{"id":"https://openalex.org/W4366287732","doi":"https://doi.org/10.3390/ijms24087388","title":"Persicae Semen Promotes Bone Union in Rat Fractures by Stimulating Osteoblastogenesis through BMP-2 and Wnt Signaling","display_name":"Persicae Semen Promotes Bone Union in Rat Fractures by Stimulating Osteoblastogenesis through BMP-2 and Wnt Signaling","publication_year":2023,"publication_date":"2023-04-17","ids":{"openalex":"https://openalex.org/W4366287732","doi":"https://doi.org/10.3390/ijms24087388","pmid":"https://pubmed.ncbi.nlm.nih.gov/37108563","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10138545"},"language":"en","primary_location":{"id":"doi:10.3390/ijms24087388","doi":"https://doi.org/10.3390/ijms24087388","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms24087388","pdf_url":"https://www.mdpi.com/1422-0067/24/8/7388/pdf?version=1681889907","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/24/8/7388/pdf?version=1681889907","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jae-Yun Jun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae-Yun Jun","raw_affiliation_strings":["Department of Anatomy, College of Korean Medicine, Kyunghee University, Seoul 02447, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Korean Medicine, Kyunghee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100368641","display_name":"Jae\u2010Hyun Kim","orcid":"https://orcid.org/0000-0003-3593-3049","observed_orcids":["https://orcid.org/0000-0003-3593-3049"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae-Hyun Kim","raw_affiliation_strings":["Department of Anatomy, College of Korean Medicine, Kyunghee University, Seoul 02447, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-3593-3049","affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Korean Medicine, Kyunghee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100382758","display_name":"Minsun Kim","orcid":"https://orcid.org/0000-0002-0323-5433","observed_orcids":["https://orcid.org/0000-0002-0323-5433"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minsun Kim","raw_affiliation_strings":["Department of Anatomy, College of Korean Medicine, Kyunghee University, Seoul 02447, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Korean Medicine, Kyunghee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031730261","display_name":"Sooyeon Hong","orcid":"https://orcid.org/0000-0002-2492-3980","observed_orcids":["https://orcid.org/0000-0002-2492-3980"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sooyeon Hong","raw_affiliation_strings":["Department of Anatomy, College of Korean Medicine, Kyunghee University, Seoul 02447, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-2492-3980","affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Korean Medicine, Kyunghee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101560459","display_name":"Myunghyun Kim","orcid":"https://orcid.org/0000-0002-3857-4291","observed_orcids":["https://orcid.org/0000-0002-3857-4291"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myunghyun Kim","raw_affiliation_strings":["Department of Anatomy, College of Korean Medicine, Kyunghee University, Seoul 02447, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Korean Medicine, Kyunghee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gwang-Hyun Ryu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Gwang-Hyun Ryu","raw_affiliation_strings":["Department of Anatomy, College of Korean Medicine, Kyunghee University, Seoul 02447, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Korean Medicine, Kyunghee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100620279","display_name":"Jae Ho Park","orcid":"https://orcid.org/0000-0003-0942-7871","observed_orcids":["https://orcid.org/0000-0003-0942-7871"]},"institutions":[{"id":"https://openalex.org/I4210149646","display_name":"Jungwon University","ror":"https://ror.org/050mgpz97","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210149646"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Park","raw_affiliation_strings":["Department of Pharmaceutical Science, Jungwon University, Goesan-eup 28024, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-0942-7871","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Science, Jungwon University, Goesan-eup 28024, Republic of Korea","institution_ids":["https://openalex.org/I4210149646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017605603","display_name":"Hyuk\u2010Sang Jung","orcid":"https://orcid.org/0000-0002-7256-9672","observed_orcids":["https://orcid.org/0000-0002-7256-9672"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hyuk-Sang Jung","raw_affiliation_strings":["Department of Anatomy, College of Korean Medicine, Kyunghee University, Seoul 02447, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-7256-9672","affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Korean Medicine, Kyunghee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037974526","display_name":"Youngjoo Sohn","orcid":"https://orcid.org/0000-0002-2159-1386","observed_orcids":["https://orcid.org/0000-0002-2159-1386"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Youngjoo Sohn","raw_affiliation_strings":["Department of Anatomy, College of Korean Medicine, Kyunghee University, Seoul 02447, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-2159-1386","affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Korean Medicine, Kyunghee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017605603","https://openalex.org/A5037974526"],"corresponding_institution_ids":["https://openalex.org/I35928602"],"apc_list":{"value":2500,"currency":"CHF","value_usd":2780},"apc_paid":{"value":2500,"currency":"CHF","value_usd":2780},"fwci":1.8318,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.82336343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"24","issue":"8","first_page":"7388","last_page":"7388"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.8345000147819519,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.8345000147819519,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.12489999830722809,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/persicae-semen","display_name":"Persicae Semen","score":0.9860000014305115},{"id":"https://openalex.org/keywords/fracture-healing","display_name":"fracture healing","score":0.9459999799728394},{"id":"https://openalex.org/keywords/bone-union","display_name":"bone union","score":0.9769999980926514},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.8629999756813049},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9100000262260437},{"id":"https://openalex.org/keywords/wnt10b","display_name":"Wnt10b","score":0.9890000224113464},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/osteogenic-gene-expression","display_name":"osteogenic gene expression","score":0.6790000200271606},{"id":"https://openalex.org/keywords/mineralization","display_name":"mineralization","score":0.656000018119812},{"id":"https://openalex.org/keywords/femoral-fracture","display_name":"femoral fracture","score":0.5989999771118164},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C2776363554","wikidata":"https://www.wikidata.org/wiki/Q14907085","display_name":"RUNX2","level":4,"score":0.8434609174728394},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.8245470523834229},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.7076324224472046},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.645314633846283},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5421913266181946},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.53582763671875},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.47142189741134644},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.4525808095932007},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.4481380581855774},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4323784112930298},{"id":"https://openalex.org/C2776441800","wikidata":"https://www.wikidata.org/wiki/Q68833","display_name":"Bone fracture","level":2,"score":0.4188153147697449},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40863025188446045},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.37320810556411743},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.3341123163700104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28876060247421265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23327350616455078},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.20958641171455383},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14852115511894226},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06742829084396362},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005264","descriptor_name":"Femoral Fractures","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012639","descriptor_name":"Seeds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms24087388","doi":"https://doi.org/10.3390/ijms24087388","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms24087388","pdf_url":"https://www.mdpi.com/1422-0067/24/8/7388/pdf?version=1681889907","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10138545","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10138545","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10138545/pdf/ijms-24-07388.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:37108563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37108563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms24087388","doi":"https://doi.org/10.3390/ijms24087388","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms24087388","pdf_url":"https://www.mdpi.com/1422-0067/24/8/7388/pdf?version=1681889907","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1573612631","display_name":null,"funder_award_id":"HF21C0092","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G1978986472","display_name":null,"funder_award_id":"2020R1A2C1007836","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G3160888509","display_name":null,"funder_award_id":"2020R1A2C1007836","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G5434208516","display_name":null,"funder_award_id":"HF21C0092","funder_id":"https://openalex.org/F4320322034","funder_display_name":"Ministry of Health and Welfare"}],"funders":[{"id":"https://openalex.org/F4320322034","display_name":"Ministry of Health and Welfare","ror":"https://ror.org/00vxgjw72"},{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366287732.pdf","grobid_xml":"https://content.openalex.org/works/W4366287732.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W110659814","https://openalex.org/W993469591","https://openalex.org/W1561515414","https://openalex.org/W1964541581","https://openalex.org/W1969670678","https://openalex.org/W1976535297","https://openalex.org/W1983666549","https://openalex.org/W1987113787","https://openalex.org/W1987504060","https://openalex.org/W1996361385","https://openalex.org/W1998696289","https://openalex.org/W2009228297","https://openalex.org/W2014452716","https://openalex.org/W2022450242","https://openalex.org/W2025422403","https://openalex.org/W2037835654","https://openalex.org/W2038457945","https://openalex.org/W2051344690","https://openalex.org/W2052520062","https://openalex.org/W2055323801","https://openalex.org/W2059650971","https://openalex.org/W2060235532","https://openalex.org/W2074242069","https://openalex.org/W2074906434","https://openalex.org/W2080444164","https://openalex.org/W2092422003","https://openalex.org/W2124385965","https://openalex.org/W2128986278","https://openalex.org/W2132946102","https://openalex.org/W2140411306","https://openalex.org/W2155861726","https://openalex.org/W2172270516","https://openalex.org/W2217100198","https://openalex.org/W2282041473","https://openalex.org/W2335178464","https://openalex.org/W2343938601","https://openalex.org/W2399171234","https://openalex.org/W2405381679","https://openalex.org/W2406702280","https://openalex.org/W2552658430","https://openalex.org/W2809157660","https://openalex.org/W2901082211","https://openalex.org/W2912590334","https://openalex.org/W2948913099","https://openalex.org/W2972105099","https://openalex.org/W3010995765","https://openalex.org/W3092007106","https://openalex.org/W3093716487","https://openalex.org/W3186886653","https://openalex.org/W4231501084","https://openalex.org/W4290839790","https://openalex.org/W4304758038"],"related_works":["https://openalex.org/W1991477586","https://openalex.org/W2382969121","https://openalex.org/W4390311791","https://openalex.org/W2511704967","https://openalex.org/W4386477094","https://openalex.org/W4410530267","https://openalex.org/W7165843085","https://openalex.org/W4310569047","https://openalex.org/W2911304434","https://openalex.org/W2731843824"],"abstract_inverted_index":{"Fractures":[0],"cause":[1],"extreme":[2],"pain":[3],"to":[4],"patients":[5],"and":[6,32,55,66,83,87,96,109,137,142,156,172,195,198],"impair":[7],"movement,":[8],"thereby":[9],"significantly":[10],"reducing":[11],"their":[12],"quality":[13],"of":[14,21,29,50,61,75,91,117,128,149,160,175,181],"life.":[15],"However,":[16],"in":[17,56,121],"fracture":[18,23,189,208],"patients,":[19],"movement":[20],"the":[22,46,59,88,107,114,129,147,165,179],"site":[24],"is":[25,45],"restricted":[26],"through":[27,39,79,140],"application":[28],"a":[30,101,203],"cast,":[31],"they":[33],"are":[34],"reliant":[35],"on":[36,63,93],"conservative":[37],"treatment":[38],"calcium":[40],"intake.":[41],"Persicae":[42],"semen":[43],"(PS)":[44],"dried":[47],"mature":[48],"seeds":[49],"Prunus":[51],"persica":[52],"(L.)":[53],"Batsch,":[54],"this":[57,182],"study":[58,183],"effects":[60],"PS":[62,76,92,118,134,145,166,186],"osteoblast":[64,151,193],"differentiation":[65,194],"bone":[67,170,196],"union":[68,171],"promotion":[69],"were":[70],"investigated.":[71],"The":[72,126,158],"osteoblast-differentiation-promoting":[73],"effect":[74,116],"was":[77,104,119],"investigated":[78,120],"alizarin":[80],"red":[81],"S":[82],"Von":[84],"Kossa":[85],"staining,":[86],"regulatory":[89],"role":[90],"BMP-2":[94,141],"(Bmp2)":[95],"Wnt":[97,143],"(Wnt10b)":[98],"signaling,":[99],"representing":[100],"key":[102],"mechanism,":[103],"demonstrated":[105],"at":[106],"protein":[108],"mRNA":[110],"levels.":[111],"In":[112],"addition,":[113],"bone-union-promoting":[115],"rats":[122],"with":[123],"fractured":[124],"femurs.":[125],"results":[127,159,180],"cell":[130],"experiments":[131,162],"showed":[132],"that":[133,164,185],"promotes":[135],"mineralization":[136],"upregulates":[138],"RUNX2":[139],"signaling.":[144],"induced":[146],"expression":[148,174],"various":[150],"genes,":[152],"including":[153],"Alpl,":[154],"Bglap,":[155],"Ibsp.":[157],"animal":[161],"show":[163],"group":[167],"had":[168],"improved":[169],"upregulated":[173],"osteogenic":[176],"genes.":[177],"Overall,":[178],"suggest":[184],"can":[187,200],"promote":[188],"recovery":[190],"by":[191],"upregulating":[192],"formation,":[197],"thus":[199],"be":[201],"considered":[202],"new":[204],"therapeutic":[205],"alternative":[206],"for":[207],"patients.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-04-20T00:00:00"}
