{"id":"https://openalex.org/W4365479280","doi":"https://doi.org/10.1002/mnfr.202200524","title":"Icariin Ameliorates Spermatogenesis Disorder in Obese Mice Induced by High\u2010Fat Diet through Regulating the Glycolytic Pathway","display_name":"Icariin Ameliorates Spermatogenesis Disorder in Obese Mice Induced by High\u2010Fat Diet through Regulating the Glycolytic Pathway","publication_year":2023,"publication_date":"2023-04-14","ids":{"openalex":"https://openalex.org/W4365479280","doi":"https://doi.org/10.1002/mnfr.202200524","pmid":"https://pubmed.ncbi.nlm.nih.gov/37057609"},"language":"en","primary_location":{"id":"doi:10.1002/mnfr.202200524","doi":"https://doi.org/10.1002/mnfr.202200524","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mnfr.202200524","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mnfr.202200524","source":{"id":"https://openalex.org/S27638457","display_name":"Molecular Nutrition & Food Research","issn_l":"1613-4125","issn":["1613-4125","1613-4133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Nutrition & Food Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mnfr.202200524","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101745559","display_name":"Min Luo","orcid":"https://orcid.org/0000-0002-5300-3462","observed_orcids":["https://orcid.org/0000-0002-5300-3462"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Luo","raw_affiliation_strings":["Clinical Anatomy and Reproductive Medicine Application Institute Department of Histology and Embryology Hengyang Medical School University of South China  Hengyang 421001 China","Reproductive Hospital of Guangxi Zhuang Autonomous Region  Nanning 530021 China","Clinical Anatomy and Reproductive Medicine Application Institute, Department of Histology and Embryology, Hengyang Medical School, University of South China, Hengyang, 421001 China","Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021 China"],"raw_orcid":"https://orcid.org/0000-0002-5300-3462","affiliations":[{"raw_affiliation_string":"Clinical Anatomy and Reproductive Medicine Application Institute Department of Histology and Embryology Hengyang Medical School University of South China  Hengyang 421001 China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"Reproductive Hospital of Guangxi Zhuang Autonomous Region  Nanning 530021 China","institution_ids":[]},{"raw_affiliation_string":"Clinical Anatomy and Reproductive Medicine Application Institute, Department of Histology and Embryology, Hengyang Medical School, University of South China, Hengyang, 421001 China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021 China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089534620","display_name":"Xiuhong Zhuge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176134282","display_name":"Guilin Medical University","ror":"https://ror.org/000prga03","country_code":"CN","type":"education","lineage":["https://openalex.org/I176134282"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiuhong Zhuge","raw_affiliation_strings":["Affiliated Hospital of Guilin Medical University  Guilin Guangxi 541001 China","Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Guilin Medical University  Guilin Guangxi 541001 China","institution_ids":["https://openalex.org/I176134282"]},{"raw_affiliation_string":"Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001 China","institution_ids":["https://openalex.org/I176134282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112114395","display_name":"Lin Ji","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin Ji","raw_affiliation_strings":["Reproductive Hospital of Guangxi Zhuang Autonomous Region  Nanning 530021 China","Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Hospital of Guangxi Zhuang Autonomous Region  Nanning 530021 China","institution_ids":[]},{"raw_affiliation_string":"Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021 China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101709512","display_name":"Jinyuan Wang","orcid":"https://orcid.org/0000-0002-8378-1249","observed_orcids":["https://orcid.org/0000-0002-8378-1249"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinyuan Wang","raw_affiliation_strings":["Clinical Anatomy and Reproductive Medicine Application Institute Department of Histology and Embryology Hengyang Medical School University of South China  Hengyang 421001 China","Clinical Anatomy and Reproductive Medicine Application Institute, Department of Histology and Embryology, Hengyang Medical School, University of South China, Hengyang, 421001 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Anatomy and Reproductive Medicine Application Institute Department of Histology and Embryology Hengyang Medical School University of South China  Hengyang 421001 China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"Clinical Anatomy and Reproductive Medicine Application Institute, Department of Histology and Embryology, Hengyang Medical School, University of South China, Hengyang, 421001 China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006904827","display_name":"Yi Mo","orcid":"https://orcid.org/0000-0001-6857-9010","observed_orcids":["https://orcid.org/0000-0001-6857-9010"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi Mo","raw_affiliation_strings":["Reproductive Hospital of Guangxi Zhuang Autonomous Region  Nanning 530021 China","Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Hospital of Guangxi Zhuang Autonomous Region  Nanning 530021 China","institution_ids":[]},{"raw_affiliation_string":"Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021 China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051601061","display_name":"Yongpeng Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongpeng Tan","raw_affiliation_strings":["Clinical Anatomy and Reproductive Medicine Application Institute Department of Histology and Embryology Hengyang Medical School University of South China  Hengyang 421001 China","Clinical Anatomy and Reproductive Medicine Application Institute, Department of Histology and Embryology, Hengyang Medical School, University of South China, Hengyang, 421001 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Anatomy and Reproductive Medicine Application Institute Department of Histology and Embryology Hengyang Medical School University of South China  Hengyang 421001 China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"Clinical Anatomy and Reproductive Medicine Application Institute, Department of Histology and Embryology, Hengyang Medical School, University of South China, Hengyang, 421001 China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035771599","display_name":"Leguang Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Leguang Zhou","raw_affiliation_strings":["Clinical Anatomy and Reproductive Medicine Application Institute Department of Histology and Embryology Hengyang Medical School University of South China  Hengyang 421001 China","Clinical Anatomy and Reproductive Medicine Application Institute, Department of Histology and Embryology, Hengyang Medical School, University of South China, Hengyang, 421001 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Anatomy and Reproductive Medicine Application Institute Department of Histology and Embryology Hengyang Medical School University of South China  Hengyang 421001 China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"Clinical Anatomy and Reproductive Medicine Application Institute, Department of Histology and Embryology, Hengyang Medical School, University of South China, Hengyang, 421001 China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040658792","display_name":"Xiaocan Lei","orcid":"https://orcid.org/0000-0001-7666-5082","observed_orcids":["https://orcid.org/0000-0001-7666-5082"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaocan Lei","raw_affiliation_strings":["Clinical Anatomy and Reproductive Medicine Application Institute Department of Histology and Embryology Hengyang Medical School University of South China  Hengyang 421001 China","Clinical Anatomy and Reproductive Medicine Application Institute, Department of Histology and Embryology, Hengyang Medical School, University of South China, Hengyang, 421001 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Anatomy and Reproductive Medicine Application Institute Department of Histology and Embryology Hengyang Medical School University of South China  Hengyang 421001 China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"Clinical Anatomy and Reproductive Medicine Application Institute, Department of Histology and Embryology, Hengyang Medical School, University of South China, Hengyang, 421001 China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109679082","display_name":"Hua Huang","orcid":"https://orcid.org/0000-0002-1713-8597","observed_orcids":["https://orcid.org/0000-0002-1713-8597"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hua Huang","raw_affiliation_strings":["Reproductive Hospital of Guangxi Zhuang Autonomous Region  Nanning 530021 China","Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Hospital of Guangxi Zhuang Autonomous Region  Nanning 530021 China","institution_ids":[]},{"raw_affiliation_string":"Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021 China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040658792","https://openalex.org/A5109679082"],"corresponding_institution_ids":["https://openalex.org/I91935597"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":4.0731,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.94345924,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"67","issue":"13","first_page":"e2200524","last_page":"e2200524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.047600001096725464,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/icariin","display_name":"icariin","score":1.0},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7289999723434448},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.9739999771118164},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.968999981880188},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/sertoli-cells","display_name":"Sertoli cells","score":0.8050000071525574},{"id":"https://openalex.org/keywords/palmitic-acid","display_name":"palmitic acid","score":0.7649999856948853},{"id":"https://openalex.org/keywords/testicular-apoptosis","display_name":"testicular apoptosis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hk2","display_name":"HK2","score":0.7549999952316284},{"id":"https://openalex.org/keywords/pkm2","display_name":"PKM2","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ldha","display_name":"LDHA","score":0.9810000061988831},{"id":"https://openalex.org/keywords/sperm-abnormalities","display_name":"sperm abnormalities","score":0.5019999742507935},{"id":"https://openalex.org/keywords/testicular-histopathology","display_name":"testicular histopathology","score":0.625}],"concepts":[{"id":"https://openalex.org/C2780685212","wikidata":"https://www.wikidata.org/wiki/Q5985057","display_name":"Icariin","level":3,"score":0.7177637815475464},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.7164048552513123},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6814597845077515},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6665014624595642},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5253856778144836},{"id":"https://openalex.org/C2777338322","wikidata":"https://www.wikidata.org/wiki/Q280156","display_name":"Male infertility","level":4,"score":0.46317440271377563},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4397861361503601},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.4126686155796051},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.41013067960739136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2827232778072357},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.27661842107772827},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.2639922499656677},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.10418286919593811},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07704585790634155},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07189440727233887},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013091","descriptor_name":"Spermatogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013091","descriptor_name":"Spermatogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013091","descriptor_name":"Spermatogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/mnfr.202200524","doi":"https://doi.org/10.1002/mnfr.202200524","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mnfr.202200524","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mnfr.202200524","source":{"id":"https://openalex.org/S27638457","display_name":"Molecular Nutrition & Food Research","issn_l":"1613-4125","issn":["1613-4125","1613-4133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Nutrition & Food Research","raw_type":"journal-article"},{"id":"pmid:37057609","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37057609","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular nutrition & food research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/mnfr.202200524","doi":"https://doi.org/10.1002/mnfr.202200524","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mnfr.202200524","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mnfr.202200524","source":{"id":"https://openalex.org/S27638457","display_name":"Molecular Nutrition & Food Research","issn_l":"1613-4125","issn":["1613-4125","1613-4133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Nutrition & Food Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4365479280.pdf","grobid_xml":"https://content.openalex.org/works/W4365479280.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1603272910","https://openalex.org/W1998976350","https://openalex.org/W2119276562","https://openalex.org/W6600247312","https://openalex.org/W6601700763","https://openalex.org/W6611801733","https://openalex.org/W6828162038"],"related_works":["https://openalex.org/W2347760180","https://openalex.org/W2379564002","https://openalex.org/W2366259827","https://openalex.org/W2390909690","https://openalex.org/W3146342177","https://openalex.org/W3201517297","https://openalex.org/W3031599465","https://openalex.org/W2351536285","https://openalex.org/W2801018659","https://openalex.org/W4280510465"],"abstract_inverted_index":{"SCOPE:":[0],"Obesity":[1],"is":[2],"a":[3,50,58,74],"global":[4],"threat":[5],"for":[6,20,143,194],"male":[7],"infertility,":[8],"which":[9],"can":[10],"cause":[11],"spermatogenic":[12,83,182],"dysfunction.":[13,26],"However,":[14],"there":[15],"are":[16,47,126,140],"no":[17],"available":[18],"drugs":[19],"the":[21,30,67,80,91,101,107,120,154,160,165,174],"treatment":[22,62,86],"of":[23,33,69,76,82,90,103,109,156,162,167],"obesity-induced":[24],"spermatogenesis":[25,37],"This":[27],"study":[28],"characterizes":[29],"protective":[31,59],"effects":[32],"icariin":[34],"(ICA)":[35],"on":[36],"dysfunction":[38,183],"in":[39,119,177,184],"obese":[40,185],"mice.":[41],"METHODS":[42],"AND":[43],"RESULTS:":[44],"Obese":[45],"mice":[46,186],"induced":[48],"by":[49,99,187],"high-fat":[51],"diet":[52],"to":[53,134],"determine":[54],"whether":[55],"ICA":[56,61,85,144,146,180],"has":[57],"effect.":[60],"reduces":[63,153],"body":[64],"weight":[65],"and":[66,79,93,105,117,139,158,164,170,172],"proportion":[68],"abnormal":[70],"sperm,":[71],"brings":[72],"about":[73],"recovery":[75],"sperm":[77],"count,":[78],"number":[81],"cells.":[84],"improves":[87,147],"histopathological":[88],"changes":[89],"testes":[92],"inhibits":[94],"testicular":[95],"apoptosis,":[96],"as":[97],"evidenced":[98],"reduced":[100],"expression":[102,108,166],"Bax":[104],"increased":[106],"Bcl-2,":[110],"PCNA,":[111],"WT1,":[112],"GATA-4,":[113],"vimentin,":[114],"HK2,":[115,168],"PKM2,":[116,169],"LDHA":[118,171],"testes.":[121],"In":[122],"vitro,":[123],"TM4":[124,150],"cells":[125,151],"treated":[127],"with":[128],"0.4":[129],"mm":[130],"palmitic":[131],"acid":[132],"(PA)":[133],"induce":[135],"Sertoli":[136],"cell":[137],"injury,":[138],"then":[141],"utilized":[142],"treatment.":[145,196],"PA-induced":[148],"decreased":[149],"viability,":[152],"levels":[155,161],"lactate,":[157],"increases":[159],"pyruvate":[163],"restores":[173],"glycolytic":[175,189],"process":[176],"vitro.":[178],"CONCLUSION:":[179],"ameliorates":[181],"regulating":[188],"activity,":[190],"providing":[191],"effective":[192],"strategies":[193],"obesity":[195]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-10-10T00:00:00"}