{"id":"https://openalex.org/W4365520344","doi":"https://doi.org/10.1016/j.ebiom.2023.104567","title":"Alterations of the intestinal mucus layer correlate with dysbiosis and immune dysregulation in human Type 1 Diabetes","display_name":"Alterations of the intestinal mucus layer correlate with dysbiosis and immune dysregulation in human Type 1 Diabetes","publication_year":2023,"publication_date":"2023-04-14","ids":{"openalex":"https://openalex.org/W4365520344","doi":"https://doi.org/10.1016/j.ebiom.2023.104567","pmid":"https://pubmed.ncbi.nlm.nih.gov/37062177","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10139895"},"language":"en","primary_location":{"id":"doi:10.1016/j.ebiom.2023.104567","doi":"https://doi.org/10.1016/j.ebiom.2023.104567","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2023.104567","pdf_url":null,"source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eBioMedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.ebiom.2023.104567","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002125483","display_name":"Marta Lo Conte","orcid":"https://orcid.org/0000-0001-7640-1888","observed_orcids":["https://orcid.org/0000-0001-7640-1888"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marta Lo Conte","raw_affiliation_strings":["Autoimmune Pathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0001-7640-1888","affiliations":[{"raw_affiliation_string":"Autoimmune Pathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214","https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002830090","display_name":"Ilaria Cosorich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilaria Cosorich","raw_affiliation_strings":["Autoimmune Pathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autoimmune Pathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214","https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049152382","display_name":"Roberto Ferrarese","orcid":"https://orcid.org/0000-0002-8232-5786","observed_orcids":["https://orcid.org/0000-0002-8232-5786"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Ferrarese","raw_affiliation_strings":["Virology and Microbiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virology and Microbiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214","https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029978769","display_name":"Martina Antonini Cencicchio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Martina Antonini Cencicchio","raw_affiliation_strings":["Autoimmune Pathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autoimmune Pathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214","https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042208951","display_name":"Angelica Nobili","orcid":"https://orcid.org/0000-0003-2884-4523","observed_orcids":["https://orcid.org/0000-0003-2884-4523"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angelica Nobili","raw_affiliation_strings":["Autoimmune Pathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autoimmune Pathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214","https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018354151","display_name":"Vittoria Palmieri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vittoria Palmieri","raw_affiliation_strings":["Autoimmune Pathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autoimmune Pathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214","https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077611338","display_name":"Luca Massimino","orcid":"https://orcid.org/0000-0003-3975-9148","observed_orcids":["https://orcid.org/0000-0003-3975-9148"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Massimino","raw_affiliation_strings":["Experimental Gastroenterology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3975-9148","affiliations":[{"raw_affiliation_string":"Experimental Gastroenterology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214","https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050946209","display_name":"Luigi Antonio Lamparelli","orcid":"https://orcid.org/0000-0002-9571-2582","observed_orcids":["https://orcid.org/0000-0002-9571-2582"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Antonio Lamparelli","raw_affiliation_strings":["Experimental Gastroenterology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9571-2582","affiliations":[{"raw_affiliation_string":"Experimental Gastroenterology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214","https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009318613","display_name":"Wenjie Liang","orcid":"https://orcid.org/0000-0002-8770-5032","observed_orcids":["https://orcid.org/0000-0002-8770-5032"]},"institutions":[{"id":"https://openalex.org/I4210086369","display_name":"Institut Necker Enfants Malades","ror":"https://ror.org/000nhq538","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210096427"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Wenjie Liang","raw_affiliation_strings":["Institut Necker Enfants Malades, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Necker Enfants Malades, Paris, France","institution_ids":["https://openalex.org/I4210086369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071288353","display_name":"Michela Riba","orcid":"https://orcid.org/0000-0003-4857-2027","observed_orcids":["https://orcid.org/0000-0003-4857-2027"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michela Riba","raw_affiliation_strings":["Center for OMICS Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for OMICS Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214","https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044579806","display_name":"Elisabetta Devecchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisabetta Devecchi","raw_affiliation_strings":["Clinical Nutrition Center, IRCCS San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Nutrition Center, IRCCS San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073988889","display_name":"Andrea Mario Bolla","orcid":"https://orcid.org/0000-0001-9366-4081","observed_orcids":["https://orcid.org/0000-0001-9366-4081"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Mario Bolla","raw_affiliation_strings":["Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085559301","display_name":"Erika Pedone","orcid":"https://orcid.org/0000-0002-2588-6528","observed_orcids":["https://orcid.org/0000-0002-2588-6528"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Erika Pedone","raw_affiliation_strings":["Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089794566","display_name":"Marina Scavini","orcid":"https://orcid.org/0000-0002-7983-6905","observed_orcids":["https://orcid.org/0000-0002-7983-6905"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marina Scavini","raw_affiliation_strings":["Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017456380","display_name":"Emanuele Bosi","orcid":"https://orcid.org/0000-0002-2371-2495","observed_orcids":["https://orcid.org/0000-0002-2371-2495"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emanuele Bosi","raw_affiliation_strings":["Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy; San Raffaele Vita Salute University, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy; San Raffaele Vita Salute University, Milan, Italy","institution_ids":["https://openalex.org/I154387261","https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046930712","display_name":"Alessio Fasano","orcid":"https://orcid.org/0000-0002-2134-0261","observed_orcids":["https://orcid.org/0000-0002-2134-0261"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessio Fasano","raw_affiliation_strings":["Department of Pediatrics, Harvard Medical School, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-2134-0261","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011530256","display_name":"Federica Ungaro","orcid":"https://orcid.org/0000-0001-5395-7795","observed_orcids":["https://orcid.org/0000-0001-5395-7795"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Ungaro","raw_affiliation_strings":["Experimental Gastroenterology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Gastroenterology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214","https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037355357","display_name":"Julien Diana","orcid":"https://orcid.org/0000-0001-7542-042X","observed_orcids":["https://orcid.org/0000-0001-7542-042X"]},"institutions":[{"id":"https://openalex.org/I4210086369","display_name":"Institut Necker Enfants Malades","ror":"https://ror.org/000nhq538","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210086369","https://openalex.org/I4210096427"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julien Diana","raw_affiliation_strings":["Institut Necker Enfants Malades, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Necker Enfants Malades, Paris, France","institution_ids":["https://openalex.org/I4210086369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029436501","display_name":"Nicasio Mancini","orcid":"https://orcid.org/0000-0003-0637-0910","observed_orcids":["https://orcid.org/0000-0003-0637-0910"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicasio Mancini","raw_affiliation_strings":["Virology and Microbiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; San Raffaele Vita Salute University, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virology and Microbiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; San Raffaele Vita Salute University, Milan, Italy","institution_ids":["https://openalex.org/I154387261","https://openalex.org/I4210133214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069868238","display_name":"Marika Falcone","orcid":"https://orcid.org/0000-0001-6080-5351","observed_orcids":["https://orcid.org/0000-0001-6080-5351"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Marika Falcone","raw_affiliation_strings":["Autoimmune Pathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy. Electronic address: falcone.marika@hsr.it"],"raw_orcid":"https://orcid.org/0000-0001-6080-5351","affiliations":[{"raw_affiliation_string":"Autoimmune Pathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy. Electronic address: falcone.marika@hsr.it","institution_ids":["https://openalex.org/I4210133214","https://openalex.org/I4387155925"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5069868238"],"corresponding_institution_ids":["https://openalex.org/I4210133214","https://openalex.org/I4387155925"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":5.1154,"has_fulltext":true,"cited_by_count":67,"citation_normalized_percentile":{"value":0.97416471,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"91","issue":null,"first_page":"104567","last_page":"104567"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.28859999775886536,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.05909999832510948,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.996999979019165},{"id":"https://openalex.org/keywords/intestinal-mucus-layer","display_name":"intestinal mucus layer","score":0.9750000238418579},{"id":"https://openalex.org/keywords/intestinal-barrier-integrity","display_name":"intestinal barrier integrity","score":0.9269999861717224},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/immune-dysregulation","display_name":"immune dysregulation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/mucin","display_name":"mucin","score":0.6800000071525574},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.7089999914169312},{"id":"https://openalex.org/keywords/zonulin","display_name":"zonulin","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lipopolysaccharide-binding-protein","display_name":"lipopolysaccharide-binding protein","score":0.9330000281333923},{"id":"https://openalex.org/keywords/intestinal-epithelial-barrier","display_name":"intestinal epithelial barrier","score":0.7929999828338623},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.6460000276565552},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C2777312293","wikidata":"https://www.wikidata.org/wiki/Q3649349","display_name":"Mucus","level":2,"score":0.7012545466423035},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.6642836332321167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6475980281829834},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6105130910873413},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5664412975311279},{"id":"https://openalex.org/C2777116383","wikidata":"https://www.wikidata.org/wiki/Q18029657","display_name":"Mucin 2","level":4,"score":0.5632808208465576},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.48580169677734375},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.44528359174728394},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4222849905490875},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11342191696166992},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009077","descriptor_name":"Mucins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009093","descriptor_name":"Mucus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1016/j.ebiom.2023.104567","doi":"https://doi.org/10.1016/j.ebiom.2023.104567","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2023.104567","pdf_url":null,"source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eBioMedicine","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.4175219","doi":"https://doi.org/10.2139/ssrn.4175219","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4175219","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10139895","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10139895","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10139895/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eBioMedicine","raw_type":"Text"},{"id":"pmid:37062177","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37062177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EBioMedicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:250810cebc2c42b29c39ffa529d71470","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/250810cebc2c42b29c39ffa529d71470","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EBioMedicine, Vol 91, Iss , Pp 104567- (2023)","raw_type":"article"},{"id":"pmh:oai:irinsubria.uninsubria.it:11383/2164551","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11383/2164551","pdf_url":null,"source":{"id":"https://openalex.org/S4377196351","display_name":"IrInSubria (University of Insubria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I115752224","host_organization_name":"University of Insubria","host_organization_lineage":["https://openalex.org/I115752224"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unisr.it:20.500.11768/198528","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.11768/198528","pdf_url":null,"source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.ebiom.2023.104567","doi":"https://doi.org/10.1016/j.ebiom.2023.104567","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ebiom.2023.104567","pdf_url":null,"source":{"id":"https://openalex.org/S2531685872","display_name":"EBioMedicine","issn_l":"2352-3964","issn":["2352-3964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eBioMedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1851420870","display_name":null,"funder_award_id":"RF19-12370721","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G2076520454","display_name":null,"funder_award_id":"2018-","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G2531075325","display_name":null,"funder_award_id":"2-SRA-2019-680-S-B","funder_id":"https://openalex.org/F4320306172","funder_display_name":"Juvenile Diabetes Research Foundation International"},{"id":"https://openalex.org/G4884061758","display_name":null,"funder_award_id":"1-INO-2018-640-A-N","funder_id":"https://openalex.org/F4320306172","funder_display_name":"Juvenile Diabetes Research Foundation International"}],"funders":[{"id":"https://openalex.org/F4320306172","display_name":"Juvenile Diabetes Research Foundation International","ror":"https://ror.org/00vqxjy61"},{"id":"https://openalex.org/F4320310820","display_name":"Juvenile Diabetes Research Foundation United States of America","ror":"https://ror.org/00vqxjy61"},{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4365520344.pdf","grobid_xml":"https://content.openalex.org/works/W4365520344.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1520219519","https://openalex.org/W1812571265","https://openalex.org/W1882231731","https://openalex.org/W1973067432","https://openalex.org/W1973955814","https://openalex.org/W1976578226","https://openalex.org/W2003342633","https://openalex.org/W2016073955","https://openalex.org/W2026489827","https://openalex.org/W2035276456","https://openalex.org/W2062011675","https://openalex.org/W2070128851","https://openalex.org/W2077590888","https://openalex.org/W2085926377","https://openalex.org/W2091063143","https://openalex.org/W2091552595","https://openalex.org/W2106145173","https://openalex.org/W2110785364","https://openalex.org/W2111304349","https://openalex.org/W2112724457","https://openalex.org/W2116525393","https://openalex.org/W2120950548","https://openalex.org/W2121635719","https://openalex.org/W2122439340","https://openalex.org/W2127934565","https://openalex.org/W2136365792","https://openalex.org/W2138715145","https://openalex.org/W2143844722","https://openalex.org/W2150173080","https://openalex.org/W2155770880","https://openalex.org/W2159954944","https://openalex.org/W2166881631","https://openalex.org/W2179438025","https://openalex.org/W2182543537","https://openalex.org/W2208996359","https://openalex.org/W2225985392","https://openalex.org/W2293034963","https://openalex.org/W2298509083","https://openalex.org/W2300482125","https://openalex.org/W2332364139","https://openalex.org/W2341646806","https://openalex.org/W2400284115","https://openalex.org/W2473163213","https://openalex.org/W2519071757","https://openalex.org/W2550313850","https://openalex.org/W2582071065","https://openalex.org/W2603850261","https://openalex.org/W2766414693","https://openalex.org/W2773437815","https://openalex.org/W2886248824","https://openalex.org/W2887633388","https://openalex.org/W2890067470","https://openalex.org/W2896617742","https://openalex.org/W2916594759","https://openalex.org/W2950737242","https://openalex.org/W2954681652","https://openalex.org/W2966098821","https://openalex.org/W3015066429","https://openalex.org/W3175009653","https://openalex.org/W4200148796","https://openalex.org/W4285744615","https://openalex.org/W6683190317"],"related_works":["https://openalex.org/W3131436487","https://openalex.org/W2597951327","https://openalex.org/W2958351251","https://openalex.org/W2920890598","https://openalex.org/W2130663829","https://openalex.org/W2463012838","https://openalex.org/W7134133455","https://openalex.org/W4309845351","https://openalex.org/W2567963033","https://openalex.org/W7206160616"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,61,76],"preclinical":[2,62],"models":[3,63],"of":[4,11,37,44,64,68,91,107,112,132,142,211],"Type":[5],"1":[6],"Diabetes":[7,196],"(T1D)":[8],"the":[9,12,23,38,45,66,69,73,89,92,162,194,208],"integrity":[10,90,102],"gut":[13,80,164],"barrier":[14,41],"(GB)":[15],"is":[16,35],"instrumental":[17],"to":[18,30,57,200,204,215],"avoid":[19],"dysregulated":[20],"crosstalk":[21],"between":[22],"commensal":[24],"microbiota":[25,165],"and":[26,29,43,50,82,114,123,129,137,145,157,183,187,202,206],"immune":[27,59,188],"cells":[28],"prevent":[31],"autoimmunity.":[32],"The":[33],"GB":[34,70,101],"composed":[36],"intestinal":[39,140,155],"epithelial":[40],"(IEB)":[42],"mucus":[46,74,93,175],"layer":[47,94,176],"containing":[48],"mucins":[49,136],"antimicrobial":[51],"peptides":[52],"(AMPs)":[53],"that":[54,174],"are":[55,178],"crucial":[56],"maintain":[58],"tolerance.":[60],"T1D":[65,78,143,181],"alterations":[67,177],"primarily":[71],"affect":[72],"layer.":[75],"human":[77],"increased":[79],"permeability":[81],"IEB":[83,108],"damage":[84,109],"have":[85],"been":[86],"demonstrated":[87],"but":[88],"was":[95],"never":[96],"assessed.":[97],"METHODS:":[98],"We":[99],"evaluated":[100],"by":[103],"measuring":[104],"serological":[105],"markers":[106],"(serological":[110],"levels":[111],"zonulin)":[113],"bacterial":[115],"translocation":[116],"such":[117],"as":[118],"lipopolysaccharide":[119],"binding":[120],"protein":[121,126],"(LBP)":[122],"myeloid":[124],"differentiation":[125],"2":[127],"(MD2),":[128],"mRNA":[130],"expression":[131],"tight":[133],"junction":[134],"proteins,":[135],"AMPs":[138],"in":[139,180],"tissue":[141,156],"patients":[144],"healthy":[146],"controls":[147],"(HC).":[148],"Simultaneously,":[149],"we":[150],"performed":[151],"immunological":[152],"profiling":[153],"on":[154,161],"16S":[158],"rRNA":[159],"analysis":[160],"mucus-associated":[163],"(MAGM).":[166],"FINDINGS:":[167],"T":[168],"cells.":[169],"INTERPRETATION:":[170],"Our":[171],"data":[172],"show":[173],"present":[179],"subjects":[182],"associated":[184],"with":[185],"dysbiosis":[186],"dysregulation.":[189],"FUNDING:":[190],"Research":[191],"Grants":[192],"from":[193,207],"Juvenile":[195],"Foundation":[197],"(Grant":[198,213],"1-INO-2018-640-A-N":[199],"MF":[201],"2-SRA-2019-680-S-B":[203],"JD)":[205],"Italian":[209],"Ministry":[210],"Health":[212],"RF19-12370721":[214],"MF).":[216]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-04-15T00:00:00"}
