{"id":"https://openalex.org/W4364320149","doi":"https://doi.org/10.4049/jimmunol.145.10.3155","title":"Frequency of human B cells that differentiate in response to anti-CD3-activated T cells.","display_name":"Frequency of human B cells that differentiate in response to anti-CD3-activated T cells.","publication_year":1990,"publication_date":"1990-11-01","ids":{"openalex":"https://openalex.org/W4364320149","doi":"https://doi.org/10.4049/jimmunol.145.10.3155"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.145.10.3155","doi":"https://doi.org/10.4049/jimmunol.145.10.3155","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.145.10.3155","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091305453","display_name":"K Amoroso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Amoroso","raw_affiliation_strings":["Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center , Dallas, TX 75235","Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center, Dallas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center , Dallas, TX 75235","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center, Dallas 75235","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043874873","display_name":"Peter E. Lipsky","orcid":"https://orcid.org/0000-0002-9287-1676","observed_orcids":["https://orcid.org/0000-0002-9287-1676"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P E Lipsky","raw_affiliation_strings":["Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center , Dallas, TX 75235","Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center, Dallas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center , Dallas, TX 75235","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center, Dallas 75235","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":2.5137,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.90102576,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"145","issue":"10","first_page":"3155","last_page":"3161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/anti-cd3-stimulation","display_name":"anti-CD3 stimulation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/t-cell-help","display_name":"T cell help","score":0.7070000171661377},{"id":"https://openalex.org/keywords/class-switch-recombination","display_name":"class switch recombination","score":0.7699999809265137},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8349999785423279},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.906000018119812},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.972000002861023},{"id":"https://openalex.org/keywords/accessory-cells","display_name":"accessory cells","score":0.8090000152587891},{"id":"https://openalex.org/keywords/t-cell-clones","display_name":"T cell clones","score":0.6589999794960022},{"id":"https://openalex.org/keywords/polyclonal-b-cell-activation","display_name":"polyclonal B cell activation","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.6401841044425964},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6369736790657043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4993462562561035},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.4762972891330719},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.47246503829956055},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.45773911476135254},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.437252938747406},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.4333111345767975},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.4209164083003998},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.41443705558776855},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.3651849329471588},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3300396203994751},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.29311609268188477},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2506408095359802},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22539547085762024},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14726704359054565},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.10264906287193298},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.0844041109085083},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.145.10.3155","doi":"https://doi.org/10.4049/jimmunol.145.10.3155","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.145.10.3155","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1563740483","https://openalex.org/W1533035693","https://openalex.org/W1966813322","https://openalex.org/W1922117764","https://openalex.org/W1550255057","https://openalex.org/W2024648633","https://openalex.org/W1864130549","https://openalex.org/W1987007421","https://openalex.org/W2017942049","https://openalex.org/W1491417940"],"abstract_inverted_index":{"Abstract":[0],"Activation":[1],"of":[2,15,33,60,72,106,115,123,165,180,191,197,205,217,222,236,278,293,302,332],"T":[3,85,90,129,151,161,175,268,322],"cells":[4,19,25,67,75,86,118,125,130,147,211,214,225,264,269,284,323,337],"by":[5,94,142,173,202,266,281,345],"mAb":[6,96],"to":[7,48,97,127,170,238,250,299,338],"the":[8,13,39,104,113,178,189,195,276,291,300,330],"CD3":[9],"molecular":[10],"complex":[11],"induces":[12],"differentiation":[14],"many":[16],"more":[17],"Ig-secreting":[18],"(ISC)":[20],"from":[21],"resting":[22],"human":[23,333],"B":[24,35,62,66,117,124,146,182,198,210,230,263,283,295,336],"in":[26,53,102,311],"bulk":[27],"cultures":[28,171,206,244],"than":[29,156],"do":[30],"other":[31,143],"modes":[32],"polyclonal":[34,144],"cell":[36,78,91,152,199,231,296],"activation.":[37],"In":[38,241],"current":[40],"experiments,":[41,243],"a":[42],"limiting":[43],"dilution":[44],"assay":[45],"was":[46,110,119,131,288],"used":[47],"demonstrate":[49,316],"that":[50,140,290,307,317],"this":[51],"increase":[52,188],"ISC":[54,109,192],"generation":[55,190],"reflects":[56],"an":[57,218],"increased":[58,229],"frequency":[59,114,179],"responding":[61,116,126,181],"cells.":[63],"Highly":[64],"purified":[65],"were":[68,245,255,285],"cultured":[69,148,159],"at":[70],"densities":[71],"between":[73],"1000":[74],"and":[76,112,137,193,226,253,260,341],"0.5":[77],"per":[79],"microwell":[80],"with":[81,149,160,207,233,325],"fresh,":[82],"mitomycin":[83,208],"C-treated":[84,209],"(T":[87],"mito)":[88],"or":[89,168],"clones":[92,153],"stimulated":[93,324],"immobilized":[95,326],"CD3.":[98],"After":[99],"5":[100],"days":[101,252],"culture,":[103],"number":[105],"wells":[107],"containing":[108],"determined,":[111],"calculated.":[120],"The":[121,163,220],"proportion":[122],"anti-CD3-stimulated":[128,150,267],"very":[132],"large":[133],"(10.7":[134],"+/-":[135],"2.8%)":[136],"greatly":[138],"surpassed":[139],"induced":[141,201],"activators.":[145],"responded":[154],"better":[155],"did":[157,186],"those":[158],"mito.":[162],"addition":[164,221],"exogenous":[166],"IL-2":[167,227],"IL-6":[169],"supported":[172],"activated":[174,265],"mito":[176],"enhanced":[177],"cells,":[183],"whereas":[184],"IL-4":[185],"not":[187],"inhibited":[194],"augmentation":[196],"responses":[200],"IL-2.":[203],"Supplementation":[204],"as":[212],"accessory":[213,224],"had":[215],"less":[216],"effect.":[219],"both":[223],"markedly":[228],"responsiveness,":[232],"precursor":[234],"frequencies":[235],"60":[237],"80%":[239],"noted.":[240],"some":[242],"carried":[246],"out":[247],"for":[248,257],"7":[249],"14":[251],"supernatants":[254],"analyzed":[256],"IgM,":[258],"IgG,":[259],"IgA":[261],"secretion.":[262],"produced":[270,280],"all":[271],"three":[272],"Ig":[273,279,304,340],"isotypes.":[274],"When":[275],"classes":[277],"single":[282],"examined,":[286],"it":[287],"observed":[289],"stimulation":[292],"individual":[294],"precursors":[297],"led":[298],"production":[301],"multiple":[303],"isotypes,":[305],"suggesting":[306],"isotype":[308,343],"switching":[309,344],"occurs":[310],"these":[312],"cultures.":[313],"These":[314],"results":[315],"under":[318],"optimum":[319],"culture":[320],"conditions,":[321],"anti-CD3":[327],"can":[328],"activate":[329],"majority":[331],"peripheral":[334],"blood":[335],"produce":[339],"induce":[342],"many.":[346]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2023-04-12T00:00:00"}
