{"id":"https://openalex.org/W4365517017","doi":"https://doi.org/10.1158/1538-7445.am2023-ct060","title":"Abstract CT060: ACTION: A randomized phase 3 study of dordaviprone (ONC201) in patients with newly diagnosed H3 K27M-mutant diffuse glioma","display_name":"Abstract CT060: ACTION: A randomized phase 3 study of dordaviprone (ONC201) in patients with newly diagnosed H3 K27M-mutant diffuse glioma","publication_year":2023,"publication_date":"2023-04-14","ids":{"openalex":"https://openalex.org/W4365517017","doi":"https://doi.org/10.1158/1538-7445.am2023-ct060"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2023-ct060","doi":"https://doi.org/10.1158/1538-7445.am2023-ct060","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-ct060","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024616176","display_name":"Isabel Arrillaga\u2010Romany","orcid":"https://orcid.org/0000-0001-5951-1225","observed_orcids":["https://orcid.org/0000-0001-5951-1225"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isabel Arrillaga-Romany","raw_affiliation_strings":["1Massachusetts General Hospital, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057541817","display_name":"Andrew B. Lassman","orcid":"https://orcid.org/0000-0001-7386-9928","observed_orcids":["https://orcid.org/0000-0001-7386-9928"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Lassman","raw_affiliation_strings":["2Columbia University Vagelos College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, New York-Presbyterian Hospital,, New York City, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Columbia University Vagelos College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, New York-Presbyterian Hospital,, New York City, NY;","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4390039230","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017360357","display_name":"Susan Lynne McGovern","orcid":"https://orcid.org/0000-0002-5286-0649","observed_orcids":["https://orcid.org/0000-0002-5286-0649"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan L. McGovern","raw_affiliation_strings":["3University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103236468","display_name":"Sabine Mueller","orcid":"https://orcid.org/0000-0002-8216-9357","observed_orcids":["https://orcid.org/0000-0002-8216-9357","https://orcid.org/0000-0002-3452-5150"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabine Mueller","raw_affiliation_strings":["4University of California, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4University of California, San Francisco, CA;","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076107697","display_name":"Burt Nabors","orcid":"https://orcid.org/0000-0001-5926-2230","observed_orcids":["https://orcid.org/0000-0001-5926-2230"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis B. Nabors","raw_affiliation_strings":["5University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010891460","display_name":"Martin J. van den Bent","orcid":"https://orcid.org/0000-0001-5710-5127","observed_orcids":["https://orcid.org/0000-0001-5710-5127"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I4210149908","display_name":"Erasmus MC Cancer Institute","ror":"https://ror.org/03r4m3349","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martin van den Bent","raw_affiliation_strings":["6Brain Tumor Center at Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Brain Tumor Center at Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands;","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110558089","display_name":"Michael A. Vogelbaum","orcid":"https://orcid.org/0000-0002-9833-2374","observed_orcids":["https://orcid.org/0000-0002-9833-2374"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Vogelbaum","raw_affiliation_strings":["7Moffitt Cancer Center, Tampa, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Moffitt Cancer Center, Tampa, FL;","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008547275","display_name":"Joshua E. Allen","orcid":"https://orcid.org/0000-0002-6835-1128","observed_orcids":["https://orcid.org/0000-0002-6835-1128"]},"institutions":[{"id":"https://openalex.org/I4210119210","display_name":"Chimerix (United States)","ror":"https://ror.org/02jsvy381","country_code":"US","type":"company","lineage":["https://openalex.org/I4210119210"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua E. Allen","raw_affiliation_strings":["8Chimerix, Inc., Durham, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Chimerix, Inc., Durham, NC;","institution_ids":["https://openalex.org/I4210119210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088834594","display_name":"Allen S. Melemed","orcid":"https://orcid.org/0000-0002-2553-1575","observed_orcids":["https://orcid.org/0000-0002-2553-1575"]},"institutions":[{"id":"https://openalex.org/I4210119210","display_name":"Chimerix (United States)","ror":"https://ror.org/02jsvy381","country_code":"US","type":"company","lineage":["https://openalex.org/I4210119210"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen S. Melemed","raw_affiliation_strings":["8Chimerix, Inc., Durham, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Chimerix, Inc., Durham, NC;","institution_ids":["https://openalex.org/I4210119210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045679809","display_name":"Rohinton S. Tarapore","orcid":"https://orcid.org/0000-0002-8070-5646","observed_orcids":["https://orcid.org/0000-0002-8070-5646"]},"institutions":[{"id":"https://openalex.org/I4210119210","display_name":"Chimerix (United States)","ror":"https://ror.org/02jsvy381","country_code":"US","type":"company","lineage":["https://openalex.org/I4210119210"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rohinton S. Tarapore","raw_affiliation_strings":["8Chimerix, Inc., Durham, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Chimerix, Inc., Durham, NC;","institution_ids":["https://openalex.org/I4210119210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009325014","display_name":"Dewen Yang","orcid":"https://orcid.org/0000-0002-4687-6927","observed_orcids":["https://orcid.org/0000-0002-4687-6927"]},"institutions":[{"id":"https://openalex.org/I4210119210","display_name":"Chimerix (United States)","ror":"https://ror.org/02jsvy381","country_code":"US","type":"company","lineage":["https://openalex.org/I4210119210"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dewen Yang","raw_affiliation_strings":["8Chimerix, Inc., Durham, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Chimerix, Inc., Durham, NC;","institution_ids":["https://openalex.org/I4210119210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021656597","display_name":"Patrick Yung Wen","orcid":"https://orcid.org/0000-0002-0774-7700","observed_orcids":["https://orcid.org/0000-0002-0774-7700","https://orcid.org/0000-0003-3224-3042","https://orcid.org/0000-0002-2452-0540"]},"institutions":[{"id":"https://openalex.org/I4210102457","display_name":"Center for Neuro-Oncology","ror":"https://ror.org/00z2tp793","country_code":"US","type":"facility","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210102457","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Wen","raw_affiliation_strings":["9Center For Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Center For Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210102457","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112042260","display_name":"Timothy Cloughsey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Cloughsey","raw_affiliation_strings":["10University of California, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10University of California, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":14,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"8_Supplement","first_page":"CT060","last_page":"CT060"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/onc201","display_name":"ONC201","score":0.9769999980926514},{"id":"https://openalex.org/keywords/h3k27m-mutation","display_name":"H3K27M mutation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/diffuse-midline-glioma","display_name":"diffuse midline glioma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/diffuse-glioma","display_name":"diffuse glioma","score":0.796999990940094},{"id":"https://openalex.org/keywords/imipridone","display_name":"imipridone","score":0.9110000133514404},{"id":"https://openalex.org/keywords/oral-targeted-therapy","display_name":"oral targeted therapy","score":0.5799999833106995},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7760000228881836},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/action-trial","display_name":"ACTION trial","score":0.593999981880188},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8452039957046509},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7021186947822571},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5653273463249207},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5541403889656067},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5222928524017334},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5109521746635437},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.47965243458747864},{"id":"https://openalex.org/C141341695","wikidata":"https://www.wikidata.org/wiki/Q2368661","display_name":"Surrogate endpoint","level":2,"score":0.4396131932735443},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4129786193370819},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.4126071333885193},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3890826404094696},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3095114231109619},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2375296652317047},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2023-ct060","doi":"https://doi.org/10.1158/1538-7445.am2023-ct060","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-ct060","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4417357706","https://openalex.org/W4386538569","https://openalex.org/W4385578318","https://openalex.org/W4392490221","https://openalex.org/W4416140369","https://openalex.org/W4410803081","https://openalex.org/W7172291531","https://openalex.org/W4308977950","https://openalex.org/W7165118446","https://openalex.org/W4392089921"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"H3":[2,101,124,207,323],"K27M-mutant":[3,102,125,208,324],"diffuse":[4,126,209,244,325],"midline":[5],"glioma":[6,175,326],"is":[7,28,36,46,107,258],"a":[8,43,108,211,240],"universally":[9],"fatal":[10],"malignancy":[11],"primarily":[12],"affecting":[13],"children":[14],"and":[15,31,61,158,197,216,344],"young":[16],"adults.":[17],"While":[18],"radiotherapy":[19,134],"(RT)":[20],"provides":[21],"transient":[22],"benefit,":[23,191],"no":[24],"effective":[25],"systemic":[26],"therapy":[27],"currently":[29,259],"available":[30],"current":[32],"standard":[33,132],"of":[34,56,63,72,117,185,193,236,315,330],"care":[35],"RT":[37],"followed":[38],"by":[39,169,176],"monitoring.":[40],"Dordaviprone":[41],"(ONC201),":[42],"first-in-class":[44],"imipridone,":[45],"an":[47],"oral,":[48],"blood-brain":[49],"barrier":[50],"penetrating,":[51],"selective":[52],"small":[53],"molecule":[54],"antagonist":[55],"dopamine":[57],"receptor":[58],"D2/3":[59],"(DRD2)":[60],"agonist":[62],"the":[64,91,262,331],"mitochondrial":[65],"protease":[66],"ClpP.":[67],"An":[68],"integrated":[69],"pooled":[70],"analysis":[71],"five":[73],"open-label":[74],"trials":[75],"previously":[76],"demonstrated":[77],"efficacy":[78,152,188],"in":[79,98,119,162,172,261,272,318],"dordaviprone-treated":[80],"patients":[81,99,120,202,229,319],"with":[82,100,121,239,265,320],"recurrent":[83],"disease.":[84,103],"This":[85],"phase":[86,312],"3":[87,115,313],"trial":[88],"will":[89,135,166,203,221],"be":[90,136,167,223,231,269],"first":[92],"randomized,":[93,109],"controlled":[94],"study":[95,116,314],"evaluating":[96],"dordaviprone":[97,118,146,316],"Methods:":[104],"ACTION":[105,257],"(NCT05580562)":[106],"double-blind,":[110],"placebo-controlled,":[111],"parallel-group,":[112],"international":[113],"Phase":[114],"newly":[122,321],"diagnosed":[123,322],"glioma.":[127],"Patients":[128,238],"who":[129],"have":[130,204],"completed":[131,217],"frontline":[133],"randomized":[137,311],"1:1:1":[138],"to":[139,268],"receive":[140],"placebo,":[141],"once-weekly":[142],"dordaviprone,":[143],"or":[144,250],"twice-weekly":[145],"on":[147,226],"two":[148],"consecutive":[149],"days.":[150],"Primary":[151],"endpoints":[153],"are":[154,254],"overall":[155],"survival":[156,160],"(OS)":[157],"progression-free":[159],"(PFS)":[161],"all":[163],"participants;":[164],"PFS":[165],"assessed":[168],"response":[170],"assessment":[171],"neuro-oncology-high":[173],"grade":[174],"blind":[177],"independent":[178],"central":[179],"review.":[180],"Other":[181],"objectives":[182],"include":[183],"assessments":[184],"safety,":[186],"additional":[187,266],"endpoints,":[189],"clinical":[190],"quality":[192],"life,":[194],"pharmacokinetics,":[195],"biomarkers,":[196],"healthcare":[198],"resource":[199],"utilization.":[200],"Eligible":[201],"histologically":[205],"confirmed":[206],"glioma,":[210,247],"Karnofsky/Lansky":[212],"performance":[213],"status":[214],"\u226570,":[215],"first-line":[218],"radiotherapy.":[219],"Eligibility":[220],"not":[222,255],"restricted":[224],"based":[225],"age;":[227],"however,":[228],"must":[230],"\u226510":[232],"kg":[233],"at":[234],"time":[235],"randomization.":[237],"primary":[241],"spinal":[242],"tumor,":[243],"intrinsic":[245],"pontine":[246],"leptomeningeal":[248],"disease,":[249],"cerebrospinal":[251],"fluid":[252],"dissemination":[253],"eligible.":[256],"enrolling":[260],"United":[263],"States,":[264],"sites":[267],"open":[270],"internationally":[271],"2023.":[273],"Citation":[274],"Format:":[275],"Isabel":[276],"Arrillaga-Romany,":[277],"Andrew":[278],"Lassman,":[279],"Susan":[280],"L.":[281],"McGovern,":[282],"Sabine":[283],"Mueller,":[284],"Louis":[285],"B.":[286],"Nabors,":[287],"Martin":[288],"van":[289],"den":[290],"Bent,":[291],"Michael":[292],"Vogelbaum,":[293],"Joshua":[294],"E.":[295],"Allen,":[296],"Allen":[297],"S.":[298,301],"Melemed,":[299],"Rohinton":[300],"Tarapore,":[302],"Dewen":[303],"Yang,":[304],"Patrick":[305],"Wen,":[306],"Timothy":[307],"Cloughsey.":[308],"ACTION:":[309],"A":[310],"(ONC201)":[317],"[abstract].":[327],"In:":[328],"Proceedings":[329],"American":[332],"Association":[333],"for":[334],"Cancer":[335,355],"Research":[336],"Annual":[337],"Meeting":[338],"2023;":[339],"Part":[340],"2":[341],"(Clinical":[342],"Trials":[343],"Late-Breaking":[345],"Research);":[346],"2023":[347],"Apr":[348],"14-19;":[349],"Orlando,":[350],"FL.":[351],"Philadelphia":[352],"(PA):":[353],"AACR;":[354],"Res":[356],"2023;83(8_Suppl):Abstract":[357],"nr":[358],"CT060.":[359]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-15T00:00:00"}
