{"id":"https://openalex.org/W4366124156","doi":"https://doi.org/10.18019/1028-4427-2023-29-2-190-203","title":"Models for purulent septic inflammation of the tibia in rats to assess the effect of bioresorbable materials with antimicrobial drugs","display_name":"Models for purulent septic inflammation of the tibia in rats to assess the effect of bioresorbable materials with antimicrobial drugs","publication_year":2023,"publication_date":"2023-04-01","ids":{"openalex":"https://openalex.org/W4366124156","doi":"https://doi.org/10.18019/1028-4427-2023-29-2-190-203"},"language":"en","primary_location":{"id":"doi:10.18019/1028-4427-2023-29-2-190-203","doi":"https://doi.org/10.18019/1028-4427-2023-29-2-190-203","is_oa":true,"landing_page_url":"https://doi.org/10.18019/1028-4427-2023-29-2-190-203","pdf_url":"https://doi.org/10.18019/1028-4427-2023-29-2-190-203","source":{"id":"https://openalex.org/S2764780686","display_name":"Genij Ortopedii","issn_l":"1028-4427","issn":["1028-4427","2542-131X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312705","host_organization_name":"Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics","host_organization_lineage":["https://openalex.org/P4310312705"],"host_organization_lineage_names":["Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genij Ortopedii","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.18019/1028-4427-2023-29-2-190-203","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048310738","display_name":"Dmitriy V. Smolentsev","orcid":"https://orcid.org/0000-0001-5386-1929","observed_orcids":["https://orcid.org/0000-0001-5386-1929"]},"institutions":[{"id":"https://openalex.org/I4210109445","display_name":"Central Scientific Research Institute of Traumatology and Orthopedics","ror":"https://ror.org/022d6m891","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210109445"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"D.V. Smolentsev","raw_affiliation_strings":["Priorov National Medical Research Center of Traumatology and Orthopaedics, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Priorov National Medical Research Center of Traumatology and Orthopaedics, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210109445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033158899","display_name":"Yulia S. Lukina","orcid":"https://orcid.org/0000-0003-0121-1232","observed_orcids":["https://orcid.org/0000-0003-0121-1232"]},"institutions":[{"id":"https://openalex.org/I4210109445","display_name":"Central Scientific Research Institute of Traumatology and Orthopedics","ror":"https://ror.org/022d6m891","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210109445"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yu.S. Lukina","raw_affiliation_strings":["Priorov National Medical Research Center of Traumatology and Orthopaedics, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Priorov National Medical Research Center of Traumatology and Orthopaedics, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210109445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055610107","display_name":"Leonid L. Bionyshev-Abramov","orcid":"https://orcid.org/0000-0002-1326-6794","observed_orcids":["https://orcid.org/0000-0002-1326-6794"]},"institutions":[{"id":"https://openalex.org/I4210109445","display_name":"Central Scientific Research Institute of Traumatology and Orthopedics","ror":"https://ror.org/022d6m891","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210109445"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L.L. Bionyshev-Abramov","raw_affiliation_strings":["Priorov National Medical Research Center of Traumatology and Orthopaedics, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Priorov National Medical Research Center of Traumatology and Orthopaedics, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210109445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058269037","display_name":"Natalia B. Serejnikova","orcid":"https://orcid.org/0000-0002-4097-1552","observed_orcids":["https://orcid.org/0000-0002-4097-1552"]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N.B. Serezhnikova","raw_affiliation_strings":["Sechenov First Moscow State Medical University, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sechenov First Moscow State Medical University, Moscow, Russian Federation","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068628848","display_name":"Maksim G. Vasiliev","orcid":"https://orcid.org/0000-0001-9810-6513","observed_orcids":["https://orcid.org/0000-0001-9810-6513"]},"institutions":[{"id":"https://openalex.org/I4210109445","display_name":"Central Scientific Research Institute of Traumatology and Orthopedics","ror":"https://ror.org/022d6m891","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210109445"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M.G. Vasiliev","raw_affiliation_strings":["Priorov National Medical Research Center of Traumatology and Orthopaedics, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Priorov National Medical Research Center of Traumatology and Orthopaedics, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210109445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027595396","display_name":"Alexander N. Senyagin","orcid":"https://orcid.org/0000-0002-4981-0149","observed_orcids":["https://orcid.org/0000-0002-4981-0149"]},"institutions":[{"id":"https://openalex.org/I126527374","display_name":"Peoples' Friendship University of Russia","ror":"https://ror.org/02dn9h927","country_code":"RU","type":"education","lineage":["https://openalex.org/I126527374"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A.N. Senyagin","raw_affiliation_strings":["Peoples' Friendship University of Russia, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peoples' Friendship University of Russia, Moscow, Russian Federation","institution_ids":["https://openalex.org/I126527374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005535671","display_name":"T. Ya. Pkhakadze","orcid":"https://orcid.org/0000-0003-4900-3555","observed_orcids":["https://orcid.org/0000-0003-4900-3555"]},"institutions":[{"id":"https://openalex.org/I4210109445","display_name":"Central Scientific Research Institute of Traumatology and Orthopedics","ror":"https://ror.org/022d6m891","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210109445"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"T.Ya. Pkhakadze","raw_affiliation_strings":["Priorov National Medical Research Center of Traumatology and Orthopaedics, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Priorov National Medical Research Center of Traumatology and Orthopaedics, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210109445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048310738"],"corresponding_institution_ids":["https://openalex.org/I4210109445"],"apc_list":null,"apc_paid":null,"fwci":0.8546,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.69410988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"29","issue":"2","first_page":"190","last_page":"203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tibia","display_name":"tibia","score":0.8679999709129333},{"id":"https://openalex.org/keywords/experimental-infection-model","display_name":"experimental infection model","score":0.7110000252723694},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9760000109672546},{"id":"https://openalex.org/keywords/bone-infection","display_name":"bone infection","score":0.5960000157356262},{"id":"https://openalex.org/keywords/sequestrum-formation","display_name":"sequestrum formation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/bioresorbable-materials","display_name":"bioresorbable materials","score":0.7929999828338623},{"id":"https://openalex.org/keywords/antimicrobial-agents","display_name":"antimicrobial agents","score":0.8999999761581421},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7902481555938721},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7114759087562561},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5295302271842957},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.4804255962371826},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4648899435997009},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33129340410232544},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22256889939308167},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.13894298672676086},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11631682515144348},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.10200080275535583},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.18019/1028-4427-2023-29-2-190-203","doi":"https://doi.org/10.18019/1028-4427-2023-29-2-190-203","is_oa":true,"landing_page_url":"https://doi.org/10.18019/1028-4427-2023-29-2-190-203","pdf_url":"https://doi.org/10.18019/1028-4427-2023-29-2-190-203","source":{"id":"https://openalex.org/S2764780686","display_name":"Genij Ortopedii","issn_l":"1028-4427","issn":["1028-4427","2542-131X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312705","host_organization_name":"Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics","host_organization_lineage":["https://openalex.org/P4310312705"],"host_organization_lineage_names":["Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genij Ortopedii","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:8aa070de78864d068f03487da708bf6b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8aa070de78864d068f03487da708bf6b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0413\u0435\u043d\u0438\u0439 o\u0440\u0442\u043e\u043f\u0435\u0434\u0438\u0438, Vol 29, Iss 2, Pp 190-203 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.18019/1028-4427-2023-29-2-190-203","doi":"https://doi.org/10.18019/1028-4427-2023-29-2-190-203","is_oa":true,"landing_page_url":"https://doi.org/10.18019/1028-4427-2023-29-2-190-203","pdf_url":"https://doi.org/10.18019/1028-4427-2023-29-2-190-203","source":{"id":"https://openalex.org/S2764780686","display_name":"Genij Ortopedii","issn_l":"1028-4427","issn":["1028-4427","2542-131X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312705","host_organization_name":"Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics","host_organization_lineage":["https://openalex.org/P4310312705"],"host_organization_lineage_names":["Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genij Ortopedii","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366124156.pdf","grobid_xml":"https://content.openalex.org/works/W4366124156.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W207161854","https://openalex.org/W1531797932","https://openalex.org/W1966495877","https://openalex.org/W1981992865","https://openalex.org/W1982985146","https://openalex.org/W2011445309","https://openalex.org/W2013052732","https://openalex.org/W2015915027","https://openalex.org/W2018081852","https://openalex.org/W2025700014","https://openalex.org/W2061249926","https://openalex.org/W2061618840","https://openalex.org/W2062856622","https://openalex.org/W2065710718","https://openalex.org/W2075359954","https://openalex.org/W2075935516","https://openalex.org/W2077521847","https://openalex.org/W2077684636","https://openalex.org/W2077755649","https://openalex.org/W2082900223","https://openalex.org/W2088293790","https://openalex.org/W2089098625","https://openalex.org/W2089308589","https://openalex.org/W2108649186","https://openalex.org/W2110813290","https://openalex.org/W2112822838","https://openalex.org/W2119064342","https://openalex.org/W2122053271","https://openalex.org/W2135704753","https://openalex.org/W2137595273","https://openalex.org/W2149678182","https://openalex.org/W2154366164","https://openalex.org/W2169302651","https://openalex.org/W2202067380","https://openalex.org/W2283479137","https://openalex.org/W2312436245","https://openalex.org/W2398221886","https://openalex.org/W2468757368","https://openalex.org/W2488964150","https://openalex.org/W2773340086","https://openalex.org/W2937939673","https://openalex.org/W3094247600","https://openalex.org/W4225128854","https://openalex.org/W4241464497"],"related_works":["https://openalex.org/W2050770454","https://openalex.org/W1587054925","https://openalex.org/W2434420710","https://openalex.org/W1913754774","https://openalex.org/W2488964150","https://openalex.org/W7095948467","https://openalex.org/W2089098625","https://openalex.org/W3111707104","https://openalex.org/W4362505808","https://openalex.org/W4323365191"],"abstract_inverted_index":{"Introduction":[0],"A":[1,180],"brief":[2],"review":[3],"of":[4,15,29,37,40,45,49,68,77,85,110,116,143,149,156,160,167,173,185,198,201,207,225,228],"modeling":[5],"purulent":[6,46,69,136],"septic":[7,47,70],"inflammation":[8,24,48,71,92,120,209],"in":[9,52,61,74,121,163,192,213],"rats,":[10],"including":[11],"with":[12,146],"the":[13,30,35,38,50,83,98,111,114,144,147,154,199,205,226],"help":[14],"an":[16,41,174,222],"active":[17,175],"bacterial":[18,176],"agent,":[19],"and":[20,64,183],"methods":[21,57,65,216],"for":[22,58,89,204],"diagnosing":[23,59],"are":[25,94,189,217],"given.":[26],"The":[27,108,196],"aim":[28],"study":[31,112],"was":[32],"to":[33,140],"demonstrate":[34],"results":[36,109,197],"development":[39,200],"effective":[42],"experimental":[43,118,202],"model":[44],"tibia":[51],"rats":[53,122],"using":[54,82,126,210],"minimally":[55,211],"invasive":[56,212],"infection":[60,137,229],"vivo.":[62],"Materials":[63],"Various":[66],"models":[67,203],"were":[72],"studied":[73],"four":[75],"groups":[76],"small":[78],"laboratory":[79],"animals,":[80],"when":[81],"inoculation":[84],"Staphylococcus":[86],"aureus.":[87],"Methods":[88],"assessing":[90],"purulent-septic":[91,119,208],"that":[93,138],"not":[95,190],"destructible":[96],"by":[97,123],"object":[99],"have":[100],"been":[101],"worked":[102],"out:":[103],"microbiological,":[104],"tomographic,":[105],"morphological.":[106],"Results":[107],"indicate":[113],"possibility":[115],"creating":[117,193],"14-60":[124],"days":[125],"S.":[127],"aureus":[128],"inoculation,":[129],"which":[130,219],"is":[131,178],"a":[132,157,164,169,186],"severe,":[133],"rapidly":[134],"progressive":[135],"leads":[139],"extensive":[141],"destruction":[142],"bone":[145,161],"formation":[148,155,184],"sequesters.":[150],"Discussion":[151],"To":[152],"guarantee":[153],"purulent-inflammatory":[158],"process":[159],"tissue":[162],"shorter":[165],"period":[166],"observation,":[168],"quantitatively":[170],"controlled":[171],"invasion":[172],"agent":[177,182],"necessary.":[179],"sclerosing":[181],"fistulous":[187],"tract":[188],"essential":[191],"inflammation.":[194],"Conclusion":[195],"creation":[206],"vivo":[214],"diagnostic":[215],"demonstrated,":[218],"will":[220],"allow":[221],"adequate":[223],"assessment":[224],"degree":[227],"before":[230],"treatment.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-04-19T00:00:00"}
