{"id":"https://openalex.org/W4362595964","doi":"https://doi.org/10.1158/1538-7445.am2023-pl05-03","title":"Abstract PL05-03: What if all your favorite proteins are druggable","display_name":"Abstract PL05-03: What if all your favorite proteins are druggable","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362595964","doi":"https://doi.org/10.1158/1538-7445.am2023-pl05-03"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2023-pl05-03","doi":"https://doi.org/10.1158/1538-7445.am2023-pl05-03","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-pl05-03","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029297375","display_name":"Gregory R. Bowman","orcid":"https://orcid.org/0000-0002-2083-4892","observed_orcids":["https://orcid.org/0000-0002-2083-4892"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory R. Bowman","raw_affiliation_strings":["1Perelman School of Med. Univ. of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Perelman School of Med. Univ. of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029297375"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"7_Supplement","first_page":"PL05","last_page":"03"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.12610000371932983,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryptic-pocket","display_name":"cryptic pocket","score":0.8410000205039978},{"id":"https://openalex.org/keywords/undruggable-proteins","display_name":"undruggable proteins","score":0.8410000205039978},{"id":"https://openalex.org/keywords/protein-dynamics","display_name":"protein dynamics","score":0.5580000281333923},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/protein-rna-interactions","display_name":"RNA-protein interactions","score":0.8679999709129333},{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.875},{"id":"https://openalex.org/keywords/folding-home","display_name":"Folding@home","score":0.8709999918937683},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.6570000052452087},{"id":"https://openalex.org/keywords/cancer-drug-targets","display_name":"cancer drug targets","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.9674868583679199},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5935015678405762},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4390592873096466},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4282950460910797},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42027634382247925},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3480076193809509},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33626869320869446},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17449736595153809},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09642568230628967}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2023-pl05-03","doi":"https://doi.org/10.1158/1538-7445.am2023-pl05-03","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-pl05-03","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6978267636","https://openalex.org/W2265102996","https://openalex.org/W2804171113","https://openalex.org/W7214942126","https://openalex.org/W4406136976","https://openalex.org/W7129059513","https://openalex.org/W7125832916","https://openalex.org/W7164377400","https://openalex.org/W4409838398","https://openalex.org/W7214192876"],"abstract_inverted_index":{"Abstract":[0],"Many":[1],"proteins":[2,48,194],"that":[3,41,70,127],"play":[4],"key":[5],"roles":[6],"in":[7,44,79,148],"cancer":[8],"are":[9,42,163,179,195],"considered":[10],"difficult":[11],"drug":[12],"targets,":[13],"if":[14,190],"not":[15],"entirely":[16],"undruggable,":[17],"due":[18,51,74],"to":[19,52,64,75,100,122,158,165,173],"an":[20],"apparent":[21],"lack":[22],"of":[23,47,200],"pockets":[24,40,72,162,178],"where":[25,160],"small":[26],"molecules":[27],"can":[28,128],"bind":[29],"with":[30],"the":[31,68,76,117,201],"affinity":[32],"and":[33,97,102,134,146,213],"specificity":[34],"required":[35],"for":[36,204],"a":[37,124,131,154,181],"drug.":[38],"\u2018Cryptic\u2019":[39],"absent":[43],"known":[45],"structures":[46],"but":[49],"form":[50,166],"protein":[53,169],"dynamics":[54],"could":[55],"alleviate":[56],"this":[57,144],"problem.":[58],"However,":[59],"it":[60],"has":[61],"been":[62],"hard":[63],"assess":[65,174],"or":[66],"exploit":[67],"opportunities":[69],"cryptic":[71,104,125,161,177],"present":[73],"inherent":[77],"difficulty":[78],"identifying":[80],"such":[81],"pockets.":[82,105],"Here,":[83],"I":[84],"will":[85],"discuss":[86],"progress":[87],"from":[88,143,167],"my":[89],"lab":[90],"on":[91,116,141,180],"combining":[92],"biophysical":[93],"experiments,":[94],"computer":[95,113],"simulations,":[96],"machine":[98,155],"learning":[99,156],"identify":[101],"target":[103],"In":[106],"one":[107],"case":[108],"study,":[109],"we":[110,151],"have":[111,152],"used":[112],"simulations":[114],"deployed":[115],"Folding@home":[118],"distributed":[119],"computing":[120],"environment":[121],"predict":[123,159],"pocket":[126],"allosterically":[129],"control":[130],"protein-RNA":[132],"interaction,":[133],"then":[135],"experimentally":[136],"confirmed":[137],"our":[138,149],"predictions.":[139],"Based":[140],"data":[142],"study":[145],"others":[147],"lab,":[150],"trained":[153],"algorithm":[157],"likely":[164],"single":[168],"structures,":[170],"enabling":[171],"us":[172],"how":[175],"prevalent":[176],"large":[182],"scale.":[183],"Citation":[184],"Format:":[185],"Gregory":[186],"R.":[187],"Bowman.":[188],"What":[189],"all":[191],"your":[192],"favorite":[193],"druggable.":[196],"[abstract].":[197],"In:":[198],"Proceedings":[199],"American":[202],"Association":[203],"Cancer":[205,224],"Research":[206],"Annual":[207],"Meeting":[208],"2023;":[209],"Part":[210],"1":[211],"(Regular":[212],"Invited":[214],"Abstracts);":[215],"2023":[216],"Apr":[217],"14-19;":[218],"Orlando,":[219],"FL.":[220],"Philadelphia":[221],"(PA):":[222],"AACR;":[223],"Res":[225],"2023;83(7_Suppl):Abstract":[226],"nr":[227],"PL05-03.":[228]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2023-04-06T00:00:00"}
