{"id":"https://openalex.org/W4366284744","doi":"https://doi.org/10.3390/jcm12082922","title":"Soluble PCSK9 Inhibition: Indications, Clinical Impact, New Molecular Insights and Practical Approach\u2014Where Do We Stand?","display_name":"Soluble PCSK9 Inhibition: Indications, Clinical Impact, New Molecular Insights and Practical Approach\u2014Where Do We Stand?","publication_year":2023,"publication_date":"2023-04-18","ids":{"openalex":"https://openalex.org/W4366284744","doi":"https://doi.org/10.3390/jcm12082922","pmid":"https://pubmed.ncbi.nlm.nih.gov/37109259","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10146045"},"language":"en","primary_location":{"id":"doi:10.3390/jcm12082922","doi":"https://doi.org/10.3390/jcm12082922","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm12082922","pdf_url":"https://www.mdpi.com/2077-0383/12/8/2922/pdf?version=1681787745","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2077-0383/12/8/2922/pdf?version=1681787745","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041025561","display_name":"Michele Bellino","orcid":"https://orcid.org/0000-0001-9792-7782","observed_orcids":["https://orcid.org/0000-0001-9792-7782"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Bellino","raw_affiliation_strings":["Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079678557","display_name":"Gennaro Galasso","orcid":"https://orcid.org/0000-0002-7265-7613","observed_orcids":["https://orcid.org/0000-0002-7265-7613"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Gennaro Galasso","raw_affiliation_strings":["Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy"],"raw_orcid":"https://orcid.org/0000-0002-7265-7613","affiliations":[{"raw_affiliation_string":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045397536","display_name":"Angelo Silverio","orcid":"https://orcid.org/0000-0001-9749-8092","observed_orcids":["https://orcid.org/0000-0001-9749-8092"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angelo Silverio","raw_affiliation_strings":["Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9749-8092","affiliations":[{"raw_affiliation_string":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michele Tedeschi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Tedeschi","raw_affiliation_strings":["Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ciro Formisano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ciro Formisano","raw_affiliation_strings":["Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060351002","display_name":"Stefano Romei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Romei","raw_affiliation_strings":["Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101470211","display_name":"Luca Esposito","orcid":"https://orcid.org/0000-0003-0515-639X","observed_orcids":["https://orcid.org/0000-0003-0515-639X"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Esposito","raw_affiliation_strings":["Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036881853","display_name":"Francesco Paolo Cancro","orcid":"https://orcid.org/0000-0001-7189-8469","observed_orcids":["https://orcid.org/0000-0001-7189-8469"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Paolo Cancro","raw_affiliation_strings":["Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051439291","display_name":"Maria Giovanna Vassallo","orcid":"https://orcid.org/0000-0001-6874-715X","observed_orcids":["https://orcid.org/0000-0001-6874-715X"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Giovanna Vassallo","raw_affiliation_strings":["Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031730971","display_name":"Giulio Accarino","orcid":"https://orcid.org/0000-0003-0480-907X","observed_orcids":["https://orcid.org/0000-0003-0480-907X"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulio Accarino","raw_affiliation_strings":["Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy"],"raw_orcid":"https://orcid.org/0000-0003-0480-907X","affiliations":[{"raw_affiliation_string":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068649190","display_name":"Monica Verdoia","orcid":"https://orcid.org/0000-0001-6506-8397","observed_orcids":["https://orcid.org/0000-0001-6506-8397"]},"institutions":[{"id":"https://openalex.org/I4210091122","display_name":"Ospedale degli Infermi","ror":"https://ror.org/00edt5124","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091122","https://openalex.org/I4210157822"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Monica Verdoia","raw_affiliation_strings":["Division of Cardiology, Ospedale Degli Infermi, ASL Biella, 13900 Biella, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6506-8397","affiliations":[{"raw_affiliation_string":"Division of Cardiology, Ospedale Degli Infermi, ASL Biella, 13900 Biella, Italy","institution_ids":["https://openalex.org/I4210091122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048987586","display_name":"Francesca Maria Di Muro","orcid":"https://orcid.org/0000-0002-2145-6555","observed_orcids":["https://orcid.org/0000-0002-2145-6555"]},"institutions":[{"id":"https://openalex.org/I4210115393","display_name":"Azienda Ospedaliero-Universitaria Careggi","ror":"https://ror.org/02crev113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210115393"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Maria Di Muro","raw_affiliation_strings":["Structural Interventional Cardiology, Department of Clinical and Experimental Medicine, Clinica Medica, Careggi University Hospital, 50139 Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Interventional Cardiology, Department of Clinical and Experimental Medicine, Clinica Medica, Careggi University Hospital, 50139 Florence, Italy","institution_ids":["https://openalex.org/I4210115393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085584750","display_name":"Carmine Vecchione","orcid":"https://orcid.org/0000-0002-2473-4565","observed_orcids":["https://orcid.org/0000-0002-2473-4565"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carmine Vecchione","raw_affiliation_strings":["Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy","Vascular Physiopathology Unit, IRCCS Neuromed Mediterranean Neurological Institute, 86077 Pozzilli, Italy","Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy; Vascular Physiopathology Unit, IRCCS Neuromed Mediterranean Neurological Institute, 86077 Pozzilli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Vascular Physiopathology Unit, IRCCS Neuromed Mediterranean Neurological Institute, 86077 Pozzilli, Italy","institution_ids":["https://openalex.org/I3018288129"]},{"raw_affiliation_string":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy; Vascular Physiopathology Unit, IRCCS Neuromed Mediterranean Neurological Institute, 86077 Pozzilli, Italy","institution_ids":["https://openalex.org/I131729948","https://openalex.org/I3018288129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047328504","display_name":"Giuseppe De Luca","orcid":"https://orcid.org/0000-0001-6031-2899","observed_orcids":["https://orcid.org/0000-0001-6031-2899","https://orcid.org/0009-0004-1757-5908"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]},{"id":"https://openalex.org/I4210113215","display_name":"IRCCS Ospedale Galeazzi - Sant'Ambrogio","ror":"https://ror.org/01vyrje42","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113215","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210139630","display_name":"Azienda Ospedaliera Universitaria Policlinico \"G. Martino\"","ror":"https://ror.org/03tf96d34","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210139630"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe De Luca","raw_affiliation_strings":["Division of Cardiology, AOU \u201cPoliclinico G. Martino\u201d, Department of Clinical and Experimental Medicine, University of Messina, 98166 Messina, Italy","Division of Cardiology, IRCCS Hospital Galeazzi-Sant\u2019Ambrogio, 20161 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6031-2899","affiliations":[{"raw_affiliation_string":"Division of Cardiology, AOU \u201cPoliclinico G. Martino\u201d, Department of Clinical and Experimental Medicine, University of Messina, 98166 Messina, Italy","institution_ids":["https://openalex.org/I112862951","https://openalex.org/I4210139630"]},{"raw_affiliation_string":"Division of Cardiology, IRCCS Hospital Galeazzi-Sant\u2019Ambrogio, 20161 Milan, Italy","institution_ids":["https://openalex.org/I4210113215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5079678557"],"corresponding_institution_ids":["https://openalex.org/I131729948"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2892},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2892},"fwci":0.4688,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.45550911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"12","issue":"8","first_page":"2922","last_page":"2922"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pcsk9-inhibitors","display_name":"PCSK9 inhibitors","score":0.8230000138282776},{"id":"https://openalex.org/keywords/alirocumab","display_name":"alirocumab","score":0.8840000033378601},{"id":"https://openalex.org/keywords/evolocumab","display_name":"evolocumab","score":1.0},{"id":"https://openalex.org/keywords/ldl-cholesterol-lowering","display_name":"LDL cholesterol lowering","score":0.8429999947547913},{"id":"https://openalex.org/keywords/atherosclerotic-cardiovascular-disease","display_name":"atherosclerotic cardiovascular disease","score":0.8809999823570251},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8939999938011169},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.6190000176429749},{"id":"https://openalex.org/keywords/cardiovascular-disease-prevention","display_name":"cardiovascular disease prevention","score":0.6520000100135803},{"id":"https://openalex.org/keywords/high-intensity-statins","display_name":"high-intensity statins","score":0.6729999780654907},{"id":"https://openalex.org/keywords/ezetimibe","display_name":"ezetimibe","score":0.9259999990463257},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.6579999923706055},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.970563530921936},{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.7281152009963989},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39326465129852295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21218883991241455},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.16728109121322632},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.10561999678611755},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/jcm12082922","doi":"https://doi.org/10.3390/jcm12082922","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm12082922","pdf_url":"https://www.mdpi.com/2077-0383/12/8/2922/pdf?version=1681787745","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10146045","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10146045","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10146045/pdf/jcm-12-02922.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Med","raw_type":"Text"},{"id":"pmid:37109259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37109259","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/jcm12082922","doi":"https://doi.org/10.3390/jcm12082922","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm12082922","pdf_url":"https://www.mdpi.com/2077-0383/12/8/2922/pdf?version=1681787745","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366284744.pdf","grobid_xml":"https://content.openalex.org/works/W4366284744.grobid-xml"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W121888607","https://openalex.org/W161816689","https://openalex.org/W1423581981","https://openalex.org/W1923289550","https://openalex.org/W1985747185","https://openalex.org/W1988996988","https://openalex.org/W1990237691","https://openalex.org/W1993621677","https://openalex.org/W1993919774","https://openalex.org/W1994718207","https://openalex.org/W1997089129","https://openalex.org/W2001328643","https://openalex.org/W2018010993","https://openalex.org/W2018489219","https://openalex.org/W2019071303","https://openalex.org/W2021283737","https://openalex.org/W2022928811","https://openalex.org/W2023735564","https://openalex.org/W2024692328","https://openalex.org/W2024930123","https://openalex.org/W2054572833","https://openalex.org/W2059210927","https://openalex.org/W2064994526","https://openalex.org/W2071885555","https://openalex.org/W2080422716","https://openalex.org/W2103487568","https://openalex.org/W2121581403","https://openalex.org/W2139575534","https://openalex.org/W2141898196","https://openalex.org/W2142267986","https://openalex.org/W2146769790","https://openalex.org/W2155259933","https://openalex.org/W2162793769","https://openalex.org/W2166934777","https://openalex.org/W2218353190","https://openalex.org/W2247997571","https://openalex.org/W2288476146","https://openalex.org/W2314193179","https://openalex.org/W2316112497","https://openalex.org/W2428638657","https://openalex.org/W2462046607","https://openalex.org/W2465758073","https://openalex.org/W2509676484","https://openalex.org/W2518726365","https://openalex.org/W2519905430","https://openalex.org/W2523797390","https://openalex.org/W2554832534","https://openalex.org/W2580016379","https://openalex.org/W2592844101","https://openalex.org/W2596179513","https://openalex.org/W2609543937","https://openalex.org/W2609836833","https://openalex.org/W2626426886","https://openalex.org/W2748800769","https://openalex.org/W2751778625","https://openalex.org/W2766784925","https://openalex.org/W2768588165","https://openalex.org/W2769252393","https://openalex.org/W2785715927","https://openalex.org/W2793047794","https://openalex.org/W2801426688","https://openalex.org/W2848978533","https://openalex.org/W2890313437","https://openalex.org/W2899997727","https://openalex.org/W2900034165","https://openalex.org/W2910292619","https://openalex.org/W2913603892","https://openalex.org/W2950663303","https://openalex.org/W2953804067","https://openalex.org/W2954453953","https://openalex.org/W2970625233","https://openalex.org/W2985333121","https://openalex.org/W3006628131","https://openalex.org/W3016410715","https://openalex.org/W3044128309","https://openalex.org/W3047793031","https://openalex.org/W3103804121","https://openalex.org/W3118373032","https://openalex.org/W3127847696","https://openalex.org/W3139032058","https://openalex.org/W3158442165","https://openalex.org/W3159850108","https://openalex.org/W3167366374","https://openalex.org/W3183857127","https://openalex.org/W3191267295","https://openalex.org/W3197001430","https://openalex.org/W3205652559","https://openalex.org/W3215627254","https://openalex.org/W4206837776","https://openalex.org/W4210610619","https://openalex.org/W4212792768","https://openalex.org/W4220838344","https://openalex.org/W4224082333","https://openalex.org/W4236673002","https://openalex.org/W4238580056","https://openalex.org/W4281261930","https://openalex.org/W4283770338","https://openalex.org/W4292623154","https://openalex.org/W4293426420","https://openalex.org/W4295290173","https://openalex.org/W4296389402","https://openalex.org/W4310962689","https://openalex.org/W6756602680"],"related_works":["https://openalex.org/W2403467442","https://openalex.org/W7221126119","https://openalex.org/W2884867893","https://openalex.org/W2912092941","https://openalex.org/W2954605165","https://openalex.org/W2252288490","https://openalex.org/W3190443797","https://openalex.org/W3103325438","https://openalex.org/W2521491914","https://openalex.org/W4414419956"],"abstract_inverted_index":{"Current":[0],"research":[1,27],"on":[2,7,256,264],"cardiovascular":[3,204],"prevention":[4],"predominantly":[5],"focuses":[6],"risk-stratification":[8],"and":[9,25,38,47,67,91,118,132,143,162,226,267],"management":[10],"of":[11,63,70,104,108,189,198,203,208,220,244,253],"patients":[12,237],"with":[13,136,171,238,261],"coronary":[14],"artery":[15],"disease":[16,73],"(CAD)":[17],"to":[18,30,39,88,129,164,213,230,235,248],"optimize":[19],"their":[20,265],"prognosis.":[21],"Several":[22,193],"basic,":[23],"translational":[24],"clinical":[26,181,268],"efforts":[28,228],"aim":[29,243],"determine":[31],"the":[32,60,68,79,85,102,137,254],"etiological":[33],"mechanisms":[34,219],"underlying":[35],"CAD":[36,52],"pathogenesis":[37],"identify":[40],"lifestyle-dependent":[41],"metabolic":[42],"risk":[43,69],"factors":[44],"or":[45],"genetic":[46],"epigenetic":[48],"parameters":[49],"responsible":[50],"for":[51],"occurrence":[53],"and/or":[54,174],"progression.":[55],"A":[56],"log-linear":[57],"association":[58],"between":[59],"absolute":[61],"exposure":[62],"LDL":[64],"cholesterol":[65],"(LDL-C)":[66],"atherosclerotic":[71],"cardio-vascular":[72],"(ASCVD)":[74],"was":[75,82,100],"well":[76,184],"documented":[77,140],"over":[78],"year.":[80],"LDL-C":[81,110,152],"identified":[83],"as":[84],"principal":[86],"enemy":[87],"fight":[89],"against,":[90],"soluble":[92,130,149,257],"proprotein":[93],"convertase":[94],"subtilisin":[95],"kexin":[96],"type":[97],"9":[98],"(PCSK9)":[99],"attributed":[101,212],"role":[103],"a":[105,201,250,262],"powerful":[106],"regulator":[107],"blood":[109],"levels.":[111],"The":[112,242],"two":[113],"currently":[114],"available":[115],"antibodies":[116,147],"(alirocumab":[117],"evolocumab)":[119],"against":[120,148],"PCSK9":[121,131,150,199,221,258],"are":[122,183,191,223],"fully":[123],"human":[124],"engineered":[125],"IgG":[126],"that":[127,196],"bind":[128],"avoid":[133],"its":[134],"interaction":[135],"LDLR.":[138],"As":[139],"by":[141,154],"modern":[142],"dedicated":[144],"\"game-changer\"":[145],"trials,":[146],"reduce":[151],"levels":[153],"at":[155],"least":[156],"60":[157],"percent":[158,166],"when":[159,167],"used":[160,168],"alone":[161],"up":[163],"85":[165],"in":[169,233],"combination":[170],"high-intensity":[172],"statins":[173],"other":[175],"hypolipidemic":[176],"therapies,":[177],"including":[178],"ezetimibe.":[179],"Their":[180],"indications":[182,266],"established,":[185],"but":[186],"new":[187,240],"areas":[188],"use":[190],"advocated.":[192],"clues":[194],"suggest":[195],"regulation":[197,222],"represents":[200],"cornerstone":[202],"prevention,":[205],"partly":[206],"because":[207],"some":[209],"pleiotropic":[210],"effects":[211],"these":[214,239],"newly":[215],"developed":[216],"drugs.":[217],"New":[218],"being":[224],"explored,":[225],"further":[227],"need":[229],"be":[231],"put":[232],"place":[234],"reach":[236],"therapies.":[241],"this":[245],"manuscript":[246],"is":[247],"perform":[249],"narrative":[251],"review":[252],"literature":[255],"inhibitor":[259],"drugs,":[260],"focus":[263],"impact.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-20T00:00:00"}
