{"id":"https://openalex.org/W4366124388","doi":"https://doi.org/10.18019/1028-4427-2023-29-2-167-172","title":"Assessment of the perioperative status in children with SMA receiving nusinersen and undergoing reconstructive orthopedic interventions","display_name":"Assessment of the perioperative status in children with SMA receiving nusinersen and undergoing reconstructive orthopedic interventions","publication_year":2023,"publication_date":"2023-04-01","ids":{"openalex":"https://openalex.org/W4366124388","doi":"https://doi.org/10.18019/1028-4427-2023-29-2-167-172"},"language":"en","primary_location":{"id":"doi:10.18019/1028-4427-2023-29-2-167-172","doi":"https://doi.org/10.18019/1028-4427-2023-29-2-167-172","is_oa":true,"landing_page_url":"http://dx.doi.org/10.18019/1028-4427-2023-29-2-167-172","pdf_url":"https://www.ilizarov-journal.com/jour/article/download/2834/3427","source":{"id":"https://openalex.org/S2764780686","display_name":"Genij Ortopedii","issn_l":"1028-4427","issn":["1028-4427","2542-131X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312705","host_organization_name":"Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics","host_organization_lineage":["https://openalex.org/P4310312705"],"host_organization_lineage_names":["Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genij Ortopedii","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.ilizarov-journal.com/jour/article/download/2834/3427","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019777822","display_name":"Vadim V. Evreinov","orcid":"https://orcid.org/0000-0002-0964-2718","observed_orcids":["https://orcid.org/0000-0002-0964-2718"]},"institutions":[{"id":"https://openalex.org/I254361107","display_name":"Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics","ror":"https://ror.org/02r9ghz18","country_code":"RU","type":"facility","lineage":["https://openalex.org/I254361107","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V.V. Evreinov","raw_affiliation_strings":["Ilizarov National Medical Research Centre for Traumatology and Orthopedics , Kurgan , Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ilizarov National Medical Research Centre for Traumatology and Orthopedics , Kurgan , Russian Federation","institution_ids":["https://openalex.org/I254361107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063700652","display_name":"A.V. Lukoyanova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I254361107","display_name":"Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics","ror":"https://ror.org/02r9ghz18","country_code":"RU","type":"facility","lineage":["https://openalex.org/I254361107","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A.V. Lukoyanova","raw_affiliation_strings":["Ilizarov National Medical Research Centre for Traumatology and Orthopedics , Kurgan , Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ilizarov National Medical Research Centre for Traumatology and Orthopedics , Kurgan , Russian Federation","institution_ids":["https://openalex.org/I254361107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046328884","display_name":"Dmitry A. Popkov","orcid":"https://orcid.org/0000-0002-8996-867X","observed_orcids":["https://orcid.org/0000-0002-8996-867X"]},"institutions":[{"id":"https://openalex.org/I254361107","display_name":"Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics","ror":"https://ror.org/02r9ghz18","country_code":"RU","type":"facility","lineage":["https://openalex.org/I254361107","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D.A. Popkov","raw_affiliation_strings":["Ilizarov National Medical Research Centre for Traumatology and Orthopedics , Kurgan , Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ilizarov National Medical Research Centre for Traumatology and Orthopedics , Kurgan , Russian Federation","institution_ids":["https://openalex.org/I254361107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033084251","display_name":"\u0422. \u0410. \u0416\u0438\u0440\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0001-6911-0812","observed_orcids":["https://orcid.org/0000-0001-6911-0812"]},"institutions":[{"id":"https://openalex.org/I4210096960","display_name":"Ural Institute of Traumatology and Orthopedics named after V.D. Chaklin","ror":"https://ror.org/00y245p24","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210096960"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"T.A. Zhirova","raw_affiliation_strings":["Ural Institute of Traumatology and orthopedics named after V. D. Chaklin , Ekaterinburg , Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ural Institute of Traumatology and orthopedics named after V. D. Chaklin , Ekaterinburg , Russian Federation","institution_ids":["https://openalex.org/I4210096960"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10714832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"2","first_page":"167","last_page":"172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-muscular-atrophy","display_name":"spinal muscular atrophy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nusinersen","display_name":"nusinersen","score":0.996999979019165},{"id":"https://openalex.org/keywords/antisense-therapy","display_name":"antisense therapy","score":0.968999981880188},{"id":"https://openalex.org/keywords/perioperative-care","display_name":"perioperative care","score":0.6740000247955322},{"id":"https://openalex.org/keywords/pediatric-anesthesia","display_name":"pediatric anesthesia","score":0.753000020980835},{"id":"https://openalex.org/keywords/orthopedic-surgery","display_name":"orthopedic surgery","score":0.8050000071525574},{"id":"https://openalex.org/keywords/skeletal-deformity-correction","display_name":"skeletal deformity correction","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hypotonia","display_name":"hypotonia","score":0.7039999961853027},{"id":"https://openalex.org/keywords/respiratory-failure","display_name":"respiratory failure","score":0.6439999938011169},{"id":"https://openalex.org/keywords/non-invasive-ventilation","display_name":"non-invasive ventilation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/postoperative-complications","display_name":"postoperative complications","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C2778558090","wikidata":"https://www.wikidata.org/wiki/Q580290","display_name":"Spinal muscular atrophy","level":3,"score":0.8730432987213135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8499810695648193},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.8188740611076355},{"id":"https://openalex.org/C161921814","wikidata":"https://www.wikidata.org/wiki/Q493743","display_name":"SMA*","level":2,"score":0.8170931935310364},{"id":"https://openalex.org/C68312169","wikidata":"https://www.wikidata.org/wiki/Q216685","display_name":"Orthopedic surgery","level":2,"score":0.553678035736084},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.45378798246383667},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.451654314994812},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4122050106525421},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2078169584274292},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1521550714969635},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.18019/1028-4427-2023-29-2-167-172","doi":"https://doi.org/10.18019/1028-4427-2023-29-2-167-172","is_oa":true,"landing_page_url":"http://dx.doi.org/10.18019/1028-4427-2023-29-2-167-172","pdf_url":"https://www.ilizarov-journal.com/jour/article/download/2834/3427","source":{"id":"https://openalex.org/S2764780686","display_name":"Genij Ortopedii","issn_l":"1028-4427","issn":["1028-4427","2542-131X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312705","host_organization_name":"Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics","host_organization_lineage":["https://openalex.org/P4310312705"],"host_organization_lineage_names":["Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genij Ortopedii","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:47aa575c8dae4c4eb4bc4180bdb36347","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/47aa575c8dae4c4eb4bc4180bdb36347","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0413\u0435\u043d\u0438\u0439 o\u0440\u0442\u043e\u043f\u0435\u0434\u0438\u0438, Vol 29, Iss 2, Pp 167-172 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.18019/1028-4427-2023-29-2-167-172","doi":"https://doi.org/10.18019/1028-4427-2023-29-2-167-172","is_oa":true,"landing_page_url":"http://dx.doi.org/10.18019/1028-4427-2023-29-2-167-172","pdf_url":"https://www.ilizarov-journal.com/jour/article/download/2834/3427","source":{"id":"https://openalex.org/S2764780686","display_name":"Genij Ortopedii","issn_l":"1028-4427","issn":["1028-4427","2542-131X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312705","host_organization_name":"Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics","host_organization_lineage":["https://openalex.org/P4310312705"],"host_organization_lineage_names":["Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genij Ortopedii","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366124388.pdf","grobid_xml":"https://content.openalex.org/works/W4366124388.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3018207271","https://openalex.org/W2895626004","https://openalex.org/W2753985863","https://openalex.org/W4366814566","https://openalex.org/W3096853646","https://openalex.org/W4394879500","https://openalex.org/W3211647745","https://openalex.org/W4414333944","https://openalex.org/W7130436042","https://openalex.org/W4310214387"],"abstract_inverted_index":{"Surgical":[0],"methods":[1,87],"for":[2,36,91,142],"treatment":[3],"of":[4,21,24,30,34,43,60,81,172,178,183,201,212,217,229,243,263,279],"spinal":[5],"muscular":[6],"atrophy":[7],"(SMA)":[8],"in":[9,64,180,206,219,245,254,266,270],"children":[10,65,107,121,131,271],"are":[11],"aimed":[12],"at":[13,40],"improving":[14],"their":[15],"positioning":[16],"and":[17,27,38,86,144,175,209,225,233],"maintaining":[18],"the":[19,41,48,58,61,75,92,103,125,152,158,164,170,176,181,184,189,198,246,261,267],"ability":[20],"verticalization.":[22],"Assessment":[23],"neurological,":[25],"somatic":[26],"motor":[28,207],"status":[29],"patients,":[31],"individual":[32],"selection":[33],"drugs":[35],"anesthesia":[37],"sedation":[39],"stage":[42],"planning":[44],"surgical":[45],"interventions":[46],"allow":[47],"anesthesiologist/resuscitator":[49],"to":[50,96,197,239],"avoid":[51],"perioperative":[52,62,247,268],"adverse":[53,264],"events.":[54],"Purpose":[55],"To":[56],"compare":[57],"course":[59],"period":[63,93,228,269],"with":[66,72,74,108,221,251,272],"SMA":[67,109,202,222,273],"who":[68,122],"received":[69,123],"pathogenetic":[70,105],"therapy":[71,250],"nusinersen":[73,218],"control":[76,126],"group":[77,117,127],"during":[78,276],"orthopedic":[79,277],"correction":[80,278],"acquired":[82],"skeletal":[83,280],"deformities.":[84,281],"Materials":[85],"The":[88,115,249],"retrospective":[89],"analysis":[90],"from":[94],"2019":[95],"2021":[97],"included":[98,119,129],"23":[99],"children.":[100],"Depending":[101],"on":[102,157],"ongoing":[104],"therapy,":[106],"were":[110,146,154,191],"divided":[111],"into":[112],"2":[113],"groups.":[114],"main":[116],"(SMA+N)":[118],"9":[120],"nusinersen;":[124],"(CG)":[128],"14":[130],"without":[132],"antisense":[133,252],"oligonucleotide":[134],"therapy.":[135],"Co-morbidities,":[136],"hemodynamic":[137],"parameters,":[138],"blood":[139],"loss,":[140],"need":[141],"analgesics":[143],"complications":[145],"studied.":[147],"Results":[148],"Insignificant":[149],"differences":[150,179],"between":[151],"groups":[153,190],"recorded":[155],"based":[156],"Hammersmith":[159],"Extended":[160],"Scale":[161],"(HFMSE).":[162],"At":[163],"same":[165],"time,":[166],"similar":[167],"comorbid":[168],"pathology,":[169],"severity":[171],"respiratory":[173,234],"failure,":[174],"absence":[177],"frequency":[182],"NIV":[185],"application":[186],"indicated":[187],"that":[188],"comparable.":[192],"This":[193],"is":[194],"probably":[195],"due":[196],"late":[199],"start":[200],"treatment,":[203],"degenerative":[204],"changes":[205],"neurons,":[208],"fatty":[210],"degeneration":[211],"muscle":[213,256],"tissue.":[214],"Conclusion":[215],"Intake":[216],"patients":[220],"type":[223,274],"II-III":[224,275],"a":[226,240],"long":[227],"illness,":[230],"severe":[231,255],"neurological":[232],"disorders":[235],"do":[236],"not":[237,259],"lead":[238],"significant":[241],"regression":[242],"symptoms":[244],"period.":[248],"oligonucleotides":[253],"hypotonia":[257],"does":[258],"exclude":[260],"risk":[262],"events":[265]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-19T00:00:00"}