{"id":"https://openalex.org/W4366242041","doi":"https://doi.org/10.1111/iej.13922","title":"Quantitative analysis of culturable bacteria, levels of endotoxins, inflammatory mediators and substance P in teeth with symptomatic irreversible pulpitis and in teeth with vital normal pulp tissues","display_name":"Quantitative analysis of culturable bacteria, levels of endotoxins, inflammatory mediators and substance P in teeth with symptomatic irreversible pulpitis and in teeth with vital normal pulp tissues","publication_year":2023,"publication_date":"2023-04-18","ids":{"openalex":"https://openalex.org/W4366242041","doi":"https://doi.org/10.1111/iej.13922","pmid":"https://pubmed.ncbi.nlm.nih.gov/37070606"},"language":"en","primary_location":{"id":"doi:10.1111/iej.13922","doi":"https://doi.org/10.1111/iej.13922","is_oa":true,"landing_page_url":"https://doi.org/10.1111/iej.13922","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/iej.13922","source":{"id":"https://openalex.org/S50094856","display_name":"International Endodontic Journal","issn_l":"0143-2885","issn":["0143-2885","1365-2591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Endodontic Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/iej.13922","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087190286","display_name":"Rodrigo Arruda\u2010Vasconcelos","orcid":"https://orcid.org/0000-0002-0968-0212","observed_orcids":["https://orcid.org/0000-0002-0968-0212"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"R. Arruda\u2010Vasconcelos","raw_affiliation_strings":["Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil"],"raw_orcid":"https://orcid.org/0000-0002-0968-0212","affiliations":[{"raw_affiliation_string":"Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086032042","display_name":"V. M. Chiarelli\u2010Neto","orcid":"https://orcid.org/0000-0001-6141-0319","observed_orcids":["https://orcid.org/0000-0001-6141-0319"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"V. M. Chiarelli\u2010Neto","raw_affiliation_strings":["Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil"],"raw_orcid":"https://orcid.org/0000-0001-6141-0319","affiliations":[{"raw_affiliation_string":"Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018157453","display_name":"Lidiane Mendes Louzada","orcid":"https://orcid.org/0000-0002-3480-8433","observed_orcids":["https://orcid.org/0000-0002-3480-8433"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"L. M. Louzada","raw_affiliation_strings":["Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil"],"raw_orcid":"https://orcid.org/0000-0002-3480-8433","affiliations":[{"raw_affiliation_string":"Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023504667","display_name":"Emelly Aveiro","orcid":"https://orcid.org/0000-0002-4940-0406","observed_orcids":["https://orcid.org/0000-0002-4940-0406"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"E. Aveiro","raw_affiliation_strings":["Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil"],"raw_orcid":"https://orcid.org/0000-0002-4940-0406","affiliations":[{"raw_affiliation_string":"Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048434192","display_name":"Esdras Gabriel Alves-Silva","orcid":"https://orcid.org/0000-0002-2309-1115","observed_orcids":["https://orcid.org/0000-0002-2309-1115","https://orcid.org/0000-0003-3223-8518"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"E. G. Alves\u2010Silva","raw_affiliation_strings":["Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil"],"raw_orcid":"https://orcid.org/0000-0003-3223-8518","affiliations":[{"raw_affiliation_string":"Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. de\u2010Jesus\u2010Soares","orcid":"https://orcid.org/0000-0002-8078-1606","observed_orcids":["https://orcid.org/0000-0002-8078-1606"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"A. de\u2010Jesus\u2010Soares","raw_affiliation_strings":["Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil"],"raw_orcid":"https://orcid.org/0000-0002-8078-1606","affiliations":[{"raw_affiliation_string":"Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059880498","display_name":"Caio C\u00e9zar Randi Ferraz","orcid":"https://orcid.org/0000-0002-1513-682X","observed_orcids":["https://orcid.org/0000-0002-1513-682X"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"C. C. R. Ferraz","raw_affiliation_strings":["Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil"],"raw_orcid":"https://orcid.org/0000-0002-1513-682X","affiliations":[{"raw_affiliation_string":"Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058358903","display_name":"Jos\u00e9 Fl\u00e1vio Affonso de Almeida","orcid":"https://orcid.org/0000-0002-5874-9247","observed_orcids":["https://orcid.org/0000-0002-5874-9247"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"J. F. A. Almeida","raw_affiliation_strings":["Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil"],"raw_orcid":"https://orcid.org/0000-0002-5874-9247","affiliations":[{"raw_affiliation_string":"Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062629622","display_name":"Marina Ang\u00e9lica Marciano","orcid":"https://orcid.org/0000-0001-6244-2531","observed_orcids":["https://orcid.org/0000-0001-6244-2531"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M. A. Marciano","raw_affiliation_strings":["Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil"],"raw_orcid":"https://orcid.org/0000-0001-6244-2531","affiliations":[{"raw_affiliation_string":"Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062407380","display_name":"Vanessa Gallego Arias Pecorari","orcid":"https://orcid.org/0000-0002-0300-5697","observed_orcids":["https://orcid.org/0000-0002-0300-5697"]},"institutions":[{"id":"https://openalex.org/I4210111188","display_name":"Universidade Paulista","ror":"https://ror.org/020v13m88","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210111188"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"V. G. A. Pecorari","raw_affiliation_strings":["BioStatistics, Universidade Paulista \u2013 UNIP  S\u00e3o Paulo Brazil"],"raw_orcid":"https://orcid.org/0000-0002-0300-5697","affiliations":[{"raw_affiliation_string":"BioStatistics, Universidade Paulista \u2013 UNIP  S\u00e3o Paulo Brazil","institution_ids":["https://openalex.org/I4210111188"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088058668","display_name":"Brenda Paula Figueiredo de Almeida Gomes","orcid":"https://orcid.org/0000-0002-8449-0646","observed_orcids":["https://orcid.org/0000-0002-8449-0646"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"B. P. F. A. Gomes","raw_affiliation_strings":["Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil"],"raw_orcid":"https://orcid.org/0000-0002-8449-0646","affiliations":[{"raw_affiliation_string":"Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas \u2013 UNICAMP  Piracicaba Brazil","institution_ids":["https://openalex.org/I181391015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088058668"],"corresponding_institution_ids":["https://openalex.org/I181391015"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":3.163,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.9126322,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"56","issue":"7","first_page":"827","last_page":"836"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12297","display_name":"Otolaryngology and Infectious Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/symptomatic-irreversible-pulpitis","display_name":"symptomatic irreversible pulpitis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/root-canal-bacteria","display_name":"root canal bacteria","score":0.6000000238418579},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.9020000100135803},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9629999995231628},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":1.0},{"id":"https://openalex.org/keywords/pulp-infection","display_name":"pulp infection","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C2779700951","wikidata":"https://www.wikidata.org/wiki/Q932843","display_name":"Pulpitis","level":3,"score":0.802172064781189},{"id":"https://openalex.org/C188442228","wikidata":"https://www.wikidata.org/wiki/Q48286","display_name":"Pulp (tooth)","level":2,"score":0.7706023454666138},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5625978112220764},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.5337470769882202},{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.5328612327575684},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4861685633659363},{"id":"https://openalex.org/C2779103545","wikidata":"https://www.wikidata.org/wiki/Q2507106","display_name":"Pulp necrosis","level":3,"score":0.48223385214805603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4508669972419739},{"id":"https://openalex.org/C189539697","wikidata":"https://www.wikidata.org/wiki/Q1125312","display_name":"Microbiological culture","level":3,"score":0.429246187210083},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4161722660064697},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33322030305862427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33056092262268066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2507452368736267},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003782","descriptor_name":"Dental Pulp","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011671","descriptor_name":"Pulpitis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/iej.13922","doi":"https://doi.org/10.1111/iej.13922","is_oa":true,"landing_page_url":"https://doi.org/10.1111/iej.13922","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/iej.13922","source":{"id":"https://openalex.org/S50094856","display_name":"International Endodontic Journal","issn_l":"0143-2885","issn":["0143-2885","1365-2591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Endodontic Journal","raw_type":"journal-article"},{"id":"pmid:37070606","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37070606","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International endodontic journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/iej.13922","doi":"https://doi.org/10.1111/iej.13922","is_oa":true,"landing_page_url":"https://doi.org/10.1111/iej.13922","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/iej.13922","source":{"id":"https://openalex.org/S50094856","display_name":"International Endodontic Journal","issn_l":"0143-2885","issn":["0143-2885","1365-2591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Endodontic Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1093756776","display_name":null,"funder_award_id":"2017/25242-8","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G121811674","display_name":null,"funder_award_id":"Finance Code 001).","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G1752096124","display_name":null,"funder_award_id":"2019/19300\u20100","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G29316538","display_name":null,"funder_award_id":"(Code 001)","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G295657101","display_name":null,"funder_award_id":"2019/","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G3412423057","display_name":"Microbiomes and immunobiological aspects in endodontic infections","funder_award_id":"15/23479-5","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G3995609221","display_name":null,"funder_award_id":"2019/10755\u20105","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G4096354359","display_name":"Decoding the microbiota correlations of teeth indicated for endodontic retreatment and the complex interrelationship between mobiloma and resistome in oral site metagenomes","funder_award_id":"21/13871-6","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G4312996506","display_name":null,"funder_award_id":"303852/2019-4","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G4402799499","display_name":null,"funder_award_id":"2015/","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G5221451932","display_name":null,"funder_award_id":"421801/2021-2","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G6438247056","display_name":null,"funder_award_id":"2021/","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G8526065104","display_name":null,"funder_award_id":"2036/17","funder_id":"https://openalex.org/F4320335141","funder_display_name":"Fundo de Apoio ao Ensino, \u00e0 Pesquisa e Extens\u00e3o, Universidade Estadual de Campinas"},{"id":"https://openalex.org/G993962816","display_name":null,"funder_award_id":"164905/2020-0","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320323854","display_name":"Universidade Estadual de Campinas","ror":"https://ror.org/04wffgt70"},{"id":"https://openalex.org/F4320335141","display_name":"Fundo de Apoio ao Ensino, \u00e0 Pesquisa e Extens\u00e3o, Universidade Estadual de Campinas","ror":"https://ror.org/04wffgt70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366242041.pdf","grobid_xml":"https://content.openalex.org/works/W4366242041.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1484641059","https://openalex.org/W1870514323","https://openalex.org/W1896347984","https://openalex.org/W1986556213","https://openalex.org/W2000999295","https://openalex.org/W2006279628","https://openalex.org/W2042560907","https://openalex.org/W2076732284","https://openalex.org/W2107137298","https://openalex.org/W2123838494","https://openalex.org/W2127435475","https://openalex.org/W2127523059","https://openalex.org/W2148549591","https://openalex.org/W2171721156","https://openalex.org/W2213691097","https://openalex.org/W2544863037","https://openalex.org/W2558246933","https://openalex.org/W2567052240","https://openalex.org/W2620800790","https://openalex.org/W2622833782","https://openalex.org/W2623220495","https://openalex.org/W2793428556","https://openalex.org/W2796753118","https://openalex.org/W2803426382","https://openalex.org/W2895960246","https://openalex.org/W2898360069","https://openalex.org/W2955829414","https://openalex.org/W2998246880","https://openalex.org/W2999695029","https://openalex.org/W3016204938","https://openalex.org/W3040905366","https://openalex.org/W3042290304","https://openalex.org/W3042487050","https://openalex.org/W3083356684","https://openalex.org/W3114232032","https://openalex.org/W4234095729"],"related_works":["https://openalex.org/W3083356684","https://openalex.org/W4385442051","https://openalex.org/W3093238529","https://openalex.org/W2519009357","https://openalex.org/W4401910889","https://openalex.org/W2505972456","https://openalex.org/W1987935098","https://openalex.org/W2099393746","https://openalex.org/W3115339531","https://openalex.org/W2225138124"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"comparatively":[2],"analyse":[3],"the":[4,57,61,72,109,120,131,148,157,203,209,216,247,250,269],"levels":[5,83,110,165,187,210,230,251],"of":[6,60,84,111,166,188,211,231,252,264,272],"culturable":[7,85,232],"bacteria,":[8,233],"endotoxins":[9,89],"(LPS),":[10],"tumour":[11],"necrosis":[12],"factor-alpha":[13],"(TNF-\u03b1),":[14],"interleukin-1":[15],"beta":[16],"(IL-1\u03b2)":[17],"and":[18,28,43,66,95,116,122,190,236],"substance":[19,96,117,191,237],"P":[20,97,118,192,238],"in":[21,49,119,156,173,178,195,208,256,268],"teeth":[22,40,45,144,174,179,196,257],"with":[23,41,46,130,145,175,180,197,224,241],"symptomatic":[24,225],"irreversible":[25,226],"pulpitis":[26,227],"(SIP)":[27],"vital":[29,242],"normal":[30,243],"pulp":[31,244],"(VNP)":[32],"tissues.":[33,245],"METHODOLOGY:":[34],"Thirty-two":[35],"patients":[36],"were":[37,54,99,140,154,168,193,254],"included":[38],"(20":[39],"SIP":[42,121,176,198],"12":[44],"VNP":[47,123,158,181],"tissues)":[48],"this":[50,265],"cross-sectional":[51],"study.":[52],"Samples":[53],"collected":[55],"from":[56,142,258],"full":[58],"length":[59],"root":[62],"canals":[63],"(microbial":[64],"analysis)":[65],"periapical":[67],"tissues":[68,159,182],"(2":[69],"mm":[70],"beyond":[71],"apex":[73],"for":[74,106],"immunological":[75],"analysis),":[76],"using":[77],"sterile":[78],"absorbent":[79],"paper":[80],"points.":[81],"The":[82,101,125,164],"bacteria":[86,139],"(culture":[87],"method),":[88],"(LAL":[90],"Pyrogent":[91],"5000),":[92],"TNF-\u03b1,":[93,114],"IL-1\u03b2":[94,115,212,253],"(ELISA)":[98],"assessed.":[100],"Mann-Whitney":[102],"test":[103],"was":[104,128,213],"used":[105],"comparisons":[107],"between":[108,215],"CFU/mL,":[112],"LPS,":[113],"groups.":[124],"statistical":[126],"analysis":[127],"performed":[129],"significance":[132],"level":[133],"set":[134],"at":[135],"5%.":[136],"RESULTS:":[137],"Culturable":[138],"recovered":[141],"all":[143],"SIP.":[146],"On":[147,202,246],"other":[149,204,248],"hand,":[150,205,249],"no":[151,206],"positive":[152],"cultures":[153],"observed":[155],"group":[160],"(p":[161,183,199,219],">":[162,220],".05).":[163,185,201,221],"LPS":[167],"approximately":[169],"four":[170],"times":[171],"higher":[172,229],"than":[177,239],"<":[184,200],"Higher":[186],"TNF-\u03b1":[189,235],"detected":[194,214],"difference":[207],"two":[217],"groups":[218,260],"CONCLUSION:":[222],"Teeth":[223],"present":[228],"endotoxins,":[234],"those":[240],"similar":[255],"both":[259],"suggesting":[261],"reduced":[262],"implications":[263],"inflammatory":[266],"mediator":[267],"early":[270],"stages":[271],"infection.":[273]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-04-20T00:00:00"}