{"id":"https://openalex.org/W4362593489","doi":"https://doi.org/10.1158/1538-7445.am2023-4571","title":"Abstract 4571: A novel ex vivo platform, 3D-EXpress, to rapidly assess the efficacy of KRAS targeting drugs alone and in combination with nivolumab using a biorepository of fresh patient tumoroids with intact tumor microenvironment","display_name":"Abstract 4571: A novel ex vivo platform, 3D-EXpress, to rapidly assess the efficacy of KRAS targeting drugs alone and in combination with nivolumab using a biorepository of fresh patient tumoroids with intact tumor microenvironment","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362593489","doi":"https://doi.org/10.1158/1538-7445.am2023-4571"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2023-4571","doi":"https://doi.org/10.1158/1538-7445.am2023-4571","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-4571","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042557844","display_name":"Jared C. Ehrhart","orcid":"https://orcid.org/0000-0003-0679-4684","observed_orcids":["https://orcid.org/0000-0003-0679-4684"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jared Ehrhart","raw_affiliation_strings":["1Nilogen Oncosystems, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Nilogen Oncosystems, Tampa, FL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009329677","display_name":"Brittney Ruedlinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brittney Ruedlinger","raw_affiliation_strings":["1Nilogen Oncosystems, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Nilogen Oncosystems, Tampa, FL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020603475","display_name":"Angie Rivera","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angie Rivera","raw_affiliation_strings":["1Nilogen Oncosystems, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Nilogen Oncosystems, Tampa, FL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070869707","display_name":"Romanus Ezeoke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Romanus Ezeoke","raw_affiliation_strings":["1Nilogen Oncosystems, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Nilogen Oncosystems, Tampa, FL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001295137","display_name":"Sharon Camacho","orcid":"https://orcid.org/0000-0003-2390-0880","observed_orcids":["https://orcid.org/0000-0003-2390-0880"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sharon Camacho","raw_affiliation_strings":["1Nilogen Oncosystems, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Nilogen Oncosystems, Tampa, FL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058574624","display_name":"Seth Currlin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seth Currlin","raw_affiliation_strings":["1Nilogen Oncosystems, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Nilogen Oncosystems, Tampa, FL","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043205942","display_name":"Soner Altiok","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soner Altiok","raw_affiliation_strings":["1Nilogen Oncosystems, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Nilogen Oncosystems, Tampa, FL","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"7_Supplement","first_page":"4571","last_page":"4571"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.4722000062465668,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.4722000062465668,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.11909999698400497,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ex-vivo-drug-screening","display_name":"ex vivo drug testing","score":0.7110000252723694},{"id":"https://openalex.org/keywords/kras-g12c-inhibitors","display_name":"KRAS G12C inhibitors","score":0.8960000276565552},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.8220000267028809},{"id":"https://openalex.org/keywords/pd-1-pd-l1-immune-checkpoint","display_name":"PD-1/PD-L1 immune checkpoint","score":0.8769999742507935},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.4860000014305115},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8730000257492065},{"id":"https://openalex.org/keywords/sotorasib","display_name":"sotorasib","score":0.7269999980926514},{"id":"https://openalex.org/keywords/adagrasib","display_name":"adagrasib","score":0.9419999718666077},{"id":"https://openalex.org/keywords/sos1-inhibitor","display_name":"SOS1 inhibitor","score":0.5479999780654907},{"id":"https://openalex.org/keywords/tumor-cell-killing","display_name":"tumor cell killing","score":0.6349999904632568},{"id":"https://openalex.org/keywords/cytokine-profiling","display_name":"cytokine profiling","score":0.6620000004768372},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.7960000038146973},{"id":"https://openalex.org/keywords/kras-mutation-status","display_name":"KRAS mutation status","score":0.6000000238418579},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.7939364314079285},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.7388433814048767},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.6817772388458252},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5647366642951965},{"id":"https://openalex.org/C2780380082","wikidata":"https://www.wikidata.org/wiki/Q12646460","display_name":"Granzyme B","level":4,"score":0.5572004318237305},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4863291382789612},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4789507985115051},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.46378055214881897},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4540749788284302},{"id":"https://openalex.org/C183193105","wikidata":"https://www.wikidata.org/wiki/Q425068","display_name":"Granzyme","level":5,"score":0.44318053126335144},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41594892740249634},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3797002136707306},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33648285269737244},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3190756142139435},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2691938877105713},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.1374349594116211},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11075925827026367},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.10227912664413452},{"id":"https://openalex.org/C2776062744","wikidata":"https://www.wikidata.org/wiki/Q21103279","display_name":"Perforin","level":4,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2023-4571","doi":"https://doi.org/10.1158/1538-7445.am2023-4571","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-4571","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393071776","https://openalex.org/W4388072438","https://openalex.org/W4362593280","https://openalex.org/W4362594318","https://openalex.org/W4308375603","https://openalex.org/W4308381367","https://openalex.org/W4308376188","https://openalex.org/W2740549875","https://openalex.org/W2887018760","https://openalex.org/W3088998159"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"3D-EXpress":[2,73],"is":[3,307],"a":[4,12,136,149,186,236,266,376],"novel":[5,355],"ex":[6,89,195,246,356],"vivo":[7,127,196,247,357],"drug":[8,54,82,250],"testing":[9],"platform":[10,74],"using":[11,185,301,375],"Biorepository":[13,124],"of":[14,51,59,78,315,365,378,389],"neverdissociated,":[15],"propagated,":[16],"or":[17],"reassembled":[18],"fresh":[19,379],"patient":[20,100,243,380],"tumoroids":[21,106,130,381],"with":[22,99,107,133,157,256,373,382],"intact":[23,305,383],"tumor":[24,32,95,164,176,200,240,257,274,280,384],"microenvironment.Tumoroids":[25],"measuring":[26],"150":[27],"\u00b5m":[28],"in":[29,155,163,239,271,335,371],"size":[30],"retain":[31],"cell":[33,67,165,177],"heterogeneity,":[34],"tumor-resident":[35],"innate":[36,259],"andadaptive":[37],"immune":[38,66,168,201,318],"cells,":[39,63],"stromal":[40],"components,":[41],"and":[42,53,65,81,86,92,102,116,143,148,154,233,260,317,327,370,402],"cell-extracellular":[43],"matrix":[44],"interaction":[45],"allowing":[46],"to":[47,245,273,311,322,328,360],"rapidlytest":[48],"the":[49,60,72,76,199,298,313,336,363,390],"efficacy":[50,77,314,364],"drugs":[52,80,321,368],"combinations":[55,83],"targeting":[56,84,367],"various":[57],"components":[58],"TME":[61],"includingtumor":[62],"stroma,":[64],"populations.":[68],"Here":[69],"we":[70,180],"employed":[71,181],"tocompare":[75],"different":[79],"KRAS":[85,109,150,275,316,366],"PD-1/PD-L1":[87],"immunecheckpoint":[88],"vivo.":[90],"Materials":[91],"Methods:":[93],"All":[94],"samples":[96,208,244],"were":[97,119,131,170,209,253],"obtained":[98],"consent":[101],"relevant":[103,331],"IRBapproval.":[104],"Cryopreserved":[105],"known":[108],"mutation":[110,276],"status,":[111],"PD-L1":[112,285],"expression,":[113],"detailedimmune":[114],"profiles":[115],"clinicopathologic":[117],"data":[118,190,295],"selected":[120],"from":[121,206],"Nilogen\u2019s":[122],"tumoroid":[123],"for":[125,159,189,211,393],"theex":[126],"assays.":[128],"3D":[129,182,303],"treated":[132],"vehicle":[134],"only,":[135],"SOS1::KRAS":[137],"inhibitor,":[138,146,152],"BI":[139],"1701963,":[140],"apotent,":[141],"selective,":[142],"covalent":[144],"KRASG12C":[145],"MRTX849,":[147],"G12C":[151],"sotorasib,alone":[153],"combination":[156,325,372],"nivolumab":[158,374],"72h.":[160],"Treatment-mediated":[161],"changes":[162],"killing":[166,178],"andtumor":[167],"microenvironment":[169,202],"analyzed.":[171],"Results:":[172],"To":[173,192],"quantify":[174],"treatment-mediated":[175],"activity":[179],"high-contentconfocal":[183],"imaging":[184],"proprietary":[187],"algorithm":[188],"analysis.":[191],"monitor":[193],"how":[194],"drugtreatments":[197],"affect":[198],"culture":[203],"supernatants":[204],"isolated":[205],"treatedtumoroid":[207],"used":[210],"multiplex":[212],"cytokine":[213],"detection":[214],"including":[215],"GM-CSF,":[216],"sCD137,":[217],"IFN\u03b3,":[218],"sFas,sFasL,":[219],"Granzyme":[220,222],"A,":[221],"B,":[223],"IL-2,":[224],"IL-4,":[225],"IL-5,":[226],"IL-6,":[227],"IL-10,":[228],"IL-13,":[229],"MIP-1\u03b1,":[230],"MIP-1\u03b2,":[231],"TNF-\u03b1,":[232],"Perforin.We":[234],"observed":[235],"significant":[237],"difference":[238],"responses":[241],"among":[242],"tested":[248],"drugsand":[249],"combinations,":[251],"which":[252],"further":[254],"correlated":[255],"resident":[258],"adaptive":[261],"immunecell":[262],"populations":[263],"detected":[264],"by":[265],"21-color":[267],"flow":[268],"cytometry":[269],"panel":[270],"addition":[272],"status,patient":[277],"smoking":[278],"history,":[279],"characteristics":[281],"as":[282,284],"well":[283],"expression":[286],"levels":[287],"analyzed":[288],"on":[289],"theassociated":[290],"TMA":[291],"slides.":[292],"Conclusion:":[293],"Our":[294],"demonstrate":[296],"that":[297],"3D-Express":[299],"platform,":[300,358],"cryopreserved":[302],"tumoroidswith":[304],"TME,":[306],"an":[308],"effective":[309],"tool":[310],"assess":[312,362],"checkpoint":[319],"inhibitorstargeting":[320],"identify":[323],"rational":[324],"therapies":[326],"develop":[329],"clinically":[330],"biomarkersfor":[332],"individualized":[333],"patients":[334],"future.":[337],"Citation":[338],"Format:":[339],"Jared":[340],"Ehrhart,":[341],"Brittney":[342],"Ruedlinger,":[343],"Angie":[344],"Rivera,":[345],"Romanus":[346],"Ezeoke,":[347],"Sharon":[348],"Camacho,":[349],"Seth":[350],"Currlin,":[351],"Soner":[352],"Altiok.":[353],"A":[354],"3D-EXpress,":[359],"rapidly":[361],"alone":[369],"biorepository":[377],"microenvironment.":[385],"[abstract].":[386],"In:":[387],"Proceedings":[388],"American":[391],"Association":[392],"Cancer":[394,413],"Research":[395],"Annual":[396],"Meeting":[397],"2023;":[398],"Part":[399],"1":[400],"(Regular":[401],"Invited":[403],"Abstracts);":[404],"2023":[405],"Apr":[406],"14-19;":[407],"Orlando,":[408],"FL.":[409],"Philadelphia":[410],"(PA):":[411],"AACR;":[412],"Res":[414],"2023;83(7_Suppl):Abstract":[415],"nr":[416],"4571.":[417]},"counts_by_year":[],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2023-04-06T00:00:00"}
