{"id":"https://openalex.org/W4366201816","doi":"https://doi.org/10.1111/cas.15814","title":"The histone demethylase Utx controls CD8 + T\u2010cell\u2010dependent antitumor immunity via epigenetic regulation of the effector function","display_name":"The histone demethylase Utx controls CD8 + T\u2010cell\u2010dependent antitumor immunity via epigenetic regulation of the effector function","publication_year":2023,"publication_date":"2023-04-17","ids":{"openalex":"https://openalex.org/W4366201816","doi":"https://doi.org/10.1111/cas.15814","pmid":"https://pubmed.ncbi.nlm.nih.gov/37068788","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10323087"},"language":"en","primary_location":{"id":"doi:10.1111/cas.15814","doi":"https://doi.org/10.1111/cas.15814","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.15814","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.15814","source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.15814","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028462009","display_name":"Haruna Noda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110672","display_name":"Ehime University Hospital","ror":"https://ror.org/01vpa9c32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210110672","https://openalex.org/I43545212"]},{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruna Noda","raw_affiliation_strings":["Breast Center, Ehime University Hospital, Toon, Japan","Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Graduate School of Medicine, Ehime University, Toon, Japan","Department of Immunology, Graduate School of Medicine, Ehime University, Toon, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Center, Ehime University Hospital, Toon, Japan","institution_ids":["https://openalex.org/I4210110672"]},{"raw_affiliation_string":"Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Graduate School of Medicine, Ehime University, Toon, Japan","institution_ids":["https://openalex.org/I43545212"]},{"raw_affiliation_string":"Department of Immunology, Graduate School of Medicine, Ehime University, Toon, Japan","institution_ids":["https://openalex.org/I43545212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025150539","display_name":"Junpei Suzuki","orcid":"https://orcid.org/0000-0003-2701-742X","observed_orcids":["https://orcid.org/0000-0003-2701-742X"]},"institutions":[{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junpei Suzuki","raw_affiliation_strings":["Department of Immunology, Graduate School of Medicine, Ehime University, Toon, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Graduate School of Medicine, Ehime University, Toon, Japan","institution_ids":["https://openalex.org/I43545212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014047038","display_name":"Yuko Matsuoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110672","display_name":"Ehime University Hospital","ror":"https://ror.org/01vpa9c32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210110672","https://openalex.org/I43545212"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuko Matsuoka","raw_affiliation_strings":["Department of Translational Research Center, Ehime University Hospital, Toon, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Research Center, Ehime University Hospital, Toon, Japan","institution_ids":["https://openalex.org/I4210110672"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Akira Matsumoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Matsumoto","raw_affiliation_strings":["Department of Infections and Host Defenses, Graduate School of Medicine, Ehime University, Toon, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infections and Host Defenses, Graduate School of Medicine, Ehime University, Toon, Japan","institution_ids":["https://openalex.org/I43545212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102946672","display_name":"Makoto Kuwahara","orcid":"https://orcid.org/0000-0002-2023-5646","observed_orcids":["https://orcid.org/0000-0002-2023-5646"]},"institutions":[{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Kuwahara","raw_affiliation_strings":["Department of Immunology, Graduate School of Medicine, Ehime University, Toon, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Graduate School of Medicine, Ehime University, Toon, Japan","institution_ids":["https://openalex.org/I43545212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112682720","display_name":"Yoshiaki Kamei","orcid":"https://orcid.org/0009-0009-0041-3298","observed_orcids":["https://orcid.org/0009-0009-0041-3298"]},"institutions":[{"id":"https://openalex.org/I4210110672","display_name":"Ehime University Hospital","ror":"https://ror.org/01vpa9c32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210110672","https://openalex.org/I43545212"]},{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiaki Kamei","raw_affiliation_strings":["Breast Center, Ehime University Hospital, Toon, Japan","Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Graduate School of Medicine, Ehime University, Toon, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Center, Ehime University Hospital, Toon, Japan","institution_ids":["https://openalex.org/I4210110672"]},{"raw_affiliation_string":"Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Graduate School of Medicine, Ehime University, Toon, Japan","institution_ids":["https://openalex.org/I43545212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091877732","display_name":"Yasutsugu Takada","orcid":"https://orcid.org/0000-0001-9743-1840","observed_orcids":["https://orcid.org/0000-0001-9743-1840"]},"institutions":[{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasutsugu Takada","raw_affiliation_strings":["Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Graduate School of Medicine, Ehime University, Toon, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Graduate School of Medicine, Ehime University, Toon, Japan","institution_ids":["https://openalex.org/I43545212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050106408","display_name":"Masakatsu Yamashita","orcid":"https://orcid.org/0000-0002-8975-3513","observed_orcids":["https://orcid.org/0000-0002-8975-3513"]},"institutions":[{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masakatsu Yamashita","raw_affiliation_strings":["Department of Immunology, Graduate School of Medicine, Ehime University, Toon, Japan","Department of Infections and Host Defenses, Graduate School of Medicine, Ehime University, Toon, Japan"],"raw_orcid":"https://orcid.org/0000-0002-8975-3513","affiliations":[{"raw_affiliation_string":"Department of Immunology, Graduate School of Medicine, Ehime University, Toon, Japan","institution_ids":["https://openalex.org/I43545212"]},{"raw_affiliation_string":"Department of Infections and Host Defenses, Graduate School of Medicine, Ehime University, Toon, Japan","institution_ids":["https://openalex.org/I43545212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050106408"],"corresponding_institution_ids":["https://openalex.org/I43545212"],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":{"value":2600,"currency":"USD","value_usd":2600},"fwci":0.9778,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.71230454,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"114","issue":"7","first_page":"2787","last_page":"2797"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6909000277519226,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6909000277519226,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.21619999408721924,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.06019999831914902,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kdm6a","display_name":"KDM6A","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.9829999804496765},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/effector-t-cell-differentiation","display_name":"effector T cell differentiation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.984000027179718},{"id":"https://openalex.org/keywords/cxcr3","display_name":"CXCR3","score":0.9290000200271606},{"id":"https://openalex.org/keywords/t-cell-migration","display_name":"T cell migration","score":0.746999979019165},{"id":"https://openalex.org/keywords/t-cell-effector-function","display_name":"T cell effector function","score":0.609000027179718},{"id":"https://openalex.org/keywords/tumor-bearing-mice","display_name":"tumor-bearing mice","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.7531226277351379},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7028294801712036},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6953523755073547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.637089192867279},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5995302200317383},{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.5365785360336304},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.499570369720459},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4426339268684387},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3846387565135956},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37872451543807983},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3657490909099579},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.318045049905777},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10014227032661438},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.05209502577781677},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.04886302351951599}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056466","descriptor_name":"Histone Demethylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056466","descriptor_name":"Histone Demethylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/cas.15814","doi":"https://doi.org/10.1111/cas.15814","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.15814","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.15814","source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10323087","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10323087","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10323087/pdf/CAS-114-2787.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Sci","raw_type":"Text"},{"id":"pmid:37068788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37068788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/cas.15814","doi":"https://doi.org/10.1111/cas.15814","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.15814","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.15814","source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5268459591","display_name":null,"funder_award_id":"KAKENHI/22K15609","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5729234264","display_name":"Role of T cell on lung homeostasis and dieseases","funder_award_id":"21K08205","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6560585609","display_name":"The enhancement of anti-tumor activity by regulating of senescent T cells","funder_award_id":"22K15609","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7358395781","display_name":null,"funder_award_id":"KAKENHI/20H03504","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8086207401","display_name":"Tumor suppressor Menin prevents CD8 T cell senescence by maintaining lysosomal Ca2+ homeostasis","funder_award_id":"22K07121","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8586119393","display_name":"Integrated regulation of T cell signaling and differentiation by glutamine","funder_award_id":"20H03504","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8737733299","display_name":null,"funder_award_id":"KAKENHI/22K07121","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366201816.pdf","grobid_xml":"https://content.openalex.org/works/W4366201816.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1577612079","https://openalex.org/W1933167787","https://openalex.org/W2009253992","https://openalex.org/W2015416439","https://openalex.org/W2034665043","https://openalex.org/W2043793366","https://openalex.org/W2084891343","https://openalex.org/W2085293170","https://openalex.org/W2089796707","https://openalex.org/W2091579735","https://openalex.org/W2096550742","https://openalex.org/W2098579403","https://openalex.org/W2107456313","https://openalex.org/W2109611466","https://openalex.org/W2122495232","https://openalex.org/W2123106337","https://openalex.org/W2123564569","https://openalex.org/W2130011407","https://openalex.org/W2130410032","https://openalex.org/W2139748322","https://openalex.org/W2149878896","https://openalex.org/W2153828473","https://openalex.org/W2159174521","https://openalex.org/W2159520551","https://openalex.org/W2161088301","https://openalex.org/W2167550136","https://openalex.org/W2202401513","https://openalex.org/W2254951225","https://openalex.org/W2343745213","https://openalex.org/W2407603036","https://openalex.org/W2408392972","https://openalex.org/W2408483783","https://openalex.org/W2534811436","https://openalex.org/W2537834447","https://openalex.org/W2785594347","https://openalex.org/W2887274658","https://openalex.org/W2897325901","https://openalex.org/W2897422388","https://openalex.org/W2910661683","https://openalex.org/W2928665623","https://openalex.org/W2945537500","https://openalex.org/W2981645912","https://openalex.org/W3016257110","https://openalex.org/W3092218844","https://openalex.org/W3118711697","https://openalex.org/W3154264608","https://openalex.org/W3173725877","https://openalex.org/W4294225382"],"related_works":["https://openalex.org/W2910661683","https://openalex.org/W7144481442","https://openalex.org/W4416446866","https://openalex.org/W2736811313","https://openalex.org/W2108194358","https://openalex.org/W2038046438","https://openalex.org/W2995768892","https://openalex.org/W2152799734","https://openalex.org/W2980240469","https://openalex.org/W2024985626"],"abstract_inverted_index":{"Abstract":[0],"CD8+":[1,23,52,90,119,138,165,177,186],"T":[2,24,91,120,139,166,178],"cells":[3,92,167],"play":[4],"a":[5,31,61],"central":[6],"role":[7,28],"in":[8,36,50,75,93,100,116,134,174],"antitumor":[9,37,57,188],"immune":[10,58,189],"responses.":[11],"Epigenetic":[12],"gene":[13],"regulation":[14,194],"is":[15,158],"essential":[16],"to":[17,168],"acquire":[18],"the":[19,27,46,56,107,126,142,153,161,196],"effector":[20,51,110,129,137,164,197],"function":[21,111],"of":[22,29,33,48,89,109,128,144,155,163,195],"cells.":[25,121,179],"However,":[26],"Utx,":[30],"demethylase":[32],"histone":[34],"H3K27,":[35],"immunity":[38],"remains":[39],"unclear.":[40],"In":[41,60],"this":[42],"study,":[43],"we":[44],"examined":[45],"roles":[47],"Utx":[49,77,101,117,135,175,184],"T\u2010cell":[53],"differentiation":[54],"and":[55,69,114],"response.":[59],"murine":[62],"tumor\u2010bearing":[63],"model,":[64],"an":[65],"increased":[66],"tumor":[67,169],"size":[68],"decreased":[70,99,133,173],"survival":[71],"rate":[72],"were":[73],"observed":[74],"T\u2010cell\u2010specific":[76],"KO":[78,102,118,136,176],"(Utx":[79],"KO)":[80],"mice":[81],"compared":[82],"with":[83],"wild\u2010type":[84],"(WT)":[85],"mice.":[86,103],"The":[87],"number":[88],"tumor\u2010infiltrating":[94],"lymphocytes":[95],"(TILs)":[96],"was":[97,112,132,150,171],"significantly":[98],"We":[104],"found":[105],"that":[106,125,183],"acquisition":[108],"delayed":[113],"attenuated":[115],"RNA":[122],"sequencing":[123],"revealed":[124],"expression":[127,143,154],"signature":[130,148],"genes":[131,149],"cells,":[140],"while":[141],"na\u00efve":[145],"or":[146],"memory":[147],"increased.":[151],"Furthermore,":[152],"Cxcr3,":[156],"which":[157],"required":[159],"for":[160],"migration":[162],"sites,":[170],"substantially":[172],"These":[180],"findings":[181],"suggest":[182],"promotes":[185],"T\u2010cell\u2010dependent":[187],"responses":[190],"partially":[191],"through":[192],"epigenetic":[193],"function.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2023-04-19T00:00:00"}
