{"id":"https://openalex.org/W4363674050","doi":"https://doi.org/10.3390/ijms24086986","title":"Genetic Polymorphisms of ENPP2 Are Possibly Associated with Pain Severity and Opioid Dose Requirements in Patients with Inflammatory Pain Conditions: Clinical Observation Study","display_name":"Genetic Polymorphisms of ENPP2 Are Possibly Associated with Pain Severity and Opioid Dose Requirements in Patients with Inflammatory Pain Conditions: Clinical Observation Study","publication_year":2023,"publication_date":"2023-04-10","ids":{"openalex":"https://openalex.org/W4363674050","doi":"https://doi.org/10.3390/ijms24086986","pmid":"https://pubmed.ncbi.nlm.nih.gov/37108150","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10139129"},"language":"en","primary_location":{"id":"doi:10.3390/ijms24086986","doi":"https://doi.org/10.3390/ijms24086986","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms24086986","pdf_url":"https://www.mdpi.com/1422-0067/24/8/6986/pdf?version=1681105784","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/24/8/6986/pdf?version=1681105784","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005474653","display_name":"Rikuhei Tsuchida","orcid":"https://orcid.org/0000-0003-2274-7917","observed_orcids":["https://orcid.org/0000-0003-2274-7917"]},"institutions":[{"id":"https://openalex.org/I4210109338","display_name":"University of Tokyo Hospital","ror":"https://ror.org/022cvpj02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210109338"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rikuhei Tsuchida","raw_affiliation_strings":["Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Hongo 7-3-1, Bunkyoku, Tokyo 113-8655, Japan"],"raw_orcid":"https://orcid.org/0000-0003-2274-7917","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Hongo 7-3-1, Bunkyoku, Tokyo 113-8655, Japan","institution_ids":["https://openalex.org/I4210109338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083932043","display_name":"Daisuke Nishizawa","orcid":"https://orcid.org/0000-0001-8286-4651","observed_orcids":["https://orcid.org/0000-0001-8286-4651"]},"institutions":[{"id":"https://openalex.org/I4210098918","display_name":"Tokyo Metropolitan Institute of Medical Science","ror":"https://ror.org/00vya8493","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210098918"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Nishizawa","raw_affiliation_strings":["Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Kami Kitazawa 2-1-6, Setagayaku, Tokyo 156-0057, Japan"],"raw_orcid":"https://orcid.org/0000-0001-8286-4651","affiliations":[{"raw_affiliation_string":"Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Kami Kitazawa 2-1-6, Setagayaku, Tokyo 156-0057, Japan","institution_ids":["https://openalex.org/I4210098918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068152127","display_name":"Ken\u2010ichi Fukuda","orcid":"https://orcid.org/0000-0003-3522-746X","observed_orcids":["https://orcid.org/0000-0003-3522-746X"]},"institutions":[{"id":"https://openalex.org/I149564915","display_name":"Tokyo Dental College","ror":"https://ror.org/0220f5b41","country_code":"JP","type":"education","lineage":["https://openalex.org/I149564915"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken-ichi Fukuda","raw_affiliation_strings":["Department of Oral Health and Clinical Science, Tokyo Dental College, Kanda Misakichou 2-9-18, Chiyodaku, Tokyo 101-0061, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Health and Clinical Science, Tokyo Dental College, Kanda Misakichou 2-9-18, Chiyodaku, Tokyo 101-0061, Japan","institution_ids":["https://openalex.org/I149564915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028341445","display_name":"Tatsuya Ichinohe","orcid":"https://orcid.org/0000-0001-5793-3379","observed_orcids":["https://orcid.org/0000-0001-5793-3379"]},"institutions":[{"id":"https://openalex.org/I149564915","display_name":"Tokyo Dental College","ror":"https://ror.org/0220f5b41","country_code":"JP","type":"education","lineage":["https://openalex.org/I149564915"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuya Ichinohe","raw_affiliation_strings":["Department of Dental Anesthesiology, Tokyo Dental College, Kanda Misakichou 2-9-18, Chiyodaku, Tokyo 101-0061, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dental Anesthesiology, Tokyo Dental College, Kanda Misakichou 2-9-18, Chiyodaku, Tokyo 101-0061, Japan","institution_ids":["https://openalex.org/I149564915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029321254","display_name":"Kuniyuki Kano","orcid":"https://orcid.org/0000-0002-4539-5750","observed_orcids":["https://orcid.org/0000-0002-4539-5750"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kuniyuki Kano","raw_affiliation_strings":["Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7-3-1, Bunkyoku, Tokyo 113-8655, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4539-5750","affiliations":[{"raw_affiliation_string":"Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7-3-1, Bunkyoku, Tokyo 113-8655, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077332068","display_name":"Makoto Kurano","orcid":"https://orcid.org/0000-0002-2596-1145","observed_orcids":["https://orcid.org/0000-0002-2596-1145"]},"institutions":[{"id":"https://openalex.org/I4210109338","display_name":"University of Tokyo Hospital","ror":"https://ror.org/022cvpj02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210109338"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Kurano","raw_affiliation_strings":["Department of Clinical Laboratory Medicine, The University of Tokyo Hospital, Hongo 7-3-1, Bunkyoku, Tokyo 113-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Medicine, The University of Tokyo Hospital, Hongo 7-3-1, Bunkyoku, Tokyo 113-8655, Japan","institution_ids":["https://openalex.org/I4210109338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061947606","display_name":"Kazutaka Ikeda","orcid":"https://orcid.org/0000-0001-8342-0278","observed_orcids":["https://orcid.org/0000-0001-8342-0278"]},"institutions":[{"id":"https://openalex.org/I4210098918","display_name":"Tokyo Metropolitan Institute of Medical Science","ror":"https://ror.org/00vya8493","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210098918"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazutaka Ikeda","raw_affiliation_strings":["Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Kami Kitazawa 2-1-6, Setagayaku, Tokyo 156-0057, Japan"],"raw_orcid":"https://orcid.org/0000-0001-8342-0278","affiliations":[{"raw_affiliation_string":"Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Kami Kitazawa 2-1-6, Setagayaku, Tokyo 156-0057, Japan","institution_ids":["https://openalex.org/I4210098918"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013210055","display_name":"Masahiko Sumitani","orcid":"https://orcid.org/0000-0002-3662-8217","observed_orcids":["https://orcid.org/0000-0002-3662-8217"]},"institutions":[{"id":"https://openalex.org/I4210109338","display_name":"University of Tokyo Hospital","ror":"https://ror.org/022cvpj02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210109338"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masahiko Sumitani","raw_affiliation_strings":["Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Hongo 7-3-1, Bunkyoku, Tokyo 113-8655, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3662-8217","affiliations":[{"raw_affiliation_string":"Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Hongo 7-3-1, Bunkyoku, Tokyo 113-8655, Japan","institution_ids":["https://openalex.org/I4210109338"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5013210055"],"corresponding_institution_ids":["https://openalex.org/I4210109338"],"apc_list":{"value":2500,"currency":"CHF","value_usd":2780},"apc_paid":{"value":2500,"currency":"CHF","value_usd":2780},"fwci":0.7062,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.66763608,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"24","issue":"8","first_page":"6986","last_page":"6986"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.490200012922287,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.490200012922287,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.2919999957084656,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.07909999787807465,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autotaxin","display_name":"autotaxin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9800000190734863},{"id":"https://openalex.org/keywords/postoperative-pain","display_name":"postoperative pain","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cancer-pain","display_name":"cancer pain","score":0.9200000166893005},{"id":"https://openalex.org/keywords/nociceptive-pain","display_name":"nociceptive pain","score":0.7860000133514404},{"id":"https://openalex.org/keywords/pain-intensity","display_name":"pain intensity","score":0.5979999899864197},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.5149999856948853},{"id":"https://openalex.org/keywords/cosmetic-surgery","display_name":"cosmetic surgery","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.7177184224128723},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6642428040504456},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.5902255177497864},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.47448304295539856},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.4673265516757965},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40505409240722656},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3306035101413727},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.16489404439926147},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1438690721988678},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10717520117759705},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.10554173588752747},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08515706658363342},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072716","descriptor_name":"Cancer Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000072716","descriptor_name":"Cancer Pain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010149","descriptor_name":"Postoperative Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010149","descriptor_name":"Postoperative Pain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059226","descriptor_name":"Nociceptive Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms24086986","doi":"https://doi.org/10.3390/ijms24086986","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms24086986","pdf_url":"https://www.mdpi.com/1422-0067/24/8/6986/pdf?version=1681105784","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10139129","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10139129","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10139129/pdf/ijms-24-06986.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:37108150","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37108150","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms24086986","doi":"https://doi.org/10.3390/ijms24086986","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms24086986","pdf_url":"https://www.mdpi.com/1422-0067/24/8/6986/pdf?version=1681105784","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G14077756","display_name":"Identification of genetic factors involved in effects and side-effects of pain treatment in cancer patients and its application to palliative care","funder_award_id":"20K09259","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2652676044","display_name":"Downstream signaling of G protein-coupled receptors  in chemotherapy-induced peripheral neuropathy","funder_award_id":"21K20983","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3722974591","display_name":null,"funder_award_id":"22ek0610028h0001","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4151903707","display_name":null,"funder_award_id":"AC220035","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5218953072","display_name":null,"funder_award_id":"22ek0610028h0001","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G6671050781","display_name":null,"funder_award_id":"AC220035","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G7552513367","display_name":"Genetic mechanisms of individual differences in onset vulnerability and treatment responsiveness in chronic pain","funder_award_id":"23K21457","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7857626140","display_name":null,"funder_award_id":"21K20983","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G848843139","display_name":"Advanced Animal Model Support","funder_award_id":"16H06276","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320309995","display_name":"Nihon University","ror":"https://ror.org/05jk51a88"},{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320322057","display_name":"National Rehabilitation Center","ror":"https://ror.org/04yt6jn66"},{"id":"https://openalex.org/F4320322832","display_name":"University of Tokyo","ror":"https://ror.org/057zh3y96"},{"id":"https://openalex.org/F4320323453","display_name":"Hyogo College of Medicine","ror":"https://ror.org/001yc7927"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4363674050.pdf","grobid_xml":"https://content.openalex.org/works/W4363674050.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W188392171","https://openalex.org/W1518834655","https://openalex.org/W1568436538","https://openalex.org/W1671871957","https://openalex.org/W1776576701","https://openalex.org/W1973065882","https://openalex.org/W1978626885","https://openalex.org/W1984486655","https://openalex.org/W1986843604","https://openalex.org/W1992203600","https://openalex.org/W2008303551","https://openalex.org/W2017462460","https://openalex.org/W2018579572","https://openalex.org/W2045850572","https://openalex.org/W2047737161","https://openalex.org/W2067358134","https://openalex.org/W2079146831","https://openalex.org/W2094210837","https://openalex.org/W2108087274","https://openalex.org/W2108812575","https://openalex.org/W2157351482","https://openalex.org/W2169294950","https://openalex.org/W2518893499","https://openalex.org/W2611903851","https://openalex.org/W2764151966","https://openalex.org/W2793282416","https://openalex.org/W2793982827","https://openalex.org/W2896712746","https://openalex.org/W2900222741","https://openalex.org/W2905421366","https://openalex.org/W2953280267","https://openalex.org/W2955830011","https://openalex.org/W3016688597","https://openalex.org/W3024279011","https://openalex.org/W3107675069","https://openalex.org/W3124806647","https://openalex.org/W3129513166","https://openalex.org/W3165839355","https://openalex.org/W4288436653","https://openalex.org/W4296613154","https://openalex.org/W4303515891"],"related_works":["https://openalex.org/W2611903851","https://openalex.org/W3124806647","https://openalex.org/W3003631547","https://openalex.org/W2094585402","https://openalex.org/W3168842659","https://openalex.org/W2042931174","https://openalex.org/W2466055935","https://openalex.org/W2792115115","https://openalex.org/W2074524706","https://openalex.org/W2030592464"],"abstract_inverted_index":{"Autotaxin,":[0],"encoded":[1],"by":[2],"the":[3,25,51,60,66,77,101,109,128,135,138,142,192],"ENPP2":[4,102],"gene,":[5],"is":[6,185],"a":[7,89,158],"known":[8],"key":[9],"element":[10],"of":[11,100,114,141,163,194],"neuropathic":[12],"pain;":[13],"however,":[14],"its":[15],"involvement":[16],"in":[17,42,79],"nociceptive":[18,188],"pain":[19,29,70,130,151,166,189],"processing":[20,190],"remains":[21],"unclear.":[22],"We":[23],"explored":[24],"associations":[26,61],"between":[27,62],"postoperative":[28,32,124,129],"intensity,":[30],"24-h":[31],"opioid":[33,74,125,177,195],"dose":[34],"requirements,":[35],"and":[36,54,69,72,104,118,191],"93":[37],"ENNP2-gene":[38],"single-nucleotide":[39],"polymorphisms":[40],"(SNPs)":[41],"362":[43],"healthy":[44],"patients":[45,81,169],"who":[46],"underwent":[47],"cosmetic":[48],"surgery":[49],"using":[50,174],"dominant,":[52],"recessive,":[53],"genotypic":[55],"models.":[56,107],"Next,":[57],"we":[58],"validated":[59],"relevant":[63,98],"SNPs":[64,99,116,144],"on":[65,76,96],"one":[67],"hand":[68],"intensity":[71,131,152],"daily":[73,176],"dosages":[75],"other":[78,171],"89":[80],"with":[82,123,149,157,168,170,187],"cancer-related":[83],"pain.":[84],"In":[85,108,134],"this":[86],"validation":[87,136],"study,":[88,111,137],"Bonferroni":[90],"correction":[91],"for":[92],"multiplicity":[93],"was":[94,132],"applied":[95],"all":[97],"gene":[103],"their":[105],"respective":[106],"exploratory":[110],"three":[112,139],"models":[113,140],"two":[115,143],"(rs7832704":[117],"rs2249015)":[119],"were":[120,145],"significantly":[121,147],"associated":[122,148,186],"doses,":[126],"although":[127],"comparable.":[133],"also":[146],"cancer":[150],"(p":[153],"<":[154],"0.017).":[155],"Patients":[156],"minor":[159],"allele":[160],"homozygosity":[161],"complained":[162],"more":[164],"severe":[165],"compared":[167],"genotypes":[172],"when":[173],"comparable":[175],"doses.":[178],"Our":[179],"findings":[180],"might":[181],"suggest":[182],"that":[183],"autotaxin":[184],"regulation":[193],"requirements.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-04-11T00:00:00"}