{"id":"https://openalex.org/W4362609782","doi":"https://doi.org/10.1158/1535-7163.22504642","title":"Supplementary Figure 1 from Inhibition of Sphingosine Phosphate Receptor 1 Signaling Enhances the Efficacy of VEGF Receptor Inhibition","display_name":"Supplementary Figure 1 from Inhibition of Sphingosine Phosphate Receptor 1 Signaling Enhances the Efficacy of VEGF Receptor Inhibition","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362609782","doi":"https://doi.org/10.1158/1535-7163.22504642"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22504642","doi":"https://doi.org/10.1158/1535-7163.22504642","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22504642","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1535-7163.22504642","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043678271","display_name":"Anthony S. Fischl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anthony S. Fischl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071614134","display_name":"Xiaoen Wang","orcid":"https://orcid.org/0000-0001-7713-7062","observed_orcids":["https://orcid.org/0000-0001-7713-7062"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoen Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019317536","display_name":"Beverly L. Falc\u00f3n","orcid":"https://orcid.org/0000-0001-7553-4013","observed_orcids":["https://orcid.org/0000-0001-7553-4013"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beverly L. Falcon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091859388","display_name":"Rowena Almonte\u2010Baldonado","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rowena Almonte-Baldonado","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025796283","display_name":"Diane M. Bodenmiller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diane Bodenmiller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Glenn Evans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glenn Evans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014009211","display_name":"Julie Stewart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Stewart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077296675","display_name":"Takako Wilson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takako Wilson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012426969","display_name":"Philip A. Hipskind","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip Hipskind","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041068728","display_name":"Jason R. Manro","orcid":"https://orcid.org/0009-0006-4046-1989","observed_orcids":["https://orcid.org/0009-0006-4046-1989"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason Manro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088453466","display_name":"Mark T. Uhlik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark T. Uhlik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003229513","display_name":"Sudhakar R. Chintharlapalli","orcid":"https://orcid.org/0009-0000-2812-8557","observed_orcids":["https://orcid.org/0009-0000-2812-8557","https://orcid.org/0000-0001-7848-1674"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sudhakar Chintharlapalli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038345698","display_name":"Damien Gerald","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Damien Gerald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075101548","display_name":"David C. Alsop","orcid":"https://orcid.org/0000-0002-8206-1995","observed_orcids":["https://orcid.org/0000-0002-8206-1995"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David C. Alsop","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073126091","display_name":"Laura E. Benjamin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura E. Benjamin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025137142","display_name":"Rupal Satish Bhatt","orcid":"https://orcid.org/0000-0003-2399-1989","observed_orcids":["https://orcid.org/0000-0003-2399-1989"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rupal S. Bhatt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s1pr1","display_name":"S1PR1","score":0.8690000176429749},{"id":"https://openalex.org/keywords/vegf-receptor-inhibition","display_name":"VEGF receptor inhibition","score":0.8840000033378601},{"id":"https://openalex.org/keywords/endothelial-barrier-function","display_name":"endothelial barrier function","score":0.9390000104904175},{"id":"https://openalex.org/keywords/endothelial-monolayer","display_name":"endothelial monolayer","score":0.8479999899864197},{"id":"https://openalex.org/keywords/s1p-signaling","display_name":"S1P signaling","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C17829176","wikidata":"https://www.wikidata.org/wiki/Q179043","display_name":"Electrical impedance","level":2,"score":0.6546176671981812},{"id":"https://openalex.org/C2776596873","wikidata":"https://www.wikidata.org/wiki/Q418267","display_name":"Sphingosine-1-phosphate","level":4,"score":0.5936117768287659},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5579001307487488},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4945084750652313},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.39229410886764526},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3449817895889282},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3367893099784851},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1979263722896576},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14031553268432617},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.13431406021118164},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.06250259280204773}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.22504642","doi":"https://doi.org/10.1158/1535-7163.22504642","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22504642","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22504642","doi":"https://doi.org/10.1158/1535-7163.22504642","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22504642","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2965537942","https://openalex.org/W2304058248","https://openalex.org/W4389033903","https://openalex.org/W2085625787","https://openalex.org/W2970542863","https://openalex.org/W2763106851","https://openalex.org/W2133189233","https://openalex.org/W1557139099","https://openalex.org/W3173392467","https://openalex.org/W2143124340"],"abstract_inverted_index":{"Figure":[0],"S1:":[1],"Impedance":[2],"barrier":[3,55],"function":[4,56],"assay:":[5],"The":[6],"effect":[7,41],"of":[8,24,57],"S1P":[9,20,66],"and":[10,42],"Ex82":[11,37,63],"was":[12],"analyzed":[13],"using":[14],"a":[15],"transendothelial":[16],"electrical":[17,30,45,70],"impedance":[18,31,46,71],"assay.":[19],"treatment":[21],"(10":[22],"nM)":[23],"an":[25],"endothelial":[26],"monolayer":[27],"strongly":[28],"increases":[29],"(B)":[32],"vs":[33],"control":[34],"(A)":[35],"whereas":[36],"has":[38],"the":[39,53,65],"opposite":[40],"significantly":[43],"decreases":[44],"(D).":[47],"These":[48],"results":[49],"are":[50],"consistent":[51],"with":[52,62],"known":[54],"S1P1.":[58],"In":[59],"addition,":[60],"pretreatment":[61],"blocked":[64],"dependent":[67],"increase":[68],"in":[69],"(C).":[72]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-04-06T00:00:00"}