{"id":"https://openalex.org/W4366208093","doi":"https://doi.org/10.3389/fnut.2023.1124987","title":"Altered zinc homeostasis in a primary cell culture model of the retinal pigment epithelium","display_name":"Altered zinc homeostasis in a primary cell culture model of the retinal pigment epithelium","publication_year":2023,"publication_date":"2023-04-17","ids":{"openalex":"https://openalex.org/W4366208093","doi":"https://doi.org/10.3389/fnut.2023.1124987","pmid":"https://pubmed.ncbi.nlm.nih.gov/37139441","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10149808"},"language":"en","primary_location":{"id":"doi:10.3389/fnut.2023.1124987","doi":"https://doi.org/10.3389/fnut.2023.1124987","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2023.1124987","pdf_url":null,"source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fnut.2023.1124987","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044252919","display_name":"Ana \u00c1lvarez-Barrios","orcid":"https://orcid.org/0000-0002-8765-8352","observed_orcids":["https://orcid.org/0000-0002-8765-8352"]},"institutions":[{"id":"https://openalex.org/I165339363","display_name":"Universidad de Oviedo","ror":"https://ror.org/006gksa02","country_code":"ES","type":"education","lineage":["https://openalex.org/I165339363"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana \u00c1lvarez-Barrios","raw_affiliation_strings":["Department of Physical and Analytical Chemistry, University of Oviedo, Juli\u00e1n Claver\u00eda, 8, Oviedo, Spain","Fundaci\u00f3n de Investigaci\u00f3n Oftalmol\u00f3gica, Oviedo, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical and Analytical Chemistry, University of Oviedo, Juli\u00e1n Claver\u00eda, 8, Oviedo, Spain","institution_ids":["https://openalex.org/I165339363"]},{"raw_affiliation_string":"Fundaci\u00f3n de Investigaci\u00f3n Oftalmol\u00f3gica, Oviedo, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102845848","display_name":"Lydia \u00c1lvarez","orcid":"https://orcid.org/0000-0002-0604-7411","observed_orcids":["https://orcid.org/0000-0002-0604-7411"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lydia \u00c1lvarez","raw_affiliation_strings":["Fundaci\u00f3n de Investigaci\u00f3n Oftalmol\u00f3gica, Oviedo, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundaci\u00f3n de Investigaci\u00f3n Oftalmol\u00f3gica, Oviedo, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033850868","display_name":"Enol Artime","orcid":"https://orcid.org/0000-0002-3272-8712","observed_orcids":["https://orcid.org/0000-0002-3272-8712"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Enol Artime","raw_affiliation_strings":["Fundaci\u00f3n de Investigaci\u00f3n Oftalmol\u00f3gica, Oviedo, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundaci\u00f3n de Investigaci\u00f3n Oftalmol\u00f3gica, Oviedo, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087430277","display_name":"Montserrat Garc\u00eda","orcid":"https://orcid.org/0000-0001-9983-546X","observed_orcids":["https://orcid.org/0000-0001-9983-546X"]},"institutions":[{"id":"https://openalex.org/I4210109730","display_name":"Fern\u00e1ndez-Vega Ophthalmological Institute","ror":"https://ror.org/01d71vb80","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210109730"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Montserrat Garc\u00eda","raw_affiliation_strings":["Instituto Oftalmol\u00f3gico Fern\u00e1ndez-Vega, Oviedo, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Oftalmol\u00f3gico Fern\u00e1ndez-Vega, Oviedo, Spain","institution_ids":["https://openalex.org/I4210109730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019297305","display_name":"Imre Lengyel","orcid":"https://orcid.org/0000-0001-7467-2174","observed_orcids":["https://orcid.org/0000-0001-7467-2174"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Imre Lengyel","raw_affiliation_strings":["Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057206339","display_name":"Rosario Pereiro","orcid":"https://orcid.org/0000-0002-5936-7726","observed_orcids":["https://orcid.org/0000-0002-5936-7726"]},"institutions":[{"id":"https://openalex.org/I165339363","display_name":"Universidad de Oviedo","ror":"https://ror.org/006gksa02","country_code":"ES","type":"education","lineage":["https://openalex.org/I165339363"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rosario Pereiro","raw_affiliation_strings":["Department of Physical and Analytical Chemistry, University of Oviedo, Juli\u00e1n Claver\u00eda, 8, Oviedo, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical and Analytical Chemistry, University of Oviedo, Juli\u00e1n Claver\u00eda, 8, Oviedo, Spain","institution_ids":["https://openalex.org/I165339363"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014478440","display_name":"H\u00e9ctor Gonz\u00e1lez\u2010Iglesias","orcid":"https://orcid.org/0000-0001-5251-0967","observed_orcids":["https://orcid.org/0000-0001-5251-0967"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210091402","display_name":"Instituto de Productos L\u00e1cteos de Asturias","ror":"https://ror.org/00bnagp43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210091402"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"H\u00e9ctor Gonz\u00e1lez-Iglesias","raw_affiliation_strings":["Instituto de Productos L\u00e1cteos de Asturias, Consejo Superior de Investigaciones Cient\u00edficas (IPLA-CSIC), Villaviciosa, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Productos L\u00e1cteos de Asturias, Consejo Superior de Investigaciones Cient\u00edficas (IPLA-CSIC), Villaviciosa, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210091402"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5014478440","https://openalex.org/A5102845848"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210091402"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":1.2439,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.74537092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":null,"first_page":"1124987","last_page":"1124987"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.6050000190734863,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.6050000190734863,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.3707999885082245,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9440000057220459},{"id":"https://openalex.org/keywords/zinc-homeostasis","display_name":"zinc homeostasis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9940000176429749},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.8960000276565552},{"id":"https://openalex.org/keywords/metallothionein","display_name":"metallothionein","score":0.9240000247955322},{"id":"https://openalex.org/keywords/zinc-transporters","display_name":"zinc transporters","score":0.7110000252723694},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7120000123977661},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.9430000185966492},{"id":"https://openalex.org/keywords/metalloproteins","display_name":"metalloproteins","score":0.6700000166893005},{"id":"https://openalex.org/keywords/metal-accumulation","display_name":"metal accumulation","score":0.30799999833106995},{"id":"https://openalex.org/keywords/copper","display_name":"copper","score":0.32499998807907104},{"id":"https://openalex.org/keywords/sodium","display_name":"sodium","score":0.8519999980926514},{"id":"https://openalex.org/keywords/potassium","display_name":"potassium","score":0.9940000176429749},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.7789999842643738},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9829999804496765},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9200000166893005},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.4300000071525574},{"id":"https://openalex.org/keywords/protein-refolding","display_name":"protein refolding","score":0.39500001072883606},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.782261848449707},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.563958466053009},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5421522259712219},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.5249485969543457},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.5067444443702698},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47134965658187866},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.46858876943588257},{"id":"https://openalex.org/C64584667","wikidata":"https://www.wikidata.org/wiki/Q161179","display_name":"Pigment","level":2,"score":0.41218075156211853},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3897196054458618},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3800131678581238},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.3628261089324951},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.335936963558197},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19437453150749207},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0836721658706665},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fnut.2023.1124987","doi":"https://doi.org/10.3389/fnut.2023.1124987","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2023.1124987","pdf_url":null,"source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10149808","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10149808","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10149808/pdf/fnut-10-1124987.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Nutr","raw_type":"Text"},{"id":"pmid:37139441","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37139441","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in nutrition","raw_type":"Journal Article"},{"id":"pmh:oai:pure.qub.ac.uk/portal:openaire/14cf678e-57eb-42c3-bf9a-9dc2b8e30443","doi":null,"is_oa":true,"landing_page_url":"https://pure.qub.ac.uk/en/publications/14cf678e-57eb-42c3-bf9a-9dc2b8e30443","pdf_url":"https://pureadmin.qub.ac.uk/ws/files/457385084/fnut_10_1124987.pdf","source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"\u00c1lvarez-Barrios, A, \u00c1lvarez, L, Artime, E, Garc\u00eda, M, Lengyel, I, Pereiro, R & Gonz\u00e1lez-Iglesias, H 2023, 'Altered zinc homeostasis in a primary cell culture model of the retinal pigment epithelium', Frontiers in Nutrition, vol. 10, 1124987. https://doi.org/10.3389/fnut.2023.1124987","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:digital.csic.es:10261/339030","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/339030","pdf_url":"https://digital.csic.es/bitstream/10261/339030/1/fnut-10-1124987.pdf","source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"art\u00edculo"},{"id":"pmh:oai:doaj.org/article:4a01447d7175445c85bdc5e121044bfc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4a01447d7175445c85bdc5e121044bfc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Nutrition, Vol 10 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnut.2023.1124987","doi":"https://doi.org/10.3389/fnut.2023.1124987","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2023.1124987","pdf_url":null,"source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2262748287","display_name":null,"funder_award_id":"501100011033","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G300979063","display_name":null,"funder_award_id":"10.13039/501100011033","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G3480869486","display_name":null,"funder_award_id":"13039","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G425668148","display_name":null,"funder_award_id":".13039/501100011033","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G5080475149","display_name":null,"funder_award_id":"10.13039","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G5594912718","display_name":null,"funder_award_id":"PID2019-107838RB-I00","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G8684520763","display_name":null,"funder_award_id":"PID2019","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F4320328810","display_name":"Fundaci\u00f3n Rafael del Pino","ror":"https://ror.org/02efm5j95"},{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":"https://ror.org/003x0zc53"},{"id":"https://openalex.org/F7296444849","display_name":"Ministerio de Universidades","ror":"https://ror.org/03zcny908"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366208093.pdf","grobid_xml":"https://content.openalex.org/works/W4366208093.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W114316392","https://openalex.org/W1438640379","https://openalex.org/W1519481032","https://openalex.org/W1785652742","https://openalex.org/W1973207504","https://openalex.org/W1978391747","https://openalex.org/W1978437552","https://openalex.org/W1984271994","https://openalex.org/W1984659998","https://openalex.org/W1992706834","https://openalex.org/W1996103543","https://openalex.org/W1998593109","https://openalex.org/W1998991620","https://openalex.org/W1999574084","https://openalex.org/W2004603626","https://openalex.org/W2009738449","https://openalex.org/W2009960960","https://openalex.org/W2016520383","https://openalex.org/W2020391754","https://openalex.org/W2021163002","https://openalex.org/W2026329770","https://openalex.org/W2029422501","https://openalex.org/W2035918997","https://openalex.org/W2036663456","https://openalex.org/W2039988441","https://openalex.org/W2048824833","https://openalex.org/W2053108757","https://openalex.org/W2055720749","https://openalex.org/W2057266930","https://openalex.org/W2060764677","https://openalex.org/W2061731519","https://openalex.org/W2078471699","https://openalex.org/W2088791095","https://openalex.org/W2098193566","https://openalex.org/W2100762672","https://openalex.org/W2102278945","https://openalex.org/W2103472715","https://openalex.org/W2111274886","https://openalex.org/W2112310296","https://openalex.org/W2114914263","https://openalex.org/W2120148313","https://openalex.org/W2122658884","https://openalex.org/W2123230988","https://openalex.org/W2130775876","https://openalex.org/W2132471916","https://openalex.org/W2136501493","https://openalex.org/W2141588316","https://openalex.org/W2154703818","https://openalex.org/W2179438025","https://openalex.org/W2330453389","https://openalex.org/W2520110281","https://openalex.org/W2528637216","https://openalex.org/W2566154985","https://openalex.org/W2576430281","https://openalex.org/W2584917966","https://openalex.org/W2740863379","https://openalex.org/W2761604622","https://openalex.org/W2774072836","https://openalex.org/W2793534505","https://openalex.org/W2896707534","https://openalex.org/W2898580429","https://openalex.org/W2905434803","https://openalex.org/W2944525985","https://openalex.org/W2972368830","https://openalex.org/W2991518215","https://openalex.org/W3028513630","https://openalex.org/W3092175833","https://openalex.org/W3105075054","https://openalex.org/W3108197638","https://openalex.org/W3119618794","https://openalex.org/W3134017539","https://openalex.org/W3177323127","https://openalex.org/W3213759958","https://openalex.org/W4206300474","https://openalex.org/W4211068092"],"related_works":["https://openalex.org/W4206329760","https://openalex.org/W2793534505","https://openalex.org/W2005925362","https://openalex.org/W1927225366","https://openalex.org/W4322741782","https://openalex.org/W3092175833","https://openalex.org/W2009960960","https://openalex.org/W23001584","https://openalex.org/W4390974487","https://openalex.org/W1522092043"],"abstract_inverted_index":{"The":[0,208,289],"retinal":[1],"pigment":[2],"epithelium":[3],"(RPE)":[4],"is":[5,24],"progressively":[6],"degenerated":[7],"during":[8,332],"age-related":[9],"macular":[10],"degeneration":[11],"(AMD),":[12],"one":[13],"of":[14,18,27,65,103,119,124,128,176,229,279,296,328],"the":[15,25,43,98,230,277],"leading":[16],"causes":[17],"irreversible":[19],"blindness,":[20],"which":[21],"clinical":[22],"hallmark":[23],"buildup":[26],"sub-RPE":[28,59,129],"extracellular":[29,297],"material.":[30],"Clinical":[31],"observations":[32],"indicate":[33],"that":[34,62],"Zn":[35,70,144,259,304,314,330],"dyshomeostasis":[36],"can":[37],"initiate":[38],"detrimental":[39],"intracellular":[40],"events":[41],"in":[42,87,142,179,182,189,192,200,215,234,271,276,309,319],"RPE.":[44],"In":[45],"this":[46],"study,":[47],"we":[48],"used":[49],"a":[50,221,325],"primary":[51,235],"human":[52],"fetal":[53],"RPE":[54,75,106,120,236,290],"cell":[55,76,183,193,291],"culture":[56,88],"model":[57,292],"producing":[58,293],"deposits":[60,298],"accumulation":[61,295],"recapitulates":[63],"features":[64],"early":[66,294],"AMD":[67,333],"to":[68,111,162,246],"study":[69],"homeostasis":[71,331],"and":[72,84,89,97,100,117,185,195,197,226,261,274,286,313,322],"metalloproteins":[73],"changes.":[74],"derived":[77],"samples":[78],"were":[79,202,264],"collected":[80],"at":[81,151,159,167,224,243,251],"10,":[82],"21":[83],"59":[85,152,168,252],"days":[86,161,169,245,253],"processed":[90],"for":[91],"RNA":[92,225],"sequencing,":[93],"elemental":[94],"mass":[95],"spectrometry":[96],"abundance":[99],"cellular":[101],"localization":[102],"specific":[104],"proteins.":[105,121],"cells":[107],"developed":[108],"processes":[109],"normal":[110],"RPE,":[112],"including":[113,282],"intercellular":[114],"unions":[115],"formation":[116],"expression":[118,217,278],"Punctate":[122],"deposition":[123],"apolipoprotein":[125],"E,":[126],"marker":[127],"material":[130],"accumulation,":[131],"was":[132],"observed":[133],"from":[134,154,238],"3":[135],"weeks":[136],"with":[137,220,268,317],"profusion":[138],"after":[139,204],"2":[140],"months":[141],"culture.":[143,207],"cytoplasmic":[145],"concentrations":[146],"significantly":[147],"decreased":[148],"0.2":[149],"times":[150],"days,":[153],"0.264":[155],"\u00b1":[156,164,240,248],"0.119":[157],"ng\u00b7\u03bcg\u22121":[158,166],"10":[160,244],"0.062":[163],"0.043":[165],"(p":[170],"<":[171,257],"0.05).":[172,258],"Conversely,":[173],"increased":[174],"levels":[175],"Cu":[177],"(1.5-fold":[178],"cytoplasm,":[180,190],"5.0-fold":[181],"nuclei":[184,194],"membranes),":[186],"Na":[187],"(3.5-fold":[188],"14.0-fold":[191],"membranes)":[196],"K":[198],"(6.8-fold":[199],"cytoplasm)":[201],"detected":[203],"59-days":[205],"long":[206],"Zn-regulating":[209],"proteins":[210,312],"metallothioneins":[211],"showed":[212],"significant":[213],"changes":[214,308],"gene":[216],"over":[218],"time,":[219],"potent":[222],"down-regulation":[223],"protein":[227],"level":[228],"most":[231],"abundant":[232],"isoform":[233],"cells,":[237],"0.141":[239],"0.016":[241],"ng\u00b7mL\u22121":[242,250],"0.056":[247],"0.023":[249],"(0.4-fold":[254],"change,":[255],"p":[256],"influx":[260],"efflux":[262],"transporters":[263],"also":[265],"deregulated,":[266],"along":[267,316],"an":[269,302],"increase":[270],"oxidative":[272],"stress":[273],"alterations":[275],"antioxidant":[280],"enzymes,":[281],"superoxide":[283],"dismutase,":[284],"catalase":[285],"glutathione":[287],"peroxidase.":[288],"provided":[299],"evidences":[300],"on":[301],"altered":[303,329],"homeostasis,":[305],"exacerbated":[306],"by":[307],"cytosolic":[310],"Zn-binding":[311],"transporters,":[315],"variations":[318],"other":[320],"metals":[321],"metalloproteins,":[323],"suggesting":[324],"potential":[326],"role":[327],"development.":[334]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-19T00:00:00"}
