{"id":"https://openalex.org/W4362592565","doi":"https://doi.org/10.1158/1538-7445.am2023-4775","title":"Abstract 4775: Knockout of Sod2 accelerates KrasG12D-driven formation of pancreatic cancerous lesions","display_name":"Abstract 4775: Knockout of Sod2 accelerates KrasG12D-driven formation of pancreatic cancerous lesions","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362592565","doi":"https://doi.org/10.1158/1538-7445.am2023-4775"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2023-4775","doi":"https://doi.org/10.1158/1538-7445.am2023-4775","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-4775","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064032500","display_name":"Alicia K. Fleming Martinez","orcid":"https://orcid.org/0000-0003-0319-9994","observed_orcids":["https://orcid.org/0000-0003-0319-9994"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alicia K. Fleming Martinez","raw_affiliation_strings":["1Mayo Clinic, Jacksonville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Jacksonville, FL;","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063883874","display_name":"Brandy H. Edenfield","orcid":"https://orcid.org/0009-0005-5571-9500","observed_orcids":["https://orcid.org/0009-0005-5571-9500"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandy H. Edenfield","raw_affiliation_strings":["1Mayo Clinic, Jacksonville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Jacksonville, FL;","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063785731","display_name":"Ir\u00e9ne Esposito","orcid":"https://orcid.org/0000-0002-0554-2402","observed_orcids":["https://orcid.org/0000-0002-0554-2402","https://orcid.org/0009-0001-4668-4642"]},"institutions":[{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Irene Esposito","raw_affiliation_strings":["2Heinrich-Heine-University and University Hospital Duesseldorf, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Heinrich-Heine-University and University Hospital Duesseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I4210089242","https://openalex.org/I44260953"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064581175","display_name":"Peter St\u00f6rz","orcid":"https://orcid.org/0000-0002-0132-5128","observed_orcids":["https://orcid.org/0000-0002-0132-5128"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Storz","raw_affiliation_strings":["1Mayo Clinic, Jacksonville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Jacksonville, FL;","institution_ids":["https://openalex.org/I4210146710"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"7_Supplement","first_page":"4775","last_page":"4775"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/manganese-superoxide-dismutase","display_name":"manganese superoxide dismutase","score":0.8989999890327454},{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.8519999980926514},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/acinar-to-ductal-metaplasia","display_name":"acinar-to-ductal metaplasia","score":0.9539999961853027},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.890999972820282},{"id":"https://openalex.org/keywords/mitochondrial-superoxide","display_name":"mitochondrial superoxide","score":0.6399999856948853},{"id":"https://openalex.org/keywords/pancreatic-intraepithelial-neoplasia","display_name":"pancreatic intraepithelial neoplasia","score":0.8849999904632568},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.6039999723434448},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C2776108821","wikidata":"https://www.wikidata.org/wiki/Q15335612","display_name":"SOD2","level":4,"score":0.8967878818511963},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.8542038202285767},{"id":"https://openalex.org/C2909925829","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic Intraepithelial Neoplasia","level":5,"score":0.5823131203651428},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5417052507400513},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.541537880897522},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5125162601470947},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.5086337327957153},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4992389678955078},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37869468331336975},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.3661680221557617},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3134838044643402},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3106813430786133},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.21294546127319336},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.1717233657836914},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13477420806884766},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06341475248336792}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2023-4775","doi":"https://doi.org/10.1158/1538-7445.am2023-4775","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-4775","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416786243","https://openalex.org/W4282941376","https://openalex.org/W7212397161","https://openalex.org/W2753872506","https://openalex.org/W2125785124","https://openalex.org/W4362594974","https://openalex.org/W2944883406","https://openalex.org/W4380030048","https://openalex.org/W1562677986","https://openalex.org/W4393096638"],"abstract_inverted_index":{"Abstract":[0],"Recent":[1],"studies":[2,42],"demonstrate":[3],"that":[4,35,45,152],"mitochondrially-generated":[5],"reactive":[6],"oxygen":[7],"species":[8],"(ROS)":[9],"downstream":[10],"of":[11,53,75,98,127,139,172,188,193,200],"oncogenic":[12],"KRAS":[13],"drive":[14],"acinar-to-ductal":[15],"metaplasia":[16],"(ADM),":[17],"a":[18,32,59,89,166],"key":[19,167],"first":[20],"step":[21],"in":[22,63,83,91,100],"the":[23,51,68,96,111,201],"pancreatic":[24,54,77,101,194],"ductal":[25],"adenocarcinoma":[26],"(PDA)":[27],"progression":[28,148],"model.":[29,115],"MnSOD/SOD2":[30],"is":[31,47,81,158],"mitochondrial":[33,69],"enzyme":[34],"converts":[36],"superoxide":[37],"into":[38,110],"hydrogen":[39],"peroxide.":[40],"Previous":[41],"have":[43],"shown":[44],"SOD2":[46,60],"biologically":[48],"relevant":[49],"to":[50,149],"study":[52],"cancer.":[55,78],"Some":[56],"patients":[57],"with":[58],"polymorphism":[61],"resulting":[62],"less":[64],"active":[65],"MnSOD":[66,80,99,164],"at":[67,72],"matrix":[70],"are":[71],"increased":[73,118],"risk":[74],"developing":[76],"Additionally,":[79],"lost":[82],"high-grade":[84],"human":[85],"PanIN,":[86],"further":[87],"suggesting":[88,151],"role":[90,97],"tumor":[92],"development.":[93],"To":[94],"elucidate":[95],"cancer":[102],"initiation":[103,171],"and":[104,125,141,213],"progression,":[105],"we":[106,162],"crossed":[107],"Sod2lox/lox":[108],"mice":[109,143],"p48Cre;LSL-KrasG12D":[112],"(KC)":[113],"mouse":[114],"We":[116],"found":[117],"ROS,":[119],"abundantly":[120],"more":[121],"abnormal":[122],"tissue":[123],"development":[124],"presence":[126],"flat":[128],"lesions":[129],"indicating":[130],"accelerated":[131],"early":[132],"progression.":[133],"However,":[134],"Kaplan":[135],"Meyer":[136],"survival":[137],"analysis":[138],"KC":[140],"KC;Sod2\u2212/\u2212":[142],"did":[144],"not":[145],"indicate":[146],"faster":[147],"cancer,":[150],"for":[153,204],"later":[154],"steps":[155],"additional":[156],"signaling":[157],"needed.":[159],"In":[160],"summary,":[161],"identify":[163],"as":[165],"antioxidant":[168],"molecule":[169],"preventing":[170],"PDA.":[173],"Citation":[174],"Format:":[175],"Alicia":[176],"K.":[177],"Fleming":[178],"Martinez,":[179],"Brandy":[180],"H.":[181],"Edenfield,":[182],"Irene":[183],"Esposito,":[184],"Peter":[185],"Storz.":[186],"Knockout":[187],"Sod2":[189],"accelerates":[190],"KrasG12D-driven":[191],"formation":[192],"cancerous":[195],"lesions.":[196],"[abstract].":[197],"In:":[198],"Proceedings":[199],"American":[202],"Association":[203],"Cancer":[205,224],"Research":[206],"Annual":[207],"Meeting":[208],"2023;":[209],"Part":[210],"1":[211],"(Regular":[212],"Invited":[214],"Abstracts);":[215],"2023":[216],"Apr":[217],"14-19;":[218],"Orlando,":[219],"FL.":[220],"Philadelphia":[221],"(PA):":[222],"AACR;":[223],"Res":[225],"2023;83(7_Suppl):Abstract":[226],"nr":[227],"4775.":[228]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2023-04-06T00:00:00"}
