{"id":"https://openalex.org/W4362596534","doi":"https://doi.org/10.1158/1538-7445.am2023-2579","title":"Abstract 2579: The tumor landscape is molded by quantitative and qualitative signaling differences between different oncogenic KRAS mutations","display_name":"Abstract 2579: The tumor landscape is molded by quantitative and qualitative signaling differences between different oncogenic KRAS mutations","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362596534","doi":"https://doi.org/10.1158/1538-7445.am2023-2579"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2023-2579","doi":"https://doi.org/10.1158/1538-7445.am2023-2579","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-2579","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065695313","display_name":"\u00d6zg\u00fcn Le Roux","orcid":"https://orcid.org/0000-0002-9885-6872","observed_orcids":["https://orcid.org/0000-0002-9885-6872"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ozgun Le Roux","raw_affiliation_strings":["1Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087099776","display_name":"Christopher M. Counter","orcid":"https://orcid.org/0000-0003-0748-3079","observed_orcids":["https://orcid.org/0000-0003-0748-3079"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M. Counter","raw_affiliation_strings":["1Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"7_Supplement","first_page":"2579","last_page":"2579"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncogenic-kras-mutations","display_name":"oncogenic KRAS mutations","score":0.8970000147819519},{"id":"https://openalex.org/keywords/g12d","display_name":"G12D","score":0.765999972820282},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.5770000219345093},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.5270000100135803},{"id":"https://openalex.org/keywords/pulmonary-carcinoma","display_name":"pulmonary carcinoma","score":0.878000020980835},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.609000027179718},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.880203127861023},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7871213555335999},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7213998436927795},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6840171217918396},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6781818866729736},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6224093437194824},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.574893593788147},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5417519211769104},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47749704122543335},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.45919692516326904},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23392540216445923}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2023-2579","doi":"https://doi.org/10.1158/1538-7445.am2023-2579","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-2579","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4282935319","https://openalex.org/W4294916416","https://openalex.org/W3182525868","https://openalex.org/W3182584751","https://openalex.org/W3161813150","https://openalex.org/W3181506106","https://openalex.org/W1988100553","https://openalex.org/W3129032231","https://openalex.org/W2566783740","https://openalex.org/W2417321294"],"abstract_inverted_index":{"Abstract":[0],"Despite":[1],"over":[2,162],"50":[3],"possible":[4],"oncogenic":[5,102,137,190,222,283],"RAS":[6,25,44,53,85,233],"mutations,":[7,34,103],"cancers":[8],"tend":[9],"to":[10,20,49,71,114,135,170,188,220,250],"have":[11],"a":[12,15,208,217,225,236,247],"bias":[13],"towards":[14],"specific":[16,43],"subset,":[17],"often":[18],"unique":[19,209,237],"each":[21,47,205],"cancer":[22],"type.":[23],"As":[24],"mutation":[26,36,86,161,176],"occur":[27],"early,":[28],"if":[29],"not":[30],"being":[31],"the":[32,40,57,63,73,82,129,136,149,163,175,179,185,189,198,290],"first":[33],"these":[35,76],"patterns":[37,87],"ostensibly":[38],"reflect":[39],"selection":[41],"of":[42,59,65,75,79,84,99,151,178,200,216,289],"mutations":[45,54,234,285],"in":[46,88,246],"tissue":[48,133],"initiate":[50,251],"tumorigenesis.":[51],"Different":[52],"can":[55],"affect":[56],"level":[58,150,173],"active":[60,152],"oncprotein":[61],"and/or":[62],"type":[64,177],"pathways":[66],"activated":[67,127],"thereof.":[68],"To":[69,182],"attempt":[70],"determine":[72],"contribution":[74],"two":[77,100],"forms":[78],"signaling":[80,186,223,241,279],"on":[81],"process":[83],"cancer,":[89],"we":[90,193],"generated":[91],"four":[92,123],"conditional":[93],"murine":[94],"Kras":[95,138,180,191],"alleles":[96,124],"containing":[97],"one":[98,160],"distinct":[101,232],"G12D":[104],"or":[105,111,117,239],"Q61R,":[106],"encoded":[107],"by":[108,148,159,275],"native":[109],"rare":[110],"common":[112],"codons":[113],"induce":[115],"low":[116],"high":[118,221],"protein":[119],"expression,":[120],"respectively.":[121],"These":[122],"were":[125,145,156],"globally":[126],"throughout":[128],"mouse,":[130],"revealing":[131,203],"different":[132,282],"susceptibilities":[134],"alleles.":[139],"We":[140,228],"observed":[141],"that":[142,204,231,243],"hematolymphopoietic":[143],"lesions":[144],"preferentially":[146,157],"initiated":[147],"RAS,":[153],"squamous":[154],"tumor":[155,201,271],"induced":[158,207],"other,":[164],"while":[165],"pulmonary":[166],"carcinomas":[167],"are":[168,244],"susceptible":[169],"both":[171],"activity":[172],"and":[174,224,260,277,302],"allele.":[181],"further":[183],"explore":[184],"responses":[187],"allele,":[192],"performed":[194],"RNAseq":[195],"analysis":[196],"at":[197],"moment":[199],"initiation,":[202],"allele":[206],"cellular":[210],"response,":[211],"ranging":[212],"from":[213],"transcriptional":[214],"features":[215],"plastic":[218],"state":[219],"stress":[226],"response.":[227],"thus":[229],"suggest":[230],"impart":[235],"quantitative":[238,276],"qualitative":[240,278],"response":[242],"selected":[245],"tissue-specific":[248],"fashion":[249],"tumorigenesis,":[252],"which":[253],"has":[254],"implications":[255],"for":[256,293],"early":[257],"detection,":[258],"interception,":[259],"prevention.":[261],"Citation":[262],"Format:":[263],"Ozgun":[264],"Le":[265],"Roux,":[266],"Christopher":[267],"M.":[268],"Counter.":[269],"The":[270],"landscape":[272],"is":[273],"molded":[274],"differences":[280],"between":[281],"KRAS":[284],"[abstract].":[286],"In:":[287],"Proceedings":[288],"American":[291],"Association":[292],"Cancer":[294,313],"Research":[295],"Annual":[296],"Meeting":[297],"2023;":[298],"Part":[299],"1":[300],"(Regular":[301],"Invited":[303],"Abstracts);":[304],"2023":[305],"Apr":[306],"14-19;":[307],"Orlando,":[308],"FL.":[309],"Philadelphia":[310],"(PA):":[311],"AACR;":[312],"Res":[314],"2023;83(7_Suppl):Abstract":[315],"nr":[316],"2579.":[317]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-04-06T00:00:00"}