{"id":"https://openalex.org/W4362734068","doi":"https://doi.org/10.1016/j.biopsych.2023.02.054","title":"The Brain Age Gap and Genetic Liability for Depression and Inflammation","display_name":"The Brain Age Gap and Genetic Liability for Depression and Inflammation","publication_year":2023,"publication_date":"2023-04-10","ids":{"openalex":"https://openalex.org/W4362734068","doi":"https://doi.org/10.1016/j.biopsych.2023.02.054"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopsych.2023.02.054","doi":"https://doi.org/10.1016/j.biopsych.2023.02.054","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biopsych.2023.02.054","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005159847","display_name":"Laura K. M. Han","orcid":"https://orcid.org/0000-0001-9647-3723","observed_orcids":["https://orcid.org/0000-0001-9647-3723"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Laura Han","raw_affiliation_strings":["Centre for Youth Mental Health, The University of Melbourne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Youth Mental Health, The University of Melbourne","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051131181","display_name":"Yara Jo Toenders","orcid":"https://orcid.org/0000-0002-4117-1143","observed_orcids":["https://orcid.org/0000-0002-4117-1143"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Yara Toenders","raw_affiliation_strings":["Leiden University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044140634","display_name":"Xueyi Shen","orcid":"https://orcid.org/0000-0002-0538-4774","observed_orcids":["https://orcid.org/0000-0002-0538-4774"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Xueyi Shen","raw_affiliation_strings":["University of Edinburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Edinburgh","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051193242","display_name":"Yuri Milaneschi","orcid":"https://orcid.org/0000-0002-3697-6617","observed_orcids":["https://orcid.org/0000-0002-3697-6617"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Yuri Milaneschi","raw_affiliation_strings":["Amsterdam UMC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amsterdam UMC","institution_ids":["https://openalex.org/I4210151833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089456652","display_name":"Heather Clare Whalley","orcid":"https://orcid.org/0000-0002-4505-8869","observed_orcids":["https://orcid.org/0000-0002-4505-8869","https://orcid.org/0000-0001-8967-683X"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Heather Whalley","raw_affiliation_strings":["University of Edinburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Edinburgh","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006025400","display_name":"Lianne Schmaal","orcid":"https://orcid.org/0000-0001-9822-048X","observed_orcids":["https://orcid.org/0000-0001-9822-048X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lianne Schmaal","raw_affiliation_strings":["Centre for Youth Mental Health, The University of Melbourne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Youth Mental Health, The University of Melbourne","institution_ids":["https://openalex.org/I165779595"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":0.2578,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.4335558,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"93","issue":"9","first_page":"S14","last_page":"S14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6190999746322632,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6190999746322632,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.09690000116825104,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.06889999657869339,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-age-gap","display_name":"brain age gap","score":0.9869999885559082},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9549999833106995},{"id":"https://openalex.org/keywords/polygenic-risk","display_name":"polygenic risk","score":0.8230000138282776},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8019999861717224},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.6930000185966492},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/structural-brain-changes","display_name":"brain structural changes","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.7398409247398376},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.6089411377906799},{"id":"https://openalex.org/C2993137441","wikidata":"https://www.wikidata.org/wiki/Q28135712","display_name":"Polygenic risk score","level":5,"score":0.5855446457862854},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4396047294139862},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3882220387458801},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.36711961030960083},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35964810848236084},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35949942469596863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22379177808761597},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.20337417721748352},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.19203338027000427},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15599459409713745},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.14834988117218018},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12003830075263977},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.biopsych.2023.02.054","doi":"https://doi.org/10.1016/j.biopsych.2023.02.054","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biopsych.2023.02.054","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7017403005","https://openalex.org/W4412990587","https://openalex.org/W4410309779","https://openalex.org/W4404651825","https://openalex.org/W3024838586","https://openalex.org/W7155637786","https://openalex.org/W4400605458","https://openalex.org/W7165690277","https://openalex.org/W3202456785","https://openalex.org/W2946352598"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-04-10T00:00:00"}
