{"id":"https://openalex.org/W4366181318","doi":"https://doi.org/10.1016/j.jid.2023.03.1611","title":"1593 The senolytic flavonoid compound fisetin extends lifespan in murine recessive dystrophic epidermolysis bullosa","display_name":"1593 The senolytic flavonoid compound fisetin extends lifespan in murine recessive dystrophic epidermolysis bullosa","publication_year":2023,"publication_date":"2023-04-17","ids":{"openalex":"https://openalex.org/W4366181318","doi":"https://doi.org/10.1016/j.jid.2023.03.1611"},"language":"en","primary_location":{"id":"doi:10.1016/j.jid.2023.03.1611","doi":"https://doi.org/10.1016/j.jid.2023.03.1611","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jid.2023.03.1611","pdf_url":"http://www.jidonline.org/article/S0022202X23017864/pdf","source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jidonline.org/article/S0022202X23017864/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021842498","display_name":"W.C. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W.C. Miller","raw_affiliation_strings":["Pediatrics, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054799853","display_name":"Craig A. Popp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Popp","raw_affiliation_strings":["Pediatrics, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080021935","display_name":"Chloe Strege","orcid":"https://orcid.org/0000-0001-5707-9416","observed_orcids":["https://orcid.org/0000-0001-5707-9416"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Strege","raw_affiliation_strings":["Pediatrics, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020584797","display_name":"W. Stone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Stone","raw_affiliation_strings":["Pediatrics, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016936679","display_name":"Cindy R. Eide","orcid":"https://orcid.org/0000-0001-7314-2550","observed_orcids":["https://orcid.org/0000-0001-7314-2550"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Eide","raw_affiliation_strings":["Pediatrics, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042491373","display_name":"Kacey Bui","orcid":"https://orcid.org/0009-0004-9254-5207","observed_orcids":["https://orcid.org/0009-0004-9254-5207"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Bui","raw_affiliation_strings":["Pediatrics, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037348152","display_name":"Christen L. Ebens","orcid":"https://orcid.org/0000-0003-2430-911X","observed_orcids":["https://orcid.org/0000-0003-2430-911X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.L. Ebens","raw_affiliation_strings":["Pediatrics, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027196879","display_name":"J.A. McGrath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J.A. McGrath","raw_affiliation_strings":["St John\u2019s Institute of Dermatology, King's College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St John\u2019s Institute of Dermatology, King's College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060519108","display_name":"Jakub Tolar","orcid":"https://orcid.org/0000-0002-0957-4380","observed_orcids":["https://orcid.org/0000-0002-0957-4380"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Tolar","raw_affiliation_strings":["Pediatrics, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, University of Minnesota Medical School Twin Cities, Minneapolis, Minnesota, United States","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04568722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"143","issue":"5","first_page":"S273","last_page":"S273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.5189999938011169,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.5189999938011169,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.3878999948501587,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/senolytics","display_name":"senolytics","score":0.8140000104904175},{"id":"https://openalex.org/keywords/fisetin","display_name":"fisetin","score":0.996999979019165},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9350000023841858},{"id":"https://openalex.org/keywords/recessive-dystrophic-epidermolysis-bullosa","display_name":"recessive dystrophic epidermolysis bullosa","score":0.9940000176429749},{"id":"https://openalex.org/keywords/lifespan-extension","display_name":"lifespan extension","score":0.9909999966621399},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.460999995470047},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.7419999837875366},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2777376040","wikidata":"https://www.wikidata.org/wiki/Q418384","display_name":"Fisetin","level":4,"score":0.8894245028495789},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.5631909966468811},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.506199300289154},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.45334574580192566},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.4147564768791199},{"id":"https://openalex.org/C2778918178","wikidata":"https://www.wikidata.org/wiki/Q611984","display_name":"Keratoconus","level":3,"score":0.4132581651210785},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3636515140533447},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34307989478111267},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34128785133361816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3194107413291931},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.24029168486595154},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.10292962193489075},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09773686528205872},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.08789345622062683},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jid.2023.03.1611","doi":"https://doi.org/10.1016/j.jid.2023.03.1611","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jid.2023.03.1611","pdf_url":"http://www.jidonline.org/article/S0022202X23017864/pdf","source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jid.2023.03.1611","doi":"https://doi.org/10.1016/j.jid.2023.03.1611","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jid.2023.03.1611","pdf_url":"http://www.jidonline.org/article/S0022202X23017864/pdf","source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366181318.pdf","grobid_xml":"https://content.openalex.org/works/W4366181318.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404665262","https://openalex.org/W2893617001","https://openalex.org/W3018586119","https://openalex.org/W4200498290","https://openalex.org/W4386944268","https://openalex.org/W4382918885","https://openalex.org/W3111531956","https://openalex.org/W2128807350","https://openalex.org/W4250038877","https://openalex.org/W4321502148"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-19T00:00:00"}
