{"id":"https://openalex.org/W4362592296","doi":"https://doi.org/10.1158/1538-7445.am2023-pl05-02","title":"Abstract PL05-02: To the tumor and beyond: Tales of a holistic miRNA delivery vehicle","display_name":"Abstract PL05-02: To the tumor and beyond: Tales of a holistic miRNA delivery vehicle","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362592296","doi":"https://doi.org/10.1158/1538-7445.am2023-pl05-02"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2023-pl05-02","doi":"https://doi.org/10.1158/1538-7445.am2023-pl05-02","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-pl05-02","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082310628","display_name":"Andrea L. Kasinski","orcid":"https://orcid.org/0000-0002-9602-7827","observed_orcids":["https://orcid.org/0000-0002-9602-7827"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrea L. Kasinski","raw_affiliation_strings":["1Purdue University, West Lafayette, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Purdue University, West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082310628"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"7_Supplement","first_page":"PL05","last_page":"02"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna-delivery","display_name":"microRNA delivery","score":0.9350000023841858},{"id":"https://openalex.org/keywords/rnai-therapeutics","display_name":"RNAi therapeutics","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.4519999921321869},{"id":"https://openalex.org/keywords/ligand-receptor-targeting","display_name":"ligand-receptor targeting","score":0.7300000190734863},{"id":"https://openalex.org/keywords/endosomal-escape","display_name":"endosomal escape","score":0.8709999918937683},{"id":"https://openalex.org/keywords/rna-stabilization","display_name":"RNA stabilization","score":0.6819999814033508},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.5659999847412109},{"id":"https://openalex.org/keywords/central-nervous-system-tumors","display_name":"central nervous system tumors","score":0.8889999985694885},{"id":"https://openalex.org/keywords/rna-therapeutics","display_name":"RNA therapeutics","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.6296053528785706},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5712413787841797},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.4633062481880188},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4622516334056854},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40970391035079956},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38064250349998474},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.333176851272583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3204098045825958},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22209715843200684},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.19447895884513855},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16543573141098022},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12841451168060303}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2023-pl05-02","doi":"https://doi.org/10.1158/1538-7445.am2023-pl05-02","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-pl05-02","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404348925","https://openalex.org/W4306836696","https://openalex.org/W2045061077","https://openalex.org/W2237638674","https://openalex.org/W145962862","https://openalex.org/W7061752044","https://openalex.org/W4210912223","https://openalex.org/W3183169161","https://openalex.org/W7119139357","https://openalex.org/W1973453901"],"abstract_inverted_index":{"Abstract":[0],"Like":[1],"the":[2,8,20,24,33,48,59,67,88,121,125,129,133,157,164,178,181,186,190,199,202,208,252,268,273,277,283,293,310,325],"challenges":[3,274],"and":[4,58,111,173,201,223,228,282,312,337],"skepticism":[5],"that":[6,85,142,150,219,244,285],"faced":[7],"antibody":[9,25],"therapeutics":[10,17,26,38,300],"field":[11],"over":[12],"a":[13,137,170,316],"decade":[14],"ago,":[15],"RNA":[16,37,126,165,182,209],"is":[18,43,76,103,166,177,192,259],"facing":[19],"same.":[21],"And,":[22],"like":[23],"field,":[27],"we":[28,233,275,279],"are":[29,151],"beginning":[30],"to":[31,54,66,73,105,107,128,215,255,288],"realize":[32],"clinical":[34,294],"impact":[35],"of":[36,51,83,90,98,153,163,169,247,296,315,324],"amiss":[39],"these":[40,248],"challenges.":[41],"This":[42],"most":[44],"clearly":[45],"highlighted":[46],"with":[47,80,237],"recent":[49],"approval":[50],"mRNA":[52],"vaccines":[53],"prevent":[55],"against":[56],"SARS-CoV-2":[57],"first":[60],"FDA":[61],"approved":[62],"RNAi":[63,92,109],"drugs":[64,71],"targeted":[65,72],"liver.":[68],"Unfortunately,":[69],"RNA-based":[70],"cancer":[74],"cells":[75],"lagging":[77],"behind,":[78],"even":[79],"countless":[81],"years":[82],"work":[84,227],"has":[86],"revealed":[87],"power":[89],"using":[91],"for":[93,263,328],"treating":[94],"oncological":[95],"diseases.":[96],"Lack":[97],"success":[99,290],"in":[100,230,267,291],"this":[101,231],"space":[102],"attributed":[104],"inability":[106],"deliver":[108,124],"safely":[110],"effectively.":[112],"A":[113],"successful":[114,257],"delivery":[115,162,258,319],"agent":[116,122,134],"requires":[117],"multiple":[118],"features.":[119,250],"First,":[120],"must":[123,135,183],"specifically":[127],"intended":[130],"cells.":[131],"Second,":[132],"have":[136,234,280],"large":[138],"therapeutic":[139,158],"window,":[140],"meaning":[141],"toxicity,":[143],"if":[144,161,195],"observed,":[145],"should":[146,210],"occur":[147],"at":[148],"doses":[149],"orders":[152],"magnitude":[154],"higher":[155],"than":[156],"dose.":[159],"Third,":[160],"by":[167],"way":[168],"specific":[171],"ligand":[172,200,253],"receptor":[174,203],"pair,":[175],"as":[176,298],"case":[179],"herein,":[180],"successfully":[184],"escape":[185],"endosome.":[187],"Simply":[188],"swelling":[189],"endosome":[191],"not":[193],"enough":[194],"noncovalent":[196],"interactions":[197],"between":[198],"cannot":[204],"be":[205,302],"disrupted.":[206],"Fourth,":[207],"include":[211],"appropriate":[212],"stabilizing":[213],"modifications":[214],"increase":[216],"intracellular":[217],"half-life":[218],"will":[220,301],"reduce":[221],"dosing":[222],"cost.":[224],"Through":[225],"hard":[226],"dedication":[229],"space,":[232],"come":[235],"up":[236],"an":[238],"inclusive,":[239],"easily":[240],"synthesized,":[241],"intramolecular":[242],"molecule":[243],"achieves":[245],"all":[246],"essential":[249],"Moreover,":[251],"used":[254],"achieve":[256,289],"also":[260],"being":[261],"evaluated":[262],"imaging":[264],"tumors":[265],"localized":[266],"central":[269],"nervous":[270],"system.":[271],"Here,":[272],"face,":[276],"hurdles":[278],"overcome,":[281],"barriers":[284],"still":[286],"remain":[287],"revealing":[292],"potential":[295],"miRNA":[297,318],"anti-cancer":[299],"presented.":[303],"Citation":[304],"Format:":[305],"Andrea":[306],"L.":[307],"Kasinski.":[308],"To":[309],"tumor":[311],"beyond:":[313],"Tales":[314],"holistic":[317],"vehicle.":[320],"[abstract].":[321],"In:":[322],"Proceedings":[323],"American":[326],"Association":[327],"Cancer":[329,348],"Research":[330],"Annual":[331],"Meeting":[332],"2023;":[333],"Part":[334],"1":[335],"(Regular":[336],"Invited":[338],"Abstracts);":[339],"2023":[340],"Apr":[341],"14-19;":[342],"Orlando,":[343],"FL.":[344],"Philadelphia":[345],"(PA):":[346],"AACR;":[347],"Res":[349],"2023;83(7_Suppl):Abstract":[350],"nr":[351],"PL05-02.":[352]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2023-04-06T00:00:00"}
