{"id":"https://openalex.org/W4366272131","doi":"https://doi.org/10.21518/ms2023-057","title":"Experience with non-immunogenic staphylokinase for intravenous thrombolysis in ischemic stroke: analysis of hospital registry data","display_name":"Experience with non-immunogenic staphylokinase for intravenous thrombolysis in ischemic stroke: analysis of hospital registry data","publication_year":2023,"publication_date":"2023-04-10","ids":{"openalex":"https://openalex.org/W4366272131","doi":"https://doi.org/10.21518/ms2023-057"},"language":"en","primary_location":{"id":"doi:10.21518/ms2023-057","doi":"https://doi.org/10.21518/ms2023-057","is_oa":true,"landing_page_url":"https://doi.org/10.21518/ms2023-057","pdf_url":"https://www.med-sovet.pro/jour/article/download/7408/6601","source":{"id":"https://openalex.org/S4210203888","display_name":"Meditsinskiy sovet = Medical Council","issn_l":"2079-701X","issn":["2079-701X","2658-5790"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4324034724","host_organization_name":"REMEDIUM GROUP LLC","host_organization_lineage":["https://openalex.org/P4324034724"],"host_organization_lineage_names":["REMEDIUM GROUP LLC"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Meditsinskiy sovet = Medical Council","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.med-sovet.pro/jour/article/download/7408/6601","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038641053","display_name":"Aleksey A. Kulesh","orcid":"https://orcid.org/0000-0001-6061-8118","observed_orcids":["https://orcid.org/0000-0001-6061-8118"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. A. Kulesh","raw_affiliation_strings":["Vagner Perm State Medical University"],"raw_orcid":"https://orcid.org/0000-0001-6061-8118","affiliations":[{"raw_affiliation_string":"Vagner Perm State Medical University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072707766","display_name":"L. I. Syromyatnikova","orcid":"https://orcid.org/0000-0002-8305-1115","observed_orcids":["https://orcid.org/0000-0002-8305-1115"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. I. Syromyatnikova","raw_affiliation_strings":["Vagner Perm State Medical University"],"raw_orcid":"https://orcid.org/0000-0002-8305-1115","affiliations":[{"raw_affiliation_string":"Vagner Perm State Medical University","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000684757","display_name":"S. Krapivin","orcid":"https://orcid.org/0009-0000-8975-7365","observed_orcids":["https://orcid.org/0009-0000-8975-7365"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Krapivin","raw_affiliation_strings":["Vagner Perm State Medical University"],"raw_orcid":"https://orcid.org/0009-0000-8975-7365","affiliations":[{"raw_affiliation_string":"Vagner Perm State Medical University","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6337,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.63092763,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":null,"issue":"3","first_page":"24","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intravenous-thrombolysis","display_name":"intravenous thrombolysis","score":0.996999979019165},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.984000027179718},{"id":"https://openalex.org/keywords/reperfusion-therapy","display_name":"reperfusion therapy","score":0.9539999961853027},{"id":"https://openalex.org/keywords/hemorrhagic-transformation","display_name":"hemorrhagic transformation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hemorrhagic-infarction","display_name":"hemorrhagic infarction","score":0.7860000133514404},{"id":"https://openalex.org/keywords/major-bleeding","display_name":"major bleeding","score":0.6639999747276306},{"id":"https://openalex.org/keywords/angioedema","display_name":"angioedema","score":0.9089999794960022},{"id":"https://openalex.org/keywords/door-to-needle-time","display_name":"door-to-needle time","score":0.824999988079071},{"id":"https://openalex.org/keywords/large-vessel-occlusion","display_name":"large vessel occlusion","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9311932921409607},{"id":"https://openalex.org/C2779440172","wikidata":"https://www.wikidata.org/wiki/Q906585","display_name":"Staphylokinase","level":4,"score":0.8975100517272949},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.8324646353721619},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.591888427734375},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.47987785935401917},{"id":"https://openalex.org/C2777798775","wikidata":"https://www.wikidata.org/wiki/Q207550","display_name":"Infarction","level":3,"score":0.440673291683197},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4314199686050415},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.4252532124519348},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4081357717514038},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3493272364139557},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.17555928230285645},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21518/ms2023-057","doi":"https://doi.org/10.21518/ms2023-057","is_oa":true,"landing_page_url":"https://doi.org/10.21518/ms2023-057","pdf_url":"https://www.med-sovet.pro/jour/article/download/7408/6601","source":{"id":"https://openalex.org/S4210203888","display_name":"Meditsinskiy sovet = Medical Council","issn_l":"2079-701X","issn":["2079-701X","2658-5790"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4324034724","host_organization_name":"REMEDIUM GROUP LLC","host_organization_lineage":["https://openalex.org/P4324034724"],"host_organization_lineage_names":["REMEDIUM GROUP LLC"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Meditsinskiy sovet = Medical Council","raw_type":"journal-article"},{"id":"pmh:oai:oai.medsovet.elpub.ru:article/7408","doi":null,"is_oa":true,"landing_page_url":"https://www.med-sovet.pro/jour/article/view/7408","pdf_url":null,"source":{"id":"https://openalex.org/S4210203888","display_name":"Meditsinskiy sovet = Medical Council","issn_l":"2079-701X","issn":["2079-701X","2658-5790"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4324034724","host_organization_name":"REMEDIUM GROUP LLC","host_organization_lineage":["https://openalex.org/P4324034724"],"host_organization_lineage_names":["REMEDIUM GROUP LLC"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Meditsinskiy sovet = Medical Council; \u2116 3 (2023); 24-29","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.21518/ms2023-057","doi":"https://doi.org/10.21518/ms2023-057","is_oa":true,"landing_page_url":"https://doi.org/10.21518/ms2023-057","pdf_url":"https://www.med-sovet.pro/jour/article/download/7408/6601","source":{"id":"https://openalex.org/S4210203888","display_name":"Meditsinskiy sovet = Medical Council","issn_l":"2079-701X","issn":["2079-701X","2658-5790"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4324034724","host_organization_name":"REMEDIUM GROUP LLC","host_organization_lineage":["https://openalex.org/P4324034724"],"host_organization_lineage_names":["REMEDIUM GROUP LLC"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Meditsinskiy sovet = Medical Council","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366272131.pdf","grobid_xml":"https://content.openalex.org/works/W4366272131.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1964527298","https://openalex.org/W2101163891","https://openalex.org/W2143566210","https://openalex.org/W2409091607","https://openalex.org/W2768091841","https://openalex.org/W2802880180","https://openalex.org/W2888749311","https://openalex.org/W3127999069","https://openalex.org/W3130625382","https://openalex.org/W3134307104","https://openalex.org/W3150269948","https://openalex.org/W3193313959","https://openalex.org/W3197516697","https://openalex.org/W4206439813","https://openalex.org/W4226325860","https://openalex.org/W4288776194","https://openalex.org/W4294991399","https://openalex.org/W4296794280","https://openalex.org/W4309691389","https://openalex.org/W4318977066","https://openalex.org/W4319009161"],"related_works":["https://openalex.org/W7161178574","https://openalex.org/W4416687892","https://openalex.org/W4401432396","https://openalex.org/W3193313959","https://openalex.org/W7130936652","https://openalex.org/W7214999287","https://openalex.org/W7162643511","https://openalex.org/W4413126959","https://openalex.org/W2594829355","https://openalex.org/W4404165289"],"abstract_inverted_index":{"Introduction.":[0],"Intravenous":[1],"thrombolysis":[2],"(IT)":[3],"is":[4,38],"the":[5,15,27,31,44,56,61,76,87,104,196,231],"primary":[6],"method":[7,238],"of":[8,18,30,34,60,63,75,86,89,103,119,125,144,151,167,178,189,198,218,222,236,239],"reperfusion":[9,45,156,240],"therapy":[10,46],"for":[11,66],"ischemic":[12,69,225],"stroke.":[13],"Over":[14],"past":[16],"couple":[17],"years,":[19],"there":[20],"has":[21],"been":[22],"a":[23,154,204],"global":[24],"trend":[25],"towards":[26],"predominant":[28],"use":[29,62],"bolus":[32],"forms":[33],"thrombolytic":[35],"drugs":[36],"that":[37],"caused":[39],"by":[40],"necessity":[41],"to":[42,48,109,135],"increase":[43],"rate":[47],"achieve":[49],"its":[50],"best":[51],"outcomes.":[52],"Aim.":[53],"To":[54],"evaluate":[55],"efficacy":[57],"and":[58,81,112,138,210,234],"safety":[59,235],"non-immunogenic":[64,96,228],"staphylokinase":[65,97,229],"IT":[67,94,223],"in":[68,71,195,224],"stroke":[70,226],"real-world":[72],"clinical":[73,84],"practice":[74],"regional":[77],"vascular":[78],"center.":[79],"Materials":[80],"methods.":[82],"The":[83,101,127,158,216],"outcomes":[85],"cohort":[88],"50":[90,219],"patients":[91,105,120,145,152,168,179,190],"who":[92],"underwent":[93],"with":[95],"were":[98,121,212],"analysed.":[99],"Results.":[100],"age":[102],"ranged":[106],"from":[107,133],"46":[108],"94":[110],"years":[111,124],"averaged":[113,139],"71.8":[114],"\u00b1":[115],"10.0":[116],"years;":[117],"22%":[118],"over":[122],"80":[123],"age.":[126],"NIHSS":[128],"score":[129],"at":[130],"admission":[131],"varied":[132],"3":[134],"23":[136,163],"scores":[137],"11":[140],"(8-14)":[141],"scores.":[142],"36%":[143],"had":[146,203],"large":[147],"artery":[148],"occlusions.":[149],"14%":[150],"received":[153],"step-wise":[155],"therapy.":[157,241],"median":[159],"door-to-needle":[160],"time":[161],"was":[162,186],"(18-26)":[164],"minutes.":[165],"52%":[166],"didn\u2019t":[169],"develop":[170],"any":[171],"infarction":[172],"area":[173],"during":[174],"control":[175],"neuroimaging.":[176],"62%":[177],"required":[180],"no":[181],"further":[182],"rehabilitation.":[183],"Hospital":[184],"mortality":[185],"12%.":[187],"18%":[188],"developed":[191],"hemorrhagic":[192,199,206],"conversion":[193],"mainly":[194],"form":[197],"infarction.":[200],"1":[201],"patient":[202],"symptomatic":[205],"conversion.":[207],"Major":[208],"bleeding":[209],"angioedema":[211],"not":[213],"observed.":[214],"Conclusion.":[215],"analysis":[217],"consecutive":[220],"cases":[221],"using":[227],"indicates":[230],"high":[232],"efficiency":[233],"this":[237]},"counts_by_year":[{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2023-04-20T00:00:00"}
