{"id":"https://openalex.org/W4362602003","doi":"https://doi.org/10.1093/brain/awad117","title":"Structural disconnection relates to functional changes after temporal lobe epilepsy surgery","display_name":"Structural disconnection relates to functional changes after temporal lobe epilepsy surgery","publication_year":2023,"publication_date":"2023-04-05","ids":{"openalex":"https://openalex.org/W4362602003","doi":"https://doi.org/10.1093/brain/awad117","pmid":"https://pubmed.ncbi.nlm.nih.gov/37018067"},"language":"en","primary_location":{"id":"doi:10.1093/brain/awad117","doi":"https://doi.org/10.1093/brain/awad117","is_oa":true,"landing_page_url":"https://doi.org/10.1093/brain/awad117","pdf_url":"https://academic.oup.com/brain/article-pdf/146/9/3913/51330427/awad117.pdf","source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/brain/article-pdf/146/9/3913/51330427/awad117.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084762082","display_name":"Lucas E Sainburg","orcid":"https://orcid.org/0000-0003-1508-5871","observed_orcids":["https://orcid.org/0000-0003-1508-5871"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucas E Sainburg","raw_affiliation_strings":["Department of Biomedical Engineering, Vanderbilt University , Nashville, TN 37232 , USA","Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA"],"raw_orcid":"https://orcid.org/0000-0003-1508-5871","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Vanderbilt University , Nashville, TN 37232 , USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026437429","display_name":"Andrew P. Janson","orcid":"https://orcid.org/0000-0002-6552-4011","observed_orcids":["https://orcid.org/0000-0002-6552-4011"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew P Janson","raw_affiliation_strings":["Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004646448","display_name":"Graham Walter Johnson","orcid":"https://orcid.org/0000-0002-9154-4315","observed_orcids":["https://orcid.org/0000-0002-9154-4315"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Graham W Johnson","raw_affiliation_strings":["Department of Biomedical Engineering, Vanderbilt University , Nashville, TN 37232 , USA","Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA"],"raw_orcid":"https://orcid.org/0000-0002-9154-4315","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Vanderbilt University , Nashville, TN 37232 , USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035434876","display_name":"Jasmine W. Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jasmine W Jiang","raw_affiliation_strings":["Department of Neurological Surgery, Vanderbilt University Medical Center , Nashville, TN 37232 , USA","Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Vanderbilt University Medical Center , Nashville, TN 37232 , USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024219876","display_name":"Baxter P. Rogers","orcid":"https://orcid.org/0000-0002-5666-2797","observed_orcids":["https://orcid.org/0000-0002-5666-2797"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baxter P Rogers","raw_affiliation_strings":["Department of Biomedical Engineering, Vanderbilt University , Nashville, TN 37232 , USA","Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Vanderbilt University , Nashville, TN 37232 , USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038256364","display_name":"Catie E. Chang","orcid":"https://orcid.org/0000-0003-1541-9579","observed_orcids":["https://orcid.org/0000-0003-1541-9579"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catie Chang","raw_affiliation_strings":["Department of Biomedical Engineering, Vanderbilt University , Nashville, TN 37232 , USA","Department of Electrical and Computer Engineering, Vanderbilt University , Nashville, TN 37212 , USA","Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA"],"raw_orcid":"https://orcid.org/0000-0003-1541-9579","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Vanderbilt University , Nashville, TN 37232 , USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Vanderbilt University , Nashville, TN 37212 , USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029905768","display_name":"Dario J. Englot","orcid":"https://orcid.org/0000-0001-8373-690X","observed_orcids":["https://orcid.org/0000-0001-8373-690X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dario J Englot","raw_affiliation_strings":["Department of Biomedical Engineering, Vanderbilt University , Nashville, TN 37232 , USA","Department of Electrical and Computer Engineering, Vanderbilt University , Nashville, TN 37212 , USA","Department of Neurological Surgery, Vanderbilt University Medical Center , Nashville, TN 37232 , USA","Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Vanderbilt University , Nashville, TN 37232 , USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Vanderbilt University , Nashville, TN 37212 , USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Neurological Surgery, Vanderbilt University Medical Center , Nashville, TN 37232 , USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043874688","display_name":"Victoria L. Morgan","orcid":"https://orcid.org/0000-0001-8263-2324","observed_orcids":["https://orcid.org/0000-0001-8263-2324"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Victoria L Morgan","raw_affiliation_strings":["Department of Biomedical Engineering, Vanderbilt University , Nashville, TN 37232 , USA","Department of Neurological Surgery, Vanderbilt University Medical Center , Nashville, TN 37232 , USA","Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA"],"raw_orcid":"https://orcid.org/0000-0001-8263-2324","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Vanderbilt University , Nashville, TN 37232 , USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Neurological Surgery, Vanderbilt University Medical Center , Nashville, TN 37232 , USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center , Nashville, TN 37232 , USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043874688"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"],"apc_list":{"value":3658,"currency":"GBP","value_usd":4550},"apc_paid":null,"fwci":3.21,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.92564076,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"146","issue":"9","first_page":"3913","last_page":"3922"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.7759000062942505,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.7759000062942505,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.20669999718666077,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/temporal-lobe-epilepsy","display_name":"temporal lobe epilepsy","score":0.9390000104904175},{"id":"https://openalex.org/keywords/epilepsy-surgery","display_name":"epilepsy surgery","score":0.9980000257492065},{"id":"https://openalex.org/keywords/structural-disconnection","display_name":"structural disconnection","score":0.902999997138977},{"id":"https://openalex.org/keywords/structural-connectivity","display_name":"structural connectivity","score":0.5640000104904175},{"id":"https://openalex.org/keywords/thalamus","display_name":"thalamus","score":0.8360000252723694},{"id":"https://openalex.org/keywords/fusiform-gyrus","display_name":"fusiform gyrus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/resting-state-fmri","display_name":"resting-state fMRI","score":0.609000027179718},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"diffusion MRI","score":0.7870000004768372},{"id":"https://openalex.org/keywords/drug-resistant-focal-epilepsy","display_name":"drug-resistant focal epilepsy","score":0.6769999861717224},{"id":"https://openalex.org/keywords/extent-of-resection","display_name":"extent of resection","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.9000564813613892},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.8579484820365906},{"id":"https://openalex.org/C2780371621","wikidata":"https://www.wikidata.org/wiki/Q3709910","display_name":"Disconnection","level":2,"score":0.8503491878509521},{"id":"https://openalex.org/C2780803581","wikidata":"https://www.wikidata.org/wiki/Q1347108","display_name":"Epilepsy surgery","level":3,"score":0.8239866495132446},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.5170972347259521},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5113961100578308},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49138155579566956},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.45246103405952454},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.3589615821838379},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3424261212348938},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.29546672105789185},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013702","descriptor_name":"Temporal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013702","descriptor_name":"Temporal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013702","descriptor_name":"Temporal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013702","descriptor_name":"Temporal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013702","descriptor_name":"Temporal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013702","descriptor_name":"Temporal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/brain/awad117","doi":"https://doi.org/10.1093/brain/awad117","is_oa":true,"landing_page_url":"https://doi.org/10.1093/brain/awad117","pdf_url":"https://academic.oup.com/brain/article-pdf/146/9/3913/51330427/awad117.pdf","source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},{"id":"pmid:37018067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37018067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain : a journal of neurology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10473561","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10473561","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10473561/pdf/awad117.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/brain/awad117","doi":"https://doi.org/10.1093/brain/awad117","is_oa":true,"landing_page_url":"https://doi.org/10.1093/brain/awad117","pdf_url":"https://academic.oup.com/brain/article-pdf/146/9/3913/51330427/awad117.pdf","source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7799999713897705,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1159271351","display_name":null,"funder_award_id":"R01 NS110130","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1937603640","display_name":null,"funder_award_id":"T32 EB021937","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G3353178536","display_name":null,"funder_award_id":"R00-NS097618","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4522499900","display_name":null,"funder_award_id":"R01-NS075270","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6399140587","display_name":null,"funder_award_id":"P50 HD103537","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7402390169","display_name":"MRI Connectivity Biomarkers of Treatment Response in Focal Epilepsy","funder_award_id":"R01NS108445","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8665227046","display_name":"Temporal Clustering Analysis for Detection of Irregular Transient fMRI Activation","funder_award_id":"R01NS055822","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000041039","display_name":null,"funder_award_id":"R01NS110130","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000047340","display_name":null,"funder_award_id":"T32EB021937","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000176422","display_name":null,"funder_award_id":"R00NS097618","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000207399","display_name":null,"funder_award_id":"R01NS075270","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000347142","display_name":null,"funder_award_id":"NS075270","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362602003.pdf","grobid_xml":"https://content.openalex.org/works/W4362602003.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W795339718","https://openalex.org/W1982127093","https://openalex.org/W2001611992","https://openalex.org/W2016978115","https://openalex.org/W2017747155","https://openalex.org/W2018536252","https://openalex.org/W2030400994","https://openalex.org/W2041216092","https://openalex.org/W2046557060","https://openalex.org/W2051201583","https://openalex.org/W2060907525","https://openalex.org/W2066404339","https://openalex.org/W2078563124","https://openalex.org/W2082641523","https://openalex.org/W2085091083","https://openalex.org/W2094435366","https://openalex.org/W2101801686","https://openalex.org/W2127309075","https://openalex.org/W2127729116","https://openalex.org/W2138092999","https://openalex.org/W2159670003","https://openalex.org/W2161502085","https://openalex.org/W2307176359","https://openalex.org/W2391545620","https://openalex.org/W2727278441","https://openalex.org/W2771435422","https://openalex.org/W2771543167","https://openalex.org/W2800686099","https://openalex.org/W2887072805","https://openalex.org/W2898204983","https://openalex.org/W2904374699","https://openalex.org/W2944607361","https://openalex.org/W2952800141","https://openalex.org/W2970898057","https://openalex.org/W2990159029","https://openalex.org/W2999787570","https://openalex.org/W3039052057","https://openalex.org/W3093274194","https://openalex.org/W3100745627","https://openalex.org/W3127178723","https://openalex.org/W3162761752","https://openalex.org/W3198673478","https://openalex.org/W3204127121","https://openalex.org/W3205137608","https://openalex.org/W4206497009","https://openalex.org/W4207021374","https://openalex.org/W4220725271","https://openalex.org/W4224212725","https://openalex.org/W4225415655","https://openalex.org/W4241074797","https://openalex.org/W4241258748","https://openalex.org/W4290375428","https://openalex.org/W4296330688","https://openalex.org/W4299516157","https://openalex.org/W6675721644"],"related_works":["https://openalex.org/W2043607309","https://openalex.org/W3032587901","https://openalex.org/W2005034415","https://openalex.org/W2034474299","https://openalex.org/W2082833331","https://openalex.org/W4324330064","https://openalex.org/W4387229259","https://openalex.org/W3201855164","https://openalex.org/W2597914676","https://openalex.org/W4361226145"],"abstract_inverted_index":{"Epilepsy":[0],"surgery":[1,39,67,104,126,156,279,349],"consists":[2],"of":[3,6,89,120,132,162,173,278,320,348],"surgical":[4],"resection":[5,34,73],"the":[7,32,50,72,82,87,109,112,121,130,194,213,227,252,260,271,276,292,314,321,327,339,346,357,361,368,386],"epileptic":[8,84,114,215,262,341,363],"focus":[9,216,263,342,364],"and":[10,105,145,203,224,267,270,329,390],"is":[11],"recommended":[12],"for":[13,345],"patients":[14,166,204],"with":[15,183,332],"drug-resistant":[16],"focal":[17,20,33,133,383],"epilepsy.":[18],"However,":[19],"brain":[21,29,60,97,136,150,388,397],"lesions":[22],"can":[23],"lead":[24,44],"to":[25,43,45,77,93,108,128,154,193,226,233,245,259,275,286,308,367],"effects":[26,131,392],"in":[27,35,59,68,96,138,143,149,159,197,235,247,251,264,291,312,325,385,395],"distant":[28,48,70,396],"regions.":[30,237,398],"Similarly,":[31],"temporal":[36,64,101,163,248],"lobe":[37,65,102,164,249],"epilepsy":[38,66,103,125,144,165,250,373],"has":[40,141],"been":[41],"shown":[42],"functional":[46,176,185,228,288,309,322,369],"changes":[47,58,95,187,230,290,311,324,370],"from":[49,71,81,111,152,212,231,243,338,360],"resection.":[51],"Here":[52],"we":[53],"hypothesize":[54],"that":[55,74,124,188,356],"there":[56],"are":[57,75],"function":[61,98,137,151,394],"caused":[62,99],"by":[63,100],"regions":[69,182,254],"due":[76],"their":[78],"structural":[79,191,210,336,358,387],"disconnection":[80,110,211,337,359],"resected":[83,113,195,214,261,340,362],"focus.":[85,115],"Therefore,":[86],"goal":[88],"this":[90,376],"study":[91,117,377],"was":[92,217],"localize":[94],"relate":[106],"them":[107],"This":[116],"takes":[118],"advantage":[119],"unique":[122],"opportunity":[123],"provides":[127,378],"investigate":[129],"disconnections":[134,384],"on":[135,206,393],"humans,":[139],"which":[140],"implications":[142],"broader":[146],"neuroscience.":[147],"Changes":[148],"pre-":[153,232,244],"post-epilepsy":[155],"were":[157,306],"quantified":[158],"a":[160,171,333,379],"group":[161],"(n":[167,200],"=":[168,201],"36)":[169],"using":[170,220],"measure":[172],"resting":[174],"state":[175],"MRI":[177,186,223,229,239,289,310,323],"activity":[178,240],"fluctuations.":[179],"We":[180],"identified":[181],"significant":[184],"had":[189],"high":[190],"connectivity":[192],"region":[196],"healthy":[198,265],"controls":[199,266],"96)":[202],"based":[205],"diffusion":[207,222],"MRI.":[208],"The":[209,318],"then":[218],"estimated":[219,335],"presurgical":[221],"related":[225,307],"post-surgery":[234,246],"these":[236],"Functional":[238],"fluctuations":[241],"increased":[242,331],"two":[253],"most":[255],"highly":[256],"structurally":[257],"connected":[258],"patients-the":[268],"thalamus":[269,293,315,328],"fusiform":[272,330],"gyrus":[273],"ipsilateral":[274],"side":[277],"(PFWE":[280],"<":[281,299,351],"0.05).":[282,352],"Broader":[283],"surgeries":[284,297],"led":[285],"larger":[287],"than":[294],"more":[295],"selective":[296],"(P":[298,350],"0.05),":[300],"but":[301],"no":[302],"other":[303],"clinical":[304],"variables":[305],"either":[313],"or":[316],"fusiform.":[317],"magnitude":[319],"both":[326],"higher":[334],"when":[343],"controlling":[344],"type":[347],"These":[353],"results":[354],"suggest":[355],"may":[365],"contribute":[366],"seen":[371],"after":[372],"surgery.":[374],"Broadly,":[375],"novel":[380],"link":[381],"between":[382],"network":[389],"downstream":[391]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}