{"id":"https://openalex.org/W4362593312","doi":"https://doi.org/10.1158/1538-7445.am2023-1129","title":"Abstract 1129: Targeting tissue-resident macrophage progenitors restores anti-tumor immunity and suppresses tumor growth","display_name":"Abstract 1129: Targeting tissue-resident macrophage progenitors restores anti-tumor immunity and suppresses tumor growth","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362593312","doi":"https://doi.org/10.1158/1538-7445.am2023-1129"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2023-1129","doi":"https://doi.org/10.1158/1538-7445.am2023-1129","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-1129","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hui Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Chen","raw_affiliation_strings":["1UCSD Moores Cancer Center, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCSD Moores Cancer Center, San Diego, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061246531","display_name":"Marc A. Paradise","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Paradise","raw_affiliation_strings":["1UCSD Moores Cancer Center, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCSD Moores Cancer Center, San Diego, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ryan Shepard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Shepard","raw_affiliation_strings":["1UCSD Moores Cancer Center, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCSD Moores Cancer Center, San Diego, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044741837","display_name":"Guangfang Wang","orcid":"https://orcid.org/0009-0006-5837-2319","observed_orcids":["https://orcid.org/0009-0006-5837-2319"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guangfang Wang","raw_affiliation_strings":["1UCSD Moores Cancer Center, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCSD Moores Cancer Center, San Diego, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045174120","display_name":"Mark W. Onaitis","orcid":"https://orcid.org/0000-0003-0997-6563","observed_orcids":["https://orcid.org/0000-0003-0997-6563"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Onaitis","raw_affiliation_strings":["1UCSD Moores Cancer Center, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCSD Moores Cancer Center, San Diego, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007491235","display_name":"Judith A. Varner","orcid":"https://orcid.org/0000-0002-9251-0600","observed_orcids":["https://orcid.org/0000-0002-9251-0600"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith Varner","raw_affiliation_strings":["1UCSD Moores Cancer Center, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UCSD Moores Cancer Center, San Diego, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"7_Supplement","first_page":"1129","last_page":"1129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tissue-resident-macrophages","display_name":"tissue-resident macrophages","score":0.9580000042915344},{"id":"https://openalex.org/keywords/macrophage-progenitors","display_name":"macrophage progenitors","score":0.9350000023841858},{"id":"https://openalex.org/keywords/macrophage-origin","display_name":"macrophage origin","score":0.7250000238418579},{"id":"https://openalex.org/keywords/c-kit","display_name":"CD117","score":0.47600001096725464},{"id":"https://openalex.org/keywords/csf1r","display_name":"CSF1R","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cdk19","display_name":"CDK19","score":0.7699999809265137},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.6010000109672546},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6470000147819519},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.9800000190734863}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6350299119949341},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6254705190658569},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6077390909194946},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6032299399375916},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5268715023994446},{"id":"https://openalex.org/C206615009","wikidata":"https://www.wikidata.org/wiki/Q4035572","display_name":"CCR2","level":5,"score":0.5100422501564026},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5051811337471008},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.493960440158844},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47784659266471863},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.46177589893341064},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4391191899776459},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.425159752368927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24776268005371094},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.22263729572296143},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21116697788238525},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.15539667010307312},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.11949068307876587},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2023-1129","doi":"https://doi.org/10.1158/1538-7445.am2023-1129","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-1129","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393085890","https://openalex.org/W3126691133","https://openalex.org/W2885491055","https://openalex.org/W4240272026","https://openalex.org/W3154148282","https://openalex.org/W7140115524","https://openalex.org/W7171508555","https://openalex.org/W3171491383","https://openalex.org/W3192950239","https://openalex.org/W3116206322"],"abstract_inverted_index":{"Abstract":[0],"Macrophages":[1],"are":[2,34,116,118,175,183],"innate":[3],"immune":[4,14,120,177,203,216],"cells":[5,26,277],"that":[6,86,115,124,170,172,259],"accumulate":[7],"rapidly":[8],"in":[9,30,91,150,188,238,248],"tumors,":[10,239],"where":[11],"they":[12,33],"promote":[13],"suppression,":[15],"tumor":[16,31,51,72,159,246,268,314],"growth":[17,52,315],"and":[18,80,93,147,155,158,167,182,201,215,219,225,244,265,312,332],"resistance":[19],"to":[20,39,45,49,287],"checkpoint":[21],"inhibitor":[22,258],"therapy.":[23],"As":[24],"these":[25,232],"play":[27],"critical":[28],"roles":[29],"progression,":[32],"the":[35,69,138,229,282,320],"focus":[36],"of":[37,71,89,112,145,196,213,222,231,251,284,319],"efforts":[38],"develop":[40],"novel":[41,256],"cancer":[42,189],"therapeutics.":[43],"Strategies":[44],"inhibit":[46],"macrophage":[47,166,263,275,307],"accumulation":[48,237,264],"suppress":[50],"by":[53,135],"blocking":[54],"their":[55,236],"recruitment":[56],"from":[57,101,126,137],"circulation":[58],"have":[59],"been":[60],"only":[61],"partially":[62],"effective.":[63],"In":[64],"this":[65],"project,":[66],"we":[67,161],"examined":[68],"origins":[70],"associated":[73,184],"macrophages":[74,90,114,123,149,174,181,193,209],"using":[75],"lineage":[76],"tracing,":[77],"flow":[78],"cytometry,":[79],"single":[81],"cell":[82],"sequencing.":[83],"We":[84,253],"found":[85],"large":[87,110],"proportions":[88],"subcutaneous":[92],"genetically":[94],"engineered":[95],"mouse":[96,249],"tumors":[97],"do":[98],"not":[99],"derive":[100],"Ly6C+":[102],"or":[103,105],"Ly6C-":[104],"CCR2+":[106],"monocytes.":[107],"Instead,":[108],"a":[109,127,255],"population":[111],"CCR2-Ly6C-F4/80hi":[113],"CD206+MerTK+":[117],"profoundly":[119],"suppressive":[121,178],"resident":[122,146,165,173,192,262,274],"arise":[125],"transcriptionally":[128],"related":[129],"proliferative":[130],"progenitor":[131,276],"subpopulation":[132],"rather":[133],"than":[134,179],"trafficking":[136],"circulation.":[139],"By":[140],"comparing":[141],"gene":[142],"expression":[143],"profiles":[144],"recruited":[148,168,180],"subcutaneous,":[151],"alveolar,":[152],"central":[153],"nervous":[154],"renal":[156],"normal":[157],"tissues,":[160],"identified":[162,254],"generic":[163],"tissue":[164,261,273],"signatures":[169,195,212],"reveal":[171],"more":[176],"with":[185],"worse":[186],"outcomes":[187],"patients.":[190],"Tissue":[191],"express":[194,210],"Myc-driven":[197],"proliferation,":[198],"cholesterol":[199],"metabolism":[200],"profound":[202],"suppression":[204],"while":[205],"bone":[206],"marrow":[207],"derived":[208],"mixed":[211],"inflammation":[214],"suppression.":[217],"Genetic":[218],"pharmacological":[220],"inhibition":[221],"c-Kit/mCsf1R,":[223],"cMyc":[224],"cyclin-dependent":[226],"kinases":[227],"suppressed":[228,260],"expansion":[230],"macrophages,":[233],"thereby":[234],"limiting":[235],"promoting":[240],"anti-tumor":[241,310],"adaptive":[242],"immunity":[243,311],"inhibiting":[245],"progression":[247],"models":[250],"cancer.":[252],"cKit/Csf1r/Cdk19":[257],"potently":[266],"inhibited":[267],"growth.":[269],"These":[270],"results":[271],"identify":[272],"as":[278],"key":[279],"targets":[280],"for":[281,323],"development":[283],"therapeutic":[285],"strategies":[286],"stimulate":[288],"anti-cancer":[289],"immunity.":[290],"Citation":[291],"Format:":[292],"Hui":[293],"Chen,":[294],"Marc":[295],"Paradise,":[296],"Ryan":[297],"Shepard,":[298],"Guangfang":[299],"Wang,":[300],"Mark":[301],"Onaitis,":[302],"Judith":[303],"Varner.":[304],"Targeting":[305],"tissue-resident":[306],"progenitors":[308],"restores":[309],"suppresses":[313],"[abstract].":[316],"In:":[317],"Proceedings":[318],"American":[321],"Association":[322],"Cancer":[324,343],"Research":[325],"Annual":[326],"Meeting":[327],"2023;":[328],"Part":[329],"1":[330],"(Regular":[331],"Invited":[333],"Abstracts);":[334],"2023":[335],"Apr":[336],"14-19;":[337],"Orlando,":[338],"FL.":[339],"Philadelphia":[340],"(PA):":[341],"AACR;":[342],"Res":[344],"2023;83(7_Suppl):Abstract":[345],"nr":[346],"1129.":[347]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2023-04-06T00:00:00"}