{"id":"https://openalex.org/W4366237417","doi":"https://doi.org/10.2174/1568026623666230413094331","title":"Chronic Hepatitis B Infection: Current and Emerging Therapeutic Strategies","display_name":"Chronic Hepatitis B Infection: Current and Emerging Therapeutic Strategies","publication_year":2023,"publication_date":"2023-04-18","ids":{"openalex":"https://openalex.org/W4366237417","doi":"https://doi.org/10.2174/1568026623666230413094331","pmid":"https://pubmed.ncbi.nlm.nih.gov/37069708"},"language":"en","primary_location":{"id":"doi:10.2174/1568026623666230413094331","doi":"https://doi.org/10.2174/1568026623666230413094331","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1568026623666230413094331","pdf_url":null,"source":{"id":"https://openalex.org/S107732428","display_name":"Current Topics in Medicinal Chemistry","issn_l":"1568-0266","issn":["1568-0266","1873-4294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Topics in Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102903961","display_name":"Ankita Singh","orcid":"https://orcid.org/0000-0003-0700-5878","observed_orcids":["https://orcid.org/0000-0003-0700-5878"]},"institutions":[{"id":"https://openalex.org/I4210123001","display_name":"Institute of Liver and Biliary Sciences","ror":"https://ror.org/02v6vej93","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210123001"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ankita Singh","raw_affiliation_strings":["Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India"],"raw_orcid":"https://orcid.org/0000-0003-0700-5878","affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India","institution_ids":["https://openalex.org/I4210123001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033955085","display_name":"Jitendra Kumar","orcid":"https://orcid.org/0000-0002-7599-5204","observed_orcids":["https://orcid.org/0000-0002-7599-5204"]},"institutions":[{"id":"https://openalex.org/I4210123001","display_name":"Institute of Liver and Biliary Sciences","ror":"https://ror.org/02v6vej93","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210123001"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jitendra Kumar","raw_affiliation_strings":["Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India"],"raw_orcid":"https://orcid.org/0000-0002-7599-5204","affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India","institution_ids":["https://openalex.org/I4210123001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101628870","display_name":"Vijay Kumar","orcid":"https://orcid.org/0000-0001-8135-1977","observed_orcids":["https://orcid.org/0000-0001-8135-1977"]},"institutions":[{"id":"https://openalex.org/I4210123001","display_name":"Institute of Liver and Biliary Sciences","ror":"https://ror.org/02v6vej93","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210123001"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Vijay Kumar","raw_affiliation_strings":["Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India"],"raw_orcid":"https://orcid.org/0000-0001-8135-1977","affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India","institution_ids":["https://openalex.org/I4210123001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101628870"],"corresponding_institution_ids":["https://openalex.org/I4210123001"],"apc_list":null,"apc_paid":null,"fwci":1.6287,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.81721971,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"23","issue":"18","first_page":"1727","last_page":"1752"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.996999979019165},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.800000011920929},{"id":"https://openalex.org/keywords/nucleos-t-ide-analogues","display_name":"nucleos(t)ide analogues","score":0.8629999756813049},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.9580000042915344},{"id":"https://openalex.org/keywords/covalently-closed-circular-dna","display_name":"covalently closed circular DNA","score":0.9890000224113464},{"id":"https://openalex.org/keywords/viral-reservoir","display_name":"viral reservoir","score":0.7279999852180481},{"id":"https://openalex.org/keywords/immunomodulators","display_name":"immunomodulators","score":0.8149999976158142},{"id":"https://openalex.org/keywords/small-molecule-antivirals","display_name":"small-molecule antivirals","score":0.8149999976158142},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.6579999923706055},{"id":"https://openalex.org/keywords/liver-disease-progression","display_name":"liver disease progression","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.6071742177009583},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4879841208457947},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4533202350139618},{"id":"https://openalex.org/C148043351","wikidata":"https://www.wikidata.org/wiki/Q4456944","display_name":"Current (fluid)","level":2,"score":0.4533190429210663},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3963410258293152},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.12247225642204285},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.048101991415023804},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000088562","descriptor_name":"Persistent Infection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004270","descriptor_name":"DNA, Circular","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004270","descriptor_name":"DNA, Circular","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/1568026623666230413094331","doi":"https://doi.org/10.2174/1568026623666230413094331","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1568026623666230413094331","pdf_url":null,"source":{"id":"https://openalex.org/S107732428","display_name":"Current Topics in Medicinal Chemistry","issn_l":"1568-0266","issn":["1568-0266","1873-4294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Topics in Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:37069708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37069708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current topics in medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1909167728","display_name":null,"funder_award_id":"BT/PR30082/Med/29/1341/2018","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G6995602750","display_name":null,"funder_award_id":"SR/S2/JCB-80)/2012","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"}],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":142,"referenced_works":["https://openalex.org/W92890196","https://openalex.org/W590783594","https://openalex.org/W766222058","https://openalex.org/W1506669191","https://openalex.org/W1536758910","https://openalex.org/W1543067125","https://openalex.org/W1939458592","https://openalex.org/W1966393716","https://openalex.org/W1974999149","https://openalex.org/W1977559293","https://openalex.org/W1978329469","https://openalex.org/W1979369583","https://openalex.org/W1986388698","https://openalex.org/W1988761020","https://openalex.org/W1990487307","https://openalex.org/W1999770898","https://openalex.org/W2004139194","https://openalex.org/W2005049682","https://openalex.org/W2006774237","https://openalex.org/W2007016356","https://openalex.org/W2007423548","https://openalex.org/W2009127910","https://openalex.org/W2010185867","https://openalex.org/W2016995625","https://openalex.org/W2017733846","https://openalex.org/W2027280548","https://openalex.org/W2029687799","https://openalex.org/W2031489362","https://openalex.org/W2032063600","https://openalex.org/W2033492998","https://openalex.org/W2036742637","https://openalex.org/W2040562731","https://openalex.org/W2042692189","https://openalex.org/W2044951291","https://openalex.org/W2046828081","https://openalex.org/W2050607746","https://openalex.org/W2058376942","https://openalex.org/W2061543400","https://openalex.org/W2063137497","https://openalex.org/W2076506726","https://openalex.org/W2079006974","https://openalex.org/W2079916692","https://openalex.org/W2083967761","https://openalex.org/W2089108066","https://openalex.org/W2093055973","https://openalex.org/W2111625427","https://openalex.org/W2112436801","https://openalex.org/W2115504968","https://openalex.org/W2118406741","https://openalex.org/W2120426460","https://openalex.org/W2121618290","https://openalex.org/W2123781724","https://openalex.org/W2127949912","https://openalex.org/W2129923672","https://openalex.org/W2130575875","https://openalex.org/W2150456870","https://openalex.org/W2151206652","https://openalex.org/W2152095262","https://openalex.org/W2156015715","https://openalex.org/W2158721163","https://openalex.org/W2158728342","https://openalex.org/W2224436307","https://openalex.org/W2230010802","https://openalex.org/W2247430603","https://openalex.org/W2290831170","https://openalex.org/W2293495463","https://openalex.org/W2294472239","https://openalex.org/W2323719395","https://openalex.org/W2336184200","https://openalex.org/W2338985227","https://openalex.org/W2398313845","https://openalex.org/W2409117115","https://openalex.org/W2416193592","https://openalex.org/W2429852859","https://openalex.org/W2468014476","https://openalex.org/W2509537204","https://openalex.org/W2512857074","https://openalex.org/W2513450606","https://openalex.org/W2518924844","https://openalex.org/W2552251488","https://openalex.org/W2567500175","https://openalex.org/W2570651242","https://openalex.org/W2595717178","https://openalex.org/W2611427234","https://openalex.org/W2612582321","https://openalex.org/W2613239025","https://openalex.org/W2623223454","https://openalex.org/W2755250741","https://openalex.org/W2766060653","https://openalex.org/W2779389699","https://openalex.org/W2793638189","https://openalex.org/W2796154244","https://openalex.org/W2890832308","https://openalex.org/W2898602894","https://openalex.org/W2907762216","https://openalex.org/W2939267111","https://openalex.org/W2962219096","https://openalex.org/W2965094856","https://openalex.org/W2972942466","https://openalex.org/W2978269631","https://openalex.org/W2980699734","https://openalex.org/W2988788411","https://openalex.org/W2989703635","https://openalex.org/W2999394169","https://openalex.org/W3002522604","https://openalex.org/W3005207785","https://openalex.org/W3007254861","https://openalex.org/W3009378833","https://openalex.org/W3010530314","https://openalex.org/W3014302917","https://openalex.org/W3014968572","https://openalex.org/W3017158293","https://openalex.org/W3020003877","https://openalex.org/W3025929240","https://openalex.org/W3040851638","https://openalex.org/W3042239708","https://openalex.org/W3081809528","https://openalex.org/W3082987907","https://openalex.org/W3084357673","https://openalex.org/W3087119991","https://openalex.org/W3089298983","https://openalex.org/W3094443688","https://openalex.org/W3104033816","https://openalex.org/W3127856336","https://openalex.org/W3162052367","https://openalex.org/W3165162313","https://openalex.org/W3174293101","https://openalex.org/W3181373216","https://openalex.org/W3185686384","https://openalex.org/W3186617101","https://openalex.org/W3188236230","https://openalex.org/W3202066002","https://openalex.org/W3203910250","https://openalex.org/W3207599520","https://openalex.org/W3209355583","https://openalex.org/W3210415611","https://openalex.org/W3212636034","https://openalex.org/W3214592746","https://openalex.org/W4205528470","https://openalex.org/W4221071853","https://openalex.org/W4282930594","https://openalex.org/W4297987253"],"related_works":["https://openalex.org/W2229864542","https://openalex.org/W4400219710","https://openalex.org/W2269573733","https://openalex.org/W7016966359","https://openalex.org/W4389056047","https://openalex.org/W2049438537","https://openalex.org/W2780354497","https://openalex.org/W3097701919","https://openalex.org/W2051269651","https://openalex.org/W4407518193"],"abstract_inverted_index":{"The":[0,38],"chronic":[1,35,239],"infection":[2,44],"of":[3,19,25,33,63,78,82,100,104,123,132,136,158,180,189,194,212],"the":[4,17,61,76,79,119,133,190,209,222],"hepatitis":[5,26],"B":[6,27],"virus":[7],"(CHB)":[8],"represents":[9],"a":[10,91,97,108,129,155],"major":[11],"public":[12],"health":[13],"problem":[14],"worldwide.":[15],"Despite":[16],"availability":[18],"an":[20],"effective":[21,52],"prophylactic":[22],"vaccine,":[23],"millions":[24],"patients":[28],"are":[29,51],"at":[30,53],"increased":[31],"risk":[32],"developing":[34],"liver":[36,64],"disease.":[37,65],"currently":[39,172],"available":[40],"treatments":[41,68],"for":[42,93,110,162],"HBV":[43,124,213,232],"include":[45],"interferon":[46],"and":[47,57,96,112,121,142,146,169,192,197,215,220],"nucleos(t)ide":[48],"analogues":[49],"that":[50,88],"suppressing":[54],"viral":[55,94,105],"load":[56],"preventing":[58],"or":[59,175,233],"delaying":[60],"progression":[62],"However,":[66,178],"these":[67],"offer":[69],"somewhat":[70],"unsatisfactory":[71],"clinical":[72,176,204,218],"cures":[73],"due":[74],"to":[75,117,229,234],"persistence":[77],"intrahepatic":[80],"pool":[81],"covalently":[83],"closed":[84],"circular":[85],"DNA":[86],"(cccDNA)":[87],"serves":[89],"as":[90],"reservoir":[92],"progenies":[95],"potential":[98],"source":[99],"recurring":[101],"infections.":[102],"Elimination":[103],"cccDNA":[106,137],"remains":[107],"challenge":[109],"scientists":[111],"pharmaceutical":[113],"industries":[114],"in":[115,150,173,217],"order":[116],"achieve":[118],"eradication":[120],"control":[122],"infection.":[125,240],"This":[126,206],"would":[127,185],"involve":[128,186],"detailed":[130],"understanding":[131],"molecular":[134],"mechanisms":[135],"formation,":[138],"its":[139],"intracellular":[140],"stability,":[141],"regulation":[143],"during":[144,238],"replication":[145],"transcription.":[147],"Recent":[148],"advances":[149],"drug":[151],"therapy":[152,184],"have":[153],"heralded":[154],"new":[156,182],"horizon":[157],"novel":[159],"therapeutic":[160],"approaches":[161],"CHB":[163],"infection,":[164],"with":[165,202],"several":[166],"promising":[167],"antiviral":[168],"immunomodulatory":[170],"agents":[171],"preclinical":[174],"testing.":[177],"approval":[179],"any":[181],"curative":[183],"rigorous":[187],"evaluation":[188],"efficacy":[191],"safety":[193],"each":[195],"treatment":[196],"defining":[198],"correct":[199],"endpoints":[200],"associated":[201],"improved":[203],"outcomes.":[205],"article":[207],"summarizes":[208],"current":[210],"landscape":[211],"treatments,":[214],"drugs":[216],"trials":[219],"highlights":[221],"most":[223],"recent":[224],"anti-HBV":[225],"small":[226],"molecules":[227],"designed":[228],"directly":[230],"target":[231],"improve":[235],"immune":[236],"response":[237]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-04-20T00:00:00"}
