{"id":"https://openalex.org/W4362640889","doi":"https://doi.org/10.1158/1541-7786.22516122.v1","title":"Supplementary Table S2 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism","display_name":"Supplementary Table S2 from HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362640889","doi":"https://doi.org/10.1158/1541-7786.22516122.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.22516122.v1","doi":"https://doi.org/10.1158/1541-7786.22516122.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.22516122.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1541-7786.22516122.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064727905","display_name":"Amy P. Chiu","orcid":"https://orcid.org/0000-0002-6617-7883","observed_orcids":["https://orcid.org/0000-0002-6617-7883"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy P. Chiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089238214","display_name":"Barbara R. Tschida","orcid":"https://orcid.org/0000-0002-4174-6082","observed_orcids":["https://orcid.org/0000-0002-4174-6082"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara R. Tschida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027996375","display_name":"Tung-Ting Sham","orcid":"https://orcid.org/0000-0002-9648-4964","observed_orcids":["https://orcid.org/0000-0002-9648-4964"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tung-Ting Sham","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9648-4964","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091288942","display_name":"Lilian H. Lo","orcid":"https://orcid.org/0000-0001-9388-9694","observed_orcids":["https://orcid.org/0000-0001-9388-9694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lilian H. Lo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022057184","display_name":"Branden S. Moriarity","orcid":"https://orcid.org/0000-0002-3031-3767","observed_orcids":["https://orcid.org/0000-0002-3031-3767"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Branden S. Moriarity","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100458658","display_name":"Xiaoxiao Li","orcid":"https://orcid.org/0000-0002-9158-9556","observed_orcids":["https://orcid.org/0000-0002-9158-9556"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-Xiao Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103235554","display_name":"Regina Cheuk\u2010Lam Lo","orcid":"https://orcid.org/0000-0001-6213-0343","observed_orcids":["https://orcid.org/0000-0001-6213-0343"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Regina C. Lo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071504404","display_name":"David E. Hinton","orcid":"https://orcid.org/0000-0002-5061-2932","observed_orcids":["https://orcid.org/0000-0002-5061-2932"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David E. Hinton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019239309","display_name":"Dewi Kenneth Rowlands","orcid":"https://orcid.org/0000-0001-5180-842X","observed_orcids":["https://orcid.org/0000-0001-5180-842X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dewi K. Rowlands","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028235293","display_name":"Chi-On Chan","orcid":"https://orcid.org/0000-0002-5166-4814","observed_orcids":["https://orcid.org/0000-0002-5166-4814"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chi-On Chan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065415277","display_name":"Daniel Kam\u2010Wah Mok","orcid":"https://orcid.org/0000-0002-6677-2949","observed_orcids":["https://orcid.org/0000-0002-6677-2949"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel K.W. Mok","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005626540","display_name":"David A. Largaespada","orcid":"https://orcid.org/0000-0002-3183-0491","observed_orcids":["https://orcid.org/0000-0002-3183-0491"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David A. Largaespada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065632144","display_name":"Nadia Warner","orcid":"https://orcid.org/0000-0002-4252-086X","observed_orcids":["https://orcid.org/0000-0002-4252-086X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nadia Warner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036163281","display_name":"Vincent W. Keng","orcid":"https://orcid.org/0000-0003-3473-0653","observed_orcids":["https://orcid.org/0000-0003-3473-0653"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincent W. Keng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.3310999870300293,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.3310999870300293,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.296099990606308,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.12479999661445618,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hbx","display_name":"HBx","score":0.722000002861023},{"id":"https://openalex.org/keywords/hepatitis-b-virus-x-protein","display_name":"hepatitis B virus X protein","score":0.7450000047683716},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.9419999718666077},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8920000195503235},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/kegg-pathways","display_name":"KEGG pathways","score":0.8700000047683716},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.7320412397384644},{"id":"https://openalex.org/C140149449","wikidata":"https://www.wikidata.org/wiki/Q17928793","display_name":"FOXO1","level":4,"score":0.6986146569252014},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.6365470886230469},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.5830496549606323},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5551950335502625},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5222854614257812},{"id":"https://openalex.org/C67567795","wikidata":"https://www.wikidata.org/wiki/Q5629069","display_name":"HBx","level":4,"score":0.513328492641449},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5106940865516663},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4600526988506317},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44390127062797546},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.42997273802757263},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4162675142288208},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3925560414791107},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3736898899078369},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3593716323375702},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3425936698913574},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2787483334541321},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21504101157188416},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08486831188201904},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.07380396127700806},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.0673196017742157}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1541-7786.22516122.v1","doi":"https://doi.org/10.1158/1541-7786.22516122.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.22516122.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22516122","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Table_S2_from_HBx-K130M_V131I_Promotes_Liver_Cancer_in_Transgenic_Mice_via_AKT_FOXO1_Signaling_Pathway_and_Arachidonic_Acid_Metabolism/22516122","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.22516122.v1","doi":"https://doi.org/10.1158/1541-7786.22516122.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.22516122.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2936054191","https://openalex.org/W4362542094","https://openalex.org/W4396690521","https://openalex.org/W6902195903","https://openalex.org/W2338681688","https://openalex.org/W4415126274","https://openalex.org/W3141970979","https://openalex.org/W4239294583","https://openalex.org/W2294090452","https://openalex.org/W2274921577"],"abstract_inverted_index":{"Supplementary":[0],"Table":[1],"S2.":[2],"KEGG":[3],"canonical":[4],"signaling":[5],"pathways":[6],"and":[7],"metabolic":[8],"pathways.":[9]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-04-07T00:00:00"}