{"id":"https://openalex.org/W4366238208","doi":"https://doi.org/10.1002/bmc.5646","title":"Estimation of purity of antimicrobial lead compound sulfonamide\u2010anthranilate derivative methyl\u2010ester\u2010toluene\u2010sulfonamide using LC to develop a new drug application","display_name":"Estimation of purity of antimicrobial lead compound sulfonamide\u2010anthranilate derivative methyl\u2010ester\u2010toluene\u2010sulfonamide using LC to develop a new drug application","publication_year":2023,"publication_date":"2023-04-18","ids":{"openalex":"https://openalex.org/W4366238208","doi":"https://doi.org/10.1002/bmc.5646","pmid":"https://pubmed.ncbi.nlm.nih.gov/37070159"},"language":"en","primary_location":{"id":"doi:10.1002/bmc.5646","doi":"https://doi.org/10.1002/bmc.5646","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bmc.5646","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bmc.5646","source":{"id":"https://openalex.org/S123979729","display_name":"Biomedical Chromatography","issn_l":"0269-3879","issn":["0269-3879","1099-0801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Chromatography","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bmc.5646","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066660125","display_name":"Girish K. Deshpande","orcid":"https://orcid.org/0000-0003-0120-2192","observed_orcids":["https://orcid.org/0000-0003-0120-2192"]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Girish K. Deshpande","raw_affiliation_strings":["Department of Chemistry, GITAM School of Science GITAM Deemed to Be University Visakhapatnam Andhra Pradesh India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, GITAM School of Science GITAM Deemed to Be University Visakhapatnam Andhra Pradesh India","institution_ids":["https://openalex.org/I885392262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042437296","display_name":"Parameswari Akshinthala","orcid":"https://orcid.org/0000-0002-1308-4587","observed_orcids":["https://orcid.org/0000-0002-1308-4587"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Parameswari Akshinthala","raw_affiliation_strings":["Department of Science and Humanities MLR Institute of Technology Hyderabad India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Science and Humanities MLR Institute of Technology Hyderabad India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028578851","display_name":"Naresh Kumar Katari","orcid":"https://orcid.org/0000-0002-5737-8528","observed_orcids":["https://orcid.org/0000-0002-5737-8528"]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Naresh Kumar Katari","raw_affiliation_strings":["Department of Chemistry, GITAM School of Science GITAM Deemed to Be University Hyderabad Telangana India"],"raw_orcid":"https://orcid.org/0000-0002-5737-8528","affiliations":[{"raw_affiliation_string":"Department of Chemistry, GITAM School of Science GITAM Deemed to Be University Hyderabad Telangana India","institution_ids":["https://openalex.org/I885392262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008654258","display_name":"Balasaheb R. Deshmukh","orcid":"https://orcid.org/0009-0005-2141-8910","observed_orcids":["https://orcid.org/0009-0005-2141-8910"]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Balasaheb Deshmukh","raw_affiliation_strings":["Department of Chemistry, GITAM School of Science GITAM Deemed to Be University Visakhapatnam Andhra Pradesh India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, GITAM School of Science GITAM Deemed to Be University Visakhapatnam Andhra Pradesh India","institution_ids":["https://openalex.org/I885392262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072439550","display_name":"Leela Prasad Kowtharapu","orcid":"https://orcid.org/0000-0003-1199-2458","observed_orcids":["https://orcid.org/0000-0003-1199-2458"]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Leela Prasad Kowtharapu","raw_affiliation_strings":["Department of Chemistry, GITAM School of Science GITAM Deemed to Be University Hyderabad Telangana India"],"raw_orcid":"https://orcid.org/0000-0003-1199-2458","affiliations":[{"raw_affiliation_string":"Department of Chemistry, GITAM School of Science GITAM Deemed to Be University Hyderabad Telangana India","institution_ids":["https://openalex.org/I885392262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051118495","display_name":"Sreenivasa Rao Battula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sreenivas Rao Battula","raw_affiliation_strings":["Department of Chemistry, GITAM School of Science GITAM Deemed to Be University Visakhapatnam Andhra Pradesh India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, GITAM School of Science GITAM Deemed to Be University Visakhapatnam Andhra Pradesh India","institution_ids":["https://openalex.org/I885392262"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070305207","display_name":"Rambabu Gundla","orcid":"https://orcid.org/0000-0003-0390-6505","observed_orcids":["https://orcid.org/0000-0003-0390-6505","https://orcid.org/0000-0002-6469-6022"]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Rambabu Gundla","raw_affiliation_strings":["Department of Chemistry, GITAM School of Science GITAM Deemed to Be University Hyderabad Telangana India"],"raw_orcid":"https://orcid.org/0000-0003-0390-6505","affiliations":[{"raw_affiliation_string":"Department of Chemistry, GITAM School of Science GITAM Deemed to Be University Hyderabad Telangana India","institution_ids":["https://openalex.org/I885392262"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051118495","https://openalex.org/A5070305207"],"corresponding_institution_ids":["https://openalex.org/I885392262"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.4794,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.4696963,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"37","issue":"8","first_page":"e5646","last_page":"e5646"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/purity-determination","display_name":"purity determination","score":0.8349999785423279},{"id":"https://openalex.org/keywords/hplc-method-development","display_name":"HPLC method development","score":0.7960000038146973},{"id":"https://openalex.org/keywords/quality-control","display_name":"quality control","score":0.546999990940094},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.5440000295639038},{"id":"https://openalex.org/keywords/method-validation","display_name":"method validation","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2781039511","wikidata":"https://www.wikidata.org/wiki/Q3208529","display_name":"Sulfonamide","level":2,"score":0.826836347579956},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8230741024017334},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6809307932853699},{"id":"https://openalex.org/C2776701986","wikidata":"https://www.wikidata.org/wiki/Q278332","display_name":"Tetrahydrofuran","level":3,"score":0.676041841506958},{"id":"https://openalex.org/C2778142098","wikidata":"https://www.wikidata.org/wiki/Q15779","display_name":"Toluene","level":2,"score":0.5924899578094482},{"id":"https://openalex.org/C2781283055","wikidata":"https://www.wikidata.org/wiki/Q139199","display_name":"Triethylamine","level":2,"score":0.5663143992424011},{"id":"https://openalex.org/C2777463227","wikidata":"https://www.wikidata.org/wiki/Q408047","display_name":"Acetonitrile","level":2,"score":0.5579316020011902},{"id":"https://openalex.org/C73826308","wikidata":"https://www.wikidata.org/wiki/Q684907","display_name":"Elution","level":2,"score":0.534854531288147},{"id":"https://openalex.org/C111771559","wikidata":"https://www.wikidata.org/wiki/Q66295","display_name":"Derivative (finance)","level":2,"score":0.47690439224243164},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.43355658650398254},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2002776861190796},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.102958083152771},{"id":"https://openalex.org/C106159729","wikidata":"https://www.wikidata.org/wiki/Q2294553","display_name":"Financial economics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014050","descriptor_name":"Toluene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/bmc.5646","doi":"https://doi.org/10.1002/bmc.5646","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bmc.5646","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bmc.5646","source":{"id":"https://openalex.org/S123979729","display_name":"Biomedical Chromatography","issn_l":"0269-3879","issn":["0269-3879","1099-0801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Chromatography","raw_type":"journal-article"},{"id":"pmid:37070159","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37070159","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical chromatography : BMC","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/bmc.5646","doi":"https://doi.org/10.1002/bmc.5646","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bmc.5646","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bmc.5646","source":{"id":"https://openalex.org/S123979729","display_name":"Biomedical Chromatography","issn_l":"0269-3879","issn":["0269-3879","1099-0801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Chromatography","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366238208.pdf","grobid_xml":"https://content.openalex.org/works/W4366238208.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1846760790","https://openalex.org/W2022107477","https://openalex.org/W2072355351","https://openalex.org/W2111272340","https://openalex.org/W2128181653","https://openalex.org/W2166808901","https://openalex.org/W2475322789","https://openalex.org/W2484521294","https://openalex.org/W3014405281","https://openalex.org/W3180048088","https://openalex.org/W3197436077","https://openalex.org/W4214737370","https://openalex.org/W4220828723","https://openalex.org/W4220832280","https://openalex.org/W4240730271","https://openalex.org/W4281656395","https://openalex.org/W4285392930","https://openalex.org/W4288760217","https://openalex.org/W4293011271","https://openalex.org/W4308736560","https://openalex.org/W6629572924"],"related_works":["https://openalex.org/W2980160749","https://openalex.org/W4327722729","https://openalex.org/W2026057321","https://openalex.org/W2772252396","https://openalex.org/W2983718287","https://openalex.org/W4392131504","https://openalex.org/W3215945145","https://openalex.org/W2033194590","https://openalex.org/W7101435306","https://openalex.org/W2032200388"],"abstract_inverted_index":{"The":[0,72,89,104,112,123,129],"newly":[1],"synthesized":[2],"lead":[3],"molecule":[4],"methyl-ester-toluene-sulfonamide":[5],"is":[6,106,145],"the":[7,31,38,142,153,158,162],"combined":[8],"derivative":[9],"of":[10,33,40,51,120,161],"sulfonamide-anthranilate.":[11],"It":[12],"was":[13,75,92,114],"estimated":[14],"by":[15,135],"gradient":[16,90],"elution":[17],"using":[18],"0.1%":[19],"triethylamine":[20],"in":[21,37,152,167],"water":[22],"with":[23,67,116],"pH":[24],"2.0":[25],"as":[26,43],"mobile":[27,44],"phase":[28,45],"A":[29],"and":[30,35,54,102,110,133,147],"mixture":[32],"acetonitrile":[34],"tetrahydrofuran":[36],"ratio":[39],"975:25":[41],"(v/v)":[42],"B":[46],"at":[47,87],"a":[48,68,117],"flow":[49],"rate":[50],"0.8":[52],"ml/min":[53],"210":[55],"nm":[56],"wavelength":[57],"on":[58],"an":[59],"Agilent":[60],"1260":[61],"infinity":[62],"series":[63],"HPLC":[64],"system":[65],"equipped":[66],"diode":[69],"array":[70],"detector.":[71],"column":[73],"used":[74],"ACE":[76],"3":[77,83],"C18-PFP":[78],"(250":[79],"\u00d7":[80],"4.6":[81],"mm,":[82],"\u03bcm":[84],"i.d.)":[85],"operating":[86],"40\u00b0C.":[88],"program":[91],"time":[93],"(min)/%":[94],"B:":[95],"0.0/50,":[96],"3.0/50,":[97],"15.0/70,":[98],"25.0/90,":[99],"30.0/90,":[100],"31/50,":[101],"38/50.":[103],"method":[105,113,130,144,163],"simple,":[107],"accurate,":[108],"rapid,":[109],"selective.":[111],"linear":[115],"concentration":[118],"range":[119],"1.6-240":[121],"\u03bcg/ml.":[122],"accuracy":[124],"data":[125,132],"obtained":[126],"were":[127],"98.5-100.5%.":[128],"validation":[131],"quality":[134,154],"design-based":[136],"robustness":[137],"study":[138],"results":[139],"indicate":[140],"that":[141],"developed":[143],"robust":[146],"fit":[148],"for":[149],"routine":[150],"use":[151],"control":[155],"laboratory.":[156],"Therefore,":[157],"ready":[159],"availability":[160],"can":[164],"be":[165],"useful":[166],"pharmaceutical":[168],"new":[169],"drug":[170],"development.":[171]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-04-20T00:00:00"}