{"id":"https://openalex.org/W4362596291","doi":"https://doi.org/10.1158/1538-7445.am2023-191","title":"Abstract 191: CTC-derived organoids from liver and pancreatic cancer patients for personalized therapy","display_name":"Abstract 191: CTC-derived organoids from liver and pancreatic cancer patients for personalized therapy","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362596291","doi":"https://doi.org/10.1158/1538-7445.am2023-191"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2023-191","doi":"https://doi.org/10.1158/1538-7445.am2023-191","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2023-191","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080602430","display_name":"Catalina Galeano\u2010Garces","orcid":"https://orcid.org/0000-0003-1882-6858","observed_orcids":["https://orcid.org/0000-0003-1882-6858"]},"institutions":[{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Catalina Galeano-Garces","raw_affiliation_strings":["1Astrin Biosciences, Inc., Saint Paul, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Astrin Biosciences, Inc., Saint Paul, MN;","institution_ids":["https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033774018","display_name":"Kaylee Judith Smith","orcid":"https://orcid.org/0000-0003-1479-6102","observed_orcids":["https://orcid.org/0000-0003-1479-6102"]},"institutions":[{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Kaylee J. Smith","raw_affiliation_strings":["1Astrin Biosciences, Inc., Saint Paul, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Astrin Biosciences, Inc., Saint Paul, MN;","institution_ids":["https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011461198","display_name":"Nicholas E. Heller","orcid":"https://orcid.org/0000-0001-8516-8707","observed_orcids":["https://orcid.org/0000-0001-8516-8707"]},"institutions":[{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Nicholas Heller","raw_affiliation_strings":["1Astrin Biosciences, Inc., Saint Paul, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Astrin Biosciences, Inc., Saint Paul, MN;","institution_ids":["https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mahdi Ahmadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mahdi Ahmadi","raw_affiliation_strings":["1Astrin Biosciences, Inc., Saint Paul, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Astrin Biosciences, Inc., Saint Paul, MN;","institution_ids":["https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087376315","display_name":"Jiarong Hong","orcid":"https://orcid.org/0000-0001-7860-2181","observed_orcids":["https://orcid.org/0000-0001-7860-2181"]},"institutions":[{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jiarong Hong","raw_affiliation_strings":["1Astrin Biosciences, Inc., Saint Paul, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Astrin Biosciences, Inc., Saint Paul, MN;","institution_ids":["https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046658297","display_name":"Jayant Parthasarathy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jayant Parthasarathy","raw_affiliation_strings":["1Astrin Biosciences, Inc., Saint Paul, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Astrin Biosciences, Inc., Saint Paul, MN;","institution_ids":["https://openalex.org/I4405258467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033796700","display_name":"Justin M. Drake","orcid":"https://orcid.org/0000-0002-8329-7748","observed_orcids":["https://orcid.org/0000-0002-8329-7748"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin M. Drake","raw_affiliation_strings":["2University of Minnesota, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"7_Supplement","first_page":"191","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.06880000233650208,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.5580000281333923},{"id":"https://openalex.org/keywords/drug-screening","display_name":"drug screening","score":0.6970000267028809},{"id":"https://openalex.org/keywords/liver-adenocarcinoma","display_name":"liver adenocarcinoma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/prostate-cancer-cell-lines","display_name":"prostate cancer cell lines","score":0.8270000219345093},{"id":"https://openalex.org/keywords/ctc-enrichment","display_name":"CTC enrichment","score":0.8059999942779541},{"id":"https://openalex.org/keywords/epcam","display_name":"EpCAM","score":0.8230000138282776},{"id":"https://openalex.org/keywords/drug-sensitivity-and-resistance","display_name":"drug sensitivity and resistance","score":0.7429999709129333},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9079999923706055},{"id":"https://openalex.org/keywords/3d-organoid-culture","display_name":"3D organoid culture","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.8970804214477539},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.6985702514648438},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5919026732444763},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5629399418830872},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.556246817111969},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.5384146571159363},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5365228056907654},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5158354640007019},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.443634569644928},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.4392586946487427},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3492095470428467},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3225020170211792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.303403377532959},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25783076882362366},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.15207025408744812},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.07745561003684998}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2023-191","doi":"https://doi.org/10.1158/1538-7445.am2023-191","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2023-191","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4407365922","https://openalex.org/W2794232533","https://openalex.org/W4414027925","https://openalex.org/W4387948624","https://openalex.org/W2996502167","https://openalex.org/W4404306044","https://openalex.org/W4280549852","https://openalex.org/W3044965022","https://openalex.org/W7215845034","https://openalex.org/W3208495384"],"abstract_inverted_index":{"Abstract":[0],"Organoids":[1],"are":[2,100,206],"a":[3,52,158,169,270,277],"widely":[4],"used":[5],"3D":[6,31],"culture":[7,23,203],"system":[8,32],"that":[9,180],"has":[10,112],"the":[11,15,36,82,255,319],"potential":[12,281],"to":[13,43,47,63,73,87,200,233,238,252,275,280],"recapitulate":[14],"profile":[16],"and":[17,124,138,147,164,194,218,229,242,261,308,331],"phenotype":[18],"of":[19,24,59,69,84,107,152,160,223,257,318],"physiological":[20,38],"cells.":[21],"The":[22,57,105],"circulating":[25],"tumor":[26,37],"cells":[27,163],"(CTCs)":[28],"in":[29,66,254],"this":[30,267],"not":[33],"only":[34],"mimics":[35],"environment":[39],"but":[40],"allows":[41],"researchers":[42],"test":[44],"therapeutic":[45,78],"responses":[46],"certain":[48],"drugs":[49],"based":[50,80,212],"on":[51,81,213,249],"patient's":[53],"own":[54],"cancer":[55,118,135,143,214,216,310],"phenotype.":[56],"purpose":[58],"our":[60,108,181,201],"study":[61],"is":[62,225],"perform":[64],"an":[65],"vitro":[67],"evaluation":[68],"patient-derived":[70],"CTC":[71,95,154,161],"organoids":[72,131,155,184,305],"more":[74],"precisely":[75],"identify":[76],"personalized":[77,278,313],"options":[79],"response":[83],"these":[85,250],"CTCs":[86,99,140],"each":[88,210,239,284],"specified":[89],"inhibitor.":[90],"Using":[91],"Astrin":[92],"Bioscience\u2019s":[93],"proprietary":[94,109],"enrichment":[96,110],"method,":[97],"collected":[98],"plated":[101],"as":[102,177,187],"organoid":[103,202],"cultures.":[104],"performance":[106],"method":[111],"been":[113],"assessed":[114],"using":[115,191,227],"both":[116],"spiked":[117],"cell":[119,136,172,230],"lines":[120,137],"(in":[121],"whole":[122],"blood)":[123],"patient":[125,139,182,211],"CTCs.":[126,188],"We":[127],"have":[128],"successfully":[129],"grown":[130],"from":[132,168,306],"four":[133],"prostate":[134,170],"across":[141],"multiple":[142],"types":[144],"including":[145],"pancreatic":[146,309],"liver":[148,153,307],"adenocarcinoma.":[149],"RNA":[150],"sequencing":[151],"expressed":[156],"EPCAM,":[157],"marker":[159],"epithelial":[162,171],"coincided":[165],"with":[166],"data":[167],"line,":[173],"LNCaP.":[174],"This":[175],"serves":[176],"robust":[178],"evidence":[179],"derived":[183],"truly":[185],"originated":[186],"Functional":[189],"assays":[190,232],"different":[192],"chemotherapies":[193],"targeted":[195],"therapies":[196,282],"will":[197,245],"be":[198,247],"applied":[199],"system.":[204],"Drugs":[205],"uniquely":[207],"selected":[208],"for":[209,283,312,322],"type,":[215],"stage":[217],"previous":[219],"failed":[220],"therapies.":[221],"Efficacy":[222],"therapy":[224,264,314],"evaluated":[226],"imaging":[228],"viability":[231],"determine":[234],"sensitivity":[235],"or":[236],"resistivity":[237],"therapy.":[240],"Transcriptomic":[241],"proteomic":[243],"analyses":[244],"also":[246],"performed":[248],"samples":[251],"aid":[253],"identification":[256],"other":[258],"predictive":[259],"biomarkers":[260],"future":[262],"novel":[263],"testing.":[265],"Thus,":[266],"platform":[268],"creates":[269],"pre-clinical":[271],"drug":[272],"screening":[273],"tool":[274],"create":[276],"guide":[279],"patient.":[285],"Citation":[286],"Format:":[287],"Catalina":[288],"Galeano-Garces,":[289],"Kaylee":[290],"J.":[291],"Smith,":[292],"Nicholas":[293],"Heller,":[294],"Mahdi":[295],"Ahmadi,":[296],"Jiarong":[297],"Hong,":[298],"Jayant":[299],"Parthasarathy,":[300],"Justin":[301],"M.":[302],"Drake.":[303],"CTC-derived":[304],"patients":[311],"[abstract].":[315],"In:":[316],"Proceedings":[317],"American":[320],"Association":[321],"Cancer":[323,342],"Research":[324],"Annual":[325],"Meeting":[326],"2023;":[327],"Part":[328],"1":[329],"(Regular":[330],"Invited":[332],"Abstracts);":[333],"2023":[334],"Apr":[335],"14-19;":[336],"Orlando,":[337],"FL.":[338],"Philadelphia":[339],"(PA):":[340],"AACR;":[341],"Res":[343],"2023;83(7_Suppl):Abstract":[344],"nr":[345],"191.":[346]},"counts_by_year":[{"year":2024,"cited_by_count":2}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-04-06T00:00:00"}