{"id":"https://openalex.org/W4363673922","doi":"https://doi.org/10.3390/antibiotics12040735","title":"A Novel Zinc (II) Porphyrin Is Synergistic with PEV2 Bacteriophage against Pseudomonas aeruginosa Infections","display_name":"A Novel Zinc (II) Porphyrin Is Synergistic with PEV2 Bacteriophage against Pseudomonas aeruginosa Infections","publication_year":2023,"publication_date":"2023-04-10","ids":{"openalex":"https://openalex.org/W4363673922","doi":"https://doi.org/10.3390/antibiotics12040735","pmid":"https://pubmed.ncbi.nlm.nih.gov/37107097","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10135120"},"language":"en","primary_location":{"id":"doi:10.3390/antibiotics12040735","doi":"https://doi.org/10.3390/antibiotics12040735","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antibiotics12040735","pdf_url":"https://www.mdpi.com/2079-6382/12/4/735/pdf?version=1681112501","source":{"id":"https://openalex.org/S2736332253","display_name":"Antibiotics","issn_l":"2079-6382","issn":["2079-6382"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibiotics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-6382/12/4/735/pdf?version=1681112501","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018337274","display_name":"Jessica Geyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127591826","display_name":"University of Dayton","ror":"https://ror.org/021v3qy27","country_code":"US","type":"education","lineage":["https://openalex.org/I127591826"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Geyer","raw_affiliation_strings":["Department of Biology, University of Dayton, Dayton, OH 45469, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Dayton, Dayton, OH 45469, USA","institution_ids":["https://openalex.org/I127591826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108834128","display_name":"Kristen A. Krupa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127591826","display_name":"University of Dayton","ror":"https://ror.org/021v3qy27","country_code":"US","type":"education","lineage":["https://openalex.org/I127591826"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen A. Krupa","raw_affiliation_strings":["Department of Chemical and Materials Engineering, University of Dayton, Dayton, OH 45469, USA","Integrated Science and Engineering Center, University of Dayton, Dayton, OH 45469, USA"],"raw_orcid":"https://orcid.org/0000-0002-4865-1342","affiliations":[{"raw_affiliation_string":"Department of Chemical and Materials Engineering, University of Dayton, Dayton, OH 45469, USA","institution_ids":["https://openalex.org/I127591826"]},{"raw_affiliation_string":"Integrated Science and Engineering Center, University of Dayton, Dayton, OH 45469, USA","institution_ids":["https://openalex.org/I127591826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065504174","display_name":"Zachary M. Harris","orcid":"https://orcid.org/0000-0002-7350-7211","observed_orcids":["https://orcid.org/0000-0002-7350-7211"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary M. Harris","raw_affiliation_strings":["Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076136205","display_name":"Ying Hui Sun","orcid":"https://orcid.org/0000-0002-2570-9206","observed_orcids":["https://orcid.org/0000-0002-2570-9206","https://orcid.org/0000-0001-9063-0409"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Sun","raw_affiliation_strings":["Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003399137","display_name":"Lokesh Sharma","orcid":"https://orcid.org/0000-0003-3040-9029","observed_orcids":["https://orcid.org/0000-0003-3040-9029"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lokesh Sharma","raw_affiliation_strings":["Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017750544","display_name":"Silvia M. W\u00fcrstle","orcid":"https://orcid.org/0000-0003-0787-3894","observed_orcids":["https://orcid.org/0000-0003-0787-3894"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Silvia W\u00fcrstle","raw_affiliation_strings":["School of Medicine, Technical University of Munich, 81675 Munich, Germany","Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA"],"raw_orcid":"https://orcid.org/0000-0003-0787-3894","affiliations":[{"raw_affiliation_string":"School of Medicine, Technical University of Munich, 81675 Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044521727","display_name":"Buqu Hu","orcid":"https://orcid.org/0000-0001-7233-987X","observed_orcids":["https://orcid.org/0000-0001-7233-987X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Buqu Hu","raw_affiliation_strings":["Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108298622","display_name":"Gail Stanley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gail Stanley","raw_affiliation_strings":["Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104490805","display_name":"Govindarajan Rajagopalan","orcid":"https://orcid.org/0000-0003-4914-8746","observed_orcids":["https://orcid.org/0000-0003-4914-8746","https://orcid.org/0000-0003-2608-8162"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Govindarajan Rajagopalan","raw_affiliation_strings":["Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044469534","display_name":"Erin Elise Pellot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127591826","display_name":"University of Dayton","ror":"https://ror.org/021v3qy27","country_code":"US","type":"education","lineage":["https://openalex.org/I127591826"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin Pellot","raw_affiliation_strings":["Department of Biology, University of Dayton, Dayton, OH 45469, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Dayton, Dayton, OH 45469, USA","institution_ids":["https://openalex.org/I127591826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086135270","display_name":"Jonathan L. Koff","orcid":"https://orcid.org/0000-0003-3240-3173","observed_orcids":["https://orcid.org/0000-0003-3240-3173"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan L. Koff","raw_affiliation_strings":["Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110022127","display_name":"Jayne B. Robinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127591826","display_name":"University of Dayton","ror":"https://ror.org/021v3qy27","country_code":"US","type":"education","lineage":["https://openalex.org/I127591826"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jayne B. Robinson","raw_affiliation_strings":["Department of Biology, University of Dayton, Dayton, OH 45469, USA","Integrated Science and Engineering Center, University of Dayton, Dayton, OH 45469, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Dayton, Dayton, OH 45469, USA","institution_ids":["https://openalex.org/I127591826"]},{"raw_affiliation_string":"Integrated Science and Engineering Center, University of Dayton, Dayton, OH 45469, USA","institution_ids":["https://openalex.org/I127591826"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110022127"],"corresponding_institution_ids":["https://openalex.org/I127591826"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2447},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2447},"fwci":0.4323,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.5030302,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"12","issue":"4","first_page":"735","last_page":"735"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.33570000529289246,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.05869999900460243,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zinc-porphyrin","display_name":"zinc porphyrin","score":0.9200000166893005},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.6050000190734863},{"id":"https://openalex.org/keywords/pulmonary-infection","display_name":"pulmonary infection","score":0.5690000057220459},{"id":"https://openalex.org/keywords/biofilm-disassembly","display_name":"biofilm disassembly","score":0.7039999961853027},{"id":"https://openalex.org/keywords/extracellular-dna","display_name":"extracellular DNA","score":0.9480000138282776},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.8431406021118164},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7900100946426392},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.7430083155632019},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.6617540121078491},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.5775109529495239},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5553354024887085},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5386862754821777},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.5298804044723511},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4545019567012787},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.4521678388118744},{"id":"https://openalex.org/C2779256223","wikidata":"https://www.wikidata.org/wiki/Q611870","display_name":"Phage therapy","level":5,"score":0.4505494236946106},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.4481198787689209},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43639451265335083},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4113868176937103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3607152998447418},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3341570794582367},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2808457314968109},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.16383323073387146},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.131020188331604},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06875365972518921},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3390/antibiotics12040735","doi":"https://doi.org/10.3390/antibiotics12040735","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antibiotics12040735","pdf_url":"https://www.mdpi.com/2079-6382/12/4/735/pdf?version=1681112501","source":{"id":"https://openalex.org/S2736332253","display_name":"Antibiotics","issn_l":"2079-6382","issn":["2079-6382"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibiotics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10135120","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10135120","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10135120/pdf/antibiotics-12-00735.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibiotics (Basel)","raw_type":"Text"},{"id":"pmid:37107097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37107097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibiotics (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.cedarville.edu:science_and_mathematics_publications-1418","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.cedarville.edu/science_and_mathematics_publications/418","pdf_url":null,"source":{"id":"https://openalex.org/S4377196552","display_name":"DigitalCommons-Cedarville (Cedarville University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169138485","host_organization_name":"Cedarville University","host_organization_lineage":["https://openalex.org/I169138485"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Science and Mathematics Faculty Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:86542ffb76884897a7d2ad93480d244d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/86542ffb76884897a7d2ad93480d244d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antibiotics, Vol 12, Iss 4, p 735 (2023)","raw_type":"article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1752444","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1752444","pdf_url":null,"source":{"id":"https://openalex.org/S4306400453","display_name":"mediaTUM \u2013 the media and publications repository of the Technical University Munich (Technical University Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/antibiotics12040735","doi":"https://doi.org/10.3390/antibiotics12040735","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antibiotics12040735","pdf_url":"https://www.mdpi.com/2079-6382/12/4/735/pdf?version=1681112501","source":{"id":"https://openalex.org/S2736332253","display_name":"Antibiotics","issn_l":"2079-6382","issn":["2079-6382"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibiotics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000905448","display_name":"Yale Clinical and Translational Science Award","funder_award_id":"UL1TR001863","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308380","display_name":"Yale University","ror":"https://ror.org/03v76x132"},{"id":"https://openalex.org/F4320310486","display_name":"University of Dayton","ror":"https://ror.org/021v3qy27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4363673922.pdf","grobid_xml":"https://content.openalex.org/works/W4363673922.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1963956238","https://openalex.org/W1979531581","https://openalex.org/W1997419062","https://openalex.org/W2001330064","https://openalex.org/W2015789053","https://openalex.org/W2018989138","https://openalex.org/W2037221728","https://openalex.org/W2042581629","https://openalex.org/W2053391951","https://openalex.org/W2073330771","https://openalex.org/W2075287054","https://openalex.org/W2079032703","https://openalex.org/W2090540974","https://openalex.org/W2090817404","https://openalex.org/W2109434556","https://openalex.org/W2115933619","https://openalex.org/W2169565674","https://openalex.org/W2252374742","https://openalex.org/W2291776655","https://openalex.org/W2480623096","https://openalex.org/W2556738030","https://openalex.org/W2560894648","https://openalex.org/W2567799817","https://openalex.org/W2588657365","https://openalex.org/W2754163809","https://openalex.org/W2789525784","https://openalex.org/W2897109701","https://openalex.org/W2902947966","https://openalex.org/W2903381708","https://openalex.org/W2911362701","https://openalex.org/W2946458716","https://openalex.org/W2949821442","https://openalex.org/W2954110626","https://openalex.org/W2969242303","https://openalex.org/W2979558755","https://openalex.org/W2980479873","https://openalex.org/W2987135928","https://openalex.org/W2990357591","https://openalex.org/W3005021171","https://openalex.org/W3016146168","https://openalex.org/W3036922684","https://openalex.org/W3089747452","https://openalex.org/W3093507631","https://openalex.org/W3112580549","https://openalex.org/W3114978647","https://openalex.org/W3120225898","https://openalex.org/W3120416717","https://openalex.org/W3132485249","https://openalex.org/W3138023999","https://openalex.org/W3161878333","https://openalex.org/W3192908650","https://openalex.org/W3195708026","https://openalex.org/W4211163608","https://openalex.org/W4225163976","https://openalex.org/W4241111610","https://openalex.org/W4297263068","https://openalex.org/W4308175313","https://openalex.org/W7018024671"],"related_works":["https://openalex.org/W7036692512","https://openalex.org/W7049079121","https://openalex.org/W3037415690","https://openalex.org/W3112580549","https://openalex.org/W7067543698","https://openalex.org/W4300865254","https://openalex.org/W3107162773","https://openalex.org/W4300865632","https://openalex.org/W3206432131","https://openalex.org/W3132993584"],"abstract_inverted_index":{"(PsA)":[0],"is":[1,162],"an":[2,92,104,121],"opportunistic":[3],"bacterial":[4],"pathogen":[5],"that":[6,46,79],"causes":[7],"life-threatening":[8],"infections":[9],"in":[10,85,88,93,120,123,128,192],"individuals":[11],"with":[12,22,71,103,183],"compromised":[13],"immune":[14],"systems":[15],"and":[16,60,64,180],"exacerbates":[17],"health":[18],"concerns":[19],"for":[20],"those":[21],"cystic":[23],"fibrosis":[24],"(CF).":[25],"PsA":[26,62,86,97,119],"rapidly":[27],"develops":[28],"antibiotic":[29],"resistance;":[30],"thus,":[31],"novel":[32,48],"therapeutics":[33],"are":[34],"urgently":[35],"needed":[36],"to":[37,151,165],"effectively":[38],"combat":[39],"this":[40],"pathogen.":[41],"Previously,":[42],"we":[43,77],"have":[44],"shown":[45],"a":[47,82,188],"cationic":[49],"Zinc":[50],"(II)":[51],"porphyrin":[52],"(ZnPor)":[53],"has":[54],"potent":[55],"bactericidal":[56,143],"activity":[57],"against":[58,118],"planktonic":[59],"biofilm-associated":[61],"cells,":[63],"disassembles":[65],"the":[66,74,141,175,193],"biofilm":[67],"matrix":[68],"via":[69],"interactions":[70],"eDNA":[72],"In":[73],"present":[75],"study,":[76],"report":[78],"ZnPor":[80,109,147,178],"caused":[81],"significant":[83],"decrease":[84],"populations":[87],"mouse":[89],"lungs":[90],"within":[91],"vivo":[94],"model":[95,126],"of":[96,131,146,177,195],"pulmonary":[98],"infection.":[99],"Additionally,":[100],"when":[101],"combined":[102],"obligately":[105],"lytic":[106],"phage":[107],"PEV2,":[108,184],"at":[110],"its":[111,181],"minimum":[112,142],"inhibitory":[113],"concentration":[114,144],"(MIC)":[115],"displayed":[116],"synergy":[117,156,182],"established":[122],"vitro":[124],"lung":[125,133],"resulting":[127],"greater":[129],"protection":[130],"H441":[132,152],"cells":[134],"versus":[135],"either":[136],"treatment":[137,194],"alone.":[138],"Concentrations":[139],"above":[140],"(MBC)":[145],"were":[148],"not":[149],"toxic":[150],"cells;":[153],"however,":[154],"no":[155],"was":[157],"observed.":[158],"This":[159],"dose-dependent":[160],"response":[161],"likely":[163],"due":[164],"ZnPor's":[166],"antiviral":[167],"activity,":[168],"reported":[169],"herein.":[170],"Together,":[171],"these":[172],"findings":[173],"show":[174],"utility":[176],"alone,":[179],"which":[185],"could":[186],"be":[187],"tunable":[189],"combination":[190],"used":[191],"antibiotic-resistant":[196],"infections.":[197]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-11T00:00:00"}