{"id":"https://openalex.org/W4362616947","doi":"https://doi.org/10.1158/2159-8290.22531730","title":"Supplementary Figures 1 - 10 from Synthetic Lethality in ATM-Deficient RAD50-Mutant Tumors Underlies Outlier Response to Cancer Therapy","display_name":"Supplementary Figures 1 - 10 from Synthetic Lethality in ATM-Deficient RAD50-Mutant Tumors Underlies Outlier Response to Cancer Therapy","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362616947","doi":"https://doi.org/10.1158/2159-8290.22531730"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.22531730","doi":"https://doi.org/10.1158/2159-8290.22531730","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2159-8290.22531730","pdf_url":"https://aacr.figshare.com/ndownloader/files/39994931","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/ndownloader/files/39994931","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022477189","display_name":"Hikmat A Al\u2010Ahmadie","orcid":"https://orcid.org/0000-0002-2938-6627","observed_orcids":["https://orcid.org/0000-0002-2938-6627"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hikmat Al-Ahmadie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064203357","display_name":"Gopa Iyer","orcid":"https://orcid.org/0000-0002-5093-6099","observed_orcids":["https://orcid.org/0000-0002-5093-6099"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gopa Iyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109210421","display_name":"Marcel Hohl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcel Hohl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002785726","display_name":"Saurabh Asthana","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saurabh Asthana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Akiko Inagaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akiko Inagaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033125884","display_name":"Nikolaus D. Schultz","orcid":"https://orcid.org/0000-0002-0131-4904","observed_orcids":["https://orcid.org/0000-0002-0131-4904"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nikolaus Schultz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090153055","display_name":"Aphrothiti J. Hanrahan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aphrothiti J. Hanrahan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042380438","display_name":"Sasinya N. Scott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sasinya N. Scott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090667008","display_name":"Angela Rose Brannon","orcid":"https://orcid.org/0000-0003-4610-0149","observed_orcids":["https://orcid.org/0000-0003-4610-0149"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Rose Brannon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010304518","display_name":"Gregory C. McDermott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory C. McDermott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091100773","display_name":"Mono Pirun","orcid":"https://orcid.org/0000-0001-7845-8060","observed_orcids":["https://orcid.org/0000-0001-7845-8060"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mono Pirun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053307625","display_name":"Irina Ostrovnaya","orcid":"https://orcid.org/0000-0003-1783-0070","observed_orcids":["https://orcid.org/0000-0003-1783-0070"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irina Ostrovnaya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Philip Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046654923","display_name":"Nicholas D. Socci","orcid":"https://orcid.org/0000-0002-8254-6925","observed_orcids":["https://orcid.org/0000-0002-8254-6925"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas D. Socci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065067520","display_name":"Agnes J. Viale","orcid":"https://orcid.org/0000-0001-8644-9017","observed_orcids":["https://orcid.org/0000-0001-8644-9017"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agnes Viale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006913373","display_name":"Gary K. Schwartz","orcid":"https://orcid.org/0000-0003-1813-5061","observed_orcids":["https://orcid.org/0000-0003-1813-5061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary K. Schwartz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010536553","display_name":"Victor E. Reuter","orcid":"https://orcid.org/0000-0002-7593-1016","observed_orcids":["https://orcid.org/0000-0002-7593-1016"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victor Reuter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086957919","display_name":"Bernard H. Bochner","orcid":"https://orcid.org/0000-0003-0846-0848","observed_orcids":["https://orcid.org/0000-0003-0846-0848"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernard H. Bochner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050435057","display_name":"Jonathan E. Rosenberg","orcid":"https://orcid.org/0000-0003-2637-4249","observed_orcids":["https://orcid.org/0000-0003-2637-4249"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan E. Rosenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064884168","display_name":"Dean F. Bajorin","orcid":"https://orcid.org/0000-0003-4001-7088","observed_orcids":["https://orcid.org/0000-0003-4001-7088"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dean F. Bajorin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110846","display_name":"Michael Fabian Berger","orcid":"https://orcid.org/0009-0009-2032-9122","observed_orcids":["https://orcid.org/0009-0009-2032-9122"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael F. Berger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013956193","display_name":"John H.J. Petrini","orcid":"https://orcid.org/0000-0001-5102-5679","observed_orcids":["https://orcid.org/0000-0001-5102-5679"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John H.J. Petrini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102710156","display_name":"David B. Solit","orcid":"https://orcid.org/0000-0002-6614-802X","observed_orcids":["https://orcid.org/0000-0002-6614-802X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David B. Solit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5053532132","display_name":"Barry S. Taylor","orcid":"https://orcid.org/0000-0002-3355-9471","observed_orcids":["https://orcid.org/0000-0002-3355-9471"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barry S. Taylor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7896000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7896000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.05290000140666962,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.05040000006556511,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.9990000128746033},{"id":"https://openalex.org/keywords/atm-deficiency","display_name":"ATM deficiency","score":0.9629999995231628},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cancer-therapy-response","display_name":"cancer therapy response","score":0.656000018119812},{"id":"https://openalex.org/keywords/tumor-histology","display_name":"tumor histology","score":0.7760000228881836},{"id":"https://openalex.org/keywords/clonality","display_name":"clonality","score":0.753000020980835},{"id":"https://openalex.org/keywords/yeast-model","display_name":"yeast model","score":0.5529999732971191},{"id":"https://openalex.org/keywords/mouse-embryonic-fibroblasts","display_name":"mouse embryonic fibroblasts","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.7832167148590088},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7292178273200989},{"id":"https://openalex.org/C20379349","wikidata":"https://www.wikidata.org/wiki/Q1720706","display_name":"Lethality","level":2,"score":0.7084269523620605},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5660955905914307},{"id":"https://openalex.org/C79337645","wikidata":"https://www.wikidata.org/wiki/Q779824","display_name":"Outlier","level":2,"score":0.493375688791275},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4704027771949768},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33200621604919434},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2960274815559387},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21541941165924072},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.156479150056839},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09158205986022949},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.07189631462097168}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/2159-8290.22531730","doi":"https://doi.org/10.1158/2159-8290.22531730","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2159-8290.22531730","pdf_url":"https://aacr.figshare.com/ndownloader/files/39994931","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2159-8290.22531730.v1","doi":"https://doi.org/10.1158/2159-8290.22531730.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2159-8290.22531730.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22531730","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figures_1_-_10_from_Synthetic_Lethality_in_ATM-Deficient_i_RAD50_i_-Mutant_Tumors_Underlies_Outlier_Response_to_Cancer_Therapy/22531730","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.22531730","doi":"https://doi.org/10.1158/2159-8290.22531730","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2159-8290.22531730","pdf_url":"https://aacr.figshare.com/ndownloader/files/39994931","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362616947.pdf","grobid_xml":"https://content.openalex.org/works/W4362616947.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2116506288","https://openalex.org/W4362617061","https://openalex.org/W2119154520","https://openalex.org/W4229758956","https://openalex.org/W2026750968","https://openalex.org/W4362526328","https://openalex.org/W4362484912","https://openalex.org/W4362621186","https://openalex.org/W4362484916","https://openalex.org/W2775550958"],"abstract_inverted_index":{"PDF":[0],"file":[1],"-":[2],"470KB,":[3],"All":[4],"supplementary":[5],"figures":[6],"including":[7],"tumor":[8],"histology,":[9],"RAD50":[10],"immunohistochemistry,":[11],"candidate":[12],"mutations":[13],"and":[14,17,20],"their":[15],"clonality,":[16],"supporting":[18],"yeast":[19],"MEF":[21],"experimental":[22],"data.":[23]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}