{"id":"https://openalex.org/W4362614907","doi":"https://doi.org/10.1158/1535-7163.22523607","title":"Supplementary Figure from Exploiting Ligand-binding Domain Dimerization for Development of Novel Androgen Receptor Inhibitors","display_name":"Supplementary Figure from Exploiting Ligand-binding Domain Dimerization for Development of Novel Androgen Receptor Inhibitors","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362614907","doi":"https://doi.org/10.1158/1535-7163.22523607"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22523607","doi":"https://doi.org/10.1158/1535-7163.22523607","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22523607","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_from_Exploiting_Ligand-binding_Domain_Dimerization_for_Development_of_Novel_Androgen_Receptor_Inhibitors/22523607/1/files/39986400.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_from_Exploiting_Ligand-binding_Domain_Dimerization_for_Development_of_Novel_Androgen_Receptor_Inhibitors/22523607/1/files/39986400.pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065896666","display_name":"Christine Helsen","orcid":"https://orcid.org/0000-0003-1048-2798","observed_orcids":["https://orcid.org/0000-0003-1048-2798"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Helsen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1048-2798","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071245980","display_name":"Tien T. Nguyen","orcid":"https://orcid.org/0000-0002-7805-029X","observed_orcids":["https://orcid.org/0000-0002-7805-029X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tien T. Nguyen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7805-029X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067515578","display_name":"Xiao Yin Lee","orcid":"https://orcid.org/0000-0002-8077-6030","observed_orcids":["https://orcid.org/0000-0002-8077-6030"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao Yin Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8077-6030","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048652927","display_name":"Roy Eerlings","orcid":"https://orcid.org/0000-0001-9661-8312","observed_orcids":["https://orcid.org/0000-0001-9661-8312"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roy Eerlings","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9661-8312","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060221835","display_name":"Nikolaos N. Louros","orcid":"https://orcid.org/0000-0002-4030-1022","observed_orcids":["https://orcid.org/0000-0002-4030-1022"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nikolaos Louros","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4030-1022","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031589452","display_name":"Joost W. H. Schymkowitz","orcid":"https://orcid.org/0000-0003-2020-0168","observed_orcids":["https://orcid.org/0000-0003-2020-0168"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joost Schymkowitz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2020-0168","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008256216","display_name":"Fr\u00e9d\u00e9ric Rousseau","orcid":"https://orcid.org/0000-0002-9189-7399","observed_orcids":["https://orcid.org/0000-0002-9189-7399"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frederic Rousseau","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9189-7399","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037570217","display_name":"Frank Claessens","orcid":"https://orcid.org/0000-0002-8676-7709","observed_orcids":["https://orcid.org/0000-0002-8676-7709"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Claessens","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8676-7709","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011858509","display_name":"Arnout R. D. Voet","orcid":"https://orcid.org/0000-0002-3329-2703","observed_orcids":["https://orcid.org/0000-0002-3329-2703"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arnout Voet","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3329-2703","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ligand-binding-domain","display_name":"ligand-binding domain","score":0.9789999723434448},{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.8399999737739563},{"id":"https://openalex.org/keywords/androgen-receptor-antagonists","display_name":"androgen receptor antagonists","score":0.9490000009536743}],"concepts":[{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.8854508399963379},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5852092504501343},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.5507432818412781},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.48473045229911804},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4722774922847748},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.468971848487854},{"id":"https://openalex.org/C25166345","wikidata":"https://www.wikidata.org/wiki/Q4914012","display_name":"Binding domain","level":3,"score":0.4407995343208313},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37329357862472534},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3704371154308319},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3013511896133423},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.29118219017982483},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22845155000686646},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15986967086791992},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08093643188476562},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.05769649147987366},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.04992133378982544},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.22523607","doi":"https://doi.org/10.1158/1535-7163.22523607","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22523607","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_from_Exploiting_Ligand-binding_Domain_Dimerization_for_Development_of_Novel_Androgen_Receptor_Inhibitors/22523607/1/files/39986400.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22523607","doi":"https://doi.org/10.1158/1535-7163.22523607","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22523607","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_from_Exploiting_Ligand-binding_Domain_Dimerization_for_Development_of_Novel_Androgen_Receptor_Inhibitors/22523607/1/files/39986400.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362614907.pdf","grobid_xml":"https://content.openalex.org/works/W4362614907.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3100735535","https://openalex.org/W3215561498","https://openalex.org/W2601029189","https://openalex.org/W3207589434","https://openalex.org/W2593249474","https://openalex.org/W2586987557","https://openalex.org/W2041170006","https://openalex.org/W2746259013","https://openalex.org/W2523986435","https://openalex.org/W3209108226"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"from":[2],"Exploiting":[3],"Ligand-binding":[4],"Domain":[5],"Dimerization":[6],"for":[7],"Development":[8],"of":[9],"Novel":[10],"Androgen":[11],"Receptor":[12],"Inhibitors":[13]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-04-07T00:00:00"}