{"id":"https://openalex.org/W4362593302","doi":"https://doi.org/10.1158/1538-7445.am2023-5012","title":"Abstract 5012: Characterizing the functional significance of PDGFRAK385I and PDGFRAK385L extracellular domain mutations in the newly defined myxoid glioneuronal tumor","display_name":"Abstract 5012: Characterizing the functional significance of PDGFRAK385I and PDGFRAK385L extracellular domain mutations in the newly defined myxoid glioneuronal tumor","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362593302","doi":"https://doi.org/10.1158/1538-7445.am2023-5012"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2023-5012","doi":"https://doi.org/10.1158/1538-7445.am2023-5012","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-5012","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077601660","display_name":"Catherine Z. Beach","orcid":"https://orcid.org/0000-0003-0750-3658","observed_orcids":["https://orcid.org/0000-0003-0750-3658"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Z. Beach","raw_affiliation_strings":["1Oregon Health & Science University, Portland, OR;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Oregon Health & Science University, Portland, OR;","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030479930","display_name":"Romel Somwar","orcid":"https://orcid.org/0000-0002-5282-6889","observed_orcids":["https://orcid.org/0000-0002-5282-6889"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Romel Somwar","raw_affiliation_strings":["2Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101545695","display_name":"Matthew D. Wood","orcid":"https://orcid.org/0000-0002-2385-8128","observed_orcids":["https://orcid.org/0000-0002-2385-8128"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew D. Wood","raw_affiliation_strings":["1Oregon Health & Science University, Portland, OR;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Oregon Health & Science University, Portland, OR;","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045185741","display_name":"Monika Ashok Davare","orcid":"https://orcid.org/0000-0003-1802-7597","observed_orcids":["https://orcid.org/0000-0003-1802-7597"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monika A. Davare","raw_affiliation_strings":["1Oregon Health & Science University, Portland, OR;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Oregon Health & Science University, Portland, OR;","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"7_Supplement","first_page":"5012","last_page":"5012"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-domain-mutations","display_name":"extracellular domain mutations","score":0.875},{"id":"https://openalex.org/keywords/variants-of-uncertain-significance","display_name":"variants of uncertain significance","score":0.8600000143051147},{"id":"https://openalex.org/keywords/oncogenicity","display_name":"oncogenicity","score":0.6710000038146973},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8109999895095825},{"id":"https://openalex.org/keywords/axitinib","display_name":"axitinib","score":0.8920000195503235},{"id":"https://openalex.org/keywords/avapritinib","display_name":"avapritinib","score":0.9750000238418579},{"id":"https://openalex.org/keywords/imatinib-resistance","display_name":"imatinib resistance","score":0.9779999852180481},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/shp2","display_name":"SHP2","score":0.8799999952316284},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ba-f3-cells","display_name":"Ba/F3 cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/central-nervous-system-tumors","display_name":"central nervous system tumors","score":0.7630000114440918},{"id":"https://openalex.org/keywords/who-2021-cns-tumor-classification","display_name":"WHO 2021 CNS tumor classification","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C37307934","wikidata":"https://www.wikidata.org/wiki/Q18030422","display_name":"PDGFRA","level":4,"score":0.9274505376815796},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6821774840354919},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6071118712425232},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5473157167434692},{"id":"https://openalex.org/C78221974","wikidata":"https://www.wikidata.org/wiki/Q18030425","display_name":"PDGFRB","level":3,"score":0.4402003884315491},{"id":"https://openalex.org/C2778472372","wikidata":"https://www.wikidata.org/wiki/Q7833138","display_name":"Trametinib","level":4,"score":0.4175611734390259},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3643220365047455},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.3224168121814728},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.3221170902252197},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2772050201892853},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18554019927978516},{"id":"https://openalex.org/C2775922572","wikidata":"https://www.wikidata.org/wiki/Q83567","display_name":"GiST","level":3,"score":0.16702523827552795},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12875968217849731}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2023-5012","doi":"https://doi.org/10.1158/1538-7445.am2023-5012","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-5012","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393189446","https://openalex.org/W2981098618","https://openalex.org/W7117902148","https://openalex.org/W4416624597","https://openalex.org/W3183920253","https://openalex.org/W2883482557","https://openalex.org/W4206341651","https://openalex.org/W4405245676","https://openalex.org/W4309017263","https://openalex.org/W7213415078"],"abstract_inverted_index":{"Abstract":[0],"In":[1,259],"2021,":[2],"the":[3,68,106,153,159,212,240,256,291,311,322,332],"World":[4],"Health":[5],"Organization":[6],"(WHO)":[7],"approved":[8],"new":[9,36],"diagnostic":[10],"guidelines":[11],"that":[12,127,211,264,282],"stratify":[13],"central":[14],"nervous":[15],"system":[16],"(CNS)":[17],"tumors":[18],"based":[19,40],"on":[20,30,41,47],"molecular,":[21],"transcriptomic,":[22],"and":[23,33,111,120,130,140,170,179,185,214,223,237,276,316,344],"epigenetic":[24],"analysis":[25,146],"instead":[26],"of":[27,49,71,79,85,100,109,147,155,162,168,173,242,293,314,331],"relying":[28],"solely":[29],"phenotypic":[31],"characterization":[32,108],"added":[34],"twenty-two":[35],"CNS":[37],"tumor":[38,60,101],"entities":[39],"these":[42,50,163,230,265],"guidelines.":[43],"Our":[44,124],"focus":[45],"is":[46,87],"one":[48],"newly":[51,323],"defined":[52,61,324],"entities\u2014myxoid":[53],"glioneuronal":[54,295,326],"tumors\u2014a":[55],"slow":[56],"growing,":[57],"mucinous":[58],"glial":[59],"by":[62,113],"a":[63,77,91,98,278],"pathognomonic":[64],"dinucleotide":[65],"substitution":[66],"in":[67,97,152,248,272,290,321],"extracellular":[69,269,318],"domain":[70,270,319],"PDGFRA":[72,74,86,169,200,206,273],"p.K385I/L.":[73],"p.K385I/L":[75,268],"remains":[76],"variant":[78],"unknown":[80],"significance,":[81],"however,":[82],"constitutive":[83,171],"activation":[84],"well":[88],"established":[89],"as":[90],"pharmacologically":[92,188,279],"actionable,":[93,189],"oncogenic":[94,275],"driver":[95],"present":[96],"variety":[99],"types.":[102],"Here":[103],"we":[104,190],"report":[105],"functional":[107,312],"PDGFRAK385I":[110,184,213,315],"PDGFRAK385L":[112,186,215,317],"assessing":[114],"transforming":[115],"potential":[116],"using":[117,203],"Ba/F3":[118,137,207],"cells":[119],"immortalized":[121],"human":[122],"astrocytes.":[123],"results":[125],"demonstrate":[126],"both":[128],"p.K385I":[129],"K385L":[131],"substitutions":[132],"are":[133,187,274],"oncogenic,":[134],"driving":[135],"cytokine-independent":[136],"cell":[138],"growth":[139],"anchorage-independent":[141],"colony":[142],"formation.":[143],"Western":[144],"blot":[145],"downstream":[148,174],"cellular":[149],"signaling":[150,175],"pathways":[151],"absence":[154],"PDGF-ligand":[156],"further":[157],"confirm":[158],"activating":[160],"nature":[161],"mutations,":[164],"showing":[165],"robust":[166],"phosphorylation":[167,172],"effectors":[176],"ERK1/2,":[177],"SHP2,":[178],"STAT3.":[180],"To":[181],"assess":[182],"whether":[183],"tested":[191],"multiple":[192],"tyrosine":[193],"kinase":[194],"inhibitors":[195,220],"with":[196],"known":[197],"activity":[198],"against":[199],"aberrant":[201],"cancers":[202],"our":[204,261],"mutant-transformed":[205],"cells.":[208],"We":[209],"found":[210],"mutants":[216,231],"were":[217],"sensitive":[218],"to":[219,234,286],"axitinib,":[221],"AZD-3229,":[222],"avapritinib":[224],"at":[225],"therapeutically":[226],"relevant":[227],"concentrations.":[228],"Further,":[229],"showed":[232],"resistance":[233,251],"imatinib,":[235],"nilotinib,":[236],"crenolanib":[238],"underscoring":[239],"importance":[241],"pharmacogenomic":[243],"investigation.":[244],"No":[245],"appreciable":[246],"difference":[247],"sensitivity":[249],"or":[250],"profiles":[252],"was":[253],"observed":[254],"between":[255],"two":[257],"mutants.":[258],"summary,":[260],"findings":[262],"indicate":[263],"previously":[266],"uncharacterized":[267],"mutations":[271,320],"represent":[277],"actionable":[280],"target":[281],"could":[283],"be":[284],"harnessed":[285],"increase":[287],"therapeutic":[288],"options":[289],"setting":[292],"myxoid":[294,325],"tumors.":[296],"Citation":[297],"Format:":[298],"Catherine":[299],"Z.":[300],"Beach,":[301],"Romel":[302],"Somwar,":[303],"Matthew":[304],"D.":[305],"Wood,":[306],"Monika":[307],"A.":[308],"Davare.":[309],"Characterizing":[310],"significance":[313],"tumor.":[327],"[abstract].":[328],"In:":[329],"Proceedings":[330],"American":[333],"Association":[334],"for":[335],"Cancer":[336,355],"Research":[337],"Annual":[338],"Meeting":[339],"2023;":[340],"Part":[341],"1":[342],"(Regular":[343],"Invited":[345],"Abstracts);":[346],"2023":[347],"Apr":[348],"14-19;":[349],"Orlando,":[350],"FL.":[351],"Philadelphia":[352],"(PA):":[353],"AACR;":[354],"Res":[356],"2023;83(7_Suppl):Abstract":[357],"nr":[358],"5012.":[359]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-06T00:00:00"}