{"id":"https://openalex.org/W4366209258","doi":"https://doi.org/10.3390/metabo13040560","title":"Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence","display_name":"Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence","publication_year":2023,"publication_date":"2023-04-15","ids":{"openalex":"https://openalex.org/W4366209258","doi":"https://doi.org/10.3390/metabo13040560","pmid":"https://pubmed.ncbi.nlm.nih.gov/37110218","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10141515"},"language":"en","primary_location":{"id":"doi:10.3390/metabo13040560","doi":"https://doi.org/10.3390/metabo13040560","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo13040560","pdf_url":"https://www.mdpi.com/2218-1989/13/4/560/pdf?version=1681720961","source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2218-1989/13/4/560/pdf?version=1681720961","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010678383","display_name":"Roopak Murali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20107917","display_name":"Sri Ramachandra Institute of Higher Education and Research","ror":"https://ror.org/0108gdg43","country_code":"IN","type":"education","lineage":["https://openalex.org/I20107917"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Roopak Murali","raw_affiliation_strings":["Department of Human Genetics, Faculty of Biomedical Sciences Technology and Research, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai 600116, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Faculty of Biomedical Sciences Technology and Research, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai 600116, India","institution_ids":["https://openalex.org/I20107917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087675119","display_name":"Vaishnavi Balasubramaniam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20107917","display_name":"Sri Ramachandra Institute of Higher Education and Research","ror":"https://ror.org/0108gdg43","country_code":"IN","type":"education","lineage":["https://openalex.org/I20107917"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vaishnavi Balasubramaniam","raw_affiliation_strings":["Department of Human Genetics, Faculty of Biomedical Sciences Technology and Research, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai 600116, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Faculty of Biomedical Sciences Technology and Research, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai 600116, India","institution_ids":["https://openalex.org/I20107917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051980026","display_name":"Satish Srinivas","orcid":"https://orcid.org/0000-0002-4952-7204","observed_orcids":["https://orcid.org/0000-0002-4952-7204"]},"institutions":[{"id":"https://openalex.org/I20107917","display_name":"Sri Ramachandra Institute of Higher Education and Research","ror":"https://ror.org/0108gdg43","country_code":"IN","type":"education","lineage":["https://openalex.org/I20107917"]},{"id":"https://openalex.org/I4210107332","display_name":"Sri Ramachandra Medical Centre","ror":"https://ror.org/01cay9k79","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210107332"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Satish Srinivas","raw_affiliation_strings":["Department of Radiation Oncology, Sri Ramachandra Medical College & Research Institute, Sri Ramachandra Institute of Higher Education & Research (Deemed to be University), Porur, Chennai 600116, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Sri Ramachandra Medical College & Research Institute, Sri Ramachandra Institute of Higher Education & Research (Deemed to be University), Porur, Chennai 600116, India","institution_ids":["https://openalex.org/I20107917","https://openalex.org/I4210107332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103877824","display_name":"Sandhya Sundaram","orcid":"https://orcid.org/0000-0001-9878-4365","observed_orcids":["https://orcid.org/0000-0001-9878-4365"]},"institutions":[{"id":"https://openalex.org/I20107917","display_name":"Sri Ramachandra Institute of Higher Education and Research","ror":"https://ror.org/0108gdg43","country_code":"IN","type":"education","lineage":["https://openalex.org/I20107917"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sandhya Sundaram","raw_affiliation_strings":["Department of Pathology, Sri Ramachandra Medical College & Research Institute, Sri Ramachandra Institute of Higher Education & Research (Deemed to be University), Porur, Chennai 600116, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sri Ramachandra Medical College & Research Institute, Sri Ramachandra Institute of Higher Education & Research (Deemed to be University), Porur, Chennai 600116, India","institution_ids":["https://openalex.org/I20107917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037944535","display_name":"Ganesh Venkatraman","orcid":"https://orcid.org/0000-0003-0179-9785","observed_orcids":["https://orcid.org/0000-0003-0179-9785"]},"institutions":[{"id":"https://openalex.org/I20107917","display_name":"Sri Ramachandra Institute of Higher Education and Research","ror":"https://ror.org/0108gdg43","country_code":"IN","type":"education","lineage":["https://openalex.org/I20107917"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ganesh Venkatraman","raw_affiliation_strings":["Department of Human Genetics, Faculty of Biomedical Sciences Technology and Research, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai 600116, India"],"raw_orcid":"https://orcid.org/0000-0003-0179-9785","affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Faculty of Biomedical Sciences Technology and Research, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai 600116, India","institution_ids":["https://openalex.org/I20107917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057308257","display_name":"Sudha R. Warrier","orcid":"https://orcid.org/0000-0003-3787-5647","observed_orcids":["https://orcid.org/0000-0003-3787-5647"]},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sudha Warrier","raw_affiliation_strings":["Cuor Stem Cellutions Pvt Ltd., Manipal Institute of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore 560065, India","Division of Cancer Stem Cells and Cardiovascular Regeneration, School of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore 560065, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cuor Stem Cellutions Pvt Ltd., Manipal Institute of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore 560065, India","institution_ids":["https://openalex.org/I164861460"]},{"raw_affiliation_string":"Division of Cancer Stem Cells and Cardiovascular Regeneration, School of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore 560065, India","institution_ids":["https://openalex.org/I164861460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059905500","display_name":"Arun Dharmarajan","orcid":"https://orcid.org/0000-0002-6715-6005","observed_orcids":["https://orcid.org/0000-0002-6715-6005"]},"institutions":[{"id":"https://openalex.org/I20107917","display_name":"Sri Ramachandra Institute of Higher Education and Research","ror":"https://ror.org/0108gdg43","country_code":"IN","type":"education","lineage":["https://openalex.org/I20107917"]},{"id":"https://openalex.org/I205640436","display_name":"Curtin University","ror":"https://ror.org/02n415q13","country_code":"AU","type":"education","lineage":["https://openalex.org/I205640436"]}],"countries":["AU","IN"],"is_corresponding":false,"raw_author_name":"Arun Dharmarajan","raw_affiliation_strings":["Curtin Health and Innovation Research Institute, Curtin University, Perth, WA 6102, Australia","Department of Biomedical Sciences, Faculty of Biomedical Sciences Technology and Research, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai 600116, India","School of Pharmacy and Biomedical Sciences, Curtin University, Perth, WA 6102, Australia","Stem Cell and Cancer Biology Laboratory, Curtin University, Perth, WA 6102, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Curtin Health and Innovation Research Institute, Curtin University, Perth, WA 6102, Australia","institution_ids":["https://openalex.org/I205640436"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Faculty of Biomedical Sciences Technology and Research, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai 600116, India","institution_ids":["https://openalex.org/I20107917"]},{"raw_affiliation_string":"School of Pharmacy and Biomedical Sciences, Curtin University, Perth, WA 6102, Australia","institution_ids":["https://openalex.org/I205640436"]},{"raw_affiliation_string":"Stem Cell and Cancer Biology Laboratory, Curtin University, Perth, WA 6102, Australia","institution_ids":["https://openalex.org/I205640436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012998953","display_name":"Rajesh Kumar Gandhirajan","orcid":"https://orcid.org/0000-0002-0039-771X","observed_orcids":["https://orcid.org/0000-0002-0039-771X"]},"institutions":[{"id":"https://openalex.org/I20107917","display_name":"Sri Ramachandra Institute of Higher Education and Research","ror":"https://ror.org/0108gdg43","country_code":"IN","type":"education","lineage":["https://openalex.org/I20107917"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Rajesh Kumar Gandhirajan","raw_affiliation_strings":["Department of Human Genetics, Faculty of Biomedical Sciences Technology and Research, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai 600116, India"],"raw_orcid":"https://orcid.org/0000-0002-0039-771X","affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Faculty of Biomedical Sciences Technology and Research, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai 600116, India","institution_ids":["https://openalex.org/I20107917"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5012998953"],"corresponding_institution_ids":["https://openalex.org/I20107917"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2447},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2447},"fwci":1.3529,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.83307774,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"13","issue":"4","first_page":"560","last_page":"560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.05810000002384186,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.949999988079071},{"id":"https://openalex.org/keywords/epithelial-ovarian-cancer","display_name":"epithelial ovarian cancer","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.9610000252723694},{"id":"https://openalex.org/keywords/metabolic-deregulation","display_name":"metabolic deregulation","score":0.6460000276565552},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.8399999737739563},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.9300000071525574},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":1.0},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"fatty acid metabolism","score":0.8349999785423279},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.9890000224113464},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":1.0},{"id":"https://openalex.org/keywords/endometriosis","display_name":"endometriosis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/ovarian-carcinogenesis","display_name":"ovarian carcinogenesis","score":0.878000020980835},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6620000004768372},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.7536379098892212},{"id":"https://openalex.org/C2777632260","wikidata":"https://www.wikidata.org/wiki/Q19000698","display_name":"Serous carcinoma","level":4,"score":0.6302192211151123},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6028984785079956},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5908123850822449},{"id":"https://openalex.org/C150173356","wikidata":"https://www.wikidata.org/wiki/Q6144101","display_name":"Serous fluid","level":2,"score":0.5870941877365112},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5600978136062622},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5465400815010071},{"id":"https://openalex.org/C3019054536","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian carcinoma","level":4,"score":0.4740331470966339},{"id":"https://openalex.org/C2778560582","wikidata":"https://www.wikidata.org/wiki/Q18347894","display_name":"Clear cell","level":3,"score":0.4478590488433838},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.41623786091804504},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35790300369262695},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26273542642593384},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.26201874017715454},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15928876399993896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/metabo13040560","doi":"https://doi.org/10.3390/metabo13040560","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo13040560","pdf_url":"https://www.mdpi.com/2218-1989/13/4/560/pdf?version=1681720961","source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10141515","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10141515","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10141515/pdf/metabolites-13-00560.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"Text"},{"id":"pmid:37110218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37110218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:fc4af6e332fd4b70ae83324d7f3f785a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fc4af6e332fd4b70ae83324d7f3f785a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Metabolites, Vol 13, Iss 4, p 560 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/metabo13040560","doi":"https://doi.org/10.3390/metabo13040560","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo13040560","pdf_url":"https://www.mdpi.com/2218-1989/13/4/560/pdf?version=1681720961","source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366209258.pdf","grobid_xml":"https://content.openalex.org/works/W4366209258.grobid-xml"},"referenced_works_count":291,"referenced_works":["https://openalex.org/W23296015","https://openalex.org/W164957562","https://openalex.org/W1154227870","https://openalex.org/W1488106034","https://openalex.org/W1501481238","https://openalex.org/W1505255521","https://openalex.org/W1531872402","https://openalex.org/W1569754812","https://openalex.org/W1574056173","https://openalex.org/W1577974112","https://openalex.org/W1582429156","https://openalex.org/W1588371609","https://openalex.org/W1761484484","https://openalex.org/W1781764024","https://openalex.org/W1883918909","https://openalex.org/W1891967301","https://openalex.org/W1941490733","https://openalex.org/W1961928411","https://openalex.org/W1963667080","https://openalex.org/W1963711666","https://openalex.org/W1966242225","https://openalex.org/W1968913625","https://openalex.org/W1969747946","https://openalex.org/W1970766774","https://openalex.org/W1971286064","https://openalex.org/W1971859682","https://openalex.org/W1973433522","https://openalex.org/W1974974158","https://openalex.org/W1975141727","https://openalex.org/W1976632546","https://openalex.org/W1980181091","https://openalex.org/W1981398841","https://openalex.org/W1987702513","https://openalex.org/W1987734980","https://openalex.org/W1987798277","https://openalex.org/W1987857671","https://openalex.org/W1991494214","https://openalex.org/W1993625584","https://openalex.org/W1993925306","https://openalex.org/W1994775044","https://openalex.org/W1996023288","https://openalex.org/W1996066317","https://openalex.org/W1998002050","https://openalex.org/W1999919904","https://openalex.org/W2000144783","https://openalex.org/W2001624798","https://openalex.org/W2002419036","https://openalex.org/W2005457938","https://openalex.org/W2006078179","https://openalex.org/W2007483962","https://openalex.org/W2008054544","https://openalex.org/W2010942899","https://openalex.org/W2014082684","https://openalex.org/W2014460958","https://openalex.org/W2014649668","https://openalex.org/W2015263925","https://openalex.org/W2016921045","https://openalex.org/W2016952838","https://openalex.org/W2019156893","https://openalex.org/W2020118391","https://openalex.org/W2022899908","https://openalex.org/W2024273611","https://openalex.org/W2027449497","https://openalex.org/W2030093162","https://openalex.org/W2033556277","https://openalex.org/W2035423971","https://openalex.org/W2035608099","https://openalex.org/W2036786349","https://openalex.org/W2038652783","https://openalex.org/W2039731227","https://openalex.org/W2040380803","https://openalex.org/W2040463387","https://openalex.org/W2040588648","https://openalex.org/W2042896192","https://openalex.org/W2044358936","https://openalex.org/W2044713924","https://openalex.org/W2045102424","https://openalex.org/W2049617964","https://openalex.org/W2052273888","https://openalex.org/W2053521827","https://openalex.org/W2054430764","https://openalex.org/W2054605948","https://openalex.org/W2055255976","https://openalex.org/W2058552694","https://openalex.org/W2058726049","https://openalex.org/W2058977958","https://openalex.org/W2060619702","https://openalex.org/W2062495971","https://openalex.org/W2064042744","https://openalex.org/W2067117419","https://openalex.org/W2068085420","https://openalex.org/W2069269337","https://openalex.org/W2069376956","https://openalex.org/W2070854644","https://openalex.org/W2071756286","https://openalex.org/W2074487053","https://openalex.org/W2074873270","https://openalex.org/W2075943620","https://openalex.org/W2078011486","https://openalex.org/W2078765363","https://openalex.org/W2080215403","https://openalex.org/W2081544673","https://openalex.org/W2082465243","https://openalex.org/W2083659501","https://openalex.org/W2084060660","https://openalex.org/W2086777866","https://openalex.org/W2087025655","https://openalex.org/W2087900616","https://openalex.org/W2089300992","https://openalex.org/W2089477889","https://openalex.org/W2089755573","https://openalex.org/W2090740451","https://openalex.org/W2096258216","https://openalex.org/W2099309860","https://openalex.org/W2101499936","https://openalex.org/W2102186262","https://openalex.org/W2102501124","https://openalex.org/W2108316315","https://openalex.org/W2109465247","https://openalex.org/W2110508238","https://openalex.org/W2112439257","https://openalex.org/W2112861594","https://openalex.org/W2114258250","https://openalex.org/W2114596030","https://openalex.org/W2114787582","https://openalex.org/W2117692326","https://openalex.org/W2119239003","https://openalex.org/W2119478570","https://openalex.org/W2121169754","https://openalex.org/W2122826701","https://openalex.org/W2124951199","https://openalex.org/W2126524529","https://openalex.org/W2128502794","https://openalex.org/W2130503287","https://openalex.org/W2135179721","https://openalex.org/W2135679869","https://openalex.org/W2136091069","https://openalex.org/W2136765222","https://openalex.org/W2139039092","https://openalex.org/W2140165323","https://openalex.org/W2140814324","https://openalex.org/W2142252299","https://openalex.org/W2143531394","https://openalex.org/W2144940777","https://openalex.org/W2145099162","https://openalex.org/W2146133266","https://openalex.org/W2149441684","https://openalex.org/W2150144117","https://openalex.org/W2150293462","https://openalex.org/W2151216008","https://openalex.org/W2153579158","https://openalex.org/W2154191201","https://openalex.org/W2157935510","https://openalex.org/W2159550690","https://openalex.org/W2159807872","https://openalex.org/W2162295781","https://openalex.org/W2162321914","https://openalex.org/W2165535625","https://openalex.org/W2168050705","https://openalex.org/W2170460043","https://openalex.org/W2170562590","https://openalex.org/W2179994591","https://openalex.org/W2186508115","https://openalex.org/W2190934640","https://openalex.org/W2215688384","https://openalex.org/W2216554257","https://openalex.org/W2219161659","https://openalex.org/W2223535266","https://openalex.org/W2267953463","https://openalex.org/W2284388501","https://openalex.org/W2284799106","https://openalex.org/W2291543304","https://openalex.org/W2305551225","https://openalex.org/W2314558022","https://openalex.org/W2317055602","https://openalex.org/W2339471430","https://openalex.org/W2366312136","https://openalex.org/W2378198729","https://openalex.org/W2410882188","https://openalex.org/W2413490488","https://openalex.org/W2421614151","https://openalex.org/W2471801298","https://openalex.org/W2480163530","https://openalex.org/W2546921687","https://openalex.org/W2547505747","https://openalex.org/W2549573446","https://openalex.org/W2562671866","https://openalex.org/W2562970182","https://openalex.org/W2564304225","https://openalex.org/W2592082118","https://openalex.org/W2594448454","https://openalex.org/W2596673995","https://openalex.org/W2605487687","https://openalex.org/W2606404839","https://openalex.org/W2607129810","https://openalex.org/W2739216894","https://openalex.org/W2751139883","https://openalex.org/W2758922445","https://openalex.org/W2769305823","https://openalex.org/W2771702893","https://openalex.org/W2780201866","https://openalex.org/W2785391206","https://openalex.org/W2790008104","https://openalex.org/W2791067291","https://openalex.org/W2793124274","https://openalex.org/W2800084163","https://openalex.org/W2808988492","https://openalex.org/W2857683645","https://openalex.org/W2883694743","https://openalex.org/W2889305184","https://openalex.org/W2891474559","https://openalex.org/W2891973735","https://openalex.org/W2892293198","https://openalex.org/W2894616573","https://openalex.org/W2897073365","https://openalex.org/W2898222099","https://openalex.org/W2901437794","https://openalex.org/W2902159788","https://openalex.org/W2902544093","https://openalex.org/W2904705859","https://openalex.org/W2905656919","https://openalex.org/W2907710771","https://openalex.org/W2910249787","https://openalex.org/W2921455619","https://openalex.org/W2922132864","https://openalex.org/W2939531727","https://openalex.org/W2944228421","https://openalex.org/W2946526918","https://openalex.org/W2950542148","https://openalex.org/W2951540630","https://openalex.org/W2952156113","https://openalex.org/W2953097438","https://openalex.org/W2953615255","https://openalex.org/W2954572947","https://openalex.org/W2967159309","https://openalex.org/W2969735896","https://openalex.org/W2979370180","https://openalex.org/W2989898587","https://openalex.org/W2991127455","https://openalex.org/W2992908616","https://openalex.org/W2994175635","https://openalex.org/W2994883821","https://openalex.org/W3003328884","https://openalex.org/W3005421475","https://openalex.org/W3011055225","https://openalex.org/W3014325383","https://openalex.org/W3014484603","https://openalex.org/W3022053420","https://openalex.org/W3034516598","https://openalex.org/W3035532414","https://openalex.org/W3041824636","https://openalex.org/W3049042785","https://openalex.org/W3103919046","https://openalex.org/W3106759953","https://openalex.org/W3118575215","https://openalex.org/W3129336920","https://openalex.org/W3134048548","https://openalex.org/W3136458354","https://openalex.org/W3157821485","https://openalex.org/W3162913615","https://openalex.org/W3163081064","https://openalex.org/W3168045009","https://openalex.org/W3171977100","https://openalex.org/W3176010718","https://openalex.org/W3186498232","https://openalex.org/W3196458428","https://openalex.org/W3198711583","https://openalex.org/W3198718329","https://openalex.org/W3208624945","https://openalex.org/W3209353468","https://openalex.org/W4212821750","https://openalex.org/W4214527250","https://openalex.org/W4280618211","https://openalex.org/W4283738906","https://openalex.org/W4285179117","https://openalex.org/W4285740521","https://openalex.org/W4288060300","https://openalex.org/W4288068925","https://openalex.org/W4289912251","https://openalex.org/W4291178130","https://openalex.org/W4293513512","https://openalex.org/W4294664017","https://openalex.org/W4295880346","https://openalex.org/W4296637715","https://openalex.org/W4322718934","https://openalex.org/W6627367144","https://openalex.org/W6648552128","https://openalex.org/W6754593953","https://openalex.org/W6771619328","https://openalex.org/W6773338867","https://openalex.org/W6795768570"],"related_works":["https://openalex.org/W2155406267","https://openalex.org/W2565666106","https://openalex.org/W4413286164","https://openalex.org/W2321997027","https://openalex.org/W4379386187","https://openalex.org/W4410436713","https://openalex.org/W4308800352","https://openalex.org/W4365452903","https://openalex.org/W2048023614","https://openalex.org/W2004828205"],"abstract_inverted_index":{"Ovarian":[0,69],"cancers":[1,21],"are":[2],"tumors":[3,30],"that":[4],"originate":[5],"from":[6],"the":[7,11,20,36,44,83,94,99,125,135,140,149,157],"different":[8],"cells":[9],"of":[10,18,29,50,82,90,96,101,127,151,159,173,187,198],"ovary":[12],"and":[13,47,66,104,117,143,162,166,179,189,203],"account":[14],"for":[15,148,208],"almost":[16],"4%":[17],"all":[19],"in":[22,107,124,183,195,204],"women":[23],"globally.":[24],"More":[25],"than":[26],"30":[27],"types":[28],"have":[31,121],"been":[32,72,112,122],"identified":[33],"based":[34],"on":[35],"cellular":[37],"origins.":[38],"Epithelial":[39],"ovarian":[40,51,128,152,184],"cancer":[41,52],"(EOC)":[42],"is":[43,78],"most":[45],"common":[46],"lethal":[48],"type":[49],"which":[53,77],"can":[54],"be":[55,193],"further":[56],"divided":[57],"into":[58],"high-grade":[59],"serous,":[60,62],"low-grade":[61],"endometrioid,":[63],"clear":[64],"cell,":[65],"mucinous":[67],"carcinoma.":[68],"carcinogenesis":[70],"has":[71,111],"long":[73],"attributed":[74],"to":[75,87,93],"endometriosis":[76],"a":[79,170],"chronic":[80],"inflammation":[81],"reproductive":[84],"tract":[85],"leading":[86],"progressive":[88],"accumulation":[89],"mutations.":[91],"Due":[92],"advent":[95],"multi-omics":[97],"datasets,":[98],"consequences":[100],"somatic":[102],"mutations":[103],"their":[105,167],"role":[106,158],"altered":[108],"tumor":[109,118,144,163],"metabolism":[110,182],"well":[113],"elucidated.":[114],"Several":[115],"oncogenes":[116,142,161],"suppressor":[119,145,164],"genes":[120,146,165],"implicated":[123],"progression":[126],"cancer.":[129,153,212],"In":[130],"this":[131],"review,":[132],"we":[133],"highlight":[134],"genetic":[136],"alterations":[137],"undergone":[138],"by":[139],"key":[141],"responsible":[147],"development":[150],"We":[154],"also":[155],"summarize":[156],"these":[160],"association":[168],"with":[169,200],"deregulated":[171],"network":[172],"fatty":[174],"acid,":[175],"glycolysis,":[176],"tricarboxylic":[177],"acid":[178,181],"amino":[180],"cancers.":[185],"Identification":[186],"genomic":[188],"metabolic":[190],"circuits":[191],"will":[192],"useful":[194],"clinical":[196],"stratification":[197],"patients":[199],"complex":[201],"etiologies":[202],"identifying":[205],"drug":[206],"targets":[207],"personalized":[209],"therapies":[210],"against":[211]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-04-19T00:00:00"}
