{"id":"https://openalex.org/W4362593006","doi":"https://doi.org/10.1158/1538-7445.am2023-6001","title":"Abstract 6001: Epigenetic regulation of BARD1 confers resistance to anti-VEGF therapy in ovarian cancer","display_name":"Abstract 6001: Epigenetic regulation of BARD1 confers resistance to anti-VEGF therapy in ovarian cancer","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362593006","doi":"https://doi.org/10.1158/1538-7445.am2023-6001"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2023-6001","doi":"https://doi.org/10.1158/1538-7445.am2023-6001","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2023-6001","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022598004","display_name":"Emine Bayraktar","orcid":"https://orcid.org/0000-0002-5189-1507","observed_orcids":["https://orcid.org/0000-0002-5189-1507"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emine Bayraktar","raw_affiliation_strings":["1UT MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010129570","display_name":"Cristian Rodriguez\u2010Aguayo","orcid":"https://orcid.org/0000-0002-7880-7723","observed_orcids":["https://orcid.org/0000-0002-7880-7723"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristian Rodriguez-Aguayo","raw_affiliation_strings":["1UT MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019709859","display_name":"Sudhir Kumar","orcid":"https://orcid.org/0000-0001-5806-3029","observed_orcids":["https://orcid.org/0000-0001-5806-3029"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudhir Kumar","raw_affiliation_strings":["2Medical College of Wisconsin, Milwaukee, WI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Medical College of Wisconsin, Milwaukee, WI;","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044349562","display_name":"Elaine Stur","orcid":"https://orcid.org/0000-0001-5962-0050","observed_orcids":["https://orcid.org/0000-0001-5962-0050"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine Stur","raw_affiliation_strings":["1UT MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042760638","display_name":"Lingegowda Selanere Mangala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lingegowda S. Mangala","raw_affiliation_strings":["1UT MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040153200","display_name":"Stephen Baylin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Baylin","raw_affiliation_strings":["3Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023542865","display_name":"Gabriel Lopez\u2010Berestein","orcid":"https://orcid.org/0000-0002-0366-0720","observed_orcids":["https://orcid.org/0000-0002-0366-0720"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel Lopez-Berestein","raw_affiliation_strings":["1UT MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043392987","display_name":"Sunila Pradeep","orcid":"https://orcid.org/0000-0003-2441-7727","observed_orcids":["https://orcid.org/0000-0003-2441-7727"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunila Pradeep","raw_affiliation_strings":["2Medical College of Wisconsin, Milwaukee, WI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Medical College of Wisconsin, Milwaukee, WI;","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100640276","display_name":"Anil K. Sood","orcid":"https://orcid.org/0000-0002-5415-9901","observed_orcids":["https://orcid.org/0000-0002-5415-9901"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil K. Sood","raw_affiliation_strings":["1UT MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"7_Supplement","first_page":"6001","last_page":"6001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.2451000064611435,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.12409999966621399,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bard1","display_name":"BARD1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.871999979019165},{"id":"https://openalex.org/keywords/anti-vegf-therapy-resistance","display_name":"anti-VEGF therapy resistance","score":0.8429999947547913},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9610000252723694},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.8140000104904175},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.640999972820282},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.722000002861023},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8259999752044678},{"id":"https://openalex.org/keywords/skov3-xenograft","display_name":"SKOV3 xenograft","score":0.7369999885559082},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.46299999952316284},{"id":"https://openalex.org/keywords/gene-expression-reprogramming","display_name":"gene expression reprogramming","score":0.4000000059604645},{"id":"https://openalex.org/keywords/adaptive-drug-resistance","display_name":"adaptive drug resistance","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6810486912727356},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6783729791641235},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.628750741481781},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.5211284756660461},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.519596517086029},{"id":"https://openalex.org/C2780737395","wikidata":"https://www.wikidata.org/wiki/Q18353741","display_name":"Epigenetic therapy","level":5,"score":0.5154665112495422},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5146928429603577},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5059234499931335},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.5014874935150146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42908427119255066},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4015933871269226},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28418201208114624},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2709296941757202},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.18426495790481567},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05628317594528198},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2023-6001","doi":"https://doi.org/10.1158/1538-7445.am2023-6001","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2023-6001","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393084851","https://openalex.org/W4413951808","https://openalex.org/W2912755610","https://openalex.org/W7081931818","https://openalex.org/W4410910610","https://openalex.org/W2074375350","https://openalex.org/W1965505719","https://openalex.org/W4223484773","https://openalex.org/W2605220782","https://openalex.org/W4256191434"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Vascular":[2],"endothelial":[3],"growth":[4],"factor":[5],"(VEGF)":[6],"is":[7,27,69],"a":[8,22,89,191,202,340,385],"key":[9],"promoter":[10],"of":[11,31,42,75,95,111,138,166,211,224,240,280,328,356,362,398,405,413,442,455],"angiogenesis":[12,364],"and":[13,35,83,118,125,127,169,206,233,242,282,295,317,378,468],"disease":[14],"progression":[15],"in":[16,78,87,112,119,154,174,195,237,258,274,288,304,343,346,351,372,376,379,391,416,449],"epithelial":[17],"ovarian":[18,34,450],"cancer":[19,46,451],"(OC).":[20],"Bevacizumab,":[21],"humanized":[23],"anti-VEGF":[24,43,63,147,447],"monoclonal":[25],"antibody,":[26],"approved":[28],"for":[29,45,389,459],"treatment":[30,149,264],"patients":[32,49],"with":[33,144,185,265],"other":[36],"cancers.":[37],"Despite":[38],"the":[39,72,93,164,225,238,259,268,271,278,309,325,347,363,403,411,456],"wide":[40],"use":[41],"therapy":[44,105,168,273,306,415,448],"treatment,":[47],"most":[48],"develop":[50],"resistant":[51,132],"disease.":[52],"Therefore,":[53],"new":[54],"combinations/strategies":[55],"are":[56],"needed":[57],"to":[58,62,70,172,246,308,394,401,446],"reduce":[59],"adaptive":[60],"resistance":[61,171,269,393,445],"antibody":[64],"(AVA)":[65],"therapy.":[66,261,396],"Our":[67,249,337,382],"aim":[68],"determine":[71,159,324],"potential":[73],"role":[74,388],"epigenetic":[76,85,101,399],"changes":[77,86,102],"AVA-adaptive":[79],"resistance.":[80,97],"We":[81],"identified":[82],"characterized":[84],"BARD1,":[88,329],"tumor":[90,196,286,344,406],"suppressor,":[91],"at":[92],"emergence":[94],"AVA":[96,104,167,173,272,395,414],"Methods:":[98],"To":[99,158,323],"define":[100],"during":[103],"induced":[106],"resistance,":[107],"we":[108,176,200,218,330],"performed":[109,201],"series":[110],"vitro":[113,377],"(methylation":[114],"array,":[115],"RNA":[116],"sequencing)":[117],"vivo":[120,155],"(orthotopic":[121],"OC":[122],"(PDX-MDA-OVCA1,":[123],"immunocompetent-IG10,":[124],"immunocompromised-SKOV3)":[126],"fibrosarcoma-HT1080,":[128],"an":[129,360],"inherently":[130],"VEGF":[131],"model)":[133],"experiments.":[134],"The":[135,262],"biological":[136,326],"effects":[137],"DNA":[139],"methylation":[140,205],"agent":[141],"(5`-Azacytidine;":[142],"5`-Aza)":[143],"B20":[145,186,241,247,281,310],"(murine":[146],"antibody)":[148],"were":[150,301,320,370],"subsequently":[151],"tested":[152],"using":[153,333],"models.":[156],"Results:":[157],"whether":[160],"5`-Aza":[161,243,266,283],"can":[162],"enhance":[163,410],"efficacy":[165,412],"overcome":[170],"OC,":[175],"established":[177],"AVA-resistant":[178,182],"SKOV3":[179,212,275,289,352],"model.":[180,276],"In":[181],"mice":[183],"treated":[184],"+":[187],"5`-Aza,":[188],"there":[189],"was":[190,222,229,256],"statistically":[192],"significant":[193,341],"reduction":[194,342],"weight":[197,287,316,345],"(p=0.03).":[198],"Next,":[199],"Human":[203],"450k":[204],"mRNA":[207],"arrays":[208],"from":[209],"xenografts":[210],"tumors.":[213],"Based":[214],"on":[215],"both":[216,375],"analyses,":[217],"demonstrated":[219],"that":[220,253],"BARD1":[221,254,298,318,332,348,357,367,390,443],"one":[223],"top":[226],"candidate":[227],"which":[228],"highly":[230],"expressed":[231],"(p=0.02)":[232],"less":[234],"methylated":[235],"(p<0.05)":[236],"combination":[239,260,279,305],"group":[244,312,350],"compared":[245,307],"alone.":[248],"data":[250,338],"also":[251],"showed":[252,339,359],"expression":[255,299,319,368,404],"restored":[257],"sequential":[263],"reverted":[267],"towards":[270],"Furthermore,":[277],"significantly":[284],"decreased":[285,371],"(p=0.005),":[290],"IG10":[291],"(p<0.05),":[292],"MDA-OVCA1":[293],"(p=0.01),":[294],"HT1080":[296],"(p<0.05).":[297],"levels":[300,369],"substantially":[302],"increased":[303],"alone":[311],"(>4-fold,":[313],"p=0.006).":[314],"Tumor":[315],"inversely":[321],"correlated.":[322],"significance":[327],"knockdown":[331,349,358],"Tet-inducible":[334],"shRNA":[335],"system.":[336],"model":[353],"(p=0.021).":[354],"RNA-sequencing":[355],"enrichment":[361],"pathway.":[365],"Moreover,":[366],"hypoxic":[373],"conditions":[374],"vivo.":[380],"Conclusion:":[381],"findings":[383],"indicate":[384],"previously":[386],"unrecognized":[387],"mediating":[392],"Use":[397],"drugs":[400],"control":[402],"suppressor":[407],"genes":[408],"may":[409],"OC.":[417],"Citation":[418],"Format:":[419],"Emine":[420],"Bayraktar,":[421],"Cristian":[422],"Rodriguez-Aguayo,":[423],"Sudhir":[424],"Kumar,":[425],"Elaine":[426],"Stur,":[427],"Lingegowda":[428],"S.":[429],"Mangala,":[430],"Stephen":[431],"Baylin,":[432],"Gabriel":[433],"Lopez-Berestein,":[434],"Sunila":[435],"Pradeep,":[436],"Anil":[437],"K.":[438],"Sood.":[439],"Epigenetic":[440],"regulation":[441],"confers":[444],"[abstract].":[452],"In:":[453],"Proceedings":[454],"American":[457],"Association":[458],"Cancer":[460,479],"Research":[461],"Annual":[462],"Meeting":[463],"2023;":[464],"Part":[465],"1":[466],"(Regular":[467],"Invited":[469],"Abstracts);":[470],"2023":[471],"Apr":[472],"14-19;":[473],"Orlando,":[474],"FL.":[475],"Philadelphia":[476],"(PA):":[477],"AACR;":[478],"Res":[480],"2023;83(7_Suppl):Abstract":[481],"nr":[482],"6001.":[483]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2023-04-06T00:00:00"}