{"id":"https://openalex.org/W4362575145","doi":"https://doi.org/10.1016/j.intimp.2023.110105","title":"Klotho alleviates contrast-induced acute kidney injury by suppressing oxidative stress, inflammation, and NF-KappaB/NLRP3-mediated pyroptosis","display_name":"Klotho alleviates contrast-induced acute kidney injury by suppressing oxidative stress, inflammation, and NF-KappaB/NLRP3-mediated pyroptosis","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362575145","doi":"https://doi.org/10.1016/j.intimp.2023.110105","pmid":"https://pubmed.ncbi.nlm.nih.gov/37018977"},"language":"en","primary_location":{"id":"doi:10.1016/j.intimp.2023.110105","doi":"https://doi.org/10.1016/j.intimp.2023.110105","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.intimp.2023.110105","pdf_url":null,"source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4362575145"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-1679704/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100560640","display_name":"Yanbin Fu","orcid":"https://orcid.org/0009-0008-9676-4246","observed_orcids":["https://orcid.org/0009-0008-9676-4246"]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanbin Fu","raw_affiliation_strings":["Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, PR China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jianfeng Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianfeng Cao","raw_affiliation_strings":["Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, PR China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074464132","display_name":"Xuebiao Wei","orcid":"https://orcid.org/0000-0002-1279-9441","observed_orcids":["https://orcid.org/0000-0002-1279-9441"]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuebiao Wei","raw_affiliation_strings":["Department of Geriatric Intensive Medicine, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Intensive Medicine, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, PR China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068688179","display_name":"Yanzhi Ge","orcid":"https://orcid.org/0000-0002-3666-5835","observed_orcids":["https://orcid.org/0000-0002-3666-5835"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanzhi Ge","raw_affiliation_strings":["The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, PR China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014856931","display_name":"Zedazhong Su","orcid":"https://orcid.org/0000-0003-3168-687X","observed_orcids":["https://orcid.org/0000-0003-3168-687X"]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zedazhong Su","raw_affiliation_strings":["Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, PR China. Electronic address: 673946537@qq.com","Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, PR China. Electronic address: 673946537@qq.com","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, PR China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114046242","display_name":"Danqing Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Danqing Yu","raw_affiliation_strings":["Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, PR China. Electronic address: yudanqing2017@126.com","Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, PR China"],"raw_orcid":"https://orcid.org/0000-0003-3168-687X","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, PR China. Electronic address: yudanqing2017@126.com","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, PR China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5014856931","https://openalex.org/A5114046242"],"corresponding_institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"],"apc_list":{"value":2930,"currency":"USD","value_usd":2930},"apc_paid":null,"fwci":14.7534,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.99472553,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"118","issue":null,"first_page":"110105","last_page":"110105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/klotho","display_name":"Klotho","score":0.953000009059906},{"id":"https://openalex.org/keywords/contrast-induced-nephropathy","display_name":"contrast-induced nephropathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7870000004768372},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8270000219345093},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":1.0},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.925000011920929},{"id":"https://openalex.org/keywords/gasdermin-d","display_name":"gasdermin D","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hk-2-cells","display_name":"HK-2 cells","score":0.7459999918937683},{"id":"https://openalex.org/keywords/contrast-media","display_name":"contrast media","score":0.44699999690055847},{"id":"https://openalex.org/keywords/percutaneous-coronary-intervention","display_name":"percutaneous coronary intervention","score":0.7889999747276306},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C9832595","wikidata":"https://www.wikidata.org/wiki/Q414050","display_name":"Klotho","level":3,"score":0.7966752052307129},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7264115810394287},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.6471621990203857},{"id":"https://openalex.org/C17172800","wikidata":"https://www.wikidata.org/wiki/Q7263707","display_name":"Pyroptosis","level":4,"score":0.631176769733429},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5381615161895752},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.5094547867774963},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5057353973388672},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5010063648223877},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46273764967918396},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.46192285418510437},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.42581063508987427},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4165263772010803},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.37268131971359253},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.348396360874176},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3483259677886963},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3315664231777191},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3308963179588318},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2804756462574005},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2777964472770691},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23382386565208435},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.22644048929214478},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22607973217964172},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069292","descriptor_name":"Pyroptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020170","descriptor_name":"Caspase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.intimp.2023.110105","doi":"https://doi.org/10.1016/j.intimp.2023.110105","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.intimp.2023.110105","pdf_url":null,"source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-1679704/v1","doi":"https://doi.org/10.21203/rs.3.rs-1679704/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1679704/v1","pdf_url":"https://www.researchsquare.com/article/rs-1679704/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:37018977","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37018977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International immunopharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-1679704/v1","doi":"https://doi.org/10.21203/rs.3.rs-1679704/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1679704/v1","pdf_url":"https://www.researchsquare.com/article/rs-1679704/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1313086315","display_name":null,"funder_award_id":"2021A1515010107","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G5747817345","display_name":null,"funder_award_id":"82002014","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6257149322","display_name":null,"funder_award_id":"20221003","funder_id":"https://openalex.org/F4320326710","funder_display_name":"Traditional Chinese Medicine Bureau of Guangdong Province"},{"id":"https://openalex.org/G894417684","display_name":null,"funder_award_id":"201903010097","funder_id":"https://openalex.org/F4320334898","funder_display_name":"Guangzhou Science and Technology Program key projects"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null},{"id":"https://openalex.org/F4320326710","display_name":"Traditional Chinese Medicine Bureau of Guangdong Province","ror":"https://ror.org/05vkkzf98"},{"id":"https://openalex.org/F4320329842","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45"},{"id":"https://openalex.org/F4320334898","display_name":"Guangzhou Science and Technology Program key projects","ror":"https://ror.org/00tjzgn92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362575145.pdf","grobid_xml":"https://content.openalex.org/works/W4362575145.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W136572523","https://openalex.org/W1633601200","https://openalex.org/W1964991771","https://openalex.org/W2033637369","https://openalex.org/W2050318470","https://openalex.org/W2060748039","https://openalex.org/W2106414700","https://openalex.org/W2158985428","https://openalex.org/W2162130726","https://openalex.org/W2302265358","https://openalex.org/W2322787356","https://openalex.org/W2583017311","https://openalex.org/W2584008148","https://openalex.org/W2611482243","https://openalex.org/W2627048017","https://openalex.org/W2749627810","https://openalex.org/W2762503592","https://openalex.org/W2767013739","https://openalex.org/W2769652680","https://openalex.org/W2789997601","https://openalex.org/W2890868108","https://openalex.org/W2901082414","https://openalex.org/W2943810953","https://openalex.org/W2951593518","https://openalex.org/W2954782052","https://openalex.org/W2974521425","https://openalex.org/W2975273448","https://openalex.org/W3004020095","https://openalex.org/W3004482242","https://openalex.org/W3017203713","https://openalex.org/W3038120084","https://openalex.org/W3093168637","https://openalex.org/W3093586967","https://openalex.org/W3130066741","https://openalex.org/W3134716288","https://openalex.org/W3164924536","https://openalex.org/W4237441880","https://openalex.org/W4248433764","https://openalex.org/W6636703200","https://openalex.org/W6791125133"],"related_works":["https://openalex.org/W2968201998","https://openalex.org/W3134716288","https://openalex.org/W3012276939","https://openalex.org/W4404430978","https://openalex.org/W7161788945","https://openalex.org/W3110599371","https://openalex.org/W4407813312","https://openalex.org/W2017130518","https://openalex.org/W2782893368","https://openalex.org/W3004020095"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Contrast-induced":[2],"acute":[3],"kidney":[4,197],"injury":[5,79],"(CI-AKI)":[6],"is":[7,27,42],"a":[8,28,246],"common":[9],"complication":[10],"following":[11],"percutaneous":[12],"coronary":[13,16],"intervention":[14],"in":[15,40,55,145,204],"artery":[17],"disease":[18],"(CAD)":[19],"patients":[20],"with":[21],"more":[22],"than":[23],"30%":[24],"incidence.":[25],"Klotho":[26,194,208],"multifunctional":[29],"protein":[30,179,233],"that":[31,243],"inhibits":[32],"oxidative":[33,212,253],"stress":[34,111,213],"and":[35,60,75,93,97,104,123,134,143,154,177,185,200,214,219,230,237,256],"inflammation,":[36],"but":[37],"its":[38],"role":[39],"CI-AKI":[41,250],"poorly":[43],"understood.":[44],"The":[45,170,240],"present":[46],"study":[47],"aimed":[48],"to":[49,156,260],"explore":[50],"the":[51,86,146,165,226,261],"effects":[52],"of":[53,168,172,181,216,228,264],"klohto":[54],"CI-AKI.":[56,265],"Methods":[57],"Six-week-old":[58],"mice":[59],"HK-2":[61],"were":[62,99,126,149,187],"divided":[63],"into":[64],"control":[65],"group,":[66,70,74],"contrast":[67],"medium":[68],"(CM)":[69],"CM":[71],"+":[72],"klotho":[73,76,224,244],"group.":[77],"Kidney":[78],"was":[80,89],"evaluated":[81],"by":[82,91,101,128,151,189],"HE":[83],"staining.":[84],"And":[85],"renal":[87,202],"function":[88,203],"shown":[90],"Scr":[92],"BUN.":[94],"Cell":[95],"viability":[96],"damage":[98],"determined":[100],"CCK-8":[102],"assay":[103,137,153],"lactate":[105],"dehydrogenase":[106],"(LDH)":[107],"activity":[108],"assay.":[109,139],"Oxidative":[110],"related":[112],"indicators":[113],"including":[114],"intracellular":[115],"reactive":[116],"oxygen":[117],"species":[118],"(ROS),":[119],"superoxidase":[120],"dismutase":[121],"(SOD),":[122],"malondialdehyde":[124],"(MDA)":[125],"tested":[127,150],"fluorescent":[129],"probe":[130],"dichloro-dihydro-fluorescein":[131],"diacetate":[132],"(DCFH-DA)":[133],"enzyme-linked":[135],"immunosorbent":[136],"(ELISA)":[138],"IL-6,":[140],"TNF-\u03b1,":[141],"IL-1\u03b2,":[142],"IL-18":[144],"cell":[147,166],"supernatant":[148],"ELISA":[152],"used":[155],"reflect":[157],"inflammation":[158,255],"responses.":[159],"Propidium":[160],"iodide":[161],"(PI)":[162],"staining":[163],"showed":[164],"death":[167],"HK-2.":[169],"expression":[171],"NF-\u03baB,":[173],"phosphorylated":[174],"NF-\u03baB":[175],"(p-NF-\u03baB),":[176],"pyroptosis-related":[178,232],"levels":[180],"NLRP3,":[182],"caspase-1,":[183,235],"GSDMD,":[184,236],"cleaved-GSDMD":[186],"detected":[188],"western":[190],"blot.":[191],"Results":[192],"Exogenous":[193],"administration":[195],"reduced":[196],"histopathological":[198],"alterations":[199],"improved":[201],"vivo.":[205],"In":[206],"vitro,":[207],"significantly":[209],"inhibited":[210,225],"CM-induced":[211],"productions":[215],"both":[217],"IL-6":[218],"TNF-\u03b1.":[220],"Moreover,":[221],"we":[222],"found":[223],"activation":[227],"p-NF-\u03baB":[229],"down-regulated":[231],"(NLRP3,":[234],"cleaved-GSDMD).":[238],"Conclusion":[239],"findings":[241],"suggested":[242],"had":[245],"protective":[247],"effect":[248],"on":[249],"via":[251],"suppressing":[252],"stress,":[254],"NF-\u03baB/NLRP3-mediated":[257],"pyroptosis,":[258],"contributing":[259],"potential":[262],"therapy":[263]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":31},{"year":2024,"cited_by_count":36},{"year":2023,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-04-06T00:00:00"}
