{"id":"https://openalex.org/W4363674582","doi":"https://doi.org/10.1016/j.biopsych.2023.02.207","title":"24. Examining the Complex Phenotypic Architecture of Tic Disorders in a Large Clinical Biobank","display_name":"24. Examining the Complex Phenotypic Architecture of Tic Disorders in a Large Clinical Biobank","publication_year":2023,"publication_date":"2023-04-10","ids":{"openalex":"https://openalex.org/W4363674582","doi":"https://doi.org/10.1016/j.biopsych.2023.02.207"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopsych.2023.02.207","doi":"https://doi.org/10.1016/j.biopsych.2023.02.207","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1016/j.biopsych.2023.02.207","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016826447","display_name":"Tyne W. Miller\u2010Fleming","orcid":"https://orcid.org/0000-0002-0398-5162","observed_orcids":["https://orcid.org/0000-0002-0398-5162"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyne Miller-Fleming","raw_affiliation_strings":["Vanderbilt University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University Medical Center","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045002668","display_name":"Emily Gantz","orcid":"https://orcid.org/0000-0002-2537-8742","observed_orcids":["https://orcid.org/0000-0002-2537-8742"]},"institutions":[{"id":"https://openalex.org/I320755355","display_name":"Children's of Alabama","ror":"https://ror.org/053bp9m60","country_code":"US","type":"funder","lineage":["https://openalex.org/I320755355"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Gantz","raw_affiliation_strings":["Children\u2019s Hospital of Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital of Alabama","institution_ids":["https://openalex.org/I320755355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101616267","display_name":"Dongmei Yu","orcid":"https://orcid.org/0000-0003-4380-1185","observed_orcids":["https://orcid.org/0000-0003-4380-1185"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dongmei Yu","raw_affiliation_strings":["Center for Human Genetics Research, Massachusetts General Hospital, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics Research, Massachusetts General Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046475243","display_name":"David Alan Isaacs","orcid":"https://orcid.org/0000-0002-9860-1052","observed_orcids":["https://orcid.org/0000-0002-9860-1052"]},"institutions":[{"id":"https://openalex.org/I1299406639","display_name":"Monroe Carell Jr. Children's Hospital","ror":"https://ror.org/00y64dx33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299406639","https://openalex.org/I4210162197","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Isaacs","raw_affiliation_strings":["Vanderbilt University Medical Center, Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University Medical Center, Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt","institution_ids":["https://openalex.org/I1299406639","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085647098","display_name":"Carol A. Mathews","orcid":"https://orcid.org/0000-0003-2208-7058","observed_orcids":["https://orcid.org/0000-0003-2208-7058"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol A. Mathews","raw_affiliation_strings":["University of Florida Genetics Institute, University of Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida Genetics Institute, University of Florida","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079732116","display_name":"Jeremiah M. Scharf","orcid":"https://orcid.org/0000-0002-4742-5896","observed_orcids":["https://orcid.org/0000-0002-4742-5896"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremiah M. Scharf","raw_affiliation_strings":["Center for Human Genetics Research, Massachusetts General Hospital, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics Research, Massachusetts General Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045051798","display_name":"Lea Karatheodoris Davis","orcid":"https://orcid.org/0000-0001-5143-2282","observed_orcids":["https://orcid.org/0000-0001-5143-2282"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lea K. Davis","raw_affiliation_strings":["Vanderbilt University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University Medical Center","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04805585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"93","issue":"9","first_page":"S79","last_page":"S79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tic-disorders","display_name":"tic disorders","score":0.9990000128746033},{"id":"https://openalex.org/keywords/electronic-health-records","display_name":"electronic health records","score":0.8320000171661377},{"id":"https://openalex.org/keywords/psychiatric-comorbidity","display_name":"psychiatric comorbidity","score":0.8629999756813049},{"id":"https://openalex.org/keywords/clinical-correlates","display_name":"clinical correlates","score":0.7039999961853027},{"id":"https://openalex.org/keywords/etiology","display_name":"etiology","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.9492050409317017},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.6979362964630127},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6801052093505859},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.5758931636810303},{"id":"https://openalex.org/C3020646490","wikidata":"https://www.wikidata.org/wiki/Q25203551","display_name":"Clinical phenotype","level":4,"score":0.5737529993057251},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41431623697280884},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.30633026361465454},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2899835705757141},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23155498504638672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15134063363075256},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12383070588111877},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07984042167663574},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.06582775712013245}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.biopsych.2023.02.207","doi":"https://doi.org/10.1016/j.biopsych.2023.02.207","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1016/j.biopsych.2023.02.207","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5199999809265137}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4401062749","https://openalex.org/W4387496638","https://openalex.org/W4296852854","https://openalex.org/W4407947281","https://openalex.org/W3031156395","https://openalex.org/W2418857415","https://openalex.org/W7163383833","https://openalex.org/W2372603292","https://openalex.org/W2924276064","https://openalex.org/W3123339397"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-04-11T00:00:00"}