{"id":"https://openalex.org/W4362594584","doi":"https://doi.org/10.1158/1538-7445.am2023-69","title":"Abstract 69: Minimally invasive brain metastases are characterized by elevated immune cell infiltrate","display_name":"Abstract 69: Minimally invasive brain metastases are characterized by elevated immune cell infiltrate","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362594584","doi":"https://doi.org/10.1158/1538-7445.am2023-69"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2023-69","doi":"https://doi.org/10.1158/1538-7445.am2023-69","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-69","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078848924","display_name":"Sarah M. Maritan","orcid":"https://orcid.org/0000-0002-9703-7429","observed_orcids":["https://orcid.org/0000-0002-9703-7429"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sarah M. Maritan","raw_affiliation_strings":["1Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada;","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035990933","display_name":"Elham Karimi","orcid":"https://orcid.org/0000-0002-2204-0789","observed_orcids":["https://orcid.org/0000-0002-2204-0789"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Elham Karimi","raw_affiliation_strings":["1Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada;","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087616570","display_name":"Matthew Dankner","orcid":"https://orcid.org/0000-0003-4869-5895","observed_orcids":["https://orcid.org/0000-0003-4869-5895"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Matthew Dankner","raw_affiliation_strings":["1Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada;","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059288166","display_name":"Miranda Yu","orcid":"https://orcid.org/0000-0002-2896-2573","observed_orcids":["https://orcid.org/0000-0002-2896-2573"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Miranda W. Yu","raw_affiliation_strings":["2Goodman Cancer Institute, Faculty of Medicine, McGill University, Montreal, Quebec, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Goodman Cancer Institute, Faculty of Medicine, McGill University, Montreal, Quebec, Canada;","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020560286","display_name":"Aldo Hern\u00e1ndez-Corchado","orcid":"https://orcid.org/0000-0003-0682-3959","observed_orcids":["https://orcid.org/0000-0003-0682-3959"]},"institutions":[{"id":"https://openalex.org/I4210148969","display_name":"McGill University and G\u00e9nome Qu\u00e9bec Innovation Centre","ror":"https://ror.org/0589bxs97","country_code":"CA","type":"education","lineage":["https://openalex.org/I2802864159","https://openalex.org/I4210148969","https://openalex.org/I5023651"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Aldo Hernandez-Corchado","raw_affiliation_strings":["3Faculty of Medicine, McGill University; Genome Quebec Innovation Centre, Montreal, Quebec, Canada;","Faculty of Medicine, McGill University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Faculty of Medicine, McGill University; Genome Quebec Innovation Centre, Montreal, Quebec, Canada;","institution_ids":["https://openalex.org/I4210148969","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Faculty of Medicine, McGill University","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082419734","display_name":"Morteza Rezanejad","orcid":"https://orcid.org/0000-0001-8744-8534","observed_orcids":["https://orcid.org/0000-0001-8744-8534"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Morteza Rezanejad","raw_affiliation_strings":["4University of Toronto, Toronto, Ontario, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4University of Toronto, Toronto, Ontario, Canada;","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008529058","display_name":"Parvaneh Fallah","orcid":"https://orcid.org/0000-0001-7885-2009","observed_orcids":["https://orcid.org/0000-0001-7885-2009"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Parvaneh Fallah","raw_affiliation_strings":["5McGill University, Montreal, Quebec, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5McGill University, Montreal, Quebec, Canada;","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030688847","display_name":"Benoit Fiset","orcid":"https://orcid.org/0000-0003-0372-8868","observed_orcids":["https://orcid.org/0000-0003-0372-8868"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Benoit Fiset","raw_affiliation_strings":["1Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada;","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101594310","display_name":"Yuhong Wei","orcid":"https://orcid.org/0000-0003-4304-1024","observed_orcids":["https://orcid.org/0000-0003-4304-1024","https://orcid.org/0000-0003-2064-4826"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yuhong Wei","raw_affiliation_strings":["1Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada;","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011238803","display_name":"St\u00e9phanie Lam","orcid":"https://orcid.org/0000-0003-1698-1061","observed_orcids":["https://orcid.org/0000-0003-1698-1061","https://orcid.org/0009-0002-4678-0252"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Stephanie Lam","raw_affiliation_strings":["6Faculty of Medicine, McGill University, Montreal, Quebec, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Faculty of Medicine, McGill University, Montreal, Quebec, Canada;","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041948364","display_name":"Ali Nehme","orcid":"https://orcid.org/0000-0001-5254-848X","observed_orcids":["https://orcid.org/0000-0001-5254-848X"]},"institutions":[{"id":"https://openalex.org/I4210148969","display_name":"McGill University and G\u00e9nome Qu\u00e9bec Innovation Centre","ror":"https://ror.org/0589bxs97","country_code":"CA","type":"education","lineage":["https://openalex.org/I2802864159","https://openalex.org/I4210148969","https://openalex.org/I5023651"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ali Nehme","raw_affiliation_strings":["7McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada;","institution_ids":["https://openalex.org/I4210148969","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035229273","display_name":"Ian R. Watson","orcid":"https://orcid.org/0000-0002-6025-3080","observed_orcids":["https://orcid.org/0000-0002-6025-3080"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ian R. Watson","raw_affiliation_strings":["2Goodman Cancer Institute, Faculty of Medicine, McGill University, Montreal, Quebec, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Goodman Cancer Institute, Faculty of Medicine, McGill University, Montreal, Quebec, Canada;","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088293962","display_name":"Morag Park","orcid":"https://orcid.org/0000-0001-5400-606X","observed_orcids":["https://orcid.org/0000-0001-5400-606X"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Morag Park","raw_affiliation_strings":["2Goodman Cancer Institute, Faculty of Medicine, McGill University, Montreal, Quebec, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Goodman Cancer Institute, Faculty of Medicine, McGill University, Montreal, Quebec, Canada;","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064882820","display_name":"Yasser Riazalhosseini","orcid":"https://orcid.org/0000-0003-0875-618X","observed_orcids":["https://orcid.org/0000-0003-0875-618X"]},"institutions":[{"id":"https://openalex.org/I4210148969","display_name":"McGill University and G\u00e9nome Qu\u00e9bec Innovation Centre","ror":"https://ror.org/0589bxs97","country_code":"CA","type":"education","lineage":["https://openalex.org/I2802864159","https://openalex.org/I4210148969","https://openalex.org/I5023651"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yasser Riazalhosseini","raw_affiliation_strings":["3Faculty of Medicine, McGill University; Genome Quebec Innovation Centre, Montreal, Quebec, Canada;","Faculty of Medicine, McGill University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Faculty of Medicine, McGill University; Genome Quebec Innovation Centre, Montreal, Quebec, Canada;","institution_ids":["https://openalex.org/I4210148969","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Faculty of Medicine, McGill University","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033383913","display_name":"Hamed Shateri Najafabadi","orcid":"https://orcid.org/0000-0003-2735-4231","observed_orcids":["https://orcid.org/0000-0003-2735-4231"]},"institutions":[{"id":"https://openalex.org/I4210148969","display_name":"McGill University and G\u00e9nome Qu\u00e9bec Innovation Centre","ror":"https://ror.org/0589bxs97","country_code":"CA","type":"education","lineage":["https://openalex.org/I2802864159","https://openalex.org/I4210148969","https://openalex.org/I5023651"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hamed Najafabadi","raw_affiliation_strings":["3Faculty of Medicine, McGill University; Genome Quebec Innovation Centre, Montreal, Quebec, Canada;","Faculty of Medicine, McGill University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Faculty of Medicine, McGill University; Genome Quebec Innovation Centre, Montreal, Quebec, Canada;","institution_ids":["https://openalex.org/I4210148969","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Faculty of Medicine, McGill University","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021101665","display_name":"Kevin Petrecca","orcid":"https://orcid.org/0000-0002-8140-6402","observed_orcids":["https://orcid.org/0000-0002-8140-6402"]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kevin Petrecca","raw_affiliation_strings":["8Montreal Neurological Institute-Hospital, McGill University Health Centre; Faculty of Medicine, McGill University, Montreal, Quebec, Canada;","Faculty of Medicine, McGill University, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Montreal Neurological Institute-Hospital, McGill University Health Centre; Faculty of Medicine, McGill University, Montreal, Quebec, Canada;","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Faculty of Medicine, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108488813","display_name":"Marie\u2010Christine Guiot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405260784","display_name":"Institut du cancer Rosalind & Morris Goodman","ror":"https://ror.org/0494tzz73","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405260784","https://openalex.org/I5023651"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marie-Christine Guiot","raw_affiliation_strings":["9Goodman Cancer Institute, Faculty of Medicine, McGill University; Montreal Neurological Institute-Hospital, McGill University Health Centre, Montreal, Quebec, Canada","Goodman Cancer Institute, Faculty of Medicine, McGill University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Goodman Cancer Institute, Faculty of Medicine, McGill University; Montreal Neurological Institute-Hospital, McGill University Health Centre, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I2801766832","https://openalex.org/I4405260784","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Goodman Cancer Institute, Faculty of Medicine, McGill University","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009869289","display_name":"Daniela F. Quail","orcid":"https://orcid.org/0000-0002-6969-3250","observed_orcids":["https://orcid.org/0000-0002-6969-3250"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Daniela F. Quail","raw_affiliation_strings":["2Goodman Cancer Institute, Faculty of Medicine, McGill University, Montreal, Quebec, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Goodman Cancer Institute, Faculty of Medicine, McGill University, Montreal, Quebec, Canada;","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082063704","display_name":"Logan A. Walsh","orcid":"https://orcid.org/0000-0001-8771-2577","observed_orcids":["https://orcid.org/0000-0001-8771-2577"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Logan A. Walsh","raw_affiliation_strings":["2Goodman Cancer Institute, Faculty of Medicine, McGill University, Montreal, Quebec, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Goodman Cancer Institute, Faculty of Medicine, McGill University, Montreal, Quebec, Canada;","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083606690","display_name":"Peter M. Siegel","orcid":"https://orcid.org/0000-0002-5568-6586","observed_orcids":["https://orcid.org/0000-0002-5568-6586"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Peter M. Siegel","raw_affiliation_strings":["1Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada;","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"7_Supplement","first_page":"69","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9739999771118164},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.7699999809265137},{"id":"https://openalex.org/keywords/interferon-gamma-pathway","display_name":"interferon-gamma pathway","score":0.8939999938011169},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.703000009059906},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.671999990940094},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8410000205039978},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.5360000133514404},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7580000162124634},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.4429999887943268},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.593999981880188},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7250000238418579},{"id":"https://openalex.org/keywords/imaging-mass-cytometry","display_name":"imaging mass cytometry","score":0.9959999918937683},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6557539701461792},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5773559808731079},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.5756099224090576},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5669485330581665},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.5448995232582092},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5224030017852783},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5160717368125916},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5098651647567749},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4619166851043701},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4556747376918793},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.44011813402175903},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.42681729793548584},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4015079140663147},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39797520637512207},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23610129952430725},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2154081165790558},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19416972994804382},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14818435907363892},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1311502754688263},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2023-69","doi":"https://doi.org/10.1158/1538-7445.am2023-69","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-69","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392369751","https://openalex.org/W4403510301","https://openalex.org/W4362594516","https://openalex.org/W7161976718","https://openalex.org/W2986259065","https://openalex.org/W4410057706","https://openalex.org/W2955609209","https://openalex.org/W4403398392","https://openalex.org/W7162497037","https://openalex.org/W3030339055"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Cancer":[2,110,431,450],"metastasis":[3],"to":[4,69,260,285],"the":[5,25,29,75,92,109,136,182,187,190,306,323,427],"brain":[6,30,59,414],"is":[7,20],"a":[8,201],"common":[9],"complication":[10],"of":[11,28,132,141,189,203,293,314,357,426],"advanced":[12],"disease":[13],"with":[14,46,52,65,108,250],"limited":[15],"therapeutic":[16],"options.":[17],"Inefficient":[18],"treatment":[19],"influenced,":[21],"in":[22,36,74,210,233,238,255,304,322],"part,":[23],"by":[24,244,344,418],"unique":[26],"composition":[27],"microenvironment.":[31],"Brain":[32],"metastases":[33,415],"(BrM)":[34],"grow":[35],"two":[37,82],"distinct":[38],"patterns,":[39],"either":[40],"as":[41,50],"minimally":[42],"invasive":[43,54,413],"(MI)":[44],"masses":[45],"well-defined":[47],"borders,":[48],"or":[49,186],"tumors":[51],"highly":[53],"(HI)":[55],"growth":[56],"into":[57,335],"surrounding":[58],"tissue.":[60],"HI":[61,96,119,213,239,261,288,332],"BrM":[62,120,155,172,235,257,280,289,333,341,358],"are":[63,342,416],"associated":[64],"poor":[66],"prognoses":[67],"compared":[68,259],"MI":[70,98,116,211,234,256,286,340],"BrM;":[71],"however,":[72],"differences":[73],"tumor":[76],"immune":[77,348,355,420],"microenvironments":[78],"(TIME)":[79],"between":[80,95],"these":[81],"lesion":[83,192],"types":[84],"remain":[85],"largely":[86],"unknown.":[87],"Here,":[88],"we":[89,147,266],"investigate":[90],"how":[91],"TIME":[93,254],"differs":[94],"and":[97,117,124,139,177,205,215,236,274,299,308,311,318,439],"BrM.":[99],"Methods:":[100],"We":[101],"use":[102],"Nanostring":[103,196],"Digital":[104,197],"Spatial":[105,198],"Profiling":[106,199],"coupled":[107],"Transcriptome":[111],"Atlas":[112],"panel":[113],"on":[114,153],"5":[115],"15":[118],"patient":[121,281],"samples":[122,156,180,325],"(lung":[123,157],"breast":[125,159,214],"cancer).":[126],"This":[127],"technique":[128],"enables":[129],"specific":[130],"isolation":[131],"cancer":[133],"cells":[134,303,317,321],"at":[135],"tumor-brain":[137],"interface":[138,184],"quantification":[140],"1,825":[142],"cancer-specific":[143],"RNA":[144],"targets.":[145],"Additionally,":[146],"perform":[148],"imaging":[149],"mass":[150],"cytometry":[151],"(IMC)":[152],"119":[154],"cancer,":[158,160],"melanoma,":[161],"other)":[162],"from":[163,173,181],"46":[164],"patients,":[165],"encompassing":[166],"over":[167],"350,000":[168],"cells.":[169],"Samples":[170],"represent":[171],"various":[174],"primary":[175],"sites,":[176],"include":[178],"patient-matched":[179],"brain-tumor":[183],"(\u2018margin\u2019)":[185],"centre":[188],"metastatic":[191],"(\u2018core\u2019).":[193],"Results:":[194],"The":[195],"revealed":[200,223],"list":[202],"106":[204],"73":[206],"differentially":[207],"expressed":[208],"genes":[209],"vs":[212],"lung":[216],"BrM,":[217,240],"respectively.":[218],"Gene":[219],"set":[220],"enrichment":[221],"analyses":[222],"that":[224,331],"an":[225,251,336,345],"interferon":[226],"gamma":[227],"(IFN\u03b3)":[228],"pathway":[229],"signature":[230],"was":[231,242],"enriched":[232],"lost":[237],"which":[241,360],"confirmed":[243],"immunohistochemical":[245],"staining":[246],"for":[247,430],"pSTAT1,":[248],"consistent":[249],"\u201cimmune":[252],"hot\u201d":[253],"when":[258],"lesions.":[262],"Using":[263],"IMC":[264],"technology,":[265],"identified":[267],"20":[268],"different":[269],"cell":[270,421],"types,":[271],"activation":[272],"states,":[273],"spatially-defined":[275],"cellular":[276],"neighbourhoods":[277],"across":[278],"our":[279],"samples.":[282],"In":[283],"comparison":[284],"samples,":[287,310],"have":[290],"lower":[291,312],"numbers":[292,313],"B":[294],"cells,":[295,298],"CD4+":[296],"T":[297,302,316,320],"CD4-":[300],"CD8-":[301],"both":[305],"core":[307],"margin":[309,324],"CD8+":[315],"regulatory":[319],"only.":[326],"Discussion:":[327],"These":[328],"data":[329],"suggest":[330],"invade":[334],"immunosuppressed":[337],"microenvironment":[338],"while":[339],"characterized":[343,417],"active":[346],"anti-tumor":[347],"infiltrate.":[349],"Together,":[350],"this":[351],"work":[352],"suggests":[353],"potential":[354],"regulation":[356],"invasion,":[359],"warrants":[361],"further":[362],"investigation.":[363],"Citation":[364],"Format:":[365],"Sarah":[366],"M.":[367,410],"Maritan,":[368],"Elham":[369],"Karimi,":[370],"Matthew":[371],"Dankner,":[372],"Miranda":[373],"W.":[374],"Yu,":[375],"Aldo":[376],"Hernandez-Corchado,":[377],"Morteza":[378],"Rezanejad,":[379],"Parvaneh":[380],"Fallah,":[381],"Benoit":[382],"Fiset,":[383],"Yuhong":[384],"Wei,":[385],"Stephanie":[386],"Lam,":[387],"Ali":[388],"Nehme,":[389],"Ian":[390],"R.":[391],"Watson,":[392],"Morag":[393],"Park,":[394],"Yasser":[395],"Riazalhosseini,":[396],"Hamed":[397],"Najafabadi,":[398],"Kevin":[399],"Petrecca,":[400],"Marie-Christine":[401],"Guiot,":[402],"Daniela":[403],"F.":[404],"Quail,":[405],"Logan":[406],"A.":[407],"Walsh,":[408],"Peter":[409],"Siegel.":[411],"Minimally":[412],"elevated":[419],"infiltrate":[422],"[abstract].":[423],"In:":[424],"Proceedings":[425],"American":[428],"Association":[429],"Research":[432],"Annual":[433],"Meeting":[434],"2023;":[435],"Part":[436],"1":[437],"(Regular":[438],"Invited":[440],"Abstracts);":[441],"2023":[442],"Apr":[443],"14-19;":[444],"Orlando,":[445],"FL.":[446],"Philadelphia":[447],"(PA):":[448],"AACR;":[449],"Res":[451],"2023;83(7_Suppl):Abstract":[452],"nr":[453],"69.":[454]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-04-06T00:00:00"}