{"id":"https://openalex.org/W4366286736","doi":"https://doi.org/10.3390/cells12081179","title":"The NuRD Complex in Neurodevelopment and Disease: A Case of Sliding Doors","display_name":"The NuRD Complex in Neurodevelopment and Disease: A Case of Sliding Doors","publication_year":2023,"publication_date":"2023-04-18","ids":{"openalex":"https://openalex.org/W4366286736","doi":"https://doi.org/10.3390/cells12081179","pmid":"https://pubmed.ncbi.nlm.nih.gov/37190088","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10136855"},"language":"en","primary_location":{"id":"doi:10.3390/cells12081179","doi":"https://doi.org/10.3390/cells12081179","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells12081179","pdf_url":"https://www.mdpi.com/2073-4409/12/8/1179/pdf?version=1681789349","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4409/12/8/1179/pdf?version=1681789349","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013194716","display_name":"Paraskevi Boulasiki","orcid":"https://orcid.org/0000-0001-5534-620X","observed_orcids":["https://orcid.org/0000-0001-5534-620X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paraskevi Boulasiki","raw_affiliation_strings":["UCL Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071895707","display_name":"Xiao Wei Tan","orcid":"https://orcid.org/0000-0003-4752-4074","observed_orcids":["https://orcid.org/0000-0003-4752-4074"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Xiao Wei Tan","raw_affiliation_strings":["UCL Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK"],"raw_orcid":"https://orcid.org/0000-0003-4752-4074","affiliations":[{"raw_affiliation_string":"UCL Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069830664","display_name":"Matteo Spinelli","orcid":"https://orcid.org/0000-0001-5776-988X","observed_orcids":["https://orcid.org/0000-0001-5776-988X"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"Matteo Spinelli","raw_affiliation_strings":["Neuroscience Department, Catholic University of the Sacred Heart, 00168 Rome, Italy","UCL Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK"],"raw_orcid":"https://orcid.org/0000-0001-5776-988X","affiliations":[{"raw_affiliation_string":"Neuroscience Department, Catholic University of the Sacred Heart, 00168 Rome, Italy","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"UCL Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":null,"display_name":"Antonella Riccio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Antonella Riccio","raw_affiliation_strings":["UCL Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2669},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2669},"fwci":0.8272,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.65349265,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"8","first_page":"1179","last_page":"1179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.486299991607666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.486299991607666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.25200000405311584,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.2223999947309494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nurd-complex","display_name":"NuRD complex","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.953000009059906},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.9639999866485596},{"id":"https://openalex.org/keywords/nucleosome-sliding","display_name":"nucleosome sliding","score":0.9340000152587891},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.8519999980926514},{"id":"https://openalex.org/keywords/neural-circuits","display_name":"neural circuits","score":0.7599999904632568},{"id":"https://openalex.org/keywords/neurodevelopmental-disorders","display_name":"neurodevelopmental disorders","score":0.9599999785423279},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6790000200271606},{"id":"https://openalex.org/keywords/complex-assembly","display_name":"complex assembly","score":0.7639999985694885},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.5099999904632568},{"id":"https://openalex.org/keywords/cognitive-development","display_name":"cognitive development","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6854135990142822},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.6634196043014526},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.6605817675590515},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6565999984741211},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5926051139831543},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5342385768890381},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.46614471077919006},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.46362757682800293},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4478694200515747},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3754222095012665},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23180454969406128}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056245","descriptor_name":"Mi-2 Nucleosome Remodeling and Deacetylase Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056245","descriptor_name":"Mi-2 Nucleosome Remodeling and Deacetylase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.3390/cells12081179","doi":"https://doi.org/10.3390/cells12081179","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells12081179","pdf_url":"https://www.mdpi.com/2073-4409/12/8/1179/pdf?version=1681789349","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10136855","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10136855","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10136855/pdf/cells-12-01179.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Text"},{"id":"pmid:37190088","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37190088","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10169674","doi":null,"is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10169674/","pdf_url":"https://discovery.ucl.ac.uk/10169674/1/cells-12-01179.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells , 12 (8) , Article 1179. (2023)","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:508d23f1571346b7b2e9edaa19edbd41","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/508d23f1571346b7b2e9edaa19edbd41","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells, Vol 12, Iss 8, p 1179 (2023)","raw_type":"article"},{"id":"pmh:oai:iris.uniss.it:11388/329409","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11388/329409","pdf_url":null,"source":{"id":"https://openalex.org/S4306401147","display_name":"UnissResearch (Universit\u00e0 degli Studi di Sassari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I159650629","host_organization_name":"University of Sassari","host_organization_lineage":["https://openalex.org/I159650629"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/cells12081179","doi":"https://doi.org/10.3390/cells12081179","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells12081179","pdf_url":"https://www.mdpi.com/2073-4409/12/8/1179/pdf?version=1681789349","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1660044801","display_name":null,"funder_award_id":"MC/U12266B","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4004121074","display_name":"Epigenetic regulation of neuronal development.","funder_award_id":"103717/Z/14/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G830246384","display_name":null,"funder_award_id":"MC_ U12266B","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8855820344","display_name":"RNA metabolism in developing neurons","funder_award_id":"217213/Z/19/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366286736.pdf","grobid_xml":"https://content.openalex.org/works/W4366286736.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W1525573602","https://openalex.org/W1964167542","https://openalex.org/W1964444099","https://openalex.org/W1973871665","https://openalex.org/W1984249881","https://openalex.org/W1988181440","https://openalex.org/W2003794997","https://openalex.org/W2008282310","https://openalex.org/W2008627757","https://openalex.org/W2016606965","https://openalex.org/W2017702380","https://openalex.org/W2025092145","https://openalex.org/W2056147363","https://openalex.org/W2057619579","https://openalex.org/W2059379142","https://openalex.org/W2067651011","https://openalex.org/W2069010410","https://openalex.org/W2071076489","https://openalex.org/W2074380974","https://openalex.org/W2074974586","https://openalex.org/W2079706646","https://openalex.org/W2085916218","https://openalex.org/W2087106147","https://openalex.org/W2088229389","https://openalex.org/W2089263351","https://openalex.org/W2092710299","https://openalex.org/W2095377293","https://openalex.org/W2096764229","https://openalex.org/W2102539783","https://openalex.org/W2111893274","https://openalex.org/W2127311839","https://openalex.org/W2134264179","https://openalex.org/W2148129287","https://openalex.org/W2156200367","https://openalex.org/W2156485051","https://openalex.org/W2158136052","https://openalex.org/W2160436756","https://openalex.org/W2168038023","https://openalex.org/W2340883705","https://openalex.org/W2398293253","https://openalex.org/W2462176300","https://openalex.org/W2500269539","https://openalex.org/W2520557077","https://openalex.org/W2546675038","https://openalex.org/W2598469016","https://openalex.org/W2618569629","https://openalex.org/W2687519416","https://openalex.org/W2762557409","https://openalex.org/W2769544142","https://openalex.org/W2791103809","https://openalex.org/W2803671769","https://openalex.org/W2808893326","https://openalex.org/W2810051411","https://openalex.org/W2810285992","https://openalex.org/W2885365445","https://openalex.org/W2886314461","https://openalex.org/W2897515450","https://openalex.org/W2899420465","https://openalex.org/W2903457010","https://openalex.org/W2914482125","https://openalex.org/W2946421021","https://openalex.org/W2963295567","https://openalex.org/W2965584346","https://openalex.org/W2966669081","https://openalex.org/W2972214124","https://openalex.org/W2980503825","https://openalex.org/W3009819277","https://openalex.org/W3012816053","https://openalex.org/W3014900738","https://openalex.org/W3041221842","https://openalex.org/W3043488994","https://openalex.org/W3093899911","https://openalex.org/W3121524583","https://openalex.org/W3157692177","https://openalex.org/W3159421809","https://openalex.org/W3209993957","https://openalex.org/W4206511833","https://openalex.org/W4210782186","https://openalex.org/W4283807660","https://openalex.org/W4320913079"],"related_works":["https://openalex.org/W2546675038","https://openalex.org/W3157692177","https://openalex.org/W7133761661","https://openalex.org/W2963295567","https://openalex.org/W1973871665","https://openalex.org/W2045228891","https://openalex.org/W2920140878","https://openalex.org/W2987505058","https://openalex.org/W3158130962","https://openalex.org/W2039594317"],"abstract_inverted_index":{"The":[0],"Nucleosome":[1],"Remodelling":[2],"and":[3,82,107,124,129,171,176,188],"Deacetylase":[4],"(NuRD)":[5],"complex":[6,40,96,169],"represents":[7],"one":[8],"of":[9,37,44,56,93,121,146,154,185],"the":[10,20,24,35,38,50,54,57,68,73,88,94,118,126,137,144,147,163,167,174,189],"major":[11],"chromatin":[12,25,61],"remodelling":[13],"complexes":[14,123],"in":[15,75,83,87,110,136,151,173,182],"mammalian":[16],"cells,":[17],"uniquely":[18],"coupling":[19],"ability":[21],"to":[22,59,100,162],"\"open\"":[23],"by":[26,53,72],"inducing":[27],"nucleosome":[28],"sliding":[29],"with":[30],"histone":[31],"deacetylase":[32],"activity.":[33],"At":[34],"core":[36],"NuRD":[39,74,95,122,168],"are":[41],"a":[42],"family":[43,149],"ATPases":[45],"named":[46],"CHDs":[47],"that":[48,103,165],"utilise":[49],"energy":[51],"produced":[52],"hydrolysis":[55],"ATP":[58],"induce":[60],"structural":[62],"changes.":[63],"Recent":[64],"studies":[65],"have":[66,97],"highlighted":[67],"prominent":[69],"role":[70,145],"played":[71],"regulating":[76],"gene":[77],"expression":[78],"during":[79],"brain":[80,186],"development":[81,109,187],"maintaining":[84],"neuronal":[85],"circuitry":[86],"adult":[89,190],"cerebellum.":[90],"Importantly,":[91],"components":[92],"been":[98],"found":[99],"carry":[101],"mutations":[102,179],"profoundly":[104],"affect":[105],"neurological":[106],"cognitive":[108],"humans.":[111],"Here,":[112],"we":[113],"discuss":[114,143],"recent":[115],"literature":[116],"concerning":[117],"molecular":[119],"structure":[120],"how":[125,177],"subunit":[127],"composition":[128,170],"numerous":[130],"permutations":[131],"greatly":[132],"determine":[133],"their":[134],"functions":[135],"nervous":[138,191],"system.":[139,192],"We":[140],"will":[141,159],"also":[142],"CHD":[148],"members":[150],"an":[152],"array":[153],"neurodevelopmental":[155],"disorders.":[156],"Special":[157],"emphasis":[158],"be":[160],"given":[161],"mechanisms":[164],"regulate":[166],"assembly":[172],"cortex":[175],"subtle":[178],"may":[180],"result":[181],"profound":[183],"defects":[184]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-04-20T00:00:00"}