{"id":"https://openalex.org/W4366083640","doi":"https://doi.org/10.1111/cns.14213","title":"Upregulation of the ZNF148 / PTX3 axis promotes malignant transformation of dendritic cells in glioma stem\u2010like cells microenvironment","display_name":"Upregulation of the ZNF148 / PTX3 axis promotes malignant transformation of dendritic cells in glioma stem\u2010like cells microenvironment","publication_year":2023,"publication_date":"2023-04-17","ids":{"openalex":"https://openalex.org/W4366083640","doi":"https://doi.org/10.1111/cns.14213","pmid":"https://pubmed.ncbi.nlm.nih.gov/37063077","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10401131"},"language":"en","primary_location":{"id":"doi:10.1111/cns.14213","doi":"https://doi.org/10.1111/cns.14213","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cns.14213","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.14213","source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience & Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.14213","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025762098","display_name":"Shan Cheng","orcid":"https://orcid.org/0000-0002-7372-9949","observed_orcids":["https://orcid.org/0000-0002-7372-9949"]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Cheng","raw_affiliation_strings":["Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"],"raw_orcid":"https://orcid.org/0000-0002-7372-9949","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100322344","display_name":"Liang Liu","orcid":"https://orcid.org/0000-0001-8630-7430","observed_orcids":["https://orcid.org/0000-0001-8630-7430"]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Liu","raw_affiliation_strings":["Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088231010","display_name":"Delin Wang","orcid":"https://orcid.org/0000-0003-0689-3199","observed_orcids":["https://orcid.org/0000-0003-0689-3199"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Delin Wang","raw_affiliation_strings":["Department of Neurosurgery, Jiande First People's Hospital, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Jiande First People's Hospital, Hangzhou, Zhejiang, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yongdong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongdong Li","raw_affiliation_strings":["Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101745020","display_name":"Suwen Li","orcid":"https://orcid.org/0000-0001-7567-071X","observed_orcids":["https://orcid.org/0000-0001-7567-071X"]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Suwen Li","raw_affiliation_strings":["Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101669674","display_name":"Jiaqi Yuan","orcid":"https://orcid.org/0009-0004-1394-7233","observed_orcids":["https://orcid.org/0009-0004-1394-7233","https://orcid.org/0000-0002-4369-8096"]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaqi Yuan","raw_affiliation_strings":["Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077434338","display_name":"Shilu Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shilu Huang","raw_affiliation_strings":["Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100623386","display_name":"Zhipeng Xu","orcid":"https://orcid.org/0000-0003-1734-2077","observed_orcids":["https://orcid.org/0000-0003-1734-2077"]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhipeng Xu","raw_affiliation_strings":["Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048178779","display_name":"Bin Jia","orcid":"https://orcid.org/0000-0002-8358-3613","observed_orcids":["https://orcid.org/0000-0002-8358-3613"]},"institutions":[{"id":"https://openalex.org/I4391768173","display_name":"State Key Laboratory of Analytical Chemistry for Life Science","ror":"https://ror.org/01xnz3256","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768173","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Jia","raw_affiliation_strings":["State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I4391768173","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024323959","display_name":"Zhe Li","orcid":"https://orcid.org/0000-0002-2755-2409","observed_orcids":["https://orcid.org/0000-0002-2755-2409"]},"institutions":[{"id":"https://openalex.org/I4391768173","display_name":"State Key Laboratory of Analytical Chemistry for Life Science","ror":"https://ror.org/01xnz3256","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768173","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Li","raw_affiliation_strings":["State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I4391768173","https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084918710","display_name":"Jun Dong","orcid":"https://orcid.org/0000-0002-0026-6680","observed_orcids":["https://orcid.org/0000-0002-0026-6680"]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Dong","raw_affiliation_strings":["Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"],"raw_orcid":"https://orcid.org/0000-0002-0026-6680","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210124971"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5084918710"],"corresponding_institution_ids":["https://openalex.org/I4210124971"],"apc_list":{"value":3410,"currency":"USD","value_usd":3410},"apc_paid":{"value":3410,"currency":"USD","value_usd":3410},"fwci":2.4713,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.90942787,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"29","issue":"9","first_page":"2690","last_page":"2704"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8300999999046326,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8300999999046326,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.14640000462532043,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pentraxin-3","display_name":"pentraxin 3","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9240000247955322},{"id":"https://openalex.org/keywords/glioma-stem-cells","display_name":"glioma stem cells","score":0.8100000023841858},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7919999957084656},{"id":"https://openalex.org/keywords/costimulatory-molecules","display_name":"costimulatory molecules","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.42399999499320984},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6140000224113464},{"id":"https://openalex.org/keywords/tumor-microenvironment-remodeling","display_name":"tumor microenvironment remodeling","score":0.5339999794960022},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.7911937236785889},{"id":"https://openalex.org/C2778297628","wikidata":"https://www.wikidata.org/wiki/Q5009843","display_name":"CD80","level":5,"score":0.7453114986419678},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.551920473575592},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.5468232035636902},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5118646025657654},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4725627303123474},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.47197824716567993},{"id":"https://openalex.org/C2779919695","wikidata":"https://www.wikidata.org/wiki/Q4201963","display_name":"CD11c","level":4,"score":0.4693739414215088},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4467082619667053},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41448843479156494},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38691458106040955},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37922078371047974},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3526020348072052},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.31040629744529724},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27225613594055176},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.19320297241210938},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16811370849609375},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099153","descriptor_name":"Pentraxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/cns.14213","doi":"https://doi.org/10.1111/cns.14213","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cns.14213","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.14213","source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience & Therapeutics","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-2210058/v1","doi":"https://doi.org/10.21203/rs.3.rs-2210058/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2210058/v1","pdf_url":"https://www.researchsquare.com/article/rs-2210058/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10401131","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10401131","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10401131/pdf/CNS-29-2690.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neurosci Ther","raw_type":"Text"},{"id":"pmid:37063077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37063077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS neuroscience & therapeutics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/cns.14213","doi":"https://doi.org/10.1111/cns.14213","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cns.14213","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.14213","source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience & Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1065076328","display_name":null,"funder_award_id":"BE2021653","funder_id":"https://openalex.org/F4320321605","funder_display_name":"Government of Jiangsu Province"},{"id":"https://openalex.org/G2176543089","display_name":null,"funder_award_id":"BE2021653","funder_id":"https://openalex.org/F4320327777","funder_display_name":"Jiangsu Provincial Key Research and Development Program"},{"id":"https://openalex.org/G4789312121","display_name":null,"funder_award_id":"BK20201172","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G5667939848","display_name":null,"funder_award_id":"ZBD2020016","funder_id":"https://openalex.org/F4320317802","funder_display_name":"Jiangsu Commission of Health"}],"funders":[{"id":"https://openalex.org/F4320317802","display_name":"Jiangsu Commission of Health","ror":null},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327777","display_name":"Jiangsu Provincial Key Research and Development Program","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366083640.pdf","grobid_xml":"https://content.openalex.org/works/W4366083640.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W1879005334","https://openalex.org/W1916067890","https://openalex.org/W1916818947","https://openalex.org/W1971115972","https://openalex.org/W1976199086","https://openalex.org/W1979038308","https://openalex.org/W1980352010","https://openalex.org/W1984484036","https://openalex.org/W1989207092","https://openalex.org/W2009763916","https://openalex.org/W2010138419","https://openalex.org/W2050175807","https://openalex.org/W2073624524","https://openalex.org/W2074795529","https://openalex.org/W2075180002","https://openalex.org/W2090454492","https://openalex.org/W2098116682","https://openalex.org/W2103959341","https://openalex.org/W2108886544","https://openalex.org/W2115327031","https://openalex.org/W2127982431","https://openalex.org/W2137808782","https://openalex.org/W2138753037","https://openalex.org/W2139418176","https://openalex.org/W2144648204","https://openalex.org/W2149401540","https://openalex.org/W2165871546","https://openalex.org/W2166434717","https://openalex.org/W2172036797","https://openalex.org/W2515153917","https://openalex.org/W2531507661","https://openalex.org/W2560724952","https://openalex.org/W2608545378","https://openalex.org/W2612805962","https://openalex.org/W2768029212","https://openalex.org/W2771657918","https://openalex.org/W2795929048","https://openalex.org/W2802586823","https://openalex.org/W2805359783","https://openalex.org/W2888305925","https://openalex.org/W2896031949","https://openalex.org/W2903490238","https://openalex.org/W2906326387","https://openalex.org/W2910311971","https://openalex.org/W2911292434","https://openalex.org/W2915071648","https://openalex.org/W2942960289","https://openalex.org/W2966748761","https://openalex.org/W2966839589","https://openalex.org/W2970536272","https://openalex.org/W2983074994","https://openalex.org/W2996545365","https://openalex.org/W2998186877","https://openalex.org/W3005468192","https://openalex.org/W3005505197","https://openalex.org/W3006333215","https://openalex.org/W3008761832","https://openalex.org/W3012086051","https://openalex.org/W3024932578","https://openalex.org/W3027491623","https://openalex.org/W3030339055","https://openalex.org/W3032465961","https://openalex.org/W3034155600","https://openalex.org/W3037638109","https://openalex.org/W3039156362","https://openalex.org/W3045620658","https://openalex.org/W3046826814","https://openalex.org/W3081247891","https://openalex.org/W3082276472","https://openalex.org/W3095643599","https://openalex.org/W3118395892","https://openalex.org/W3195345186","https://openalex.org/W4210738594","https://openalex.org/W4211107967","https://openalex.org/W4211233744","https://openalex.org/W4214745762","https://openalex.org/W4281667939","https://openalex.org/W4285900171","https://openalex.org/W4309183974","https://openalex.org/W4310675771"],"related_works":["https://openalex.org/W4309504767","https://openalex.org/W2939681859","https://openalex.org/W2054745835","https://openalex.org/W7018924655","https://openalex.org/W1525911437","https://openalex.org/W6908686564","https://openalex.org/W2406194323","https://openalex.org/W2150777176","https://openalex.org/W2621580733","https://openalex.org/W2740321131"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,77,92,227,302],"recent":[2],"development":[3],"of":[4,22,79,94,127,137,186,201,209,216,223,248,260,263,275,290,296,314],"dendritic":[5],"cell":[6,20,35],"(DC)-based":[7],"immunotherapy":[8],"has":[9,38,44],"resulted":[10,39],"in":[11,13,24,29,31,40,60,108,189,196,211,225,285,299,309],"advances":[12],"glioblastoma":[14],"multiforme":[15],"(GBM)":[16],"treatment.":[17],"However,":[18,182],"the":[19,25,52,125,132,153,183,205,214,221,239,256,271,278,288,294,311],"fate":[21],"DCs":[23,59,75,161,315],"GBM":[26,331],"microenvironment,":[27],"especially":[28],"microenvironments":[30],"which":[32],"glioma":[33],"stem":[34],"(GSCs)-mediated":[36],"remodeling":[37],"highly":[41,69],"immunosuppressive":[42],"conditions,":[43],"not":[45],"yet":[46],"been":[47],"fully":[48],"investigated.":[49],"METHODS:":[50],"Observed":[51],"interaction":[53],"between":[54,155],"GSCs":[55],"and":[56,66,72,89,99,114,118,129,135,144,157,170,172,180,207,219,243,254,258,269,273,320],"primary":[57],"cultured":[58],"a":[61,326],"dual-color":[62],"tracing":[63],"model,":[64],"monoclonal":[65],"continuously":[67],"passaged":[68],"proliferative":[70],"DCs,":[71],"named":[73],"transformed":[74],"(t-DCs).":[76],"expression":[78,93,184,215,253,268],"DC-specific":[80,165],"surface":[81,166],"markers":[82],"was":[83,110,235],"analyzed":[84],"using":[85,112],"RT-PCR,":[86],"chromosome":[87],"karyotype,":[88],"flow":[90],"cytometry.":[91],"long":[95],"pentraxin":[96],"3":[97],"(PTX3)":[98],"its":[100],"transcription":[101,228],"factor":[102,229],"zinc":[103,230],"finger":[104,231],"protein":[105,232],"148":[106,233],"(ZNF148)":[107,234],"t-DCs":[109,190,210,224],"detected":[111],"qRT-PCR":[113],"western":[115],"blot.":[116],"CCK8":[117],"transwell":[119],"assays":[120],"were":[121,149],"conducted":[122],"to":[123,151,194,238,332],"assess":[124],"effect":[126,295],"ZNF148":[128,156,249,264,291],"PTX3":[130,202,240,245,252,267,283,297],"on":[131],"proliferation,":[133],"migration,":[134],"invasion":[136],"t-DCs.":[138,261,286,300],"Bioinformatics":[139],"analysis,":[140],"dual-luciferase":[141],"reporter":[142],"assay,":[143],"chromatin":[145],"immunoprecipitation":[146],"(ChIP)-qPCR":[147],"assay":[148],"used":[150],"explore":[152],"relation":[154],"PTX3.":[158],"RESULTS:":[159],"Transformed":[160],"(t-DCs)":[162],"still":[163],"expressed":[164],"markers,":[167],"namely,":[168,176],"CD80":[169],"CD11c,":[171],"immune-related":[173],"costimulatory":[174,217],"molecules,":[175,218],"CD80,":[177],"CD86,":[178],"CD40,":[179],"ICAM-1.":[181],"levels":[185],"these":[187],"molecules":[188],"decreased":[191,213,251],"moderately":[192],"compared":[193],"those":[195],"naive":[197],"DCs.":[198],"Stable":[199],"overexpression":[200,284,298],"further":[203],"promoted":[204,270],"proliferation":[206,257,272],"migration":[208,259,274],"vitro,":[212],"increased":[220,266],"tumorigenicity":[222],"vivo.":[226],"directly":[236],"bound":[237],"promoter":[241],"region":[242],"enhanced":[244],"expression.":[246],"Downregulation":[247],"significantly":[250,265],"reduced":[255],"Overexpression":[262],"t-DCs,":[276],"achieving":[277],"same":[279],"biological":[280],"effects":[281],"as":[282,325],"Simultaneously,":[287],"downregulation":[289],"partially":[292],"reversed":[293],"CONCLUSION:":[301],"ZNF148/PTX3":[303],"axis":[304,322],"played":[305],"an":[306],"important":[307],"role":[308],"regulating":[310],"malignant":[312],"transformation":[313],"after":[316],"cross-talk":[317],"with":[318],"GSCs,":[319],"this":[321],"may":[323],"serve":[324],"new":[327],"target":[328],"for":[329],"sensitizing":[330],"DC-based":[333],"immunotherapy.":[334]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":13}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-19T00:00:00"}