422","https://openalex.org/W2091848990","https://openalex.org/W2092617134","https://openalex.org/W2093705034","https://openalex.org/W2096616470","https://openalex.org/W2097733789","https://openalex.org/W2098954540","https://openalex.org/W2100834680","https://openalex.org/W2101095291","https://openalex.org/W2102037549","https://openalex.org/W2107153418","https://openalex.org/W2107553434","https://openalex.org/W2108323291","https://openalex.org/W2109525494","https://openalex.org/W2110836981","https://openalex.org/W2111161262","https://openalex.org/W2112057120","https://openalex.org/W2113544323","https://openalex.org/W2115736737","https://openalex.org/W2116422482","https://openalex.org/W2117493229","https://openalex.org/W2118205675","https://openalex.org/W2119435263","https://openalex.org/W2120254551","https://openalex.org/W2123303185","https://openalex.org/W2127205046","https://openalex.org/W2129141672","https://openalex.org/W2130003736","https://openalex.org/W2130819559","https://openalex.org/W2132247162","https://openalex.org/W2137507114","https://openalex.org/W2139175045","https://openalex.org/W2142433114","https://openalex.org/W2144741217","https://openalex.org/W2145864070","https://openalex.org/W2149387197","https://openalex.org/W2150678612","https://openalex.org/W2153406260","https://openalex.org/W2153844283","https://openalex.org/W2157569416","https://openalex.org/W2157886311","https://openalex.org/W2157962067","https://openalex.org/W2161074777","https://openalex.org/W2161091841","https://openalex.org/W2162166699","https://openalex.org/W2168669893","https://openalex.org/W2170119446","https://openalex.org/W2175500475","https://openalex.org/W2291402961","https://openalex.org/W2301038687","https://openalex.org/W2301044272","https://openalex.org/W2305244369","https://openalex.org/W2341289486","https://openalex.org/W2341432578","https://openalex.org/W2414840542","https://openalex.org/W2467219218","https://openalex.org/W2474232167","https://openalex.org/W2527362689","https://openalex.org/W2529727810","https://openalex.org/W2548633484","https://openalex.org/W2560597144","https://openalex.org/W2611921452","https://openalex.org/W2763583311","https://openalex.org/W2763960561","https://openalex.org/W2770290595","https://openalex.org/W2772548919","https://openalex.org/W2778033786","https://openalex.org/W2779155953","https://openalex.org/W2782367417","https://openalex.org/W2782601603","https://openalex.org/W2782685575","https://openalex.org/W2802794587","https://openalex.org/W2808886946","https://openalex.org/W2809293015","https://openalex.org/W2862742070","https://openalex.org/W2887845560","https://openalex.org/W2890042587","https://openalex.org/W2900746171","https://openalex.org/W2901068426","https://openalex.org/W2905245827","https://openalex.org/W2905827542","https://openalex.org/W2913136103","https://openalex.org/W2919706530","https://openalex.org/W2924232389","https://openalex.org/W2946793191","https://openalex.org/W2957498182","https://openalex.org/W2959661609","https://openalex.org/W2970741653","https://openalex.org/W2973649648","https://openalex.org/W2975360268","https://openalex.org/W2975504634","https://openalex.org/W2984346248","https://openalex.org/W2997036921","https://openalex.org/W3012091956","https://openalex.org/W3018590946","https://openalex.org/W3081530044","https://openalex.org/W3091948129","https://openalex.org/W3091981841","https://openalex.org/W3094167654","https://openalex.org/W3096757170","https://openalex.org/W3116290443","https://openalex.org/W3128657608","https://openalex.org/W3129727704","https://openalex.org/W3135495269","https://openalex.org/W3158519393","https://openalex.org/W3164752908","https://openalex.org/W3168967718","https://openalex.org/W3179003079","https://openalex.org/W3183411120","https://openalex.org/W3186872020","https://openalex.org/W3197196598","https://openalex.org/W3200593920","https://openalex.org/W3211501837","https://openalex.org/W4206123846","https://openalex.org/W4210961478","https://openalex.org/W4223641985","https://openalex.org/W4226229241","https://openalex.org/W4281401386","https://openalex.org/W4281624193","https://openalex.org/W4286294929","https://openalex.org/W4291993576","https://openalex.org/W4292092891","https://openalex.org/W4296793417","https://openalex.org/W4309080193","https://openalex.org/W4313278999","https://openalex.org/W4313333788","https://openalex.org/W4321373980"],"related_works":["https://openalex.org/W4306385315","https://openalex.org/W2001717792","https://openalex.org/W2513641194","https://openalex.org/W2020744745","https://openalex.org/W2803151969","https://openalex.org/W2742515757","https://openalex.org/W4294363553","https://openalex.org/W2312720913","https://openalex.org/W1598422965","https://openalex.org/W2783643850"],"abstract_inverted_index":{",":[0],"macrophages":[1,39,44,51,58,73,82,100,155,168],"are":[2,10,83,101],"endowed":[3],"with":[4],"a":[5,18,157],"continuum":[6],"of":[7,79,106,110,131,143,154,162],"phenotypes":[8],"that":[9,22],"rarely":[11],"strictly":[12],"pro-inflammatory":[13,43],"or":[14,71,123],"anti-inflammatory":[15,50,72,99],"and":[16,49,65,94,113,129,137,152],"exhibit":[17],"broad":[19],"expression":[20],"profile":[21],"sweeps":[23],"over":[24],"the":[25,104,108,127,144,149,160],"whole":[26],"polarization":[27,68,153],"spectrum.":[28],"Schematically,":[29],"three":[30],"main":[31],"macrophage":[32],"subpopulations":[33],"coexist":[34],"in":[35,86,103,126,148,170],"human":[36],"tissues:":[37],"na\u00efve":[38],"also":[40,52,119],"called":[41],"M0,":[42],"referred":[45],"as":[46,54],"M1":[47],"macrophages,":[48],"known":[53],"M2":[55],"macrophages.":[56],"Na\u00efve":[57],"display":[59],"phagocytic":[60],"functions,":[61],"recognize":[62],"pathogenic":[63],"agents,":[64],"rapidly":[66],"undergo":[67],"towards":[69],"pro":[70],"to":[74,166],"acquire":[75],"their":[76],"full":[77],"panel":[78],"functions.":[80,96],"Pro-inflammatory":[81],"widely":[84],"involved":[85,147],"inflammatory":[87],"response,":[88],"during":[89],"which":[90],"they":[91],"exert":[92],"anti-microbial":[93],"anti-tumoral":[95],"By":[97],"contrast,":[98],"implicated":[102],"resolution":[105],"inflammation,":[107],"phagocytosis":[109],"cell":[111],"debris":[112],"tissue":[114],"reparation":[115],"following":[116],"injuries.":[117],"Macrophages":[118],"play":[120],"important":[121],"deleterious":[122],"beneficial":[124],"roles":[125],"initiation":[128],"progression":[130],"different":[132],"pathophysiological":[133],"settings":[134],"including":[135],"solid":[136],"hematopoietic":[138],"cancers.":[139],"A":[140],"better":[141],"understanding":[142],"molecular":[145],"mechanisms":[146],"generation,":[150],"activation":[151],"is":[156],"prerequisite":[158],"for":[159],"development":[161],"new":[163],"therapeutic":[164],"strategies":[165],"modulate":[167],"functions":[169],"pathological":[171],"situations.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":35},{"year":2025,"cited_by_count":41},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-20T00:00:00"}
