{"id":"https://openalex.org/W4366122007","doi":"https://doi.org/10.3390/md21040245","title":"Extraction, Structural Characterization, and In Vivo Anti-Inflammatory Effect of Alginate from Cystoseira crinita (Desf.) Borry Harvested in the Bulgarian Black Sea","display_name":"Extraction, Structural Characterization, and In Vivo Anti-Inflammatory Effect of Alginate from Cystoseira crinita (Desf.) Borry Harvested in the Bulgarian Black Sea","publication_year":2023,"publication_date":"2023-04-16","ids":{"openalex":"https://openalex.org/W4366122007","doi":"https://doi.org/10.3390/md21040245","pmid":"https://pubmed.ncbi.nlm.nih.gov/37103384","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10141736"},"language":"en","primary_location":{"id":"doi:10.3390/md21040245","doi":"https://doi.org/10.3390/md21040245","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md21040245","pdf_url":"https://www.mdpi.com/1660-3397/21/4/245/pdf?version=1681631121","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4366122007"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1660-3397/21/4/245/pdf?version=1681631121","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056367652","display_name":"Vesela Kokova","orcid":"https://orcid.org/0000-0002-5578-7862","observed_orcids":["https://orcid.org/0000-0002-5578-7862"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":true,"raw_author_name":"Vesela Kokova","raw_affiliation_strings":["Department of Pharmacology, Toxicology, and Pharmacotherapy, Faculty of Pharmacy, Medical University-Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0002-5578-7862","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Toxicology, and Pharmacotherapy, Faculty of Pharmacy, Medical University-Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067465190","display_name":"Paolina Lukova","orcid":"https://orcid.org/0000-0003-2864-4388","observed_orcids":["https://orcid.org/0000-0003-2864-4388"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Paolina Lukova","raw_affiliation_strings":["Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0003-2864-4388","affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012468357","display_name":"Alexandra Baldzhieva","orcid":"https://orcid.org/0000-0002-9370-8205","observed_orcids":["https://orcid.org/0000-0002-9370-8205"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Alexandra Baldzhieva","raw_affiliation_strings":["Department of Microbiology and Immunology, Faculty of Pharmacy, Medical University-Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria","Research Institute at Medical University-Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0002-9370-8205","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Faculty of Pharmacy, Medical University-Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]},{"raw_affiliation_string":"Research Institute at Medical University-Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031555225","display_name":"Plamen Katsarov","orcid":"https://orcid.org/0000-0002-9158-6208","observed_orcids":["https://orcid.org/0000-0002-9158-6208"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Plamen Katsarov","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University-Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria","Research Institute at Medical University-Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0002-9158-6208","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University-Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]},{"raw_affiliation_string":"Research Institute at Medical University-Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077951159","display_name":"C\u00e9dric Delattre","orcid":"https://orcid.org/0000-0003-3605-1929","observed_orcids":["https://orcid.org/0000-0003-3605-1929"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I169645620","display_name":"Institut Pascal","ror":"https://ror.org/03vgfxd91","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I169645620","https://openalex.org/I198244214","https://openalex.org/I4210095849","https://openalex.org/I4210128870"]},{"id":"https://openalex.org/I185839726","display_name":"Institut Universitaire de France","ror":"https://ror.org/055khg266","country_code":"FR","type":"education","lineage":["https://openalex.org/I185839726"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4387154249","display_name":"Clermont Auvergne INP","ror":"https://ror.org/001f39w38","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214","https://openalex.org/I4387154249"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9dric Delattre","raw_affiliation_strings":["Clermont Auvergne INP, CNRS, Institut Pascal, Universit\u00e9 Clermont Auvergne, 63000 Clermont-Ferrand, France","Institut Universitaire de France (IUF), 1 Rue Descartes, 75005 Paris, France"],"raw_orcid":"https://orcid.org/0000-0003-3605-1929","affiliations":[{"raw_affiliation_string":"Clermont Auvergne INP, CNRS, Institut Pascal, Universit\u00e9 Clermont Auvergne, 63000 Clermont-Ferrand, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I169645620","https://openalex.org/I198244214","https://openalex.org/I4387154249"]},{"raw_affiliation_string":"Institut Universitaire de France (IUF), 1 Rue Descartes, 75005 Paris, France","institution_ids":["https://openalex.org/I185839726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026419565","display_name":"Roland Molini\u00e9","orcid":"https://orcid.org/0000-0003-4399-8838","observed_orcids":["https://orcid.org/0000-0003-4399-8838"]},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210114827","display_name":"Biologie des Plantes et Innovation","ror":"https://ror.org/02hr3zx73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210114827","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4387152401","display_name":"UMR Transfrontali\u00e8re BioEcoAgro","ror":"https://ror.org/032v67m28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I157674565","https://openalex.org/I2279609970","https://openalex.org/I4210088668","https://openalex.org/I4210116330","https://openalex.org/I4387152401","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Roland Molini\u00e9","raw_affiliation_strings":["UMRT INRAE 1158 BioEcoAgro, BIOlogie des Plantes et Innovation (BIOPI), Avenue des Facult\u00e9s, IUT d\u2019Amiens, Universit\u00e9 de Picardie Jules Verne, Le Bailly, 80025 Amiens, France"],"raw_orcid":"https://orcid.org/0000-0003-4399-8838","affiliations":[{"raw_affiliation_string":"UMRT INRAE 1158 BioEcoAgro, BIOlogie des Plantes et Innovation (BIOPI), Avenue des Facult\u00e9s, IUT d\u2019Amiens, Universit\u00e9 de Picardie Jules Verne, Le Bailly, 80025 Amiens, France","institution_ids":["https://openalex.org/I4210088668","https://openalex.org/I4210114827","https://openalex.org/I4387152401","https://openalex.org/I4647051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054556115","display_name":"Emmanuel Petit","orcid":"https://orcid.org/0000-0003-1533-6909","observed_orcids":["https://orcid.org/0000-0003-1533-6909"]},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210114827","display_name":"Biologie des Plantes et Innovation","ror":"https://ror.org/02hr3zx73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210114827","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4387152401","display_name":"UMR Transfrontali\u00e8re BioEcoAgro","ror":"https://ror.org/032v67m28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I157674565","https://openalex.org/I2279609970","https://openalex.org/I4210088668","https://openalex.org/I4210116330","https://openalex.org/I4387152401","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emmanuel Petit","raw_affiliation_strings":["UMRT INRAE 1158 BioEcoAgro, BIOlogie des Plantes et Innovation (BIOPI), Avenue des Facult\u00e9s, IUT d\u2019Amiens, Universit\u00e9 de Picardie Jules Verne, Le Bailly, 80025 Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMRT INRAE 1158 BioEcoAgro, BIOlogie des Plantes et Innovation (BIOPI), Avenue des Facult\u00e9s, IUT d\u2019Amiens, Universit\u00e9 de Picardie Jules Verne, Le Bailly, 80025 Amiens, France","institution_ids":["https://openalex.org/I4210088668","https://openalex.org/I4210114827","https://openalex.org/I4387152401","https://openalex.org/I4647051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004764057","display_name":"Redouan Elboutachfaiti","orcid":"https://orcid.org/0000-0002-5772-8030","observed_orcids":["https://orcid.org/0000-0002-5772-8030"]},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210114827","display_name":"Biologie des Plantes et Innovation","ror":"https://ror.org/02hr3zx73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210114827","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4387152401","display_name":"UMR Transfrontali\u00e8re BioEcoAgro","ror":"https://ror.org/032v67m28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I157674565","https://openalex.org/I2279609970","https://openalex.org/I4210088668","https://openalex.org/I4210116330","https://openalex.org/I4387152401","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Redouan Elboutachfaiti","raw_affiliation_strings":["UMRT INRAE 1158 BioEcoAgro, BIOlogie des Plantes et Innovation (BIOPI), Avenue des Facult\u00e9s, IUT d\u2019Amiens, Universit\u00e9 de Picardie Jules Verne, Le Bailly, 80025 Amiens, France"],"raw_orcid":"https://orcid.org/0000-0002-5772-8030","affiliations":[{"raw_affiliation_string":"UMRT INRAE 1158 BioEcoAgro, BIOlogie des Plantes et Innovation (BIOPI), Avenue des Facult\u00e9s, IUT d\u2019Amiens, Universit\u00e9 de Picardie Jules Verne, Le Bailly, 80025 Amiens, France","institution_ids":["https://openalex.org/I4210088668","https://openalex.org/I4210114827","https://openalex.org/I4387152401","https://openalex.org/I4647051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029209850","display_name":"Marianna Murdjeva","orcid":"https://orcid.org/0000-0002-1357-6717","observed_orcids":["https://orcid.org/0000-0002-1357-6717"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Marianna Murdjeva","raw_affiliation_strings":["Department of Microbiology and Immunology, Faculty of Pharmacy, Medical University-Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria","Research Institute at Medical University-Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Faculty of Pharmacy, Medical University-Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]},{"raw_affiliation_string":"Research Institute at Medical University-Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028922686","display_name":"Elisaveta Apostolova","orcid":"https://orcid.org/0000-0002-5167-3278","observed_orcids":["https://orcid.org/0000-0002-5167-3278"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Elisaveta Apostolova","raw_affiliation_strings":["Department of Pharmacology, Toxicology, and Pharmacotherapy, Faculty of Pharmacy, Medical University-Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0002-5167-3278","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Toxicology, and Pharmacotherapy, Faculty of Pharmacy, Medical University-Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I2801117330"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5056367652"],"corresponding_institution_ids":["https://openalex.org/I2801117330"],"apc_list":{"value":2500,"currency":"CHF","value_usd":2780},"apc_paid":{"value":2500,"currency":"CHF","value_usd":2780},"fwci":4.0148,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.94320357,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"21","issue":"4","first_page":"245","last_page":"245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10869","display_name":"Polysaccharides and Plant Cell Walls","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alginate","display_name":"alginate","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cystoseira-crinita","display_name":"Cystoseira crinita","score":0.9990000128746033},{"id":"https://openalex.org/keywords/brown-algae-polysaccharides","display_name":"brown algae polysaccharides","score":0.7570000290870667},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9010000228881836},{"id":"https://openalex.org/keywords/structural-characterization","display_name":"structural characterization","score":0.6110000014305115},{"id":"https://openalex.org/keywords/molecular-weight-distribution","display_name":"molecular weight distribution","score":0.6470000147819519},{"id":"https://openalex.org/keywords/histamine-induced-paw-edema","display_name":"histamine-induced paw edema","score":0.8100000023841858},{"id":"https://openalex.org/keywords/peritonitis","display_name":"peritonitis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7770000100135803},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9229999780654907},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.996999979019165},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.996999979019165},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.718999981880188},{"id":"https://openalex.org/keywords/marine-natural-products","display_name":"marine natural products","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6255325675010681},{"id":"https://openalex.org/C2781227287","wikidata":"https://www.wikidata.org/wiki/Q421991","display_name":"Carrageenan","level":2,"score":0.5781646966934204},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4704001843929291},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.4595685303211212},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4515126049518585},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4437946379184723},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.44261133670806885},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.4334127604961395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2806602716445923},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24964067339897156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21638774871826172},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21424493193626404},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000459","descriptor_name":"Phaeophyceae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002031","descriptor_name":"Bulgaria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010538","descriptor_name":"Peritonitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D010538","descriptor_name":"Peritonitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059038","descriptor_name":"Black Sea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/md21040245","doi":"https://doi.org/10.3390/md21040245","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md21040245","pdf_url":"https://www.mdpi.com/1660-3397/21/4/245/pdf?version=1681631121","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10141736","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10141736","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10141736/pdf/marinedrugs-21-00245.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mar Drugs","raw_type":"Text"},{"id":"pmid:37103384","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37103384","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine drugs","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-04089123v1","doi":null,"is_oa":false,"landing_page_url":"https://u-picardie.hal.science/hal-04089123","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Marine drugs, 2023, 21 (4), pp.245. ⟨10.3390/md21040245⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:7cce20b353b643b0b210b0e15d6de2ca","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7cce20b353b643b0b210b0e15d6de2ca","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Marine Drugs, Vol 21, Iss 4, p 245 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/md21040245","doi":"https://doi.org/10.3390/md21040245","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md21040245","pdf_url":"https://www.mdpi.com/1660-3397/21/4/245/pdf?version=1681631121","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366122007.pdf","grobid_xml":"https://content.openalex.org/works/W4366122007.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W649072342","https://openalex.org/W1490473298","https://openalex.org/W1515608624","https://openalex.org/W1524838485","https://openalex.org/W1559903407","https://openalex.org/W1902714314","https://openalex.org/W1969286355","https://openalex.org/W1969983782","https://openalex.org/W1971500643","https://openalex.org/W1972065170","https://openalex.org/W1980640848","https://openalex.org/W1985914247","https://openalex.org/W1989625938","https://openalex.org/W1990795568","https://openalex.org/W1997659764","https://openalex.org/W1998926818","https://openalex.org/W2004080374","https://openalex.org/W2019263194","https://openalex.org/W2029622682","https://openalex.org/W2032226719","https://openalex.org/W2032345508","https://openalex.org/W2040662056","https://openalex.org/W2051460936","https://openalex.org/W2052459196","https://openalex.org/W2053132358","https://openalex.org/W2053148165","https://openalex.org/W2054577008","https://openalex.org/W2059670662","https://openalex.org/W2060870743","https://openalex.org/W2064130230","https://openalex.org/W2070196288","https://openalex.org/W2072029917","https://openalex.org/W2073289209","https://openalex.org/W2078703069","https://openalex.org/W2079090273","https://openalex.org/W2085448435","https://openalex.org/W2091274095","https://openalex.org/W2122296266","https://openalex.org/W2126427853","https://openalex.org/W2128635872","https://openalex.org/W2136761361","https://openalex.org/W2155226889","https://openalex.org/W2169475850","https://openalex.org/W2189533272","https://openalex.org/W2282370420","https://openalex.org/W2413069830","https://openalex.org/W2426879375","https://openalex.org/W2561959357","https://openalex.org/W2616608463","https://openalex.org/W2738004873","https://openalex.org/W2837893003","https://openalex.org/W2891275837","https://openalex.org/W2956529984","https://openalex.org/W2996385292","https://openalex.org/W3005214175","https://openalex.org/W3007730713","https://openalex.org/W3114750010","https://openalex.org/W3125954883","https://openalex.org/W3178912772","https://openalex.org/W4224440756","https://openalex.org/W4241715686","https://openalex.org/W4281630077","https://openalex.org/W4282824868","https://openalex.org/W4294988491","https://openalex.org/W4297348611","https://openalex.org/W4309312268","https://openalex.org/W6660621175"],"related_works":["https://openalex.org/W4403767845","https://openalex.org/W4309312268","https://openalex.org/W2018008087","https://openalex.org/W4392106999","https://openalex.org/W2406626954","https://openalex.org/W2006969026","https://openalex.org/W1969286355","https://openalex.org/W4406089712","https://openalex.org/W2610317047"],"abstract_inverted_index":{"The":[0,37,67,81,149],"aim":[1],"of":[2,14,40,54,59,70,88,93,102,109,121,130,145,151,166,178,186,194,203,208],"this":[3],"study":[4],"was":[5,73,132,173],"to":[6],"identify":[7],"the":[8,22,52,71,119,167,176,179,192,195,200],"chemical":[9],"composition":[10],"and":[11,44,51,78,98,111,153],"sequential":[12],"structure":[13],"alginate":[15,83,106,141,187],"isolated":[16],"from":[17],"C.":[18,104,139],"crinita":[19,105,140],"harvested":[20],"in":[21,31,35,46,56,62,107,118,127,135,142,155,160,175,199],"Bulgarian":[23],"Black":[24],"Sea,":[25],"as":[26,28],"well":[27],"its":[29],"effects":[30],"histamine-induced":[32],"paw":[33,122],"inflammation":[34],"rats.":[36],"serum":[38,128,156],"levels":[39,53,129,177,193],"TNF-\u03b1,":[41],"IL-1\u03b2,":[42],"IL-6,":[43],"IL-10":[45],"rats":[47,63,161,204],"with":[48,138,163,205],"systemic":[49],"inflammation,":[50],"TNF-\u03b1":[55,152,198],"a":[57,90,99,143,206],"model":[58,120,207],"acute":[60],"peritonitis":[61],"were":[64,157],"also":[65],"investigated.":[66],"structural":[68],"characterization":[69],"polysaccharide":[72],"obtained":[74],"by":[75],"FTIR,":[76],"SEC-MALS,":[77],"1H":[79],"NMR.":[80],"extracted":[82],"had":[84],"an":[85],"M/G":[86],"ratio":[87],"1.018,":[89],"molecular":[91],"weight":[92],"7.31":[94],"\u00d7":[95],"104":[96],"g/mol,":[97],"polydispersity":[100],"index":[101],"1.38.":[103],"doses":[108,165],"25":[110,146],"100":[112],"mg/kg":[113,147],"showed":[114],"well-defined":[115],"anti-inflammatory":[116,180],"activity":[117],"edema.":[123],"A":[124,183],"significant":[125],"decrease":[126],"IL-1\u03b2":[131],"observed":[133,174],"only":[134],"animals":[136],"treated":[137,162],"dose":[144,185],"bw.":[148],"concentrations":[150],"IL-6":[154],"significantly":[158,190],"reduced":[159],"both":[164],"polysaccharide,":[168],"but":[169],"no":[170],"statistical":[171],"significance":[172],"cytokine":[181,197],"IL-10.":[182],"single":[184],"did":[188],"not":[189],"alter":[191],"pro-inflammatory":[196],"peritoneal":[201],"fluid":[202],"peritonitis.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2023-04-19T00:00:00"}