{"id":"https://openalex.org/W4366291977","doi":"https://doi.org/10.3389/fmed.2023.1105894","title":"Premorbid use of selective beta-blockers improves sepsis incidence and course: Human cohort and animal model studies","display_name":"Premorbid use of selective beta-blockers improves sepsis incidence and course: Human cohort and animal model studies","publication_year":2023,"publication_date":"2023-04-18","ids":{"openalex":"https://openalex.org/W4366291977","doi":"https://doi.org/10.3389/fmed.2023.1105894","pmid":"https://pubmed.ncbi.nlm.nih.gov/37144032","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10151496"},"language":"en","primary_location":{"id":"doi:10.3389/fmed.2023.1105894","doi":"https://doi.org/10.3389/fmed.2023.1105894","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2023.1105894","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2023.1105894/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fmed.2023.1105894/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087292362","display_name":"Shiao\u2010Ya Hong","orcid":"https://orcid.org/0000-0003-4302-1509","observed_orcids":["https://orcid.org/0000-0003-4302-1509"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I4210155547","display_name":"Cardinal Tien Hospital","ror":"https://ror.org/04ksqpz49","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210155547"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shiao-Ya Hong","raw_affiliation_strings":["Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan","Medical Research Center, Cardinal Tien Hospital, New Taipei City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Medical Research Center, Cardinal Tien Hospital, New Taipei City, Taiwan","institution_ids":["https://openalex.org/I4210155547"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022398404","display_name":"Chih\u2010Cheng Lai","orcid":"https://orcid.org/0000-0002-6334-2388","observed_orcids":["https://orcid.org/0000-0002-6334-2388"]},"institutions":[{"id":"https://openalex.org/I4210136334","display_name":"Chi Mei Medical Center","ror":"https://ror.org/02y2htg06","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210136334"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chih-Cheng Lai","raw_affiliation_strings":["Division of Hospital Medicine, Department of Internal Medicine, Chi Mei Medical Center, Tainan City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hospital Medicine, Department of Internal Medicine, Chi Mei Medical Center, Tainan City, Taiwan","institution_ids":["https://openalex.org/I4210136334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047523954","display_name":"Nai-Chi Teng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165441096","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I165441096"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Nai-Chi Teng","raw_affiliation_strings":["Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, Taiwan","institution_ids":["https://openalex.org/I165441096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058477490","display_name":"Chao\u2010Hsien Chen","orcid":"https://orcid.org/0000-0002-2176-3504","observed_orcids":["https://orcid.org/0000-0002-2176-3504"]},"institutions":[{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]},{"id":"https://openalex.org/I35926432","display_name":"Mackay Medical University","ror":"https://ror.org/00t89kj24","country_code":"TW","type":"education","lineage":["https://openalex.org/I35926432"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chao-Hsien Chen","raw_affiliation_strings":["Department of Medicine, MacKay Medical College, New Taipei City, Taiwan","Division of Pulmonary Medicine, Department of Internal Medicine, MacKay Memorial Hospital, Taipei City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, MacKay Medical College, New Taipei City, Taiwan","institution_ids":["https://openalex.org/I35926432"]},{"raw_affiliation_string":"Division of Pulmonary Medicine, Department of Internal Medicine, MacKay Memorial Hospital, Taipei City, Taiwan","institution_ids":["https://openalex.org/I2802753785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028050870","display_name":"Chun\u2010Chun Hsu","orcid":"https://orcid.org/0000-0002-2319-2151","observed_orcids":["https://orcid.org/0000-0002-2319-2151"]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chun-Chun Hsu","raw_affiliation_strings":["School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei City, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056334556","display_name":"Nai\u2010Ju Chan","orcid":"https://orcid.org/0000-0001-7842-9761","observed_orcids":["https://orcid.org/0000-0001-7842-9761"]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Nai-Ju Chan","raw_affiliation_strings":["Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei City, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006925381","display_name":"Cheng\u2010Yi Wang","orcid":"https://orcid.org/0000-0001-7426-0743","observed_orcids":["https://orcid.org/0000-0001-7426-0743"]},"institutions":[{"id":"https://openalex.org/I114150738","display_name":"Fu Jen Catholic University","ror":"https://ror.org/04je98850","country_code":"TW","type":"education","lineage":["https://openalex.org/I114150738"]},{"id":"https://openalex.org/I4210155547","display_name":"Cardinal Tien Hospital","ror":"https://ror.org/04ksqpz49","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210155547"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Cheng-Yi Wang","raw_affiliation_strings":["Department of Internal Medicine, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan","institution_ids":["https://openalex.org/I114150738","https://openalex.org/I4210155547"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100457125","display_name":"Ya\u2010Hui Wang","orcid":"https://orcid.org/0000-0001-8118-3547","observed_orcids":["https://orcid.org/0000-0001-8118-3547"]},"institutions":[{"id":"https://openalex.org/I4210155547","display_name":"Cardinal Tien Hospital","ror":"https://ror.org/04ksqpz49","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210155547"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Ya-Hui Wang","raw_affiliation_strings":["Medical Research Center, Cardinal Tien Hospital, New Taipei City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Cardinal Tien Hospital, New Taipei City, Taiwan","institution_ids":["https://openalex.org/I4210155547"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023661207","display_name":"You Shuei Lin","orcid":"https://orcid.org/0000-0003-1364-0245","observed_orcids":["https://orcid.org/0000-0003-1364-0245"]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"You Shuei Lin","raw_affiliation_strings":["Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan","Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei City, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"last","author":{"id":null,"display_name":"Likwang Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165441096","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I165441096"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Likwang Chen","raw_affiliation_strings":["Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, Taiwan","institution_ids":["https://openalex.org/I165441096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5006925381","https://openalex.org/A5023661207","https://openalex.org/A5100457125"],"corresponding_institution_ids":["https://openalex.org/I114150738","https://openalex.org/I4210155547","https://openalex.org/I47519274"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":1.7201,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.82921948,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":null,"first_page":"1105894","last_page":"1105894"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis-incidence","display_name":"sepsis incidence","score":0.8379999995231628},{"id":"https://openalex.org/keywords/atenolol","display_name":"atenolol","score":0.9599999785423279},{"id":"https://openalex.org/keywords/metoprolol","display_name":"metoprolol","score":0.9649999737739563},{"id":"https://openalex.org/keywords/bisoprolol","display_name":"bisoprolol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/soluble-pd-l1","display_name":"soluble PD-L1","score":0.796999990940094},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.6700000166893005},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9929999709129333},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9319999814033508},{"id":"https://openalex.org/keywords/lipopolysaccharide-induced-sepsis","display_name":"lipopolysaccharide-induced sepsis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.5230000019073486},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.7730000019073486},{"id":"https://openalex.org/keywords/sepsis-mortality","display_name":"sepsis mortality","score":0.8410000205039978},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.7074471712112427},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5452235341072083},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.541722297668457},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5261701345443726},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5024869441986084},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41609835624694824},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32366377115249634},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09521564841270447},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09155252575874329},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fmed.2023.1105894","doi":"https://doi.org/10.3389/fmed.2023.1105894","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2023.1105894","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2023.1105894/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10151496","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10151496","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10151496/pdf/fmed-10-1105894.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Med (Lausanne)","raw_type":"Text"},{"id":"pmid:37144032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37144032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:580f7dd1fc1543c1bff7dbb55b96abca","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/580f7dd1fc1543c1bff7dbb55b96abca","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Medicine, Vol 10 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmed.2023.1105894","doi":"https://doi.org/10.3389/fmed.2023.1105894","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2023.1105894","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2023.1105894/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1052468712","display_name":null,"funder_award_id":"MOST 105-","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G1380344853","display_name":null,"funder_award_id":"CTH 110A-2201, CTH 110A-2206, CTH 111A-2201","funder_id":"https://openalex.org/F4320326159","funder_display_name":"Cardinal Tien Hospital"},{"id":"https://openalex.org/G2106663266","display_name":"Activation of Adenosine A3 Receptors Suppresses Airway Hypersensitivity: Role of Pulmonary C-Fiber Afferents","funder_award_id":"MOST105-2320-B038-055-MY2","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G3590762296","display_name":null,"funder_award_id":"and MOST 111-2314-B-567-003","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G4450056460","display_name":"Development of Novel Therapeutic Strategies by Exploring the Pathogenesis of Idiopathic Pulmonary Fibrosis","funder_award_id":"MOST110-2314-B567-004","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G4955380882","display_name":"Dual Targeting of Cancer Cells and Tams as a Novel Strategy to Improve Immunotherapy for Nsclc","funder_award_id":"MOST111-2314-B567-003","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G5068921315","display_name":null,"funder_award_id":"CTH 111A-2201","funder_id":"https://openalex.org/F4320326159","funder_display_name":"Cardinal Tien Hospital"},{"id":"https://openalex.org/G5131997464","display_name":null,"funder_award_id":"MOST 105-2320-B-038-055-MY2, MOST 110-2314-B-567-004, and MOST 111-2314-B-567-003","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G5220391832","display_name":null,"funder_award_id":"CTH 110A-2201","funder_id":"https://openalex.org/F4320326159","funder_display_name":"Cardinal Tien Hospital"},{"id":"https://openalex.org/G533722315","display_name":null,"funder_award_id":"CTH 110A-2206","funder_id":"https://openalex.org/F4320326159","funder_display_name":"Cardinal Tien Hospital"}],"funders":[{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320322845","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29"},{"id":"https://openalex.org/F4320326159","display_name":"Cardinal Tien Hospital","ror":"https://ror.org/04ksqpz49"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366291977.pdf","grobid_xml":"https://content.openalex.org/works/W4366291977.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W35149409","https://openalex.org/W165973742","https://openalex.org/W1920087348","https://openalex.org/W1967763328","https://openalex.org/W1996064706","https://openalex.org/W2049927822","https://openalex.org/W2059492229","https://openalex.org/W2067989244","https://openalex.org/W2068818475","https://openalex.org/W2080621208","https://openalex.org/W2080898127","https://openalex.org/W2104918392","https://openalex.org/W2114769524","https://openalex.org/W2115476870","https://openalex.org/W2118858814","https://openalex.org/W2118901081","https://openalex.org/W2123645879","https://openalex.org/W2136030067","https://openalex.org/W2144589352","https://openalex.org/W2146114351","https://openalex.org/W2156751422","https://openalex.org/W2170325512","https://openalex.org/W2280404143","https://openalex.org/W2429977049","https://openalex.org/W2570138519","https://openalex.org/W2581605534","https://openalex.org/W2594373983","https://openalex.org/W2639193008","https://openalex.org/W2727039071","https://openalex.org/W2733419125","https://openalex.org/W2800259696","https://openalex.org/W2802659818","https://openalex.org/W2890890047","https://openalex.org/W2891115123","https://openalex.org/W2895870451","https://openalex.org/W2903474482","https://openalex.org/W2912104965","https://openalex.org/W2922334084","https://openalex.org/W2971522116","https://openalex.org/W2998853022","https://openalex.org/W3005048654","https://openalex.org/W3006912435","https://openalex.org/W3014329149","https://openalex.org/W3023757607","https://openalex.org/W3044276813","https://openalex.org/W3045454797","https://openalex.org/W3159871862","https://openalex.org/W4200134243","https://openalex.org/W6774522274"],"related_works":["https://openalex.org/W3160524341","https://openalex.org/W4398783404","https://openalex.org/W4206526823","https://openalex.org/W3215649764","https://openalex.org/W3109089783","https://openalex.org/W2971522116","https://openalex.org/W7153304891","https://openalex.org/W3159871862","https://openalex.org/W2639193008","https://openalex.org/W4387974861"],"abstract_inverted_index":{"Introduction":[0],"Beta-blockers":[1],"are":[2],"widely":[3],"prescribed":[4,67],"to":[5,19,107,281],"manage":[6],"hypertension":[7],"and":[8,11,42,50,61,92,134,168,244,256,259],"cardiovascular":[9],"diseases":[10],"have":[12],"been":[13],"suggested":[14],"as":[15],"an":[16],"attractive":[17],"therapy":[18],"improve":[20],"the":[21,28,44,84,218,233,272,282],"prognosis":[22],"of":[23,31,57,115,150,159,174,201,221,263,274,285],"sepsis.":[24],"Herein,":[25],"we":[26],"investigated":[27],"potential":[29],"benefits":[30],"premorbid":[32,291],"selective":[33,121,294],"beta-blocker":[34,122],"use":[35],"in":[36,48,51,119,125,135,139,204,226,254,257,260,271,287],"sepsis":[37,59,106,116,160,175,181,252,286],"with":[38,96,155,186,223,290,293],"a":[39,156,179,267],"real-world":[40],"database":[41],"explored":[43],"underlying":[45],"mechanism":[46],"by":[47],"vivo":[49,258],"vitro":[52,261],"experiments.":[53],"Methods":[54],"A":[55,146],"total":[56],"64,070":[58,62],"patients":[60,289],"matched":[63],"controls":[64],"who":[65],"were":[66,81,99],"at":[68],"least":[69],"one":[70],"anti-hypertensive":[71],"drug":[72],"for":[73,83,101,269],"more":[74],"than":[75,124,138,176],"300":[76],"days":[77],"within":[78],"1":[79],"year":[80],"selected":[82],"nested":[85],"case\u2013control":[86],"study.":[87],"Female":[88],"C57BL/6":[89],"J":[90],"mice":[91,184],"THP-1":[93,238],"cells":[94],"stimulated":[95],"lipopolysaccharide":[97],"(LPS)":[98],"used":[100],"studying":[102],"systemic":[103],"responses":[104],"during":[105],"validate":[108],"our":[109],"clinical":[110],"findings.":[111],"Results":[112],"The":[113],"risk":[114,158,173],"was":[117,153],"lower":[118,157,172],"current":[120],"users":[123,137,170],"non-users":[126,140],"(adjusted":[127],"OR":[128],"(aOR),":[129],"0.842;":[130],"95%":[131,143,163],"CI,":[132,144,164],"0.755\u20130.939),":[133],"recent":[136],"(aOR,":[141,161],"0.773;":[142],"0.737\u20130.810).":[145],"mean":[147],"daily":[148],"dose":[149],"\u22650.5":[151],"DDD":[152],"associated":[154],"0.7;":[162],"0.676\u20130.725).":[165],"Metoprolol,":[166],"atenolol,":[167],"bisoprolol":[169],"had":[171,188,194],"non-users.":[177],"In":[178],"LPS-induced":[180,199],"mouse":[182],"model,":[183],"pre-fed":[185],"atenolol":[187,193,215,230,270],"significantly":[189,208],"reduced":[190,209,283],"mortality.":[191],"While":[192],"some":[195],"mild":[196],"effects":[197],"on":[198,236],"release":[200],"inflammatory":[202,224],"cytokines":[203,225],"septic":[205,227],"mice,":[206,255],"it":[207],"serum":[210],"soluble":[211],"PD-L1":[212,234,264],"levels.":[213],"Notably,":[214],"treatment":[216,292],"reversed":[217],"negative":[219],"correlation":[220],"sPD-L1":[222],"mice.":[228],"Moreover,":[229],"markedly":[231],"downregulated":[232],"expression":[235,265],"LPS-stimulated":[237],"monocytes/macrophages":[239],"via":[240],"targeting":[241],"ROS-induced":[242],"NF-\u03baB":[243],"STAT3":[245],"activation.":[246],"Conclusion":[247],"Atenolol":[248],"pretreatment":[249],"can":[250],"reduce":[251],"mortality":[253],"studies":[262],"suggest":[266],"role":[268],"modulation":[273],"immune":[275],"homeostasis.":[276],"These":[277],"findings":[278],"may":[279],"contribute":[280],"incidence":[284],"hypertensive":[288],"beta-blockers,":[295],"especially":[296],"atenolol.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-20T00:00:00"}