{"id":"https://openalex.org/W4366089650","doi":"https://doi.org/10.3390/ijms24087382","title":"Polystyrene Microplastics Induce Oxidative Stress in Mouse Hepatocytes in Relation to Their Size","display_name":"Polystyrene Microplastics Induce Oxidative Stress in Mouse Hepatocytes in Relation to Their Size","publication_year":2023,"publication_date":"2023-04-17","ids":{"openalex":"https://openalex.org/W4366089650","doi":"https://doi.org/10.3390/ijms24087382","pmid":"https://pubmed.ncbi.nlm.nih.gov/37108543","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10138773"},"language":"en","primary_location":{"id":"doi:10.3390/ijms24087382","doi":"https://doi.org/10.3390/ijms24087382","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms24087382","pdf_url":"https://www.mdpi.com/1422-0067/24/8/7382/pdf?version=1681720871","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/24/8/7382/pdf?version=1681720871","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030409934","display_name":"Hui Zou","orcid":"https://orcid.org/0000-0003-2637-3895","observed_orcids":["https://orcid.org/0000-0003-2637-3895"]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Zou","raw_affiliation_strings":["College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]},{"raw_affiliation_string":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020059326","display_name":"Huayi Qu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huayi Qu","raw_affiliation_strings":["College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]},{"raw_affiliation_string":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064264153","display_name":"Yusheng Bian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yusheng Bian","raw_affiliation_strings":["College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]},{"raw_affiliation_string":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031044364","display_name":"Jian Ge Sun","orcid":"https://orcid.org/0000-0002-4209-7555","observed_orcids":["https://orcid.org/0000-0002-4209-7555"]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Sun","raw_affiliation_strings":["College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]},{"raw_affiliation_string":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100453580","display_name":"Tao Wang","orcid":"https://orcid.org/0000-0002-7056-5272","observed_orcids":["https://orcid.org/0000-0002-7056-5272"]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Wang","raw_affiliation_strings":["College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]},{"raw_affiliation_string":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110950466","display_name":"Yonggang Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yonggang Ma","raw_affiliation_strings":["College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]},{"raw_affiliation_string":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048877983","display_name":"Yan Yuan","orcid":"https://orcid.org/0000-0002-1658-5328","observed_orcids":["https://orcid.org/0000-0002-1658-5328"]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Yuan","raw_affiliation_strings":["College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]},{"raw_affiliation_string":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069820887","display_name":"Jianhong Gu","orcid":"https://orcid.org/0000-0002-3226-4604","observed_orcids":["https://orcid.org/0000-0002-3226-4604"]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianhong Gu","raw_affiliation_strings":["College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]},{"raw_affiliation_string":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036404570","display_name":"Jianchun Bian","orcid":"https://orcid.org/0000-0001-8023-0751","observed_orcids":["https://orcid.org/0000-0001-8023-0751"]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianchun Bian","raw_affiliation_strings":["College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China"],"raw_orcid":"https://orcid.org/0000-0001-8023-0751","affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]},{"raw_affiliation_string":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015002344","display_name":"Zongping Liu","orcid":"https://orcid.org/0000-0001-9071-8363","observed_orcids":["https://orcid.org/0000-0001-9071-8363"]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zongping Liu","raw_affiliation_strings":["College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China"],"raw_orcid":"https://orcid.org/0000-0001-9071-8363","affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]},{"raw_affiliation_string":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China","institution_ids":["https://openalex.org/I78978612"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015002344"],"corresponding_institution_ids":["https://openalex.org/I78978612"],"apc_list":{"value":2500,"currency":"CHF","value_usd":2780},"apc_paid":{"value":2500,"currency":"CHF","value_usd":2780},"fwci":6.4244,"has_fulltext":true,"cited_by_count":101,"citation_normalized_percentile":{"value":0.98521138,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"24","issue":"8","first_page":"7382","last_page":"7382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10753","display_name":"Microplastics and Plastic Pollution","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10753","display_name":"Microplastics and Plastic Pollution","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10419","display_name":"Pharmaceutical and Antibiotic Environmental Impacts","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polystyrene-microplastics","display_name":"polystyrene microplastics","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microplastic-particle-size","display_name":"microplastic particle size","score":0.8080000281333923},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.6399999856948853},{"id":"https://openalex.org/keywords/sirt3","display_name":"SIRT3","score":0.8560000061988831},{"id":"https://openalex.org/keywords/manganese-superoxide-dismutase","display_name":"manganese superoxide dismutase","score":0.9779999852180481},{"id":"https://openalex.org/keywords/mitochondrial-damage","display_name":"mitochondrial damage","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hepatocyte-ultrastructure","display_name":"hepatocyte ultrastructure","score":0.5049999952316284},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.9002864956855774},{"id":"https://openalex.org/C2780401329","wikidata":"https://www.wikidata.org/wiki/Q6839919","display_name":"Microplastics","level":2,"score":0.8490263819694519},{"id":"https://openalex.org/C2776108821","wikidata":"https://www.wikidata.org/wiki/Q15335612","display_name":"SOD2","level":4,"score":0.6286750435829163},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6020588278770447},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5259659290313721},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4911961257457733},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.440355509519577},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.41803044080734253},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21959006786346436},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20052510499954224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12591981887817383},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000080545","descriptor_name":"Microplastics","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010969","descriptor_name":"Plastics","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011137","descriptor_name":"Polystyrenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms24087382","doi":"https://doi.org/10.3390/ijms24087382","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms24087382","pdf_url":"https://www.mdpi.com/1422-0067/24/8/7382/pdf?version=1681720871","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10138773","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10138773","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10138773/pdf/ijms-24-07382.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:37108543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37108543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms24087382","doi":"https://doi.org/10.3390/ijms24087382","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms24087382","pdf_url":"https://www.mdpi.com/1422-0067/24/8/7382/pdf?version=1681720871","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3135976634","display_name":null,"funder_award_id":"31802260 and 31772808","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4390683432","display_name":null,"funder_award_id":"31702305, 31872533, 31802260 and 31772808","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G667729329","display_name":null,"funder_award_id":"31872533","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7335246869","display_name":null,"funder_award_id":"31702305","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327518","display_name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366089650.pdf","grobid_xml":"https://content.openalex.org/works/W4366089650.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1893714901","https://openalex.org/W1948872103","https://openalex.org/W1974055353","https://openalex.org/W2000989164","https://openalex.org/W2039374791","https://openalex.org/W2133892291","https://openalex.org/W2143362587","https://openalex.org/W2221731984","https://openalex.org/W2295281563","https://openalex.org/W2328451459","https://openalex.org/W2583342343","https://openalex.org/W2589153907","https://openalex.org/W2608368045","https://openalex.org/W2733051448","https://openalex.org/W2756212562","https://openalex.org/W2777346605","https://openalex.org/W2789500366","https://openalex.org/W2800110090","https://openalex.org/W2900078865","https://openalex.org/W2900112088","https://openalex.org/W2901527430","https://openalex.org/W2903835006","https://openalex.org/W2936115923","https://openalex.org/W2945056371","https://openalex.org/W2977747666","https://openalex.org/W2994935455","https://openalex.org/W3007335941","https://openalex.org/W3012171454","https://openalex.org/W3081997571","https://openalex.org/W3090593801","https://openalex.org/W3120386464","https://openalex.org/W3139042604","https://openalex.org/W3158150483","https://openalex.org/W3159219239","https://openalex.org/W3171670357","https://openalex.org/W3174286241","https://openalex.org/W3201130521","https://openalex.org/W3203904740","https://openalex.org/W3206865592","https://openalex.org/W3213280299","https://openalex.org/W4200138644","https://openalex.org/W4200324043","https://openalex.org/W4212769157","https://openalex.org/W4224326562","https://openalex.org/W4280617650","https://openalex.org/W4285027415","https://openalex.org/W4293317188","https://openalex.org/W4296448717","https://openalex.org/W4306742778","https://openalex.org/W7073577038"],"related_works":["https://openalex.org/W4412572607","https://openalex.org/W4401858330","https://openalex.org/W4388735783","https://openalex.org/W6949446769","https://openalex.org/W4386475933","https://openalex.org/W4414721531","https://openalex.org/W7202086286","https://openalex.org/W7162440018","https://openalex.org/W7162249949","https://openalex.org/W4323039101"],"abstract_inverted_index":{"Microplastics":[0],"have":[1],"become":[2],"a":[3,67],"new":[4],"type":[5],"of":[6,17,48,96,106,126,147],"environmental":[7],"pollutant":[8],"that":[9,63,86,130],"can":[10],"accumulate":[11],"in":[12,42,57,69,108,136,139,165,179,187],"various":[13],"tissues":[14],"and":[15,20,35,72,77,80,101,152,159,182],"organs":[16],"the":[18,46,58,92,109,121,140,160,166,188,196],"body":[19,70],"cause":[21],"chronic":[22],"damage.":[23],"In":[24,171],"this":[25],"study,":[26],"two":[27],"different":[28,51],"size":[29],"polystyrene":[30],"microplastics":[31],"(PS-MPs,":[32],"5":[33,110,141,167,189],"\u03bcm":[34,111,142,168,190,198],"0.5":[36,197],"\u03bcm)":[37],"exposure":[38,65,87,113,132,174],"models":[39],"were":[40],"established":[41],"mice":[43],"to":[44,88,91,176],"investigate":[45],"effects":[47],"PS-MPs":[49,64,89,131,143,169,173,191,199],"with":[50,120,195],"particle":[52],"sizes":[53],"on":[54],"oxidative":[55,134,177],"stress":[56,135,178],"liver.":[59],"The":[60,75,104,124,145],"results":[61,84],"showed":[62,85,129],"caused":[66,183],"decrease":[68],"weight":[71],"liver-to-body":[73],"weight.":[74],"hematoxylin":[76],"eosin":[78],"staining":[79],"transmission":[81],"electron":[82],"microscopy":[83],"led":[90,175],"disorganized":[93],"cellular":[94],"structure":[95],"liver":[97],"tissue,":[98],"nuclear":[99],"crinkling,":[100],"mitochondrial":[102],"vacuolation.":[103],"extent":[105],"damage":[107,186],"PS-MP":[112],"group":[114,192],"was":[115,156,162],"more":[116,163,184],"extensive":[117],"when":[118,193],"compared":[119,194],"other":[122],"group.":[123,144,170,200],"evaluation":[125],"oxidative-stress-related":[127,148],"indicators":[128],"exacerbated":[133],"hepatocytes,":[137],"especially":[138],"expression":[146],"proteins":[149],"sirtuin":[150],"3(SIRT3)":[151],"superoxide":[153],"dismutase":[154],"(SOD2)":[155],"significantly":[157],"reduced,":[158],"reduction":[161],"pronounced":[164],"conclusion,":[172],"mouse":[180],"hepatocytes":[181],"severe":[185]},"counts_by_year":[{"year":2026,"cited_by_count":41},{"year":2025,"cited_by_count":35},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-04-19T00:00:00"}