{"id":"https://openalex.org/W4366290171","doi":"https://doi.org/10.3390/pharmaceutics15041258","title":"Comparison of Compartmental and Non-Compartmental Analysis to Detect Biopharmaceutical Similarity of Intravenous Nanomaterial-Based Rifabutin Formulations","display_name":"Comparison of Compartmental and Non-Compartmental Analysis to Detect Biopharmaceutical Similarity of Intravenous Nanomaterial-Based Rifabutin Formulations","publication_year":2023,"publication_date":"2023-04-17","ids":{"openalex":"https://openalex.org/W4366290171","doi":"https://doi.org/10.3390/pharmaceutics15041258","pmid":"https://pubmed.ncbi.nlm.nih.gov/37111743","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10145013"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics15041258","doi":"https://doi.org/10.3390/pharmaceutics15041258","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics15041258","pdf_url":"https://www.mdpi.com/1999-4923/15/4/1258/pdf?version=1681727350","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/15/4/1258/pdf?version=1681727350","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054020101","display_name":"Nadezhda Osipova","orcid":"https://orcid.org/0000-0002-2814-9064","observed_orcids":["https://orcid.org/0000-0002-2814-9064"]},"institutions":[{"id":"https://openalex.org/I4210117032","display_name":"Nanosystem (Russia)","ror":"https://ror.org/01na16w26","country_code":"RU","type":"company","lineage":["https://openalex.org/I4210117032"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nadezhda Osipova","raw_affiliation_strings":["Nanosystem Ltd., Kolomenskiy Proezd 13A, 115446 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanosystem Ltd., Kolomenskiy Proezd 13A, 115446 Moscow, Russia","institution_ids":["https://openalex.org/I4210117032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069933799","display_name":"Andrey Budko","orcid":"https://orcid.org/0000-0001-6594-4051","observed_orcids":["https://orcid.org/0000-0001-6594-4051"]},"institutions":[{"id":"https://openalex.org/I4210090957","display_name":"Russian Cancer Research Center NN Blokhin","ror":"https://ror.org/00ab9fg88","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210090957"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Andrey Budko","raw_affiliation_strings":["N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science, Kashirskoye Shosse 24, 115478 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Science, Kashirskoye Shosse 24, 115478 Moscow, Russia","institution_ids":["https://openalex.org/I4210090957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107393717","display_name":"Olga Maksimenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117032","display_name":"Nanosystem (Russia)","ror":"https://ror.org/01na16w26","country_code":"RU","type":"company","lineage":["https://openalex.org/I4210117032"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Olga Maksimenko","raw_affiliation_strings":["Nanosystem Ltd., Kolomenskiy Proezd 13A, 115446 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanosystem Ltd., Kolomenskiy Proezd 13A, 115446 Moscow, Russia","institution_ids":["https://openalex.org/I4210117032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087900707","display_name":"\u0415\u043b\u0435\u043d\u0430 \u0412\u043b\u0430\u0434\u0438\u043c\u0438\u0440\u043e\u0432\u043d\u0430 \u0428\u0438\u043f\u0443\u043b\u043e","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117032","display_name":"Nanosystem (Russia)","ror":"https://ror.org/01na16w26","country_code":"RU","type":"company","lineage":["https://openalex.org/I4210117032"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Elena Shipulo","raw_affiliation_strings":["Nanosystem Ltd., Kolomenskiy Proezd 13A, 115446 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanosystem Ltd., Kolomenskiy Proezd 13A, 115446 Moscow, Russia","institution_ids":["https://openalex.org/I4210117032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037019148","display_name":"Ludmila V. Vanchugova","orcid":"https://orcid.org/0000-0003-4195-2609","observed_orcids":["https://orcid.org/0000-0003-4195-2609"]},"institutions":[{"id":"https://openalex.org/I4210117032","display_name":"Nanosystem (Russia)","ror":"https://ror.org/01na16w26","country_code":"RU","type":"company","lineage":["https://openalex.org/I4210117032"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ludmila Vanchugova","raw_affiliation_strings":["Nanosystem Ltd., Kolomenskiy Proezd 13A, 115446 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanosystem Ltd., Kolomenskiy Proezd 13A, 115446 Moscow, Russia","institution_ids":["https://openalex.org/I4210117032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100732345","display_name":"Wenqian Chen","orcid":"https://orcid.org/0000-0001-8867-3012","observed_orcids":["https://orcid.org/0000-0001-8867-3012"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wenqian Chen","raw_affiliation_strings":["Department of Pharmacy, Faculty of Science, 4 Science Drive 2, Singapore 117544, Singapore"],"raw_orcid":"https://orcid.org/0000-0001-8867-3012","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Science, 4 Science Drive 2, Singapore 117544, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048247977","display_name":"Svetlana Emmanuilovna Gelperina","orcid":"https://orcid.org/0000-0003-1113-6715","observed_orcids":["https://orcid.org/0000-0003-1113-6715"]},"institutions":[{"id":"https://openalex.org/I4210117032","display_name":"Nanosystem (Russia)","ror":"https://ror.org/01na16w26","country_code":"RU","type":"company","lineage":["https://openalex.org/I4210117032"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Svetlana Gelperina","raw_affiliation_strings":["Nanosystem Ltd., Kolomenskiy Proezd 13A, 115446 Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0003-1113-6715","affiliations":[{"raw_affiliation_string":"Nanosystem Ltd., Kolomenskiy Proezd 13A, 115446 Moscow, Russia","institution_ids":["https://openalex.org/I4210117032"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054757705","display_name":"Matthias Gerhard Wacker","orcid":"https://orcid.org/0000-0002-2789-6463","observed_orcids":["https://orcid.org/0000-0002-2789-6463"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Matthias G. Wacker","raw_affiliation_strings":["Department of Pharmacy, Faculty of Science, 4 Science Drive 2, Singapore 117544, Singapore"],"raw_orcid":"https://orcid.org/0000-0002-2789-6463","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Science, 4 Science Drive 2, Singapore 117544, Singapore","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048247977","https://openalex.org/A5054757705"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210117032"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2892},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2892},"fwci":0.8592,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.61817741,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"15","issue":"4","first_page":"1258","last_page":"1258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rifabutin","display_name":"rifabutin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bioequivalence","display_name":"bioequivalence","score":0.7889999747276306},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.6859999895095825},{"id":"https://openalex.org/keywords/plga-nanoparticles","display_name":"PLGA nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/compartmental-modeling","display_name":"compartmental modeling","score":0.7319999933242798},{"id":"https://openalex.org/keywords/non-compartmental-analysis","display_name":"non-compartmental analysis","score":0.972000002861023},{"id":"https://openalex.org/keywords/intravenous-formulation","display_name":"intravenous formulation","score":0.5389999747276306},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.8109999895095825},{"id":"https://openalex.org/keywords/particle-size","display_name":"particle size","score":0.7289999723434448},{"id":"https://openalex.org/keywords/hiv-tb-co-infection","display_name":"HIV/TB coinfection","score":0.7070000171661377},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C2780867798","wikidata":"https://www.wikidata.org/wiki/Q1135705","display_name":"Rifabutin","level":4,"score":0.8909375071525574},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.7343606948852539},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6798237562179565},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5737383365631104},{"id":"https://openalex.org/C42404028","wikidata":"https://www.wikidata.org/wiki/Q864940","display_name":"Bioequivalence","level":3,"score":0.5395355224609375},{"id":"https://openalex.org/C2910701995","wikidata":"https://www.wikidata.org/wiki/Q679692","display_name":"Biopharmaceutics","level":5,"score":0.5347662568092346},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.5257474184036255},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5003478527069092},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.4879309833049774},{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.47961461544036865},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2955513000488281},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2851003408432007},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.26748421788215637},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2374831736087799},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.22048616409301758},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.19597864151000977},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1081169843673706},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07533600926399231},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.06304606795310974},{"id":"https://openalex.org/C2776962512","wikidata":"https://www.wikidata.org/wiki/Q118551","display_name":"Clarithromycin","level":3,"score":0.06031292676925659},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/pharmaceutics15041258","doi":"https://doi.org/10.3390/pharmaceutics15041258","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics15041258","pdf_url":"https://www.mdpi.com/1999-4923/15/4/1258/pdf?version=1681727350","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10145013","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10145013","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10145013/pdf/pharmaceutics-15-01258.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmid:37111743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37111743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c8f1483caacb496ca24e0afc6f0f49cb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c8f1483caacb496ca24e0afc6f0f49cb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 15, Iss 4, p 1258 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics15041258","doi":"https://doi.org/10.3390/pharmaceutics15041258","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics15041258","pdf_url":"https://www.mdpi.com/1999-4923/15/4/1258/pdf?version=1681727350","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320751","display_name":"Ministry of Education - Singapore","ror":"https://ror.org/01kcva023"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366290171.pdf","grobid_xml":"https://content.openalex.org/works/W4366290171.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1996170794","https://openalex.org/W2027236774","https://openalex.org/W2053560002","https://openalex.org/W2065630028","https://openalex.org/W2089663335","https://openalex.org/W2097200325","https://openalex.org/W2150559484","https://openalex.org/W2170551272","https://openalex.org/W2304970015","https://openalex.org/W2587959917","https://openalex.org/W2950576572","https://openalex.org/W2958974345","https://openalex.org/W2994867934","https://openalex.org/W3007443409","https://openalex.org/W3037832972","https://openalex.org/W3127087607","https://openalex.org/W3176253971","https://openalex.org/W3180307759","https://openalex.org/W3196688930","https://openalex.org/W4309546547","https://openalex.org/W4311886108","https://openalex.org/W4313830801"],"related_works":["https://openalex.org/W2046422808","https://openalex.org/W3134109912","https://openalex.org/W2342202830","https://openalex.org/W2752440501","https://openalex.org/W2382915207","https://openalex.org/W4384558514","https://openalex.org/W2899206436","https://openalex.org/W2617216977","https://openalex.org/W1533468719","https://openalex.org/W2279803802"],"abstract_inverted_index":{"Pharmacometric":[0],"analysis":[1,30,154,258,323],"is":[2],"often":[3],"used":[4],"to":[5,65,141,225,248,266,286,292,309],"quantify":[6],"the":[7,15,24,41,52,58,87,148,158,176,182,187,194,204,211,216,230,252,260,273,317],"differences":[8],"and":[9,49,76,91,101,110,179,190,197],"similarities":[10],"between":[11,272],"formulation":[12,109,231,275],"prototypes.":[13,276],"In":[14,57],"regulatory":[16],"framework,":[17],"it":[18],"plays":[19],"a":[20,122,133,142,241,249,287,310],"significant":[21,145],"role":[22],"in":[23,107,114,121,125,136,147,149,229,240,251,294],"evaluation":[25],"of":[26,55,89,94,163,167,181,199,244,270,299,303,320],"bioequivalence.":[27],"While":[28],"non-compartmental":[29,220],"provides":[31],"an":[32,115,267],"unbiased":[33],"data":[34],"evaluation,":[35],"mechanistic":[36,256,321],"compartmental":[37,257,322],"models":[38],"such":[39],"as":[40,119,184,186,246],"physiologically-based":[42,261],"nanocarrier":[43,262],"biopharmaceutics":[44,263],"model":[45,264],"promise":[46],"improved":[47],"sensitivity":[48,319],"resolution":[50],"for":[51,69,86],"underlying":[53],"causes":[54],"inequivalence.":[56,201],"present":[59],"investigation,":[60],"both":[61,175],"techniques":[62],"were":[63],"applied":[64],"two":[66,274],"nanomaterial-based":[67],"formulations":[68,104],"intravenous":[70],"injection,":[71],"namely,":[72],"albumin-stabilized":[73,128,168,236],"rifabutin":[74,82,169,237,278],"nanoparticles":[75,234,279],"rifabutin-loaded":[77],"PLGA":[78,304],"nanoparticles.":[79,170],"The":[80,103,127,171],"antibiotic":[81],"holds":[83],"great":[84],"potential":[85],"treatment":[88],"severe":[90],"acute":[92],"infections":[93],"patients":[95],"co-infected":[96],"with":[97,326],"human":[98],"immunodeficiency":[99],"virus":[100],"tuberculosis.":[102],"differ":[105],"significantly":[106],"their":[108],"material":[111],"attributes,":[112],"resulting":[113],"altered":[116],"biodistribution":[117,123,180],"pattern":[118],"confirmed":[120],"study":[124,314],"rats.":[126],"delivery":[129],"system":[130],"further":[131],"undergoes":[132],"dose-dependent":[134],"change":[135,146,228,250],"particle":[137,295],"size":[138],"which":[139],"leads":[140],"small":[143],"yet":[144],"vivo":[150],"performance.":[151],"A":[152,227,255,297],"second":[153],"was":[155],"conducted":[156],"comparing":[157],"dose":[159,165,172,253,283,301],"fraction-scaled":[160],"pharmacokinetic":[161,205],"profiles":[162],"three":[164],"levels":[166,284],"strength":[173],"affects":[174],"nanomaterial-related":[177],"absorption":[178],"carrier":[183],"well":[185],"drug-related":[188],"distribution":[189],"elimination":[191],"parameters,":[192],"increasing":[193],"background":[195],"noise":[196],"difficulty":[198],"detecting":[200],"Depending":[202],"on":[203,306],"parameter":[206],"(e.g.,":[207],"AUC,":[208],"Cmax,":[209],"Clobs),":[210],"relative":[212],"(percentage)":[213],"difference":[214,269],"from":[215,223],"average":[217,268],"observed":[218],"using":[219,259],"modeling":[221],"ranged":[222],"85%":[224],"5.2%.":[226],"type":[232],"(PLGA":[233],"vs.":[235],"nanoparticles)":[238],"resulted":[239],"similar":[242],"level":[243],"inequivalence":[245],"compared":[247],"strength.":[254],"led":[265,285,308],"152.46%":[271],"Albumin-stabilized":[277],"tested":[280],"at":[281],"different":[282,300],"128.30%":[288],"difference,":[289],"potentially":[290],"due":[291],"changes":[293],"size.":[296],"comparison":[298],"strengths":[302],"nanoparticles,":[305],"average,":[307],"3.87%":[311],"difference.":[312],"This":[313],"impressively":[315],"illustrates":[316],"superior":[318],"when":[324],"dealing":[325],"nanomedicines.":[327]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-04-20T00:00:00"}