{"id":"https://openalex.org/W4362624951","doi":"https://doi.org/10.1158/1535-7163.22521780","title":"Figure S6 from BRCA1/MAD2L1 Deficiency Disrupts the Spindle Assembly Checkpoint to Confer Vinorelbine Resistance in Mesothelioma","display_name":"Figure S6 from BRCA1/MAD2L1 Deficiency Disrupts the Spindle Assembly Checkpoint to Confer Vinorelbine Resistance in Mesothelioma","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362624951","doi":"https://doi.org/10.1158/1535-7163.22521780"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22521780","doi":"https://doi.org/10.1158/1535-7163.22521780","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22521780","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.22521780","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030815513","display_name":"Sara Busacca","orcid":"https://orcid.org/0000-0002-1863-8737","observed_orcids":["https://orcid.org/0000-0002-1863-8737"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara Busacca","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1863-8737","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082210179","display_name":"Laura O\u2019Regan","orcid":"https://orcid.org/0000-0002-6101-6300","observed_orcids":["https://orcid.org/0000-0002-6101-6300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura O'Regan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115589674","display_name":"Anita P. Singh","orcid":"https://orcid.org/0000-0002-2975-3503","observed_orcids":["https://orcid.org/0000-0002-2975-3503"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anita Singh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054800980","display_name":"Annabel Jane Sharkey","orcid":"https://orcid.org/0000-0001-5989-9151","observed_orcids":["https://orcid.org/0000-0001-5989-9151"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annabel J. Sharkey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5989-9151","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038892498","display_name":"Alan G. Dawson","orcid":"https://orcid.org/0000-0002-7413-6870","observed_orcids":["https://orcid.org/0000-0002-7413-6870"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan G. Dawson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Joanna Dzialo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanna Dzialo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078246296","display_name":"Aimee Parsons","orcid":"https://orcid.org/0000-0002-7383-8037","observed_orcids":["https://orcid.org/0000-0002-7383-8037"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aimee Parsons","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7383-8037","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033987963","display_name":"Neelam Kumar","orcid":"https://orcid.org/0000-0002-4346-2112","observed_orcids":["https://orcid.org/0000-0002-4346-2112"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neelam Kumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059735044","display_name":"Laurel M. Schunselaar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laurel M. Schunselaar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015673151","display_name":"Naomi Guppy","orcid":"https://orcid.org/0000-0003-1004-3605","observed_orcids":["https://orcid.org/0000-0003-1004-3605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naomi Guppy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036171216","display_name":"Apostolos Nakas","orcid":"https://orcid.org/0000-0001-6993-1514","observed_orcids":["https://orcid.org/0000-0001-6993-1514"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Apostolos Nakas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079505616","display_name":"Michael T. Sheaff","orcid":"https://orcid.org/0000-0001-9189-0181","observed_orcids":["https://orcid.org/0000-0001-9189-0181"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Sheaff","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9189-0181","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071440718","display_name":"Aaron Scott Mansfield","orcid":"https://orcid.org/0000-0002-9483-6903","observed_orcids":["https://orcid.org/0000-0002-9483-6903"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aaron S. Mansfield","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9483-6903","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064561541","display_name":"Sam M. Janes","orcid":"https://orcid.org/0000-0002-6634-5939","observed_orcids":["https://orcid.org/0000-0002-6634-5939"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sam M. Janes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6634-5939","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Paul Baas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Baas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025469280","display_name":"Andrew M. Fry","orcid":"https://orcid.org/0000-0003-4417-7329","observed_orcids":["https://orcid.org/0000-0003-4417-7329"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew M. Fry","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4417-7329","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011181919","display_name":"Dean Anthony Fennell","orcid":"https://orcid.org/0000-0001-7373-1312","observed_orcids":["https://orcid.org/0000-0001-7373-1312"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dean A. Fennell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mad2","display_name":"Mad2","score":1.0},{"id":"https://openalex.org/keywords/spindle-assembly-checkpoint","display_name":"spindle assembly checkpoint","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mesothelioma","display_name":"mesothelioma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cyclin-b","display_name":"cyclin B","score":0.9769999980926514},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5989999771118164},{"id":"https://openalex.org/keywords/msto-211h-cells","display_name":"MSTO-211H cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C2780350996","wikidata":"https://www.wikidata.org/wiki/Q420532","display_name":"Vinorelbine","level":4,"score":0.8966432213783264},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.7079180479049683},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4515402317047119},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44550222158432007},{"id":"https://openalex.org/C175732170","wikidata":"https://www.wikidata.org/wiki/Q9064829","display_name":"Spindle checkpoint","level":5,"score":0.4168117344379425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35834014415740967},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.314536452293396},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13934236764907837},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.13877812027931213},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.12602534890174866},{"id":"https://openalex.org/C47432576","wikidata":"https://www.wikidata.org/wiki/Q918594","display_name":"Spindle apparatus","level":4,"score":0.09389066696166992},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06379571557044983},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.0},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1535-7163.22521780","doi":"https://doi.org/10.1158/1535-7163.22521780","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22521780","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.22521780.v1","doi":"https://doi.org/10.1158/1535-7163.22521780.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22521780.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22521780","doi":"https://doi.org/10.1158/1535-7163.22521780","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22521780","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362529924","https://openalex.org/W4362624522","https://openalex.org/W4392690023","https://openalex.org/W4362637631","https://openalex.org/W4362637063","https://openalex.org/W3095250576","https://openalex.org/W4362624663","https://openalex.org/W4362624977","https://openalex.org/W4362614713","https://openalex.org/W4362614903"],"abstract_inverted_index":{"Cyclin":[0],"B":[1,20],"expression":[2,17],"is":[3],"not":[4],"altered":[5],"after":[6,28],"silencing":[7],"of":[8,18,32],"BRCA1":[9],"or":[10,41],"treatment":[11,31],"with":[12,37],"vinorelbine.":[13],"Western":[14],"blots":[15],"showing":[16],"cyclin":[19],"in":[21],"MSTO-211H":[22],"and":[23,30,34],"REN":[24],"cells":[25,36],"24":[26],"hours":[27],"silencing,":[29],"parental":[33],"resistant":[35],"vinorelbine":[38],"50nM":[39],"(REN/RVR)":[40],"100":[42],"nM":[43],"(MSTO-211H/MVR)":[44],"for":[45],"48":[46],"hours.":[47]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-07T00:00:00"}